Helical Tomotherapy for Cancer Treatment: A Rapid Health Technology Assessment<sup>Δ</sup>_Chinese Journal of Evidence-Based Medicine

Authors：

 YANGZong-xia ¹ ^# ,  SHENJian-tong ¹ ^# ,  LIYou-ping ¹ , ZHAOKun ² , SHICheng-hu ¹ , XIAOYue ² , YUJia-jie ¹ , GUOWu-dong ² , LICui-cui ¹ , WANGYing-qiang ¹ , LIXiang-lian ¹ , on behalf of the Rapid Health Technology Assessment Working Group of Chinese Evidence-Based Medicine Centre

1. Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China;
2. National Health Development Research Center, Peking University, Beijing 100191, China;

Corresponding author：

LIYou-ping, Email: yzmylab@hotmail.com

Keywords：

Rapid health technology assessment; Cancer; Helical tomotherapy

DOI：

10.7507/1672-2531.20140174

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To rapidly review the effectiveness, safety, costs and applicability of helical tomotherapy (HT), so as to provide currently-available best evidence for decision makers of government health policies. Methods We electronically searched databases including PubMed, EMbase, The Cochrane Library, CNKI, WanFang Data, VIP, CBM and other relevant professional websites. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, assessed quality, and then performed descriptive analysis. Results a) We finally included 150 studies, encompassing 5 health technology assessments (HTAs), 18 clinical controlled trials (CCTs), and 127 observational studies. b) Four included HTAs were published during 2006-2009, providing fairly less evidence of low quality and the results of 145 primary studies showed that:HT was mainly used in the treatments of 14 types of cancer, with relatively low total toxicity and high survival rates. Although the quality of the included studies was poor, there was much evidence about prostate cancer, head and neck cancer, nasopharynx cancer, cervical cancer, lung cancer and liver cancer, with accumulatively enough sample size and fairly reliable results in HT's efficacy and safety. And c) a total of 56 clinical trials had bee registered in Clinicaltrials.gov, most of which were registered by the occident; among them, 9 had been come to the end, yet without results published. Conclusion Current evidence of this study showed that, HT is safe and effective in clinic. But the abovementioned conclusion needs to be verified by conducting more high quality studies with long-term follow-up. The costs of HT in procurement, maintenance and application are high; and the skills, training and qualification of operators are required. We suggest that the procurement of HT should be reduced; it should be allocated rationally and effectively used after comprehensive assessment in China's cancer epidemiology characteristics, health resource allocation, disease burden, medical service level, etc.; and also high quality studies with long-term follow-up should be financially supported on the basis of establishing projects, so as to provide local evidence and consistently guide and improve scientific decision making.

Citation： YANGZong-xia, SHENJian-tong, LIYou-ping, ZHAOKun, SHICheng-hu, XIAOYue, YUJia-jie, GUOWu-dong, LICui-cui, WANGYing-qiang, LIXiang-lian, on behalf of the Rapid Health Technology Assessment Working Group of Chinese Evidence-Based Medicine Centre. Helical Tomotherapy for Cancer Treatment: A Rapid Health Technology Assessment^Δ. Chinese Journal of Evidence-Based Medicine, 2014, 14(9): 1052-1069. doi: 10.7507/1672-2531.20140174 Copy

