Expression and Clinical Significance of Survivin in Cervical Cancer: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 ZHANGJing ¹ , WANGYu-juan ¹ , HUOJun-ling ¹ , ZHANGLi ¹ ,  WANGZan-hong ²

1. Shanxi Medical University, Taiyuan 030001, China;
2. Department of Gynecology, Shanxi Academy of Medical Sciences, Shanxi Da Yi Hospital, Taiyuan 030032, China;

Corresponding author：

WANGZan-hong, Email: wangzanhong@126.com

Keywords：

Survivin; Cervical cancer; Systematic review; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.20140038

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the correlation between the expression of survivin and cervical cancer and its clinical pathologic features. Methods Systematic and comprehensive literature was searched in The Cochrane Library (Issue 1, 2013), PubMed, MEDLINE (Ovid), CNKI, CBM and WanFang Data from inception to May 2013, to retrieve case-control studies published in the foreign and domestic areas on the correlation between the expression of survivin and cervical cancer and its clinical pathologic features. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted the data, and evaluated the quality of the included studies. Then meta-analysis was conducted using RevMan 5.1 software. Results A total of 13 studies involving 1 530 women (658 cervical cancer patients, 563 cervical intraepithelial neoplasis (CIN), 658 normal cervical. The results of meta-analysis showed that, a) as for the positive rate of survivin expression, significant differences were found between cervical cancer and CIN (OR=4.63, 95%CI 3.49 to 6.13, P < 0.000 01), cervical cancer and normal cervical tissues (OR=38.23, 95%CI 23.92 to 61.11, P < 0.000 01), and CIN and normal cervical tissues (OR=9.61, 95%CI 6.11 to 15.09, P < 0.000 01). b) Significant differences were found between clinical stages Ⅰ-Ⅱ and clinical stages Ⅲ-Ⅳ (OR=0.17, 95%CI 0.07 to 0.41, P < 0.000 1), cervical cancer with lymph node metastasis and that without lymph node metastasis (OR=3.57, 95%CI 2.20 to 5.78, P < 0.000 01), high and moderate/low differentiated ESCC tissues (OR=0.31, 95%CI 0.13 to 0.76, P=0.01), and shallow and deep muscular infiltration (OR=0.12, 95%CI 0.02 to 0.68, P=0.02). No significant difference was found between cervical cancer with laterouterus or haemal infiltration and that without latero-uterus or haemal infiltration (OR=24.15, 95%CI 0.07 to 8 199.76, P=0.28). Conclusion Current foreign and domestic evidence shows that, survivin expression is significantly correlated to cervical cancer and its clinically pathologic features, which may participate in the whole course of carcinogenesis of cervical cancer, but it is not considered to be an absolute factor for estimating the survival rate of patients with cervical cancer. Due to the quality limitation of the included studies, more large scale, well-designed and high quality studies are needed for further verifying the aforementioned conclusion.

Citation： ZHANGJing, WANGYu-juan, HUOJun-ling, ZHANGLi, WANGZan-hong. Expression and Clinical Significance of Survivin in Cervical Cancer: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2014, 14(2): 216-224. doi: 10.7507/1672-2531.20140038 Copy

