Stasis-resolving and Detoxifying Effect of Xuebijing Injection on Severe Pneumonia: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 ZHUMing-jin ,  ZHANGGeng , HUMa-hong , ChenYang-bo , JIChun-lian

Intensive Care Unit, Zhejiang Tongde Hospital, Hangzhou 310012, China;

Corresponding author：

ZHANGGeng, Email: docbright@163.com

Keywords：

Xuebijing injection; Severe pneumonia; Systematic review; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.20140080

Video：

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Objective To systematically review the effectiveness of Xuebijing injection combined with routine therapy versus routine therapy alone in treating severe pneumonia. Methods Databases including PubMed (1990-2013.4), EMbase (1990-2013.4), The Cochran Library (Issue 4, 2013), CNKI (1982-2013.4), WangFang Data (1990-2013.4), VIP (1989-2013.4) and CBM (1978-2013.4) were searched from inception to April, 2013, for randomized controlled trials (RCTs) on Xuebijing injection for severe pneumonia. Studies were screened according to the inclusion and exclusion criteria, data were extracted, and methodological quality was evaluated. Meta-analysis was then performed using RevMan 5.2 software. Results A total of 12 studies involving 860 patients were included. The results of meta-analysis showed that, routine therapy plus Xuebijing injection had higher total effective and excellent rates, and the combined therapy reduced the average hospitalization days, and they had better improvement in WBC, CRP, CPIS, IL-6, IL-8, TNF-α. Conclusion This current evidence shows that Xuebijing injection has a better clinical efficacy in treating severe pneumonia. Traditional Chinese herbs with the function of "promoting blood circulation to remove blood stasis" may exert their pharmacological effects via a multi-target way in treating severe pneumonia, which have a great potential for both clinical work and scientific research. Due to the limited quality and quantity of the included studies, better designed RCTs are needed to support Xuebijing's clinical efficacy in the treatment of severe pneumonia.

Citation： ZHUMing-jin, ZHANGGeng, HUMa-hong, ChenYang-bo, JIChun-lian. Stasis-resolving and Detoxifying Effect of Xuebijing Injection on Severe Pneumonia: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2014, 14(4): 462-468. doi: 10.7507/1672-2531.20140080 Copy

1.	白云苹, 王海峰, 王明航, 等.中药复方针剂血必净注射液辅助治疗重症肺炎随机对照试验的系统评价.中国中西医结合急救杂志, 2012, 19(5):257-262.
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3.	Mandell LA, Wunderink RG, Anzueto A, et al.Infectious Diseases Society of America/American Thoracic Society consensus guidelines for the management of community acquired pneumonia in adults.Clin Infect Dis, 2007(44):S27-72.
4.	Higgins JPT, Green S (editors).Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[Updated March 2011].The Cochrane Collaboration, 2011.Available at:www.cochrane-handbook.org.
5.	Qi F, Liang ZX, She DY, et al.A clinical study on the effects and mechanism of xuebijing injection in severe pneumonia patients.J Traditional Chinese Medicine, 2011, 31(1):46-49.
6.	程兴梅, 陈晓英, 沈维.血必净联合抗生素治疗重症肺炎的临床研究.中国保健营养(下旬刊), 2012, 22(11):4337-4338.
7.	方志成, 周昌娥, 郑翔, 等.血必净联合乌司他丁治疗重症肺炎的临床研究.临床和实验医学杂志, 2013, 12(4):268-270.
8.	王志钢, 龙英姿, 张国明.血必净治疗老年重症肺炎的疗效观察.江西医药, 2013, 48(1):41-42.
9.	邢柏, 曾琦, 王日兴, 等.血必净注射液对重症肺炎患者的肺保护作用.中国中西医结合急救杂志, 2007, 14(5):317-318.
10.	陈建南, 何平, 孙定卫.血必净注射液对重症肺炎患者的影响研究.中国全科医学, 2010, 13(9):3081-3083.
11.	刘龙, 蔡国良.血必净注射液对重症肺炎患者血清中IL-6、IL-10的影响.西部医学, 2011, 23(10):1862-1864.
12.	傅园花, 葛国平.血必净注射液结合西医常规疗法治疗老年重症肺炎疗效观察.上海中医药杂志, 2011, 45(1):39-40.
13.	张琦, 许玲华, 李萍.血必净注射液治疗老年重症肺炎患者疗效观察.中国医药导报, 2008, 5(33):68-69.
14.	周干, 林峰, 左文杰.血必净注射液治疗重症肺炎84例疗效观察.药物评价研究, 2012, 35(3):197-198.
15.	卢万向.中西药联合治疗老年重症社区获得性肺炎临床体会.内蒙古中医药, 2012, 31(10):21-22.
16.	赵俊.血必净联合泰能治疗高原老年性重症肺炎疗效观察.中国医学创新, 2010, 7(23):90-91.
17.	张淑文, 孙成栋, 文艳, 等.血必净注射液对脓毒症大鼠血清炎症介质及T h1/2的影响.中国危重病急救医学, 2006, 18(11):673-676.
18.	卞兆祥, 商洪才, 吴泰相, 等.中药注射剂不良反应/不良事件的反思.中国循证医学杂志, 2010, 10(2):116-121.
19.	任德权.理性看待中药注射剂促其科学发展.中国循证医学杂志, 2010, 10(2):105-106.
20.	崔小花, 王莉, 李幼平, 等.鱼腥草注射液治疗呼吸系统疾病有效性评价.中国循证医学杂志, 2011, 11(7):786-798.
21.	王今达, 雪琳.细菌、内毒素、炎性介质并治——治疗重症脓毒病的新对策.中国危重病急救医学, 1998, 10(6):323-325.
22.	孙军平, 汪建新, 郭丽娜.内毒素致兔急性肺损伤及血必净保护作用.军医进修学院学报, 2009, 30(1):102-104.
23.	明自强, 俞林明, 吕银祥, 等.血必净注射液治疗脓毒症患者抗炎作用观察.现代中西医结合杂志, 2007, 16(6):731-732.
24.	张宏, 王梦义, 陈樱, 等.G-菌肺感染早期活血化瘀中药干预治疗对细胞因子释放的影响.中国中西医结合急救杂志, 2001, 8(4):219-221.

