Subclinical Hypothyroidism of Health Check-up Population of West China Hospital, Sichuan University: A Cross-sectional Study_Chinese Journal of Evidence-Based Medicine

Authors：

 QINKen ¹ , TANGGuo-hua ¹ , LILi ¹ , ZHANGFan ¹ , WUQin-qin ¹ , YANGYing ¹ , HUANGYan ¹ , LIAOXiao-yang ²

1. Department of Health Management Center, West China Hospital of Sichuan University, Chengdu 610041, China;
2. Department of General Medical Center, West China Hospital of Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Hypothyroidism; Subclinical; Metabolic syndrome; Prevalence; Cross-sectional survey

DOI：

10.7507/1672-2531.20140070

Video：

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Objective To investigate the prevalence of subclinical hypothyroidism (SCH) in health check-up population of West China Hospital of Sichuan University from 2011 to 2012 and to discuss the relationship between SCH and metabolic syndrome (MS). Methods Those who received thyroid function tests and health examination in the West China Hospital of Sichuan University from 2011 to 2012 were enrolled in the study. The data of medical history, blood pressure, height, weight, thyroid function, TG, HDL-C, FPG were collected. All data were analyzed by SPSS 18.0 software. Results A total of 11 976 persons (7 488 male and 4 488 female) received thyroid function tests. There were 1 820 persons (884 males and 936 females, 15.20%) who suffered from SCH. The SCH prevalence was significantly higher in females (20.86%) than that in males (11.81%) (P < 0.01). The people over 60 years old had the highest SCH prevalence. There were 1 145 persons (1 005 males and 140 females) suffered from MS among all 11 976 persons. The MS prevalence was significantly higher in males (13.42%) than that in females (3.12%) (P < 0.01). The SCH prevalence of the MS group was higher, which in the health group was lower (P < 0.01). The TSH level in the MS group was higher, while it was lower in the health group. Conclusion The prevalence of SCH is higher in health check-up population; and SCH apparently increases the risk of morbidity of MS.

Citation： QINKen, TANGGuo-hua, LILi, ZHANGFan, WUQin-qin, YANGYing, HUANGYan, LIAOXiao-yang. Subclinical Hypothyroidism of Health Check-up Population of West China Hospital, Sichuan University: A Cross-sectional Study. Chinese Journal of Evidence-Based Medicine, 2014, 14(4): 404-407. doi: 10.7507/1672-2531.20140070 Copy

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2.	Beyhan Z, Ertrk K, Ukaya G, et al.Restoration of euthyroidism does not improve cardiovascular risk factors in patients with subclinical hypothyroidism in the short term.J Endocrinal Invest, 2006, 29(6):505-510.
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8.	王佳妮, 单忠艳, 滕卫平, 等.血清促甲状腺激素与代谢综合征及其组分的相关关系研究.中国实用内科杂志, 2010, 30(6):534-536.
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10.	Duntas LH.Thyroid disease and lipids.Thyroid, 2002, 12(2):287-293.
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12.	王微波, 金迎, 滕卫平.不同碘摄入量地区正常人群血清TSH水平的流行病学对比研究.中华内分泌代谢杂志, 2002, 18(3):355-356.
13.	Bandyopadhyay SK, Basu AK, Pal SK, et al.A study on dyslipidaemia in subclinical hypothyroidism.J Indian Med Assoc, 2006, 104(11):622-626.
14.	Saravanan P, Dayan CM.Thyroid autoantibodies.Endocrinnol Metab North Am, 2001, 30(3):315-338.
15.	Milionis HJ, Efstathiadou Z, Tselepis AD, et al.Lipoprotein (a) levels and apolipoprotein (a) isoform size in patients with subclinical hypothyroidism:effect of treatment with levothyroxine.Thyroid, 2003, 13(3):365-369.
16.	Duggal J, Singh S, Barsano CP, et al.Cardiovascular risk with subclinical hyperthyroidism and hypothyroidism:pathophysiology and management.J Cardiometab Syndr, 2007, 2(3):198-206.
17.	Prisant LM, Gujral JS, Mulloy AL.Hyperthyroidism:a secondary cause of isolated systolic hypertension.J Clin Hypertens, 2006, 8(3):596-599.
18.	蔡云飞, 时景璞.亚临床甲状腺功能减退与收缩压水平的关系.中华流行病学杂志, 2011, 32(1):55-59.
19.	Velkoska NV, Krstevska B, Bosevski M, et al.Dyslipidaemia and hypertension in patients with subclinical hypothyroidism.Prilozi, 2009, 30(2):93-102.
20.	Luboshitzky R, Aviv A, Herer P, et al.Risk factors for cardiovascular disease in women with subclinical hypothyroidism.Thyroid, 2002, 12(5):421-425.
21.	Ferreira MM, Teixeira PF, Mansur VA, et al.Ambulatory blood pressure monitoring in normotensive patients with subclinical hypothyroidism.Arq Bras Cardiol, 2010, 94(6):806-812.
22.	Waterhouse DF, Walsh CD, Sheehan F, et al.An examination of the relationship between normal range thyrotropin and cardiovascular risk parameters:a study in healthy women.Thyroid, 2007, 17(3):243-248.
23.	VondraK, Vrbikova J, Dvorakova K.Thyroid gland disease in adult patients with diabetes mellitus.Minerva Endocrinol, 2005, 30(4):217.
24.	Chen H, Wu T, Jap T, et al.Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in Type 2 diabetic patients.Diabetic Med, 2007, 24(12):1336-1344.
25.	刘建英, 章燕, 陈国兰, 等.亚临床甲状腺功能减退与代谢综合征和糖尿病的相关性研究进展.临床荟萃, 2010, 25(5):449-451.