1.	Summary W. WHO cancer control:Knowledge into action. Available at:http://wwwwhoint/cancer.[Accessed on Oct 28 2012].
2.	Janssens ACJW, Ioannidis JPA, Bedrosian S, et al. Strengthening the reporting of genetic risk prediction studies (GRIPS):explanation and elaboration. J Clin Epidemiol, 2011, 64:e1-e22.
3.	殷蔚伯, 谷铣之.肿瘤放射治疗学.北京:中国协和医科大学出版社. 2007:71-72.
4.	Rizos EC, Salanti G, Kontoyiannis DP, et al. Homophily and co-occurrence patterns shape randomized trials agendas:illustration in antifungal agents. J Clin Epidemiol, 2011, 64:830-842.
5.	张金葆.螺旋断层放疗系统的先进性评估分析.中国医疗设备, 2009, 24(4):136-139.
6.	VillegasPortero JCVaR. Helical tomotherapy. Current Uses and Utility. 2008:69-73.
7.	Centre TNHS. Helical Tomotherapy Hi-ART^TM System for external cancer radiotherapy. 2006:107-110.
8.	AHTA. TomoTherapy HI-ART System Radiotherapy planning and treatment for cancer patients. 2009:84-87.
9.	Boudreau RCM, Nkansah E. Tomotherapy, gamma knife, and cyberknife therapies for patients with tumours of the lung, central nervous system, or intra-abdomen:a systematic review of clinical effectiveness and cost-effectiveness. 2009:66-68.
10.	Katchamart W, Faulkner A, Feldman B, et al. PubMed had a higher sensitivity than Ovid-MEDLINE in the search for systematic reviews. J Clin Epidemiol, 2011, 64:805-807.
11.	Teh BS, Dong L, McGary JE, et al. Rectal wall sparing by dosimetric effect of rectal balloon used during intensity-modulated radiation therapy (IMRT) for prostate cancer. Med Dosim, 2005, 30:25-30.
12.	Cozzarini C, Fiorino C, Di Muzio N, et al. Significant reduction of acute toxicity following pelvic irradiation with helical tomotherapy in patients with localized prostate cancer. Radiother Oncol, 2007, 84:164-170.
13.	Cheng JC, Schultheiss TE, Nguyen KH, et al. Acute toxicity in definitive versus postprostatectomy image-guided radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys, 2008, 71:351-357.
14.	Engels B, Soete G, Tournel K, et al. Helical tomotherapy with simultaneous integrated boost for high-risk and lymph node-positive prostate cancer:early report on acute and late toxicity. Technol Cancer Res Treat, 2009, 8:353-359.
15.	Di Muzio N, Fiorino C, Cozzarini C, et al. Phase I-Ⅱ study of hypofractionated simultaneous integrated boost with tomotherapy for prostate cancer. Int J Radiat Oncol Biol Phys, 2009, 74:392-398.
16.	尹雷明.前列腺癌三种不同放疗技术剂量学研究和螺旋断层放疗前列腺癌毒副反应的临床观察.解放军总医院. 2009:6-49.
17.	Alongi F, Cozzarini C, Fiorino C, et al. Optimal acute toxicity profile for concomitant pelvic irradiation in 153 prostate cancer patients with tomotherapy. International Institute of Anticancer Research, 2010, 77(1):153-159..
18.	Schwarz R, Petersen C, Janke Y, et al. IMRT with helical tomotherapy for primary treatment of prostate cancer-Preliminary toxicity and remission data. Strahlenther Onkol, 2010, 186(1):60.
19.	Di Muzio N, Fiorino C, Cozzarini C, et al. High-dose moderately hypofractionated tomotherapy for localized prostate cancer:promising 3-year results. Int J Radiat Oncol Biol Phys, Int J Radiat Oncol Biol Phys, 2010, 78(1):S349.
20.	Pervez N, Small C, MacKenzie M, et al. Acute toxicity in high-risk prostate cancer patients treated with androgen suppression and hypofractionated intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys, 2010, 76:57-64.
21.	Drodge S, Pervez N, Ghosh S, et al. Late toxicity in high-risk prostate cancer treated with androgen suppression and hypofractionated intensity modulated radiotherapy. Int J Radiat Oncol Biol Phys, 2010, 78(1):S353.
22.	Cendales R, Schnitman F, Schiappacasse L, et al. Early report on acute toxicity after IMRT/IGRT with Tomotherapy in localized prostate cancer. Radiother Oncol, 2010, 96:S400.
23.	Alongi F, Cozzarini C, Fiorlno C, et al. Excellent acutetoxicity of salvage tomotherapy to prostatic bed and pelvis in 55 patients. Radiother Oncol, 2010, 96:S420.
24.	Ayakawa S, Shibamoto Y, Sugie C, et al. Helical tomotherapy with a 2.2-GY daily fraction and dose reduction for the rectum for localized prostate cancer. Int J Radiat Oncol Biol Phys, 2011, 81(1):S413-S414.
25.	Cammarota F, Toledo D, Borrelli D, et al. Exclusive radiotherapy of prostate cancer with helical tomotherapy:initial experience. Strahlenther Onkol, 2011, 187(10):700.
26.	Longobardi B, Berardi G, Fiorino C, et al. Anatomical and clinical predictors of acute bowel toxicity in whole pelvis irradiation for prostate cancer with tomotherapy. Radiother Oncol, 2011, 101:460-464.
27.	Le D, Drodge CS, Pervez N, et al. Acute and late toxicity in high-risk prostate cancer treated with androgen suppression and hypofractionated intensity modulated radiotherapy. Int J Radiat Oncol Biol Phys, 2011, 81(1):S101.
28.	Romeo A, Gunelli R, De Giorgi U, et al. Early clinical experience of helical tomotherapy for hypofractionated re-irradiation of recurrent localized prostate cancer. Anticancer Research, 2011, 31(5):1877.
29.	Geier M, Astner ST, Duma MN, et al. Dose-escalated simultaneous integrated-boost treatment of prostate cancer patients via helical tomotherapy. Strahlenther Onkol, 2012, 188:410-416.
30.	Lopez Guerra JL, Isa N, Matute R, et al. Hypofractionated helical tomotherapy using 2.5-2.6 Gy daily fractions for localized prostate cancer. Clin Transl Oncol, 2013, 15:271-277.
31.	Tomita N, Soga N, Ogura Y, et al. Preliminary results of intensity-modulated radiation therapy with helical tomotherapy for prostate cancer. J Cancer Res Clin Oncol, 2012, 138:1931-1936.
32.	Borrelli D, Toledo D, Cammarota F, et al. Tomotherapy in postoperative patients with prostate cancer:evaluation of acute toxicity. Anticancer Research, 2011, 31 (5):1903.
33.	Berardi G, Alongi F, Fiorino C, et al. Hypofractionated tomotherapy treatment (HTT) in prostate cancer lymph nodal relapse detected by 11C-choline PET/CT. Strahlenther Onkol, 2011, 187(10):677.
34.	Garibaldi E, Bresciani S, Delmastro E, et al. Helical tomotherapy in high/very high risk and in nodal recurrences of prostate cancer:preliminary results. Strahlentherapie und Onkologie, 2011, 187(10):677-678.
35.	Cozzarini C, Fiorino C, Di Muzio N, et al. Hypofractionated adjuvant radiotherapy with helical tomotherapy after radical prostatectomy:planning data and toxicity results of a Phase I-Ⅱ study. Radiother Oncol, 2008, 88:26-33.
36.	Russo D, Papaleo A, Leone A, et al. Comparison of dosimetric results and toxicity patterns between SIB-IMRT and high-dose 3D-CRT in prostate cancer. Anticancer Research, 2011, 31(5):1915-1916.
37.	Keiler L, Dobbins D, Kulasekere R, et al. Tomotherapy for prostate adenocarcinoma:a report on acute toxicity. Radiother Oncol, 2007, 84:171-176.
38.	Alongi F, Fiorino C, Cozzarini C, et al. IMRT significantly reduces acute toxicity of whole-pelvis irradiation in patients treated with post-operative adjuvant or salvage radiotherapy after radical prostatectomy. Radiother Oncol, 2009, 93:207-212.
39.	Marques C, Sa A, Pappalardi B, et al. Hypofractionated helical tomotherapy vs. conventional IMRT in prostate cancer. Journal of Medical Imaging and Radiation Sciences, 2011, 42(3):160.
40.	Hicks A, Mix M, Ashton S. Acute toxicity in the treatment of prostate cancer:a comparison of conventional IGRT, helical tomotherapy and calypso technology. Am J Clin Oncol-Canc, 2011, 34(2):212-213.
41.	Pervez N, Krauze AV, Yee D, et al. Quality-of-life outcomes in high-risk prostate cancer patients treated with helical tomotherapy in a hypofractionated radiation schedule with long-term androgen suppression. Curr Oncol, 2012, 19:e201-210.
42.	Chen AM, Jennelle RL, Sreeraman R, et al. Initial clinical experience with helical tomotherapy for head and neck cancer. Head Neck, 2009, 31:1571-1578.
43.	Farrag A, Voordeckers M, Tournel K, et al. Pattern of locoregional failure after tomotherapy in head and neck cancer. Eur J Cancer, 2009, 7(2-3):479.
44.	Yoo EJ, Kay CS, Kim JY, et al. Helical tomotherapy for recurrent or second primary head and neck cancer in prior irradiated territory. Radiother Oncol, 2010, 96:S317.
45.	Farrag A, Voordeckers M, Tournel K, et al. Pattern of failure after helical tomotherapy in head and neck cancer. Strahlenther Onkol, 2010, 186(9):511-516.
46.	Ricchetti F, Bacigalupo A, Vagge S, et al. Is alopecia still a problem in head and neck patients treated with tomotherapy? Radiother Oncol, 2010, 96:S321.
47.	Bolle S, Rothe Thomas F, Malika A, et al. Tomotherapy for head and neck cancer:clinical outcomes and patterns of failure. Strahlentherapie und Onkologie, 2011, 187(10):697.
48.	Chizzali B, Thamm R, Duma M, et al. Longitudinal evaluation of quality of life of patients with head-and-neck cancer treated with helical tomotherapy. Strahlenther Onkol, 2011, 187(10):697.
49.	Dell'Oca I, Fiorino C, Fodor A, et al. Simultaneous integrated boost 18FDG-PET based helical tomotherapy in radical locally advanced head and neck cancer. Radiother Oncol, 2011, 99:S335.
50.	Garibaldi E, Bresciani S, Salatino A, et al. Helical tomotherapy in advanced and recurrence head and neck cancer:preliminary results. Strahlenther Onkol, 2011, 187(10):677.
51.	Goy Y, Prosch C, Bajrovic A, et al. Tomotherapy in locally advanced head and neck cancer-does it reduce xerostomia? Radiother Oncol, 2011, 98(10):167.
52.	Schiappacasse L, Coche B, Romero S, et al. Simultaneous integrated boost (SIB) and simultaneous modulated accelerated radiation therapy (SMART) for head & neck cancer patients using helical tomotherapy:experience of centre oscar lambret. Strahlenther Onkol, 2011, 187(10):687.
53.	You SH, Kim SY, Lee CG, et al. Is there a clinical benefit to adaptive planning during tomotherapy in patients with head and neck cancer at risk for xerostomia? Am J Clin Oncol, 2012, 35:261-266.
54.	Voordeckers M, Farrag A, Everaert H, et al. Parotid gland sparing with helical tomotherapy in head-and-neck cancer. Int J Radiat Oncol Biol Phys, 2012, 84:443-448.
55.	Goy Y, Prosch C, Tennstedt P, et al. Tomotherapy in head and neck cancer:mind each gland. Strahlenther Onkol, 2011, 187(10):687.
