Objective To systematically review the effectiveness of Shenmai injection for leukopenia after the tumor radiation and chemotherapy. Methods Such databases as PubMed (1966 to June 2013), The Cochrane Library (Issue 5, 2013), Web of Science (1980 to June 2013), VIP (1989 to June 2013), WanFang Data (1990 to June 2013), CNKI (1980 to June 2013) and CBM (1981 to June 2013) were searched to collect randomized controlled trials (RCTs) on Shenmai injection in treating leukopenia after the tumor radiation and chemotherapy. Literature selection, data extraction and methodological quality assessment of the included studies was conducted by two reviewers independently. Then meta-analysis was performed using RevMan 5.2 software. Results A total of 11 studies involving 1 009 patients were included. The results of meta-analysis showed that when Shenmai injection and normal oral drugs for rising leucocyte were used in the treatment of leukopenia after the tumor radiation and chemotherapy, significant differences were found in significant effectiveness (RR=1.57, 95%CI 1.39 to 1.78, P < 0.000 01), and total effectiveness (RR=1.27, 95%CI 1.19 to 1.36, P < 0.000 01), but no significant difference was found in effectiveness (RR=0.90, 95%CI 0.74 to 1.09, P=0.27). Conclusion In the treatment of leucopenia through tumor radiation and chemotherapy, Shenmai injection is superior to normal oral drugs in effectiveness. However, the above conclusion should be further confirmed by conducting more large-scale and welldesigned RCTs due to the limited quantity and quality of the included studies.

Citation： LIUXiang-xiang, XIYa-ming, WANGLi-na. Effectiveness of Shenmai Injection for Leukopenia after Tumor Radiation and Chemotherapy: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(4): 484-491. doi: 10.7507/1672-2531.20140083 Copy