1.	Parking DM, Bray F, Ferlay J, et al. Global cancer statistics in 2002. CA Cancer J Clin, 2005, 55(2):74-108.
2.	Elliott PM, Tattersall MH, Coppleson M, et al. Changing character of cervical cancer in young women. Br Med J, 1989, 298(2):288-290.
3.	Uchida H, Tanaka T, Sasaki K, et al. Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo. Mol Ther, 2004, 10(1):162-171.
4.	顾美芳, 张美云, 庄讯.宫颈癌组织中survivin基因表达的临床意义.南京医科大学学报, 2008, 28(2):232-235.
5.	Wells G, Shea B, ÓConnell D, et al. Newcastle-Ottawa Quality Assessment Scale-Case Control Studies.[2012-06-15]. Available at: http://www.ohri.ca/programs/clinical-epidemiology/oxford-asp.
6.	Ambrosini G, Adida DC, Airier DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med, 1997, 3(8):917-921.
7.	Lee JP, Chang KH, Han JH, et al. Survivin, a novel anti-apoptosis inhibitor, expression in uterine cervical cancer and relationship with prognostic factors. Int J Gynecol Cancer, 2005, 15(1):113-119.
8.	刘凤英, 徐晓明, 刘毅智, 等.子宫颈癌组织中人乳头状瘤病毒16 E6 mRNA表达与survivin蛋白表达的相关性.中华妇产科杂志, 2005, 40(9):627-630.
9.	李鲁宏, 张鹏飞.抑癌基因Fhit基因及凋亡抑制蛋白Survivin在宫颈鳞状细胞癌组织中的表达及其意义.福州:福建医科大学, 2005.
10.	褚静萍, 王言奎. Survivin在宫颈鳞癌组织中的表达及其与p53基因表达和HPV-16感染相关性的研究.青岛:青岛大学, 2005.
11.	Mu YQ, Liu RH, Zhau FX. Analyses of Bcl-2, Survivin, and CD44v6 expressions and human papillomavirus infection in cervical carcinomas. Scand J Infect Dis, 2007, 39(5):441-448.
12.	张培荣, 郑锦花, 王艳萍, 等. Survivin和PTEN蛋白在宫颈鳞状细胞癌中的表达及临床意义.临床肿瘤学杂志, 2007, 12(4):271-275.
13.	马宁, 李小姝, 张婵丽, 等. Survivin与MIF在宫颈癌组织中的表达及意义.肿瘤基础与临床, 2008, 21(5):388-391.
14.	李娜, 贾金华. CyclinE、Survivin及HPV16-E6蛋白在宫颈上皮癌变过程中的表达及意义.石家庄:河北医科大学, 2008.
15.	王秋兰.宫颈癌中Ezrin和Survivin的表达及其与浸润和转移的关系.中国妇幼保健, 2010, 25(10):1405-1407.
16.	徐雅会, 王德华. Survivin与Ki67在宫颈癌中的表达及相关性研究.天津:天津医科大学, 2010.
17.	罗靖, 左巧富, 王玮. Survivin和p16INK4a在宫颈癌及其癌前病变中的表达及相关性.医学临床研究, 2010, 27(6):1031-1034.
18.	王会娟, 刘玉玲. Survivin、FHIT及bFGF在宫颈鳞癌组织中的表达及意义.郑州:郑州大学, 2011.
19.	Wu SF, Zhang JW, Qian WY, et al. Altered expression of survivin, Fas and FasL contributed to cervical cancer development and metastasis. Eur Rev Med Pharmacol Sci, 2012, 16(15):2044-2050.
20.	Sauber RH, Mann W, Knauer SK. Nuclear and cytoplasmic survivin:molectular mechanism, prognostic, and therapeutic potential. Cancer Res, 2007, 67(13):5999-6002.
21.	董德刚, 郭恩绵, 张瑶, 等.白藜芦醇对宫颈癌HeLa细胞基质金属蛋白酶及其组织抑制剂的影响.中华肿瘤防治杂志, 2007, 14(7):489-491.
22.	Lu S, Zhang B, Wang Z. Expression of survivin, cyclin d1, p21waf1, caspase-3 in cervical cancer and its relation with prognosis. J Huazhong Univ Sci Technolog Med Sci, 2005, 25(1):78-81.
23.	Lu D, Qian J, Yin X, et al. Expression of PTEN and survivin in cervical cancer promising biological markers for early diagnosis and prognostic evaluation. Br J Biomed Sci, 2012, 69(4):143-146.
24.	朗雁, 熊永炎, 陈惠桢.宫颈癌前病变和宫颈癌组织中凋亡相关基因survivin的表达及其与人乳头状瘤病毒感染的关系.第一军医大学学报, 2005, 25(10):1276-1279.
25.	李淼, 钱智, 韩晓宇.宫颈癌组织survivin与VEGF表达及其生物学意义的探讨.中华肿瘤防治杂志, 2011, 18(22):1786-1788.