56.	Chen AM, Marsano J, Perks J, et al. Comparison of IMRT techniques in the radiotherapeutic management of head and neck cancer:is tomotherapy "better" than step-and-shoot IMRT? Technol Cancer Res Treat, 2011, 10:171-177.
57.	杜镭, 马林, 周桂霞, 等.螺旋断层放疗45例鼻咽癌近期临床观察.军医进修学院学报, 2009, 30(3):311-314.
58.	路娜.鼻咽癌螺旋断层放疗过程中靶区和危及器官变化及近期临床观察.中国人民解放军军医进修学院. 2010:5-48.
59.	Goto Y. Reirradiadion of locally recurrent nasopharyngeal cancer with intensity-modulated radiotherapy using helical tomotherapy. Jpn J Radiol, 2010, 55(8):1018-1024.
60.	Kodaira L, Furutani K, Tachibana H, et al. Intensity modulated radiotherapy combined with concomitant chemotherapy using helical tomotherapy for patients with nasopharyngeal carcinoma. Radiother Oncol, 2010, 96:S320-S321.
61.	Ma L, Du L, Feng L, et al. Short-term clinical observations of 73 nasopharyngeal carcinoma patients treated with tomotherapy. Int J Radiat Oncol Biol Phys, 2010, 78(1):S475-S476.
62.	Marrone I. Tomotherapy in nasopharynx and paranasal sinuses cancers. Radiotherapy and Oncology, 2010, 96:S334.
63.	Bacigalupo A, Vagge S, Bosetti D, et al. Preliminary experience with helical tomotherapy using simultaneous integrated boost (SIB) in nasopharynx cancer. Radiother Oncol, 2011, 98:S31-S32.
64.	Kodaira T, Tomita N, Tachibana H, et al. Aichi cancer center initial experience of intensity modulated radiation therapy for nasopharyngeal cancer using helical tomotherapy. Int J Radiat Oncol Biol Phys, 2009, 73:1129-1134.
65.	Feng L, Hou J, Cai B, et al. Clinical observation in nasopharyngeal carcinoma treated with anti-EGFR monoclonal antibodies followed by helical tomotherapy. Journal of Clinical Oncology, 2011, 29(1):S35.
66.	Shueng PW, Shen BJ, Wu LJ, et al. Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma. Radiat Oncol, 2011, 6:95.
67.	杜镭, 马林, 冯林春, 等. 121例鼻咽癌螺旋断层治疗结果分析.中华放射肿瘤学杂志, 2012, 21(2):97-100.
68.	Goto Y, Ito J, Tomita N, et al. Re-irradiation combined with concurrent chemotherapy for patients with locally recurrent nasopharyngeal carcinoma:Clinical advantage of intensity modulated radiotherapy using helical tomotherapy. Int J Radiat Oncol Bilo Phys, 2010, 78(1):S460-S561.
69.	Chen AM, Yang CC, Marsano J, et al. Intensity-modulated radiotherapy for nasopharyngeal carcinoma:improvement of the therapeutic ratio with helical tomotherapy vs segmental multileaf collimator-based techniques. Br J Radiol, 2012, 85:e537-543.
70.	Bral S, Versmessen H, Duchateau M, et al. Toxicity report of a phase I/Ⅱ dose escalation study in inoperable locally advanced non-small cell lung cancer with helical tomotherapy and concurrent chemotherapy. Eur J Cancer, 2009, 7(2-3):535.
71.	Cannon D, Adkison JB, Chappell RJ, et al. Interim results of a phase I risk-stratified dose escalation study using hypofractionated helical tomotherapy for non-small cell lung cancer. Int J Radiat Oncol Bilo Phys, 2010, 78(1):S107-S108.
72.	Bral S, Duchateau M, Versmessen H, et al. Toxicity and outcome results of a class solution with moderately hypofractionated radiotherapy in inoperable Stage Ⅲ non-small cell lung cancer using helical tomotherapy. Int J Radiat Oncol Biol Phys, 2010, 77:1352-1359.
73.	Caruso C, Monaco A, Cianciulli M, et al. Stage ⅢA and ⅢB NSCLC treated with sequential chemoradiotherapy using helical tomotherapy. Eur J Cancer, 2011, 47:S606.
74.	Dell'Oca I, Cananeo GM, Pasetti M, et al. Hypofractionated 18-FDG PET based Helical Tomotherapy in locally advanced NSCLC:feasibility and toxicity profile. Radiother Oncol, 2010, 96:S345.
75.	Gayar HE, Nettleton J, Gayar OH, et al. Clinical outcomes of inoperable, early stage non-small cell lung cancer patients treated with image guided stereotactic body radiation therapy delivered by helical tomotherapy. Int J Radiat Oncol Bilo Phys, 2010, 78(1):S536.
76.	Monaco A, Caruso C, Giammarino D, et al. Radiotherapy for inoperable non-small cell lung cancer using helical tomotherapy. Tumori, 2012, 98:86-89.
77.	Kim JY, Kay CS, Kim YS, et al. Helical tomotherapy for simultaneous multitarget radiotherapy for pulmonary metastasis. Int J Radiat Oncol Biol Phys, 2009, 75:703-710.
78.	Parisi E, Romeo A, Ghigi G, et al. Accelerated hypofractionated radiotherapy in inoperable locally advanced lung cancer using tomotherapy:our experience. Strahlenther Onkol, 2011, 187(10):680.
79.	Song CH, Pyo H, Moon SH, et al. Treatment-related pneumonitis and acute esophagitis in non-small-cell lung cancer patients treated with chemotherapy and helical tomotherapy. Int J Radiat Oncol Biol Phys, 2010, 78:651-658.
80.	Cardinale RM, Flannery T, Tsai H, et al. Incidence and prognostic factors of radiation pneumonitis from lung cancer IMRT in a community setting. Int J Radiat Oncol Bilo Phys, 2011, 81(1):S609-S610.
81.	Chang CC, Chi KH, Kao SJ, et al. Upfront gefitinib/erlotinib treatment followed by concomitant radiotherapy for advanced lung cancer:a mono-institutional experience. Lung Cancer, 2011, 73:189-194.
82.	Vogelius IS, Westerly DC, Cannon GM, et al. Hypofractionation does not increase radiation pneumonitis risk with modern conformal radiation delivery techniques. Acta Oncol, 2010, 49:1052-1057.
83.	Schiappacasse L, Cendales R, Sallabanda K, et al. Preliminary results of helical tomotherapy in patients with complex-shaped meningiomas close to the optic pathway. Med Dosim, 2011, 36:416-422.
84.	Combs SE, Sterzing F, Uhl M, et al. Helical tomotherapy for meningiomas of the skull base and in paraspinal regions with complex anatomy and/or multiple lesions. Tumori, 2011, 97:484-491.
85.	Gupta T, Wadasadawala T, Master Z, et al. Encouraging early clinical outcomes with helical tomotherapy-based image-guided intensity-modulated radiation therapy for residual, recurrent, and/or progressive benign/low-grade intracranial tumors:a comprehensive evaluation. Int J Radiat Oncol Biol Phys, 2012, 82:756-764.
86.	Toledo D, Borrelli D, Cammarota F, et al. Helical tomotherapy-based image-guided intensity-modulated radiation therapy for intracranial tumors:a comprehensive evaluation. Strahlenther Onkol, 2011, 187(10):697.
87.	Rodrigues G, Yartsev S, Yaremko B, et al. Phase I trial of simultaneous in-field boost with helical tomotherapy for patients with one to three brain metastases. Int J Radiat Oncol Biol Phys, 2011, 80:1128-1133.
88.	Sanghera P, Lightstone AW, Hyde DE, et al. Case report. Fractionated helical tomotherapy as an alternative to radiosurgery in patients unwilling to undergo additional radiosurgery for recurrent brain metastases. Br J Radiol, 2010, 83(986):e25-30.
89.	Sterzing F, Welzel T, Sroka-Perez G, et al. Reirradiation of multiple brain metastases with helical tomotherapy:A multifocal simultaneous integrated boost for eight or more lesions. Strahlenther Onkol, 2009, 185 (2):89-93.
90.	Tomita N, Kodaira T, Tachibana H, et al. Helical tomotherapy for brain metastases:dosimetric evaluation of treatment plans and early clinical results. Technol Cancer Res Treat, 2008, 7:417-424.
91.	Galeandro M, Ciammella P, Donini E, et al. Clinical and radiological outcomes of stereotactic radiotherapy with tomotherapy for patients with oligometastatic brain lesions. Radiother Oncol, 2011, 99:S161-S162.
92.	Brunet B, Bauman G, Abdulkarim B, et al. A multi-centre phase I study of tomotherapy in patients with benign primary brain tumour:prospective analysis on quality of life at one year. Radiotherapy and Oncology, 2010, 96:S21.
93.	Sugie C, Shibamoto Y, Ayakawa S, et al. Clinical experiences with helical tomotherapy for craniospinal irradiation:Evaluation of acute toxicity and dose distribution. Int J Radiat Oncol Biol Phys, 2010, 78(3):S275-S276.
94.	Fumagalli I, Coche-Dequeant B, Reynaert N, et al. Cerebro-spinal irradiation with Tomotherapy. Radiother Oncol, 2010, 96:X1-X11.
95.	De Ridder M, Tournel K, Van Nieuwenhove Y, et al. Phase Ⅱ study of preoperative helical tomotherapy for rectal cancer. Int J Radiat Oncol Biol Phys, 2008, 70:728-734.
96.	Ugurluer G, Ballerini G, Letenneur G, et al. Helical tomotherapy (HT) for the treatment of anal canal cancer:Preliminary clinical results, and dosimetric comparison between HT and intensity-modulated or 3D conformal radiotherapy. Eur J Cancer, 2009, 7(2):331.
97.	Slim N, Passoni P, Fiorino C, et al. Adaptive image-guided tomotherapy concomitant to chemotherapy in rectal cancer:early clinical experience. Strahlenther Onkol, 2011, 187(10):683.
98.	Passoni P, Fiorino C, Maggiulli E, et al. Early clinical experience in adaptive image-guided tomotherapy of rectal cancer. Radiother Oncol, 2010, 99:S391.
99.	Engels B, Everaert H, Gevaert T, et al. Phase Ⅱ study of helical tomotherapy for oligometastatic colorectal cancer. Ann Oncol, 2011, 22:362-368.
100.	Engels B, Tournel K, Everaert H, et al. Phase Ⅱ study of preoperative helical tomotherapy with a simultaneous integrated boost for rectal cancer. Int J Radiat Oncol Biol Phys, 2012, 83:142-148.
101.	Nguyen NP, Vock J, Sroka T, et al. Feasibility of image-guided radiotherapy based on tomotherapy for the treatment of locally advanced anal carcinoma. Anticancer Res, 2011, 31:4393-4396.
102.	Kay C, Yoo E, Lee Y, Kim Y. Clinical experience of helical tomotherapy in patients with recurrent rectal cancer after prior radiotherapy. Ann Oncol, 2010, 21:vi106-vi107.
103.	Chen YJ, Suh S, Nelson RA, et al. Setup variations in radiotherapy of anal cancer:advantages of target volume reduction using image-guided radiation treatment. Int J Radiat Oncol Biol Phys, 2012, 84:289-295.
104.	Loewen SK, Joseph K, Syme A, et al. Helical tomotherapy in the treatment of anal cancer:treatment planning and acute toxicity data. Int J Radiat Oncol Bilo Phys, 2011, 81(1):S377.
105.	Siker ML, Qi XS, Hu B, et al. Helical tomotherapy for anal cancer:initial clinical outcomes and organ motion. Journal of Clinical Oncology, 2011, 29(1):201.
106.	Engels B, Gevaert T, Everaert H, et al. Phase Ⅱ study of helical tomotherapy in the multidisciplinary treatment of oligometastatic colorectal cancer. Radiat Oncol, 2012, 7:34.
