Value of Contrast-enhanced Ultrasound in Diagnosis of Benign and Malignant Renal Tumors: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 WANGYan ¹ , ZHAOYu-ling ² , ZENGChun-hong ¹ ,  YAOLan-hui ¹

1. Ultrasound Diagnostic Department, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China;
2. Ultrasound Department, Maternal and Child Health Hospital of Xinjiang, Huocheng County 835200, Xinjiang, China;

Corresponding author：

YAOLan-hui, Email: yaolanhui6082@yahoo.com.cn

Keywords：

Contrast-enhanced ultrasound; Renal tumor; Systematic review; Meta-analysis; Diagnostic test

DOI：

10.7507/1672-2531.20140195

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the value of contrast-enhanced ultrasound in diagnosis of benign and malignant renal tumors. Methods Such databases as PubMed, EMbase, The Cochrane Library (Issue 9, 2013), CBM, CNKI, WanFang Data and VIP were searched by Sep 31^st, 2013. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed the methodological quality of included studies. Then meta-analysis was performed using Meta-Disc 1.4 software. Results Seven studies involving 462 patients were finally included. ROC curve showed shoulder-arm shape. The results of Spearman suggested significance of the threshold effect. The results of meta-analysis showed that, the area under curve (AUC) was 0.98. Conclusion Contrast-enhanced ultrasound can improve diagnostic accuracy, which is of important value in the diagnosis and differential diagnosis of benign and malignant renal tumors. Due to limited quality and quantity of the included studies, the abovementioned conclusion still needs to be verified by conducting more high quality studies.

Citation： WANGYan, ZHAOYu-ling, ZENGChun-hong, YAOLan-hui. Value of Contrast-enhanced Ultrasound in Diagnosis of Benign and Malignant Renal Tumors: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(10): 1206-1209. doi: 10.7507/1672-2531.20140195 Copy

1.	Setola SV, Catalano O, Sandomenico F, et al. Contrast-enhanced sonography of the kidney. Abdom Imaging, 2007, 32(1):21-28.
2.	Nilsson A. Contrast-enhanced ultrasound of kidneys. Eur Radiol, 2004, 14(suppl 8):104-109.
3.	Tamai H, Takiguchi Y, Oka M, et al. Contrast-enhanced ultrasonography in the diagnosis of solid renal tumors. J Ultrasound Med, 2005, 24(12):1635-1640.
4.	Siegel CL, Middleton WD, Teefey SA, et al. Angiomyolipoma and renal cell carcinoma:US differentiation. Radiology, 1996, 198(3):789-793.
5.	Kim JK, Park SY, Shon JH, et al. Angiomyolipoma with minimal fat:differentiation from renal cell carcinoma at biphasic helical CT. Radiology, 2004, 230(3):677-684.
6.	Whiting P, Rutjes Aw, Reitsma JB, et al. The development of QUADAS:a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol, 2003, 10(3):25-38.
7.	顾继英, 杜联芳, 李凡, 等.超声造影对肾脏良恶性肿瘤的鉴别诊断价值.中国超声医学杂志, 2008, 24(1):1017-1019.
8.	金进晓, 臧国礼, 陈日曙, 等.超声造影对肾脏良恶性肿瘤的诊断价值.浙江创伤外科, 2012, 17(4):566-567.
9.	王颖, 江怡, 赵云歆, 等.超声造影在肾肿瘤诊断和鉴别诊断中的价值.上海医学影像, 2009, 18(4):285-287.
10.	马文琦, 杜晓鹏, 周琦, 等.实时超声造影对肾脏肿瘤诊断价值的应用研究.现代泌尿外科杂志, 2013, 18(1):49-51.
11.	李萍.超声造影在肾实质良恶性病灶诊断中的应用.上海交通大学, 2009.
12.	程蔚然.超声造影在肾脏肿瘤诊断及鉴别诊断中的应用价值.河北医学, 2013, 19(7):977-980.
13.	Xu ZF, Xu XH, Xiu XY, et al. Renal cell carcinoma and renal angiomyolipoma, different diagnosis with real-time contrast-enhanced ultrasonography. J Ultrasound Med, 2010, 29(5):709-717.
14.	伍于添.超声诊断方法和设备的前沿技术.中国超声医学杂志, 2004, 20(6):470-475.
15.	Salvatore S, Quaia E, Bertolotto M, et al. The application of ultrasound contrast agents in the characterization of renal tumors. World J Urol, 2004, 22(5):316-322.
16.	Mitterberger M, Pelzer A, Colleselli D, et al. Contrast-enhanced ultrasound for diagnosis of prostate cancer and kidney leisions. EJR, 2007, 64(2):231-238.
17.	杜联芳, 李凡, 姜露莹, 等.超声造影在肾占位性病变中的应用.中华超声影像学杂志, 2006, 11(51):813-815.
18.	傅宁华, 杨斌, 孟庆欣, 等.肾恶性肿瘤超声造影与病理对照分析.中国医学影像技术, 2008, 24(5):725-727.

