Diagnostic Value of Neuron Specific Enolase for Malignant Pleural Effusion: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 JIANGYAO-Wen ¹ , LIUPeng ¹ , LINGYUN-Fei ² ,  HUHai ¹

1. Department of Emergency, West China Hospital, Sichuan University, Chengdu 610041, China;
2. West China School of Medicine, Sichuan University, Chengdu 610041, China;

Corresponding author：

HUHai, Email: hhtg2014@126.com

Keywords：

Neuron specific enolase(NSE); Pleural effusion; Diagnosis; Meta-analysis

DOI：

10.7507/1672-2531.20140099

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the diagnostic value of neuron specific enolase (NSE) for malignant pleural effusion. Methods We comprehensively searched databases including The Cochrane Library (Issue 1, 2012), EMbase, MEDLINE, CBM, CNKI, WanFang Data and VIP from inception to January 2012 to collect studies about the diagnostic value of NSE for malignant pleural effusion. Literature screening according to the inclusion and exclusion criteria, data extraction and methodological quality assessment were completed by two reviewers independently. Then Meta-DiSc software (version 1.4) was used for pooling analysis. Results A total of 12 studies were finally included. The results of meta-analysis showed that the value of pooled specificity, sensitivity, positive likelihood radio, negative likelihood radio and diagnostic odds ratio (DOR) were 0.79 (0.76 to 0.84), 0.55 (0.51 to 0.59), 3.2 (1.94 to 5.29), 0.58 (0.45 to 0.74), 7.56 (3.74 to 15.30), respectively; and the area under SROC curve (AUC) was 0.813 1. Conclusion Using NSE as a maker to diagnose malignant pleural effusion is of certain clinical value, which is used to differentiate benign and malignant pleural effusion.

Citation： JIANGYAO-Wen, LIUPeng, LINGYUN-Fei, HUHai. Diagnostic Value of Neuron Specific Enolase for Malignant Pleural Effusion: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(5): 598-603. doi: 10.7507/1672-2531.20140099 Copy

1.	Chernow B, Sahn SA. Carcinomatous involvement of the pleura:an analysis of 96 patients. Am J Med, 1977, 63(5):695-702.
2.	Prakash BS, Reiman HM. Comparison of needle biopsy with cytologic analysis for the evaluation of pleural effusion:analysis of 414 cases. Mayo Clin Proc, 1985, 60(2):158-164.
3.	Johnston WW. The malignant pleural effusion. A review of cytopathologic diagnoses of 584 specimens from 472 consecutive patients. Cancer, 1985, 56(4):905-909.
4.	Menard O, Dousset B, Jacob C, et al. Improvement of the diagnosis of the cause of pleural effusion in patients with lung cancer by simultaneous quantification of carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) pleural levels. Eur J Cancer, 1993, 29(13):1806-1809.
5.	Filiz K, Zeynep T, Abdurrahman C, et al. Diagnostic usefulness of tumour marker levels in pleural effusions of malignant and benign origin. Clinica Chimica Acta, 2000, 300(1):43-55.
6.	Ghayumi SM, Mehrabi S, Doroudchi M, et al. Diagnostic value of tumor markers for differentiating malignant and benign pleural effusions of Iranian patients. Pathol Oncol Res, 2005, 11(4):236-241.
7.	盛家和, 肖伟强, 许青霞, 等.癌性胸水患者血清和胸水中水溶性细胞角蛋白19片段、癌胚抗原和神经元特异性烯醇化酶检测.郑州大学学报(医学版), 2008, 43(4):768-771.
8.	倪宁, 李韶英.多种肿瘤标志物联合检测对胸腔积液鉴别诊断的意义.辽宁医学杂志, 2004, 18(6):308-309.
9.	王群慧, 张树才, 古淑香, 等.检测糖链抗原CA242对恶性胸液的诊断价值.中国肺癌杂志, 2002, 5(1):44-47.
10.	端木和运, 曹惠娟.联合检测CA125、CA153、CEA、NSE和SF鉴别结核性与癌性积液.江苏医药, 2011, 37(23):2778-2780.
11.	黄河, 熊盛道, 张家洪, 等.黏蛋白类糖链抗原CA724与肿瘤标志物癌胚抗原、神经元特异度烯醇化酶、细胞角质蛋白19的可溶片段联合检测对良恶性胸腔积液鉴别诊断的意义.临床荟萃, 2010, 25(12):1075-1078.
12.	唐华平, 李双保, 张明泳, 等.三项肿瘤标志物联检对胸腔积液的鉴别诊断价值.齐鲁医学杂志, 2002, 17(1):35-36.
13.	杨桐树, 李文辉, 孙喜文, 等.血清五种肿瘤标志物联合检测在肺癌诊断中的意义.实用肿瘤学杂志, 2010, 24(3):243-246.
14.	陈连周, 郑璐, 李雯, 等.肿瘤标志物检测在良恶性胸腔积液鉴别诊断的应用.中国热带医学, 2008, 8(10):1709-1710.
15.	Korczyns P, Krenke R, Safianowska A, et al. Diagnostic utility of pleural fluid and serum markers in differentiation between malignant and non-malignant pleural effusions. Eur J Med Res, 2009, 14(Suppl 4):128-133.
16.	Romero S, Izquierdo M, Mauri M, et al. Diagnostic usefulness of neurospecific enolase determination in pleural fluid. Med Clin (Barc), 1989, 93(15):568-571.
17.	刁骧, 艾昌林, 秦莉, 等译. QUADAS的制定:用于系统评价诊断性研究质量的工具.中国循证医学杂志, 2007, (04):296-306.
18.	李盈, 顾怀婷. 《中国循证医学杂志》发表系统评价/Meta分析的文献计量分析.中国循证医学杂志, 2012, 12(10):1279-1282.
19.	Penny F, Marie E, Weswood A, 等. QUADAS评价:一种用于诊断性研究的质量评价工具(修订版).中国循证医学杂志, 2007, 7(7): 531-536.
20.	邓可刚.诊断性研究的检索资源与检索方法.中国循证医学杂志, 2007, 7(4):307-310.
21.	刘关键, 吴泰相.诊断性试验的Meta分析-SROC曲线法介绍.中国循证医学杂志, 2003, 3(1):41-44.
22.	马清光, 邓嘉佳, 乔英, 等.国内癌胚抗原检测诊断非小细胞肺癌的系统评价.中国循证医学杂志, 2011, 11(10):1140-1143.

