Risk Factors of Angina Pectoris Complicated with Atherosclerotic Thrombotic Cerebral Infarction in China: A Cross-sectional Study_Chinese Journal of Evidence-Based Medicine

Authors：

 WANGJian-hua ¹ , XIAOLei ² , ZHANGZhe ² , HELi-yun ³ , YANShi-yan ³ , WANGXin ³ ,  YANGGuan-lin ¹

1. Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China;
2. Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China;
3. Clinical Evaluation Center of China Academy of Chinese Medical Sciences, Beijing 100700, China;

Corresponding author：

YANGGuan-lin, Email: yangguanlin945@163.com

Keywords：

Angina pectoris complicated with atheroschlerotic thrombotic cerebral infarction; Angina pectoris; Atherosclerotic thrombotic cerebral infarction; Risk factor; Epidemiological study

DOI：

10.7507/1672-2531.20140071

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Objective To compare the risk factors of angina pectoris and atherosclerotic thrombotic cerebral infarction, and to study the possible risk factors of angina pectoris complicated with atherosclerotic thrombotic cerebral infarction (XNHB abbr. in Chinese) and provide the basis for the prevention of XNHB. Methods Clinical epidemiological cross-sectional survey methods were used. Information of angina pectoris patients, atherosclerotic thrombotic cerebral infarction patients and XNHB patients were collected. The statistical software SPSS 17.0 was used to analyze the single risk factors, and then logistic regression analysis was used to filter the independent risk factors of XNHB. Results 1 002 cases of angina pectoris, 963 cases of atherosclerotic thormbotic cerebral infaction and 982 cases of XNHB were included. There were significant differences among the three diseases in the following index:age (P=0.000 0), gender (P < 0.000 1), resting lifestyle (P=0.000 0), body mass index (BMI) (P=0.000 0), diabetes (P=0.001 9), hypertension (P < 0.000 1), diabetes complicated with hypertension (P < 0.000 1), smoking (P < 0.000 1), alcohol consumption (P < 0.000 1), and the combination of more than 3 risk factors (P=0.000 0). Age (OR=1.690, 95%CI 1.420 to 2.012), hypertension (OR=1.558, 95%CI 1.312 to 1.850), abnormal BMI (OR=1.356, 95%CI 1.158 to 1.587) and resting lifestyle (OR=1.319, 95%CI 1.107 to 1.572) were shown as the independent risk factors of XNHB filtering by logistic multiple regression analysis. Conclusion The elderly with hypertension, abnormal BMI or live a resting way of life are more likely to have XNHB, so positive control of risk factors should be needed.

Citation： WANGJian-hua, XIAOLei, ZHANGZhe, HELi-yun, YANShi-yan, WANGXin, YANGGuan-lin. Risk Factors of Angina Pectoris Complicated with Atherosclerotic Thrombotic Cerebral Infarction in China: A Cross-sectional Study. Chinese Journal of Evidence-Based Medicine, 2014, 14(4): 408-413. doi: 10.7507/1672-2531.20140071 Copy