1. Parking DM, Bray F, Ferlay J, et al. Global cancer statistics in 2002. CA Cancer J Clin, 2005, 55(2):74-108.
2. Elliott PM, Tattersall MH, Coppleson M, et al. Changing character of cervical cancer in young women. Br Med J, 1989, 298(2):288-290.
3. Uchida H, Tanaka T, Sasaki K, et al. Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo. Mol Ther, 2004, 10(1):162-171.
4. 顾美芳, 张美云, 庄讯.宫颈癌组织中survivin基因表达的临床意义.南京医科大学学报, 2008, 28(2):232-235.
5. Wells G, Shea B, ÓConnell D, et al. Newcastle-Ottawa Quality Assessment Scale-Case Control Studies.[2012-06-15]. Available at: http://www.ohri.ca/programs/clinical-epidemiology/oxford-asp.
6. Ambrosini G, Adida DC, Airier DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med, 1997, 3(8):917-921.
7. Lee JP, Chang KH, Han JH, et al. Survivin, a novel anti-apoptosis inhibitor, expression in uterine cervical cancer and relationship with prognostic factors. Int J Gynecol Cancer, 2005, 15(1):113-119.
8. 刘凤英, 徐晓明, 刘毅智, 等.子宫颈癌组织中人乳头状瘤病毒16 E6 mRNA表达与survivin蛋白表达的相关性.中华妇产科杂志, 2005, 40(9):627-630.
9. 李鲁宏, 张鹏飞.抑癌基因Fhit基因及凋亡抑制蛋白Survivin在宫颈鳞状细胞癌组织中的表达及其意义.福州:福建医科大学, 2005.
10. 褚静萍, 王言奎. Survivin在宫颈鳞癌组织中的表达及其与p53基因表达和HPV-16感染相关性的研究.青岛:青岛大学, 2005.
11. Mu YQ, Liu RH, Zhau FX. Analyses of Bcl-2, Survivin, and CD44v6 expressions and human papillomavirus infection in cervical carcinomas. Scand J Infect Dis, 2007, 39(5):441-448.
12. 张培荣, 郑锦花, 王艳萍, 等. Survivin和PTEN蛋白在宫颈鳞状细胞癌中的表达及临床意义.临床肿瘤学杂志, 2007, 12(4):271-275.
13. 马宁, 李小姝, 张婵丽, 等. Survivin与MIF在宫颈癌组织中的表达及意义.肿瘤基础与临床, 2008, 21(5):388-391.
14. 李娜, 贾金华. CyclinE、Survivin及HPV16-E6蛋白在宫颈上皮癌变过程中的表达及意义.石家庄:河北医科大学, 2008.
15. 王秋兰.宫颈癌中Ezrin和Survivin的表达及其与浸润和转移的关系.中国妇幼保健, 2010, 25(10):1405-1407.
16. 徐雅会, 王德华. Survivin与Ki67在宫颈癌中的表达及相关性研究.天津:天津医科大学, 2010.
17. 罗靖, 左巧富, 王玮. Survivin和p16INK4a在宫颈癌及其癌前病变中的表达及相关性.医学临床研究, 2010, 27(6):1031-1034.
18. 王会娟, 刘玉玲. Survivin、FHIT及bFGF在宫颈鳞癌组织中的表达及意义.郑州:郑州大学, 2011.
19. Wu SF, Zhang JW, Qian WY, et al. Altered expression of survivin, Fas and FasL contributed to cervical cancer development and metastasis. Eur Rev Med Pharmacol Sci, 2012, 16(15):2044-2050.
20. Sauber RH, Mann W, Knauer SK. Nuclear and cytoplasmic survivin:molectular mechanism, prognostic, and therapeutic potential. Cancer Res, 2007, 67(13):5999-6002.
21. 董德刚, 郭恩绵, 张瑶, 等.白藜芦醇对宫颈癌HeLa细胞基质金属蛋白酶及其组织抑制剂的影响.中华肿瘤防治杂志, 2007, 14(7):489-491.
22. Lu S, Zhang B, Wang Z. Expression of survivin, cyclin d1, p21waf1, caspase-3 in cervical cancer and its relation with prognosis. J Huazhong Univ Sci Technolog Med Sci, 2005, 25(1):78-81.
23. Lu D, Qian J, Yin X, et al. Expression of PTEN and survivin in cervical cancer promising biological markers for early diagnosis and prognostic evaluation. Br J Biomed Sci, 2012, 69(4):143-146.
24. 朗雁, 熊永炎, 陈惠桢.宫颈癌前病变和宫颈癌组织中凋亡相关基因survivin的表达及其与人乳头状瘤病毒感染的关系.第一军医大学学报, 2005, 25(10):1276-1279.
25. 李淼, 钱智, 韩晓宇.宫颈癌组织survivin与VEGF表达及其生物学意义的探讨.中华肿瘤防治杂志, 2011, 18(22):1786-1788.

Chinese Journal of Evidence-Based Medicine

Expression and Clinical Significance of Survivin in Cervical Cancer: A Systematic Review

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content