107.	Kim YJ, Kim JY, Yoo SH, et al. High control rate for lymph nodes in cervical cancer treated with high-dose radiotherapy using helical tomotherapy. Technol Cancer Res Treat, 2013, 12(1):45-51.
108.	Kim YJ, Kim JY, Kang S, et al. High lymph node control rate in the cervical cancer treated with high dose radiotherapy using tomotherapy. IJGC, 2011, 21(3):S326.
109.	Marnitz S, Stromberger C, Kawgan-Kagan M, et al. Helical tomotherapy in cervical cancer patients:simultaneous integrated boost concept:technique and acute toxicity. Strahlenther Onkol, 2010, 186:572-579.
110.	Schwarz JK, Wahab S, Grigsby PW. Prospective phase I-Ⅱ trial of helical tomotherapy with or without chemotherapy for postoperative cervical cancer patients. Int J Radiat Oncol Biol Phys, 2011, 81:1258-1263.
111.	Chang AJ, Richardson S, Grigsby PW, et al. Split-field helical tomotherapy with or without chemotherapy for definitive treatment of cervical cancer. Int J Radiat Oncol Biol Phys, 2012, 82:263-269.
112.	Marnitz S, Kohler C, Burova E, et al. Helical tomotherapy with simultaneous integrated boost after laparoscopic staging in patients with cervical cancer:analysis of feasibility and early toxicity. Int J Radiat Oncol Biol Phys, 2012, 82:e137-143.
113.	Hsieh CH, Wei MC, Lee HY, et al. Whole pelvic helical tomotherapy for locally advanced cervical cancer:technical implementation of IMRT with helical tomotherapy. Radiat Oncol, 2009, 4:62.
114.	周桂霞, 解传彬, 葛瑞刚, 等.宫颈癌术后螺旋断层放疗与常规调强放疗急性反应分析.军医进修学院学报, 2011, 32(5):411-413, 422.
115.	赵潇, 周桂霞, 解传滨.宫颈癌术后螺旋断层放疗与常规调强放疗近期疗效分析.军医进修学院学报, 2012, 33(10):1039-1041.
116.	赵潇, 周桂霞, 解传滨, 等.根治性调强放疗宫颈癌不同治疗模式的急性反应研究.军医进修学院学报. 2012, 33(9):910-912.
117.	McIntosh A, Hagspiel KD, Al-Osaimi AM, et al. Accelerated treatment using intensity-modulated radiation therapy plus concurrent capecitabine for unresectable hepatocellular carcinoma. Cancer, 2009, 115:5117-5125.
118.	Jang JW, Kay CS, You CR, et al. Simultaneous multitarget irradiation using helical tomotherapy for advanced hepatocellular carcinoma with multiple extrahepatic metastases. Int J Radiat Oncol Biol Phys, 2009, 74:412-418.
119.	Baisden JM, Kahaleh M, Weiss GR, et al. Multimodality treatment with helical tomotherapy intensity modulated radiotherapy, capecitabine, and photodynamic therapy is feasible and well tolerated in patients with hilar cholangiocarcinoma. Gastrointest Cancer Res, 2008, 2:219-224.
120.	Chi KH, Liao CS, Chang CC, et al. Blockade and Radiotherapy in Hepatocellular Carcinoma. Int J Radiat Oncol Biol Phys, 2010, 78(1):188-193.
121.	Jang H, Son S, Song J, et al. Hypofractionated radiotherapy for the patients with unresectable primary hepatocellular carcinoma using tomotherapy Hi-Art:analysis of the efficacy and toxicity. Int J Radiat Oncol Biol Phys, 2011, 81(1):S361.
122.	Kay C, Kim J, Yoo E, et al. Helical tomotherapy for lung metastases in hepatocellular carcinoma. Int J Radiat Oncol Biol Phys, 2010, 78(1):S584.
123.	Ernst I, Moustakis C, Buether F, et al. 4D list mode-based PET/CT target delineation in tomotherapy of liver tumors. Int J Radiat Oncol Biol Phys, 2011, 81(1):S362-S363.
124.	Jung SM, Jang JW, You CR, et al. Role of intrahepatic tumor control in the prognosis of patients with hepatocellular carcinoma and extrahepatic metastases. J Hepatol, 2012, 54:S527.
125.	Caudrelier JM, Esche B, Montgomery L, et al. Preliminary results of a prospective clinical trial evaluating intensity-modulated radiation therapy delivered by helical tomotherapy for locoregional breast radiation including the internal mammary nodes. Radiother Oncol, 2010, 96:S28.
126.	Cendales R, Schiappacasse L, Schnitman F, et al. Helical tomotherapy in patients with breast cancer and complex treatment volumes. Clin Transl Oncol, 2011, 13:268-274.
127.	Franco P, Cante D, Catuzzo P, et al. Adjuvant whole breast radiation therapy delivered with static angle tomotherapy employing tomodirect:early results and toxicity. Radiother Oncol, 2011, 99:S293-S294.
128.	Franzetti-Pellanda A, Ballerini G, Schombourg K, et al. A new clinical approach for right breast cancer treatment:unique combination of tomodirect IMRT and helical IMRT techniques. Radiother Oncol, 2011, 99:S292.
129.	Uhl M, Sterzing F, Habl G, et al. Helical tomotherapy and breast cancer:skin toxicity of the first 85 breast cancer patients treated with tomotherapy. Strahlenther Onkol, 2011, 187(10):689.
130.	Chira C, Jacob J, Campana F, et al. A simultaneous integrated boost technique in the adjuvant treatment of breast cancer:feasibility and early toxicity results. Strahlenther Onkol, 2011, 187(10):699-700.
131.	Garcia G, Marrone I, Minguez C, et al. Tomotherapy versus topotherapy in breast cancer patients:experience of grupo IMO. Strahlenther Onkol, 2011, 187(10):688.
132.	Van Parijs H, Vinh-Hung V, Adriaenssens N, et al. Short course radiotherapy (RT) with simultaneous integrated boost (SIB) for stage I-Ⅱ breast cancer, interim analysis of a randomized clinical trial. Strahlenther Onkol, 2011, 187(8):515.
133.	Giraud P, Sylvestre A, Zefkili S, et al. Helical tomotherapy for resected malignant pleural mesothelioma:dosimetric evaluation and toxicity. Radiother Oncol, 2011, 101:303-306.
134.	Sylvestre A, Mahe MA, Lisbona A, et al. Mesothelioma at era of helical tomotherapy:results of two institutions in combining chemotherapy, surgery and radiotherapy. Lung Cancer, 2011, 74:486-491.
135.	Abbiero ND, Ciammella P, Galeandro M, et al. Local relapse of malignant pleural mesothelioma:a monoistitutional study of salvage hypofractionated radiotherapy with tomotherapy. Radiother Oncol, 2011, 99:S343.
136.	Ebara T, Kawamura H, Kaminuma T, et al. Hemithoracic intensity-modulated radiotherapy using helical tomotherapy for patients after extrapleural pneumonectomy for malignant pleural mesothelioma. J Radiat Res, 2012, 53:288-294.
137.	Giraud P, Sylvestre A, Lisbona A, et al. Value of tomotherapy in malignant pleural mesothelioma:first clinical results. Rev Mal Respir, 2011, 28:609-617.
138.	Fodor A, Fiorino C, Dell'Gca I, et al. Could a PET-guided concomitant boost dose escalation help in progressive malignant pleural mesothelioma? Radiother Oncol, 2010, 96:S340-S1.
139.	Shueng PW, Wu LJ, Chen SY, et al. Concurrent chemoradiotherapy with helical tomotherapy for oropharyngeal cancer:a preliminary result. Int J Radiat Oncol Biol Phys, 2010, 77:715-721.
140.	Fortin I, Fortin B, Fillion E, et al. Is helical tomotherapy a new standard for the treatment of oropharyngeal carcinoma? Preliminary results of the notre-dame hospital comparing linac based intensity modulated radiotherapy to helical tomotherapy. Int J Radiat Oncol Biol Phys, 2011, 81(1):S498-S498.
141.	Cianciulli M, Caruso C, Monaco A, et al. Helical tomotherapy in the treatment of locally advanced squamous cell oral carcinoma. Eur J Cancer, 2011, 47:S565.
142.	Hsieh CH, Kuo YS, Liao LJ, et al. Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer. BMC Cancer, 2011, 11:37.
143.	Cosinschi A, Khanfir K, Joosten A, et al. Carotid dose sparing in definitive irradiation of T1no squamous cell laryngeal carcinoma using helical tomotherapy. Int J Radiat Oncol Biol Phys, 2011, 81(1):S518-S519.
144.	Kim B, Soisson ET, Duma C, et al. Image-guided helical Tomotherapy for treatment of spine tumors. Clin Neurol Neurosurg, 2008, 110:357-362.
145.	Sheehan JP, Shaffrey CI, Schlesinger D, et al. Radiosurgery in the treatment of spinal metastases:tumor control, survival, and quality of life after helical tomotherapy. Neurosurgery, 2009, 65:1052-1061.
146.	Sterzing F, Hauswald H, Uhl M, et al. Spinal cord sparing reirradiation with helical tomotherapy. Cancer, 2010, 116:3961-3968.
147.	Choi Y, Kim JW, Lee IJ, et al. Helical tomotherapy for spine oligometastases from gastrointestinal malignancies. Radiation Oncol J, 2011, 29:219-227.
148.	Kim B, Soisson E, Duma C, et al. Treatment of recurrent high grade gliomas with hypofractionated stereotactic image-guided helical tomotherapy. Clin Neurol Neurosurg, 2011, 113:509-512.
149.	Astaniyah NT, Le D, Pervez N, et al. Phase I study of hypofractionated intensity modulated radiation therapy with concurrent and adjuvant temozolomide in patients with glioblastoma multiforme. Int J Radiat Oncol Biol Phys, 2010, 78(1):S168.
150.	Miwa K, Matsuo M, Shinoda J, et al. Hypofractionated high-dose irradiation planned by methionine pet for the treatment of glioblastoma multiforme. Neuro-Oncology, 2010, 12:iii443.
151.	AlHussain H, Malone S, Gertler S, et al. Results of a prospective trial evaluating accelerated radiation therapy using tomotherapy simultaneous integrated boost (ARTOSIB) with concurrent and adjuvant temozolomide (TMZ) chemotherapy in the treatment of glioblastoma multiforme (GBM). Int J Radiat Oncol Biol Phys, 2011, 81(1):S270-S271.
152.	Shueng PW, Lin SC, Chong NS, et al. Total marrow irradiation with helical tomotherapy for bone marrow transplantation of multiple myeloma:first experience in Asia. Technol Cancer Res Treat, 2009, 8:29-38.
153.	Somlo G, Spielberger R, Frankel P, et al. Total marrow irradiation:a new ablative regimen as part of tandem autologous stem cell transplantation for patients with multiple myeloma. Clin Cancer Res, 2011, 17:174-182.
154.	Chargari C, Hijal T, Bouscary D, et al. The role of helical tomotherapy in the treatment of bone plasmacytoma. Med Dosim, 2012, 37:26-30.
155.	Bijdekerke P, Verellen D, Tournel K, et al. TomoTherapy:implications on daily workload and scheduling patients. Radiother Oncol. 2008, 86:224-230.
156.	Burnet NG, Adams EJ, Fairfoul J, et al. Practical aspects of implementation of helical tomotherapy for intensity-modulated and image-guided radiotherapy. Clinical Oncology, 2010, 22 (4):294-312.
157.	张金葆, 卢爱国.螺旋断层放疗系统的验收与质量保证规范.医疗卫生装备, 2010, 31(11):124-126.
158.	张思维, 陈万青, 郑荣寿, 等. 2003-2007年中国癌症死亡分析.中国肿瘤, 2011, 21(3):171-178.
159.	代敏, 李霓, 李倩, 等.中国肿瘤预防控制概况.中国肿瘤, 2011, 20(12):868-873.