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1. Sheppard MR, Vinay K, Abul KA, et al.Robbins basic pathology:with student consult online access, 8^th edition.Philadelphia:Saunders, 2007:201-265.
2. Shen Q, Zhu TB.Tissue factor (TF) enhanced the expression of macrophage inflammatory protein-1α(MIP-1α) in cultured human umbilical vein endothelial cells.Chin J Atle, 2006, 14(6):286-288.
3. 张艳, 杨关林, 阎峻, 等.心脑动脉粥样硬化中医证型与血脂的相关性研究.辽宁中医杂志, 2010, 37(3):419-420.
4. 贾连群, 杨关林.动脉粥样硬化中医痰浊血瘀证候的现代生物学基础研究.中西医结合心脑血管病杂志, 2010, 8(1):95-96.
5. 中华医学会心血管病学分会.不稳定性心绞痛和非ST段抬高心肌梗死诊断与治疗指南.中华心血管病杂志, 2007, 35(4):295-304.
6. 中国《慢性稳定性心绞痛诊断与治疗指南》新闻发布会暨高层专家研讨会.慢性稳定性心绞痛诊断与治疗指南.中华心血管病杂志, 2007, 35(3):195-206.
7. 中华医学会第四届全国脑血管病学术会议.各类脑血管病诊断要点.中华神经内科杂志, 1996, 29(6):379-395.
8. 中华医学会神经病学分会第六届全国脑血管病学术会议.中国脑血管病防治指南.中风与神经疾病杂志, 2005, 22(5):388-393.
9. 刘志隆, 简春燕, 周志超, 等.厂矿职工心脑血管疾病流行病学调查分析.临床医药实践, 2009, 18(10):95-96.
10. 吴华英, 李静.苏北地区城镇人口心脑血管疾病主要危险因素的流行病学研究.中国社区医师, 2008, 18(10):158-159.
11. 郑黎强, 李觉, 胡大一, 等.辽宁农村地区主要心脑血管疾病危险因素的流行病学调查.山西医药杂志, 2006, 35(12):1065-1067.
12. 杨凯.心脑血管病危险因素流行病学调查及分析.吉林医学, 2013, 34(18):3611-3612.
13. 劳云飞, 王启林, 谢怀平.从青少年的行为危险因素谈预防心脑血管疾病的干预措施.中国健康教育, 1998, 14(9):16-17.
14. 吴刚.心脑血管疾病:预防重点在低龄, 中国劳动保障报, 2006-12-15(003).
15. Esposito E, Iacono A, Raso GM, et al.Rabxifene a selective estrogen receptor modulator, reduces carrageenan-induced acute inflammation in normal and ovariectomized rats.Endocrinology, 2005, 146(8):3301-3308.
16. Dantas APV, Sandberg K.Estrogen regulation of tumor necrosis factor-alpha-A missing link between menopause and cardiovascular risk in women.Hypertension, 2005, 46(2):21-22.
17. Christian RG, Timothy PP, Elizabeth JK.Aging and estrogen modulation of infalmmatory responses after injury.Exp Gerontol, 2007, 42(3):451-456.
18. Koh KK, Yoon BK.Controversies regarding hormone therapy.Insights from inflammation and hemostasis.Cardiovasc Res, 2006, 70(2):22-30.
19. Last JM.A dictionary of epidemiology, 2^nd edition.New York:Oxford University, 1988:169-263.
20. Hulley SB, Cummings SR, Browner WS, et al.Designing clinical research:an epidemiologic approach.2^nd Edition.Baltimore:Lippincott Williams and Wilkins, 2001:131-186.
21. Samuel P, Antonisamy B, Raghupathy P, et al.Socio-economic status and cardiovascular risk factors in rural and urban areas of Vellore, Tamilnadu, South India.Int J Epidemiol, 2012, 41(5):1315-1327.
22. Tinti F, Mitterhofer AP, Muiesan P.Liver transplantation:role of immunosuppression, renal dysfunction and cardiovascular risk factors.Minerva Chir, 2012, 67(1):1-13.
23. Hwang WJ, Hong O.Work-related cardiovascular disease risk factors using a socioecological approach:implications for practice and research.Eur J Cardiovasc Nurs, 2012, 11(1):114-126.
24. Subramanyam MA, Diez-Roux AV, Hickson DA, et al.Subjective social status and psychosocial and metabolic risk factors for cardiovascular disease among African Americans in the Jackson Heart Study.Soc Sci Med, 2012, 14(8):86-93.
25. White JS.Sugar-sweetened beverage link to cardiovascular risk factors is unsupported.Am J Clin Nutr, 2012, 95(3):773.
26. El Oudi M, Aouni Z, Mazigh C, et al.Total homocysteine levels and cardiovascular risk factors in healthy Tunisians.East Mediterr Health J, 2011, 17(12):937-942.
27. Williams DM, Fraser A, Sayers A, et al.Associations of 25-hydroxyvitamin D2 and D3 with cardiovascular risk factors in childhood:cross-sectional findings from the avon longitudinal study of parents and children.J Clin Endocrinol Metab, 2012, 16(2):115-132.
28. Selvarajah S, Haniff J, Kaur G, et al.Risk-factor clustering:clustering of cardiovascular risk factors in a middle-income country:a call for urgency.Eur J Prev Cardiolog, 2012, 24(1):91-96.
29. Justin ZM, Patel A, Jan S, et al.Socio-economic position:socioeconomic distribution of cardiovascular risk factors and knowledge in rural India.Int J Epidemiol, 2012, 16(9):581-604.
30. Fraser A, Nelson SM, Macdonald-Wallis C, et al.Associations of pregnancy pomplications with calculated CVD risk and cardiovascular risk factors in middle age:the avon longitudinal study of parents and children.Circulation, 2012, 17(9):352-389.
31. Chung CP, Giles JT, Petri M, et al.Prevalence of traditional modifiable cardiovascular risk factors in patients with rheumatoid arthritis:comparison with control subjects from the multi-ethnic study of atherosclerosis.Semin Arthritis Rheum, 2012, 41(4):535-544.
32. Dzakula A, Ivezić J, Zilić M, et al.Cardiovascular risk factors and visiting nurse intervention--evaluation of a croatian survey and intervention model:the crohort study.Coll Antropol, 2012, 36(1):21-25.
33. Andrić A, Vuletić S.Community nurse assessment of cardiovascular behavioural risk factors-a qualitative analysis within the CroHort study.Coll Antropol, 2012, 36(1):27-34.

Chinese Journal of Evidence-Based Medicine

Risk Factors of Angina Pectoris Complicated with Atherosclerotic Thrombotic Cerebral Infarction in China: A Cross-sectional Study

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