1. 白云苹, 王海峰, 王明航, 等.中药复方针剂血必净注射液辅助治疗重症肺炎随机对照试验的系统评价.中国中西医结合急救杂志, 2012, 19(5):257-262.
2. Niederman MS, Mandell LA, Anzueto A, et al.Guidelines for the management of adults with community-acquired pneumonia.Diagnosis, assessment of severity, antimicrobial therapy, and prevention.Am J Respir Crit Care Med, 2001, 163(7):1730-1754.
3. Mandell LA, Wunderink RG, Anzueto A, et al.Infectious Diseases Society of America/American Thoracic Society consensus guidelines for the management of community acquired pneumonia in adults.Clin Infect Dis, 2007(44):S27-72.
4. Higgins JPT, Green S (editors).Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[Updated March 2011].The Cochrane Collaboration, 2011.Available at:www.cochrane-handbook.org.
5. Qi F, Liang ZX, She DY, et al.A clinical study on the effects and mechanism of xuebijing injection in severe pneumonia patients.J Traditional Chinese Medicine, 2011, 31(1):46-49.
6. 程兴梅, 陈晓英, 沈维.血必净联合抗生素治疗重症肺炎的临床研究.中国保健营养(下旬刊), 2012, 22(11):4337-4338.
7. 方志成, 周昌娥, 郑翔, 等.血必净联合乌司他丁治疗重症肺炎的临床研究.临床和实验医学杂志, 2013, 12(4):268-270.
8. 王志钢, 龙英姿, 张国明.血必净治疗老年重症肺炎的疗效观察.江西医药, 2013, 48(1):41-42.
9. 邢柏, 曾琦, 王日兴, 等.血必净注射液对重症肺炎患者的肺保护作用.中国中西医结合急救杂志, 2007, 14(5):317-318.
10. 陈建南, 何平, 孙定卫.血必净注射液对重症肺炎患者的影响研究.中国全科医学, 2010, 13(9):3081-3083.
11. 刘龙, 蔡国良.血必净注射液对重症肺炎患者血清中IL-6、IL-10的影响.西部医学, 2011, 23(10):1862-1864.
12. 傅园花, 葛国平.血必净注射液结合西医常规疗法治疗老年重症肺炎疗效观察.上海中医药杂志, 2011, 45(1):39-40.
13. 张琦, 许玲华, 李萍.血必净注射液治疗老年重症肺炎患者疗效观察.中国医药导报, 2008, 5(33):68-69.
14. 周干, 林峰, 左文杰.血必净注射液治疗重症肺炎84例疗效观察.药物评价研究, 2012, 35(3):197-198.
15. 卢万向.中西药联合治疗老年重症社区获得性肺炎临床体会.内蒙古中医药, 2012, 31(10):21-22.
16. 赵俊.血必净联合泰能治疗高原老年性重症肺炎疗效观察.中国医学创新, 2010, 7(23):90-91.
17. 张淑文, 孙成栋, 文艳, 等.血必净注射液对脓毒症大鼠血清炎症介质及T h1/2的影响.中国危重病急救医学, 2006, 18(11):673-676.
18. 卞兆祥, 商洪才, 吴泰相, 等.中药注射剂不良反应/不良事件的反思.中国循证医学杂志, 2010, 10(2):116-121.
19. 任德权.理性看待中药注射剂促其科学发展.中国循证医学杂志, 2010, 10(2):105-106.
20. 崔小花, 王莉, 李幼平, 等.鱼腥草注射液治疗呼吸系统疾病有效性评价.中国循证医学杂志, 2011, 11(7):786-798.
21. 王今达, 雪琳.细菌、内毒素、炎性介质并治——治疗重症脓毒病的新对策.中国危重病急救医学, 1998, 10(6):323-325.
22. 孙军平, 汪建新, 郭丽娜.内毒素致兔急性肺损伤及血必净保护作用.军医进修学院学报, 2009, 30(1):102-104.
23. 明自强, 俞林明, 吕银祥, 等.血必净注射液治疗脓毒症患者抗炎作用观察.现代中西医结合杂志, 2007, 16(6):731-732.
24. 张宏, 王梦义, 陈樱, 等.G-菌肺感染早期活血化瘀中药干预治疗对细胞因子释放的影响.中国中西医结合急救杂志, 2001, 8(4):219-221.

Chinese Journal of Evidence-Based Medicine

Stasis-resolving and Detoxifying Effect of Xuebijing Injection on Severe Pneumonia: A Systematic Review

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