1. Summary W. WHO cancer control:Knowledge into action. Available at:http://wwwwhoint/cancer.[Accessed on Oct 28 2012].
2. Janssens ACJW, Ioannidis JPA, Bedrosian S, et al. Strengthening the reporting of genetic risk prediction studies (GRIPS):explanation and elaboration. J Clin Epidemiol, 2011, 64:e1-e22.
3. 殷蔚伯, 谷铣之.肿瘤放射治疗学.北京:中国协和医科大学出版社. 2007:71-72.
4. Rizos EC, Salanti G, Kontoyiannis DP, et al. Homophily and co-occurrence patterns shape randomized trials agendas:illustration in antifungal agents. J Clin Epidemiol, 2011, 64:830-842.
5. 张金葆.螺旋断层放疗系统的先进性评估分析.中国医疗设备, 2009, 24(4):136-139.
6. VillegasPortero JCVaR. Helical tomotherapy. Current Uses and Utility. 2008:69-73.
7. Centre TNHS. Helical Tomotherapy Hi-ART^TM System for external cancer radiotherapy. 2006:107-110.
8. AHTA. TomoTherapy HI-ART System Radiotherapy planning and treatment for cancer patients. 2009:84-87.
9. Boudreau RCM, Nkansah E. Tomotherapy, gamma knife, and cyberknife therapies for patients with tumours of the lung, central nervous system, or intra-abdomen:a systematic review of clinical effectiveness and cost-effectiveness. 2009:66-68.
10. Katchamart W, Faulkner A, Feldman B, et al. PubMed had a higher sensitivity than Ovid-MEDLINE in the search for systematic reviews. J Clin Epidemiol, 2011, 64:805-807.
11. Teh BS, Dong L, McGary JE, et al. Rectal wall sparing by dosimetric effect of rectal balloon used during intensity-modulated radiation therapy (IMRT) for prostate cancer. Med Dosim, 2005, 30:25-30.
12. Cozzarini C, Fiorino C, Di Muzio N, et al. Significant reduction of acute toxicity following pelvic irradiation with helical tomotherapy in patients with localized prostate cancer. Radiother Oncol, 2007, 84:164-170.
13. Cheng JC, Schultheiss TE, Nguyen KH, et al. Acute toxicity in definitive versus postprostatectomy image-guided radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys, 2008, 71:351-357.
14. Engels B, Soete G, Tournel K, et al. Helical tomotherapy with simultaneous integrated boost for high-risk and lymph node-positive prostate cancer:early report on acute and late toxicity. Technol Cancer Res Treat, 2009, 8:353-359.
15. Di Muzio N, Fiorino C, Cozzarini C, et al. Phase I-Ⅱ study of hypofractionated simultaneous integrated boost with tomotherapy for prostate cancer. Int J Radiat Oncol Biol Phys, 2009, 74:392-398.
16. 尹雷明.前列腺癌三种不同放疗技术剂量学研究和螺旋断层放疗前列腺癌毒副反应的临床观察.解放军总医院. 2009:6-49.
17. Alongi F, Cozzarini C, Fiorino C, et al. Optimal acute toxicity profile for concomitant pelvic irradiation in 153 prostate cancer patients with tomotherapy. International Institute of Anticancer Research, 2010, 77(1):153-159..
18. Schwarz R, Petersen C, Janke Y, et al. IMRT with helical tomotherapy for primary treatment of prostate cancer-Preliminary toxicity and remission data. Strahlenther Onkol, 2010, 186(1):60.
19. Di Muzio N, Fiorino C, Cozzarini C, et al. High-dose moderately hypofractionated tomotherapy for localized prostate cancer:promising 3-year results. Int J Radiat Oncol Biol Phys, Int J Radiat Oncol Biol Phys, 2010, 78(1):S349.
20. Pervez N, Small C, MacKenzie M, et al. Acute toxicity in high-risk prostate cancer patients treated with androgen suppression and hypofractionated intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys, 2010, 76:57-64.
21. Drodge S, Pervez N, Ghosh S, et al. Late toxicity in high-risk prostate cancer treated with androgen suppression and hypofractionated intensity modulated radiotherapy. Int J Radiat Oncol Biol Phys, 2010, 78(1):S353.
22. Cendales R, Schnitman F, Schiappacasse L, et al. Early report on acute toxicity after IMRT/IGRT with Tomotherapy in localized prostate cancer. Radiother Oncol, 2010, 96:S400.
23. Alongi F, Cozzarini C, Fiorlno C, et al. Excellent acutetoxicity of salvage tomotherapy to prostatic bed and pelvis in 55 patients. Radiother Oncol, 2010, 96:S420.
24. Ayakawa S, Shibamoto Y, Sugie C, et al. Helical tomotherapy with a 2.2-GY daily fraction and dose reduction for the rectum for localized prostate cancer. Int J Radiat Oncol Biol Phys, 2011, 81(1):S413-S414.
25. Cammarota F, Toledo D, Borrelli D, et al. Exclusive radiotherapy of prostate cancer with helical tomotherapy:initial experience. Strahlenther Onkol, 2011, 187(10):700.
26. Longobardi B, Berardi G, Fiorino C, et al. Anatomical and clinical predictors of acute bowel toxicity in whole pelvis irradiation for prostate cancer with tomotherapy. Radiother Oncol, 2011, 101:460-464.
27. Le D, Drodge CS, Pervez N, et al. Acute and late toxicity in high-risk prostate cancer treated with androgen suppression and hypofractionated intensity modulated radiotherapy. Int J Radiat Oncol Biol Phys, 2011, 81(1):S101.
28. Romeo A, Gunelli R, De Giorgi U, et al. Early clinical experience of helical tomotherapy for hypofractionated re-irradiation of recurrent localized prostate cancer. Anticancer Research, 2011, 31(5):1877.
29. Geier M, Astner ST, Duma MN, et al. Dose-escalated simultaneous integrated-boost treatment of prostate cancer patients via helical tomotherapy. Strahlenther Onkol, 2012, 188:410-416.
30. Lopez Guerra JL, Isa N, Matute R, et al. Hypofractionated helical tomotherapy using 2.5-2.6 Gy daily fractions for localized prostate cancer. Clin Transl Oncol, 2013, 15:271-277.
31. Tomita N, Soga N, Ogura Y, et al. Preliminary results of intensity-modulated radiation therapy with helical tomotherapy for prostate cancer. J Cancer Res Clin Oncol, 2012, 138:1931-1936.
32. Borrelli D, Toledo D, Cammarota F, et al. Tomotherapy in postoperative patients with prostate cancer:evaluation of acute toxicity. Anticancer Research, 2011, 31 (5):1903.
33. Berardi G, Alongi F, Fiorino C, et al. Hypofractionated tomotherapy treatment (HTT) in prostate cancer lymph nodal relapse detected by 11C-choline PET/CT. Strahlenther Onkol, 2011, 187(10):677.
34. Garibaldi E, Bresciani S, Delmastro E, et al. Helical tomotherapy in high/very high risk and in nodal recurrences of prostate cancer:preliminary results. Strahlentherapie und Onkologie, 2011, 187(10):677-678.
35. Cozzarini C, Fiorino C, Di Muzio N, et al. Hypofractionated adjuvant radiotherapy with helical tomotherapy after radical prostatectomy:planning data and toxicity results of a Phase I-Ⅱ study. Radiother Oncol, 2008, 88:26-33.
36. Russo D, Papaleo A, Leone A, et al. Comparison of dosimetric results and toxicity patterns between SIB-IMRT and high-dose 3D-CRT in prostate cancer. Anticancer Research, 2011, 31(5):1915-1916.
37. Keiler L, Dobbins D, Kulasekere R, et al. Tomotherapy for prostate adenocarcinoma:a report on acute toxicity. Radiother Oncol, 2007, 84:171-176.
38. Alongi F, Fiorino C, Cozzarini C, et al. IMRT significantly reduces acute toxicity of whole-pelvis irradiation in patients treated with post-operative adjuvant or salvage radiotherapy after radical prostatectomy. Radiother Oncol, 2009, 93:207-212.
39. Marques C, Sa A, Pappalardi B, et al. Hypofractionated helical tomotherapy vs. conventional IMRT in prostate cancer. Journal of Medical Imaging and Radiation Sciences, 2011, 42(3):160.
40. Hicks A, Mix M, Ashton S. Acute toxicity in the treatment of prostate cancer:a comparison of conventional IGRT, helical tomotherapy and calypso technology. Am J Clin Oncol-Canc, 2011, 34(2):212-213.
41. Pervez N, Krauze AV, Yee D, et al. Quality-of-life outcomes in high-risk prostate cancer patients treated with helical tomotherapy in a hypofractionated radiation schedule with long-term androgen suppression. Curr Oncol, 2012, 19:e201-210.
