TUOBu-xiong 1 , LIHui 1 , LIChao-min 1 , YANGYu-ying 2
  • 1. Department of Cardiovascular Disease, No. 451 Hospital of PLA, Xi'an 710054, China;
  • 2. Department of Cadre Ward, No. 451 Hospital of PLA, Xi'an 710054, China;
YANGYu-ying, Email: hdxyyy@sina.com.cn
Chinese population; Elderly primary hypertension; MBPS; Risk factor; Systematic review; Meta-analysis; Case control trial
10.7507/1672-2531.20140177
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Objective To systematically review the risk factors in elderly patients with primary hypertension with morning blood pressure surge in China, so asto provide references for clinical treatment and prevention of complications. Methods Such databases as PubMed, EMbase, The Cochrane Library (Issue 11, 2013), CNKI, VIP and WanFang Data were electronically searched for the case-control studies about morning blood pressure surge (MBPS) among elderly patients with primary hypertension in China from January 2006 to June 2014 were collected. Literature was screened according to inclusion and exclusion criteria, data were extracted and the methodological quality of the included studies was assessed, and then meta-analysis was conducted using RevMan 5.2 software. Results A total of 16 studies involving 2 007 cases were finally included, of which 956 cases were detected with MBPS. The results of meta-analysis showed that significant differences were found in glucose levels (MD=0.42, 95%CI 0.04 to 0.81, P=0.03), urinary microalbumin levels (MD=23.85, 95%CI 6.64 to 41.07, P=0.007), incidences of cerebrovascular events (OR=1.96, 95%CI 1.25 to 3.08, P=0.004), carotid atherosclerosis (OR=5.13, 95%CI 1.70 to 15.45, P=0.004) and left ventricular hypertrophy (OR=2.49, 95%CI 1.70 to 3.64, P < 0.000 01), left ventricular mass (MD=12.89, 95%CI 3.94 to 21.84, P=0.005), and carotid artery intima-media thickness (MD=0.08, 95%CI 0.02 to 0.14, P=0.009); while no significant difference was found in gender (OR=1.12, 95%CI 0.84 to 1.49, P=0.44), total cholesterol levels (MD=0.01, 95%CI-0.11 to 0.12, P=0.92), and creatinine levels (MD=1.77, 95%CI-1.16 to 4.70, P=0.24) between patients with or without MBPS. Conclusion Current evidence shows that glucose levels, early kidney damage, emergent cerebrovascular events and the reconstruction of the artery and the left ventricle are risk factors of abnormal MBPS in China. However, the above conclusion needs to be verified by further conducting high quality prospective studies.

Citation： TUOBu-xiong, LIHui, LIChao-min, YANGYu-ying. Risk Factors of Morning Blood Pressure Surge among Elderly Patients with Primary Hypertension in China: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(9): 1083-1090. doi: 10.7507/1672-2531.20140177 Copy

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