1. Chernow B, Sahn SA. Carcinomatous involvement of the pleura:an analysis of 96 patients. Am J Med, 1977, 63(5):695-702.
2. Prakash BS, Reiman HM. Comparison of needle biopsy with cytologic analysis for the evaluation of pleural effusion:analysis of 414 cases. Mayo Clin Proc, 1985, 60(2):158-164.
3. Johnston WW. The malignant pleural effusion. A review of cytopathologic diagnoses of 584 specimens from 472 consecutive patients. Cancer, 1985, 56(4):905-909.
4. Menard O, Dousset B, Jacob C, et al. Improvement of the diagnosis of the cause of pleural effusion in patients with lung cancer by simultaneous quantification of carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) pleural levels. Eur J Cancer, 1993, 29(13):1806-1809.
5. Filiz K, Zeynep T, Abdurrahman C, et al. Diagnostic usefulness of tumour marker levels in pleural effusions of malignant and benign origin. Clinica Chimica Acta, 2000, 300(1):43-55.
6. Ghayumi SM, Mehrabi S, Doroudchi M, et al. Diagnostic value of tumor markers for differentiating malignant and benign pleural effusions of Iranian patients. Pathol Oncol Res, 2005, 11(4):236-241.
7. 盛家和, 肖伟强, 许青霞, 等.癌性胸水患者血清和胸水中水溶性细胞角蛋白19片段、癌胚抗原和神经元特异性烯醇化酶检测.郑州大学学报(医学版), 2008, 43(4):768-771.
8. 倪宁, 李韶英.多种肿瘤标志物联合检测对胸腔积液鉴别诊断的意义.辽宁医学杂志, 2004, 18(6):308-309.
9. 王群慧, 张树才, 古淑香, 等.检测糖链抗原CA242对恶性胸液的诊断价值.中国肺癌杂志, 2002, 5(1):44-47.
10. 端木和运, 曹惠娟.联合检测CA125、CA153、CEA、NSE和SF鉴别结核性与癌性积液.江苏医药, 2011, 37(23):2778-2780.
11. 黄河, 熊盛道, 张家洪, 等.黏蛋白类糖链抗原CA724与肿瘤标志物癌胚抗原、神经元特异度烯醇化酶、细胞角质蛋白19的可溶片段联合检测对良恶性胸腔积液鉴别诊断的意义.临床荟萃, 2010, 25(12):1075-1078.
12. 唐华平, 李双保, 张明泳, 等.三项肿瘤标志物联检对胸腔积液的鉴别诊断价值.齐鲁医学杂志, 2002, 17(1):35-36.
13. 杨桐树, 李文辉, 孙喜文, 等.血清五种肿瘤标志物联合检测在肺癌诊断中的意义.实用肿瘤学杂志, 2010, 24(3):243-246.
14. 陈连周, 郑璐, 李雯, 等.肿瘤标志物检测在良恶性胸腔积液鉴别诊断的应用.中国热带医学, 2008, 8(10):1709-1710.
15. Korczyns P, Krenke R, Safianowska A, et al. Diagnostic utility of pleural fluid and serum markers in differentiation between malignant and non-malignant pleural effusions. Eur J Med Res, 2009, 14(Suppl 4):128-133.
16. Romero S, Izquierdo M, Mauri M, et al. Diagnostic usefulness of neurospecific enolase determination in pleural fluid. Med Clin (Barc), 1989, 93(15):568-571.
17. 刁骧, 艾昌林, 秦莉, 等译. QUADAS的制定:用于系统评价诊断性研究质量的工具.中国循证医学杂志, 2007, (04):296-306.
18. 李盈, 顾怀婷. 《中国循证医学杂志》发表系统评价/Meta分析的文献计量分析.中国循证医学杂志, 2012, 12(10):1279-1282.
19. Penny F, Marie E, Weswood A, 等. QUADAS评价:一种用于诊断性研究的质量评价工具(修订版).中国循证医学杂志, 2007, 7(7): 531-536.
20. 邓可刚.诊断性研究的检索资源与检索方法.中国循证医学杂志, 2007, 7(4):307-310.
21. 刘关键, 吴泰相.诊断性试验的Meta分析-SROC曲线法介绍.中国循证医学杂志, 2003, 3(1):41-44.
22. 马清光, 邓嘉佳, 乔英, 等.国内癌胚抗原检测诊断非小细胞肺癌的系统评价.中国循证医学杂志, 2011, 11(10):1140-1143.

Chinese Journal of Evidence-Based Medicine

Diagnostic Value of Neuron Specific Enolase for Malignant Pleural Effusion: A Meta-Analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content