42. Chen AM, Jennelle RL, Sreeraman R, et al. Initial clinical experience with helical tomotherapy for head and neck cancer. Head Neck, 2009, 31:1571-1578.
43. Farrag A, Voordeckers M, Tournel K, et al. Pattern of locoregional failure after tomotherapy in head and neck cancer. Eur J Cancer, 2009, 7(2-3):479.
44. Yoo EJ, Kay CS, Kim JY, et al. Helical tomotherapy for recurrent or second primary head and neck cancer in prior irradiated territory. Radiother Oncol, 2010, 96:S317.
45. Farrag A, Voordeckers M, Tournel K, et al. Pattern of failure after helical tomotherapy in head and neck cancer. Strahlenther Onkol, 2010, 186(9):511-516.
46. Ricchetti F, Bacigalupo A, Vagge S, et al. Is alopecia still a problem in head and neck patients treated with tomotherapy? Radiother Oncol, 2010, 96:S321.
47. Bolle S, Rothe Thomas F, Malika A, et al. Tomotherapy for head and neck cancer:clinical outcomes and patterns of failure. Strahlentherapie und Onkologie, 2011, 187(10):697.
48. Chizzali B, Thamm R, Duma M, et al. Longitudinal evaluation of quality of life of patients with head-and-neck cancer treated with helical tomotherapy. Strahlenther Onkol, 2011, 187(10):697.
49. Dell'Oca I, Fiorino C, Fodor A, et al. Simultaneous integrated boost 18FDG-PET based helical tomotherapy in radical locally advanced head and neck cancer. Radiother Oncol, 2011, 99:S335.
50. Garibaldi E, Bresciani S, Salatino A, et al. Helical tomotherapy in advanced and recurrence head and neck cancer:preliminary results. Strahlenther Onkol, 2011, 187(10):677.
51. Goy Y, Prosch C, Bajrovic A, et al. Tomotherapy in locally advanced head and neck cancer-does it reduce xerostomia? Radiother Oncol, 2011, 98(10):167.
52. Schiappacasse L, Coche B, Romero S, et al. Simultaneous integrated boost (SIB) and simultaneous modulated accelerated radiation therapy (SMART) for head & neck cancer patients using helical tomotherapy:experience of centre oscar lambret. Strahlenther Onkol, 2011, 187(10):687.
53. You SH, Kim SY, Lee CG, et al. Is there a clinical benefit to adaptive planning during tomotherapy in patients with head and neck cancer at risk for xerostomia? Am J Clin Oncol, 2012, 35:261-266.
54. Voordeckers M, Farrag A, Everaert H, et al. Parotid gland sparing with helical tomotherapy in head-and-neck cancer. Int J Radiat Oncol Biol Phys, 2012, 84:443-448.
55. Goy Y, Prosch C, Tennstedt P, et al. Tomotherapy in head and neck cancer:mind each gland. Strahlenther Onkol, 2011, 187(10):687.
56. Chen AM, Marsano J, Perks J, et al. Comparison of IMRT techniques in the radiotherapeutic management of head and neck cancer:is tomotherapy "better" than step-and-shoot IMRT? Technol Cancer Res Treat, 2011, 10:171-177.
57. 杜镭, 马林, 周桂霞, 等.螺旋断层放疗45例鼻咽癌近期临床观察.军医进修学院学报, 2009, 30(3):311-314.
58. 路娜.鼻咽癌螺旋断层放疗过程中靶区和危及器官变化及近期临床观察.中国人民解放军军医进修学院. 2010:5-48.
59. Goto Y. Reirradiadion of locally recurrent nasopharyngeal cancer with intensity-modulated radiotherapy using helical tomotherapy. Jpn J Radiol, 2010, 55(8):1018-1024.
60. Kodaira L, Furutani K, Tachibana H, et al. Intensity modulated radiotherapy combined with concomitant chemotherapy using helical tomotherapy for patients with nasopharyngeal carcinoma. Radiother Oncol, 2010, 96:S320-S321.
61. Ma L, Du L, Feng L, et al. Short-term clinical observations of 73 nasopharyngeal carcinoma patients treated with tomotherapy. Int J Radiat Oncol Biol Phys, 2010, 78(1):S475-S476.
62. Marrone I. Tomotherapy in nasopharynx and paranasal sinuses cancers. Radiotherapy and Oncology, 2010, 96:S334.
63. Bacigalupo A, Vagge S, Bosetti D, et al. Preliminary experience with helical tomotherapy using simultaneous integrated boost (SIB) in nasopharynx cancer. Radiother Oncol, 2011, 98:S31-S32.
64. Kodaira T, Tomita N, Tachibana H, et al. Aichi cancer center initial experience of intensity modulated radiation therapy for nasopharyngeal cancer using helical tomotherapy. Int J Radiat Oncol Biol Phys, 2009, 73:1129-1134.
65. Feng L, Hou J, Cai B, et al. Clinical observation in nasopharyngeal carcinoma treated with anti-EGFR monoclonal antibodies followed by helical tomotherapy. Journal of Clinical Oncology, 2011, 29(1):S35.
66. Shueng PW, Shen BJ, Wu LJ, et al. Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma. Radiat Oncol, 2011, 6:95.
67. 杜镭, 马林, 冯林春, 等. 121例鼻咽癌螺旋断层治疗结果分析.中华放射肿瘤学杂志, 2012, 21(2):97-100.
68. Goto Y, Ito J, Tomita N, et al. Re-irradiation combined with concurrent chemotherapy for patients with locally recurrent nasopharyngeal carcinoma:Clinical advantage of intensity modulated radiotherapy using helical tomotherapy. Int J Radiat Oncol Bilo Phys, 2010, 78(1):S460-S561.
69. Chen AM, Yang CC, Marsano J, et al. Intensity-modulated radiotherapy for nasopharyngeal carcinoma:improvement of the therapeutic ratio with helical tomotherapy vs segmental multileaf collimator-based techniques. Br J Radiol, 2012, 85:e537-543.
70. Bral S, Versmessen H, Duchateau M, et al. Toxicity report of a phase I/Ⅱ dose escalation study in inoperable locally advanced non-small cell lung cancer with helical tomotherapy and concurrent chemotherapy. Eur J Cancer, 2009, 7(2-3):535.
71. Cannon D, Adkison JB, Chappell RJ, et al. Interim results of a phase I risk-stratified dose escalation study using hypofractionated helical tomotherapy for non-small cell lung cancer. Int J Radiat Oncol Bilo Phys, 2010, 78(1):S107-S108.
72. Bral S, Duchateau M, Versmessen H, et al. Toxicity and outcome results of a class solution with moderately hypofractionated radiotherapy in inoperable Stage Ⅲ non-small cell lung cancer using helical tomotherapy. Int J Radiat Oncol Biol Phys, 2010, 77:1352-1359.
73. Caruso C, Monaco A, Cianciulli M, et al. Stage ⅢA and ⅢB NSCLC treated with sequential chemoradiotherapy using helical tomotherapy. Eur J Cancer, 2011, 47:S606.
74. Dell'Oca I, Cananeo GM, Pasetti M, et al. Hypofractionated 18-FDG PET based Helical Tomotherapy in locally advanced NSCLC:feasibility and toxicity profile. Radiother Oncol, 2010, 96:S345.
75. Gayar HE, Nettleton J, Gayar OH, et al. Clinical outcomes of inoperable, early stage non-small cell lung cancer patients treated with image guided stereotactic body radiation therapy delivered by helical tomotherapy. Int J Radiat Oncol Bilo Phys, 2010, 78(1):S536.
76. Monaco A, Caruso C, Giammarino D, et al. Radiotherapy for inoperable non-small cell lung cancer using helical tomotherapy. Tumori, 2012, 98:86-89.
77. Kim JY, Kay CS, Kim YS, et al. Helical tomotherapy for simultaneous multitarget radiotherapy for pulmonary metastasis. Int J Radiat Oncol Biol Phys, 2009, 75:703-710.
78. Parisi E, Romeo A, Ghigi G, et al. Accelerated hypofractionated radiotherapy in inoperable locally advanced lung cancer using tomotherapy:our experience. Strahlenther Onkol, 2011, 187(10):680.
79. Song CH, Pyo H, Moon SH, et al. Treatment-related pneumonitis and acute esophagitis in non-small-cell lung cancer patients treated with chemotherapy and helical tomotherapy. Int J Radiat Oncol Biol Phys, 2010, 78:651-658.
80. Cardinale RM, Flannery T, Tsai H, et al. Incidence and prognostic factors of radiation pneumonitis from lung cancer IMRT in a community setting. Int J Radiat Oncol Bilo Phys, 2011, 81(1):S609-S610.
81. Chang CC, Chi KH, Kao SJ, et al. Upfront gefitinib/erlotinib treatment followed by concomitant radiotherapy for advanced lung cancer:a mono-institutional experience. Lung Cancer, 2011, 73:189-194.
82. Vogelius IS, Westerly DC, Cannon GM, et al. Hypofractionation does not increase radiation pneumonitis risk with modern conformal radiation delivery techniques. Acta Oncol, 2010, 49:1052-1057.