1. Surks MI, OrtizE, Daniels GH, et al.Subclinical thyroid disease:scientific review and guide lines for diagnosis and management.JAMA, 2004, 291(2):228-238.
2. Beyhan Z, Ertrk K, Ukaya G, et al.Restoration of euthyroidism does not improve cardiovascular risk factors in patients with subclinical hypothyroidism in the short term.J Endocrinal Invest, 2006, 29(6):505-510.
3. Owen PJ, Lazarus JH.Subclinical hypothyroidism:the case for treatment.Trends Endocrinol Metab, 2003, 14(2):257-261.
4. Duntas LH, Wartofsky L.Cardiovascular risk and subclinical hypothyroidism:focus on lipids and new emerging risk factors.What is the evidence?Thyroid, 2007, 17(11):1075-1084.
5. 中华医学会糖尿病学分会代谢综合征研究协作组.中华医学会糖尿病学分会关于代谢综合征的建议.中华糖尿病杂志, 2004, 12(3):156-161.
6. 史轶繁.协和内分泌和代谢学.第2版.科学出版社, 2000:1012.
7. 滕卫平.开展亚临床甲状腺功能减退症的临床研究.中华内分泌代谢杂志, 2004, 20(2):93-95.
8. 王佳妮, 单忠艳, 滕卫平, 等.血清促甲状腺激素与代谢综合征及其组分的相关关系研究.中国实用内科杂志, 2010, 30(6):534-536.
9. Roos A, Bakker SJ, Links TP, et al.Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects.J Clin Endocrinol Metab, 2007, 92(2):491-496.
10. Duntas LH.Thyroid disease and lipids.Thyroid, 2002, 12(2):287-293.
11. Walsh JP, Bremner AP, Bulsara MK, et al.Thyroid dysfunction and serum lipids:a community-based study.Clin Endocrinol (Oxf), 2005, 63(6):670-675.
12. 王微波, 金迎, 滕卫平.不同碘摄入量地区正常人群血清TSH水平的流行病学对比研究.中华内分泌代谢杂志, 2002, 18(3):355-356.
13. Bandyopadhyay SK, Basu AK, Pal SK, et al.A study on dyslipidaemia in subclinical hypothyroidism.J Indian Med Assoc, 2006, 104(11):622-626.
14. Saravanan P, Dayan CM.Thyroid autoantibodies.Endocrinnol Metab North Am, 2001, 30(3):315-338.
15. Milionis HJ, Efstathiadou Z, Tselepis AD, et al.Lipoprotein (a) levels and apolipoprotein (a) isoform size in patients with subclinical hypothyroidism:effect of treatment with levothyroxine.Thyroid, 2003, 13(3):365-369.
16. Duggal J, Singh S, Barsano CP, et al.Cardiovascular risk with subclinical hyperthyroidism and hypothyroidism:pathophysiology and management.J Cardiometab Syndr, 2007, 2(3):198-206.
17. Prisant LM, Gujral JS, Mulloy AL.Hyperthyroidism:a secondary cause of isolated systolic hypertension.J Clin Hypertens, 2006, 8(3):596-599.
18. 蔡云飞, 时景璞.亚临床甲状腺功能减退与收缩压水平的关系.中华流行病学杂志, 2011, 32(1):55-59.
19. Velkoska NV, Krstevska B, Bosevski M, et al.Dyslipidaemia and hypertension in patients with subclinical hypothyroidism.Prilozi, 2009, 30(2):93-102.
20. Luboshitzky R, Aviv A, Herer P, et al.Risk factors for cardiovascular disease in women with subclinical hypothyroidism.Thyroid, 2002, 12(5):421-425.
21. Ferreira MM, Teixeira PF, Mansur VA, et al.Ambulatory blood pressure monitoring in normotensive patients with subclinical hypothyroidism.Arq Bras Cardiol, 2010, 94(6):806-812.
22. Waterhouse DF, Walsh CD, Sheehan F, et al.An examination of the relationship between normal range thyrotropin and cardiovascular risk parameters:a study in healthy women.Thyroid, 2007, 17(3):243-248.
23. VondraK, Vrbikova J, Dvorakova K.Thyroid gland disease in adult patients with diabetes mellitus.Minerva Endocrinol, 2005, 30(4):217.
24. Chen H, Wu T, Jap T, et al.Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in Type 2 diabetic patients.Diabetic Med, 2007, 24(12):1336-1344.
25. 刘建英, 章燕, 陈国兰, 等.亚临床甲状腺功能减退与代谢综合征和糖尿病的相关性研究进展.临床荟萃, 2010, 25(5):449-451.

Chinese Journal of Evidence-Based Medicine

Subclinical Hypothyroidism of Health Check-up Population of West China Hospital, Sichuan University: A Cross-sectional Study

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