83. Schiappacasse L, Cendales R, Sallabanda K, et al. Preliminary results of helical tomotherapy in patients with complex-shaped meningiomas close to the optic pathway. Med Dosim, 2011, 36:416-422.
84. Combs SE, Sterzing F, Uhl M, et al. Helical tomotherapy for meningiomas of the skull base and in paraspinal regions with complex anatomy and/or multiple lesions. Tumori, 2011, 97:484-491.
85. Gupta T, Wadasadawala T, Master Z, et al. Encouraging early clinical outcomes with helical tomotherapy-based image-guided intensity-modulated radiation therapy for residual, recurrent, and/or progressive benign/low-grade intracranial tumors:a comprehensive evaluation. Int J Radiat Oncol Biol Phys, 2012, 82:756-764.
86. Toledo D, Borrelli D, Cammarota F, et al. Helical tomotherapy-based image-guided intensity-modulated radiation therapy for intracranial tumors:a comprehensive evaluation. Strahlenther Onkol, 2011, 187(10):697.
87. Rodrigues G, Yartsev S, Yaremko B, et al. Phase I trial of simultaneous in-field boost with helical tomotherapy for patients with one to three brain metastases. Int J Radiat Oncol Biol Phys, 2011, 80:1128-1133.
88. Sanghera P, Lightstone AW, Hyde DE, et al. Case report. Fractionated helical tomotherapy as an alternative to radiosurgery in patients unwilling to undergo additional radiosurgery for recurrent brain metastases. Br J Radiol, 2010, 83(986):e25-30.
89. Sterzing F, Welzel T, Sroka-Perez G, et al. Reirradiation of multiple brain metastases with helical tomotherapy:A multifocal simultaneous integrated boost for eight or more lesions. Strahlenther Onkol, 2009, 185 (2):89-93.
90. Tomita N, Kodaira T, Tachibana H, et al. Helical tomotherapy for brain metastases:dosimetric evaluation of treatment plans and early clinical results. Technol Cancer Res Treat, 2008, 7:417-424.
91. Galeandro M, Ciammella P, Donini E, et al. Clinical and radiological outcomes of stereotactic radiotherapy with tomotherapy for patients with oligometastatic brain lesions. Radiother Oncol, 2011, 99:S161-S162.
92. Brunet B, Bauman G, Abdulkarim B, et al. A multi-centre phase I study of tomotherapy in patients with benign primary brain tumour:prospective analysis on quality of life at one year. Radiotherapy and Oncology, 2010, 96:S21.
93. Sugie C, Shibamoto Y, Ayakawa S, et al. Clinical experiences with helical tomotherapy for craniospinal irradiation:Evaluation of acute toxicity and dose distribution. Int J Radiat Oncol Biol Phys, 2010, 78(3):S275-S276.
94. Fumagalli I, Coche-Dequeant B, Reynaert N, et al. Cerebro-spinal irradiation with Tomotherapy. Radiother Oncol, 2010, 96:X1-X11.
95. De Ridder M, Tournel K, Van Nieuwenhove Y, et al. Phase Ⅱ study of preoperative helical tomotherapy for rectal cancer. Int J Radiat Oncol Biol Phys, 2008, 70:728-734.
96. Ugurluer G, Ballerini G, Letenneur G, et al. Helical tomotherapy (HT) for the treatment of anal canal cancer:Preliminary clinical results, and dosimetric comparison between HT and intensity-modulated or 3D conformal radiotherapy. Eur J Cancer, 2009, 7(2):331.
97. Slim N, Passoni P, Fiorino C, et al. Adaptive image-guided tomotherapy concomitant to chemotherapy in rectal cancer:early clinical experience. Strahlenther Onkol, 2011, 187(10):683.
98. Passoni P, Fiorino C, Maggiulli E, et al. Early clinical experience in adaptive image-guided tomotherapy of rectal cancer. Radiother Oncol, 2010, 99:S391.
99. Engels B, Everaert H, Gevaert T, et al. Phase Ⅱ study of helical tomotherapy for oligometastatic colorectal cancer. Ann Oncol, 2011, 22:362-368.
100. Engels B, Tournel K, Everaert H, et al. Phase Ⅱ study of preoperative helical tomotherapy with a simultaneous integrated boost for rectal cancer. Int J Radiat Oncol Biol Phys, 2012, 83:142-148.
101. Nguyen NP, Vock J, Sroka T, et al. Feasibility of image-guided radiotherapy based on tomotherapy for the treatment of locally advanced anal carcinoma. Anticancer Res, 2011, 31:4393-4396.
102. Kay C, Yoo E, Lee Y, Kim Y. Clinical experience of helical tomotherapy in patients with recurrent rectal cancer after prior radiotherapy. Ann Oncol, 2010, 21:vi106-vi107.
103. Chen YJ, Suh S, Nelson RA, et al. Setup variations in radiotherapy of anal cancer:advantages of target volume reduction using image-guided radiation treatment. Int J Radiat Oncol Biol Phys, 2012, 84:289-295.
104. Loewen SK, Joseph K, Syme A, et al. Helical tomotherapy in the treatment of anal cancer:treatment planning and acute toxicity data. Int J Radiat Oncol Bilo Phys, 2011, 81(1):S377.
105. Siker ML, Qi XS, Hu B, et al. Helical tomotherapy for anal cancer:initial clinical outcomes and organ motion. Journal of Clinical Oncology, 2011, 29(1):201.
106. Engels B, Gevaert T, Everaert H, et al. Phase Ⅱ study of helical tomotherapy in the multidisciplinary treatment of oligometastatic colorectal cancer. Radiat Oncol, 2012, 7:34.
107. Kim YJ, Kim JY, Yoo SH, et al. High control rate for lymph nodes in cervical cancer treated with high-dose radiotherapy using helical tomotherapy. Technol Cancer Res Treat, 2013, 12(1):45-51.
108. Kim YJ, Kim JY, Kang S, et al. High lymph node control rate in the cervical cancer treated with high dose radiotherapy using tomotherapy. IJGC, 2011, 21(3):S326.
109. Marnitz S, Stromberger C, Kawgan-Kagan M, et al. Helical tomotherapy in cervical cancer patients:simultaneous integrated boost concept:technique and acute toxicity. Strahlenther Onkol, 2010, 186:572-579.
110. Schwarz JK, Wahab S, Grigsby PW. Prospective phase I-Ⅱ trial of helical tomotherapy with or without chemotherapy for postoperative cervical cancer patients. Int J Radiat Oncol Biol Phys, 2011, 81:1258-1263.
111. Chang AJ, Richardson S, Grigsby PW, et al. Split-field helical tomotherapy with or without chemotherapy for definitive treatment of cervical cancer. Int J Radiat Oncol Biol Phys, 2012, 82:263-269.
112. Marnitz S, Kohler C, Burova E, et al. Helical tomotherapy with simultaneous integrated boost after laparoscopic staging in patients with cervical cancer:analysis of feasibility and early toxicity. Int J Radiat Oncol Biol Phys, 2012, 82:e137-143.
113. Hsieh CH, Wei MC, Lee HY, et al. Whole pelvic helical tomotherapy for locally advanced cervical cancer:technical implementation of IMRT with helical tomotherapy. Radiat Oncol, 2009, 4:62.
114. 周桂霞, 解传彬, 葛瑞刚, 等.宫颈癌术后螺旋断层放疗与常规调强放疗急性反应分析.军医进修学院学报, 2011, 32(5):411-413, 422.
115. 赵潇, 周桂霞, 解传滨.宫颈癌术后螺旋断层放疗与常规调强放疗近期疗效分析.军医进修学院学报, 2012, 33(10):1039-1041.
116. 赵潇, 周桂霞, 解传滨, 等.根治性调强放疗宫颈癌不同治疗模式的急性反应研究.军医进修学院学报. 2012, 33(9):910-912.
117. McIntosh A, Hagspiel KD, Al-Osaimi AM, et al. Accelerated treatment using intensity-modulated radiation therapy plus concurrent capecitabine for unresectable hepatocellular carcinoma. Cancer, 2009, 115:5117-5125.
118. Jang JW, Kay CS, You CR, et al. Simultaneous multitarget irradiation using helical tomotherapy for advanced hepatocellular carcinoma with multiple extrahepatic metastases. Int J Radiat Oncol Biol Phys, 2009, 74:412-418.
119. Baisden JM, Kahaleh M, Weiss GR, et al. Multimodality treatment with helical tomotherapy intensity modulated radiotherapy, capecitabine, and photodynamic therapy is feasible and well tolerated in patients with hilar cholangiocarcinoma. Gastrointest Cancer Res, 2008, 2:219-224.
120. Chi KH, Liao CS, Chang CC, et al. Blockade and Radiotherapy in Hepatocellular Carcinoma. Int J Radiat Oncol Biol Phys, 2010, 78(1):188-193.
121. Jang H, Son S, Song J, et al. Hypofractionated radiotherapy for the patients with unresectable primary hepatocellular carcinoma using tomotherapy Hi-Art:analysis of the efficacy and toxicity. Int J Radiat Oncol Biol Phys, 2011, 81(1):S361.
122. Kay C, Kim J, Yoo E, et al. Helical tomotherapy for lung metastases in hepatocellular carcinoma. Int J Radiat Oncol Biol Phys, 2010, 78(1):S584.
123. Ernst I, Moustakis C, Buether F, et al. 4D list mode-based PET/CT target delineation in tomotherapy of liver tumors. Int J Radiat Oncol Biol Phys, 2011, 81(1):S362-S363.
124. Jung SM, Jang JW, You CR, et al. Role of intrahepatic tumor control in the prognosis of patients with hepatocellular carcinoma and extrahepatic metastases. J Hepatol, 2012, 54:S527.
125. Caudrelier JM, Esche B, Montgomery L, et al. Preliminary results of a prospective clinical trial evaluating intensity-modulated radiation therapy delivered by helical tomotherapy for locoregional breast radiation including the internal mammary nodes. Radiother Oncol, 2010, 96:S28.
126. Cendales R, Schiappacasse L, Schnitman F, et al. Helical tomotherapy in patients with breast cancer and complex treatment volumes. Clin Transl Oncol, 2011, 13:268-274.
127. Franco P, Cante D, Catuzzo P, et al. Adjuvant whole breast radiation therapy delivered with static angle tomotherapy employing tomodirect:early results and toxicity. Radiother Oncol, 2011, 99:S293-S294.
128. Franzetti-Pellanda A, Ballerini G, Schombourg K, et al. A new clinical approach for right breast cancer treatment:unique combination of tomodirect IMRT and helical IMRT techniques. Radiother Oncol, 2011, 99:S292.
129. Uhl M, Sterzing F, Habl G, et al. Helical tomotherapy and breast cancer:skin toxicity of the first 85 breast cancer patients treated with tomotherapy. Strahlenther Onkol, 2011, 187(10):689.
130. Chira C, Jacob J, Campana F, et al. A simultaneous integrated boost technique in the adjuvant treatment of breast cancer:feasibility and early toxicity results. Strahlenther Onkol, 2011, 187(10):699-700.
131. Garcia G, Marrone I, Minguez C, et al. Tomotherapy versus topotherapy in breast cancer patients:experience of grupo IMO. Strahlenther Onkol, 2011, 187(10):688.
132. Van Parijs H, Vinh-Hung V, Adriaenssens N, et al. Short course radiotherapy (RT) with simultaneous integrated boost (SIB) for stage I-Ⅱ breast cancer, interim analysis of a randomized clinical trial. Strahlenther Onkol, 2011, 187(8):515.
133. Giraud P, Sylvestre A, Zefkili S, et al. Helical tomotherapy for resected malignant pleural mesothelioma:dosimetric evaluation and toxicity. Radiother Oncol, 2011, 101:303-306.
134. Sylvestre A, Mahe MA, Lisbona A, et al. Mesothelioma at era of helical tomotherapy:results of two institutions in combining chemotherapy, surgery and radiotherapy. Lung Cancer, 2011, 74:486-491.
135. Abbiero ND, Ciammella P, Galeandro M, et al. Local relapse of malignant pleural mesothelioma:a monoistitutional study of salvage hypofractionated radiotherapy with tomotherapy. Radiother Oncol, 2011, 99:S343.
136. Ebara T, Kawamura H, Kaminuma T, et al. Hemithoracic intensity-modulated radiotherapy using helical tomotherapy for patients after extrapleural pneumonectomy for malignant pleural mesothelioma. J Radiat Res, 2012, 53:288-294.
137. Giraud P, Sylvestre A, Lisbona A, et al. Value of tomotherapy in malignant pleural mesothelioma:first clinical results. Rev Mal Respir, 2011, 28:609-617.
138. Fodor A, Fiorino C, Dell'Gca I, et al. Could a PET-guided concomitant boost dose escalation help in progressive malignant pleural mesothelioma? Radiother Oncol, 2010, 96:S340-S1.
139. Shueng PW, Wu LJ, Chen SY, et al. Concurrent chemoradiotherapy with helical tomotherapy for oropharyngeal cancer:a preliminary result. Int J Radiat Oncol Biol Phys, 2010, 77:715-721.
140. Fortin I, Fortin B, Fillion E, et al. Is helical tomotherapy a new standard for the treatment of oropharyngeal carcinoma? Preliminary results of the notre-dame hospital comparing linac based intensity modulated radiotherapy to helical tomotherapy. Int J Radiat Oncol Biol Phys, 2011, 81(1):S498-S498.
141. Cianciulli M, Caruso C, Monaco A, et al. Helical tomotherapy in the treatment of locally advanced squamous cell oral carcinoma. Eur J Cancer, 2011, 47:S565.
142. Hsieh CH, Kuo YS, Liao LJ, et al. Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer. BMC Cancer, 2011, 11:37.
143. Cosinschi A, Khanfir K, Joosten A, et al. Carotid dose sparing in definitive irradiation of T1no squamous cell laryngeal carcinoma using helical tomotherapy. Int J Radiat Oncol Biol Phys, 2011, 81(1):S518-S519.
144. Kim B, Soisson ET, Duma C, et al. Image-guided helical Tomotherapy for treatment of spine tumors. Clin Neurol Neurosurg, 2008, 110:357-362.
145. Sheehan JP, Shaffrey CI, Schlesinger D, et al. Radiosurgery in the treatment of spinal metastases:tumor control, survival, and quality of life after helical tomotherapy. Neurosurgery, 2009, 65:1052-1061.
146. Sterzing F, Hauswald H, Uhl M, et al. Spinal cord sparing reirradiation with helical tomotherapy. Cancer, 2010, 116:3961-3968.
147. Choi Y, Kim JW, Lee IJ, et al. Helical tomotherapy for spine oligometastases from gastrointestinal malignancies. Radiation Oncol J, 2011, 29:219-227.
148. Kim B, Soisson E, Duma C, et al. Treatment of recurrent high grade gliomas with hypofractionated stereotactic image-guided helical tomotherapy. Clin Neurol Neurosurg, 2011, 113:509-512.
149. Astaniyah NT, Le D, Pervez N, et al. Phase I study of hypofractionated intensity modulated radiation therapy with concurrent and adjuvant temozolomide in patients with glioblastoma multiforme. Int J Radiat Oncol Biol Phys, 2010, 78(1):S168.
150. Miwa K, Matsuo M, Shinoda J, et al. Hypofractionated high-dose irradiation planned by methionine pet for the treatment of glioblastoma multiforme. Neuro-Oncology, 2010, 12:iii443.
151. AlHussain H, Malone S, Gertler S, et al. Results of a prospective trial evaluating accelerated radiation therapy using tomotherapy simultaneous integrated boost (ARTOSIB) with concurrent and adjuvant temozolomide (TMZ) chemotherapy in the treatment of glioblastoma multiforme (GBM). Int J Radiat Oncol Biol Phys, 2011, 81(1):S270-S271.
152. Shueng PW, Lin SC, Chong NS, et al. Total marrow irradiation with helical tomotherapy for bone marrow transplantation of multiple myeloma:first experience in Asia. Technol Cancer Res Treat, 2009, 8:29-38.
153. Somlo G, Spielberger R, Frankel P, et al. Total marrow irradiation:a new ablative regimen as part of tandem autologous stem cell transplantation for patients with multiple myeloma. Clin Cancer Res, 2011, 17:174-182.
154. Chargari C, Hijal T, Bouscary D, et al. The role of helical tomotherapy in the treatment of bone plasmacytoma. Med Dosim, 2012, 37:26-30.
155. Bijdekerke P, Verellen D, Tournel K, et al. TomoTherapy:implications on daily workload and scheduling patients. Radiother Oncol. 2008, 86:224-230.
156. Burnet NG, Adams EJ, Fairfoul J, et al. Practical aspects of implementation of helical tomotherapy for intensity-modulated and image-guided radiotherapy. Clinical Oncology, 2010, 22 (4):294-312.
157. 张金葆, 卢爱国.螺旋断层放疗系统的验收与质量保证规范.医疗卫生装备, 2010, 31(11):124-126.
158. 张思维, 陈万青, 郑荣寿, 等. 2003-2007年中国癌症死亡分析.中国肿瘤, 2011, 21(3):171-178.
159. 代敏, 李霓, 李倩, 等.中国肿瘤预防控制概况.中国肿瘤, 2011, 20(12):868-873.

Chinese Journal of Evidence-Based Medicine

Helical Tomotherapy for Cancer Treatment: A Rapid Health Technology Assessment^Δ

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content

Chinese Journal of Evidence-Based Medicine

Helical Tomotherapy for Cancer Treatment: A Rapid Health Technology AssessmentΔ

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content

Helical Tomotherapy for Cancer Treatment: A Rapid Health Technology Assessment^Δ