1. Setola SV, Catalano O, Sandomenico F, et al. Contrast-enhanced sonography of the kidney. Abdom Imaging, 2007, 32(1):21-28.
2. Nilsson A. Contrast-enhanced ultrasound of kidneys. Eur Radiol, 2004, 14(suppl 8):104-109.
3. Tamai H, Takiguchi Y, Oka M, et al. Contrast-enhanced ultrasonography in the diagnosis of solid renal tumors. J Ultrasound Med, 2005, 24(12):1635-1640.
4. Siegel CL, Middleton WD, Teefey SA, et al. Angiomyolipoma and renal cell carcinoma:US differentiation. Radiology, 1996, 198(3):789-793.
5. Kim JK, Park SY, Shon JH, et al. Angiomyolipoma with minimal fat:differentiation from renal cell carcinoma at biphasic helical CT. Radiology, 2004, 230(3):677-684.
6. Whiting P, Rutjes Aw, Reitsma JB, et al. The development of QUADAS:a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol, 2003, 10(3):25-38.
7. 顾继英, 杜联芳, 李凡, 等.超声造影对肾脏良恶性肿瘤的鉴别诊断价值.中国超声医学杂志, 2008, 24(1):1017-1019.
8. 金进晓, 臧国礼, 陈日曙, 等.超声造影对肾脏良恶性肿瘤的诊断价值.浙江创伤外科, 2012, 17(4):566-567.
9. 王颖, 江怡, 赵云歆, 等.超声造影在肾肿瘤诊断和鉴别诊断中的价值.上海医学影像, 2009, 18(4):285-287.
10. 马文琦, 杜晓鹏, 周琦, 等.实时超声造影对肾脏肿瘤诊断价值的应用研究.现代泌尿外科杂志, 2013, 18(1):49-51.
11. 李萍.超声造影在肾实质良恶性病灶诊断中的应用.上海交通大学, 2009.
12. 程蔚然.超声造影在肾脏肿瘤诊断及鉴别诊断中的应用价值.河北医学, 2013, 19(7):977-980.
13. Xu ZF, Xu XH, Xiu XY, et al. Renal cell carcinoma and renal angiomyolipoma, different diagnosis with real-time contrast-enhanced ultrasonography. J Ultrasound Med, 2010, 29(5):709-717.
14. 伍于添.超声诊断方法和设备的前沿技术.中国超声医学杂志, 2004, 20(6):470-475.
15. Salvatore S, Quaia E, Bertolotto M, et al. The application of ultrasound contrast agents in the characterization of renal tumors. World J Urol, 2004, 22(5):316-322.
16. Mitterberger M, Pelzer A, Colleselli D, et al. Contrast-enhanced ultrasound for diagnosis of prostate cancer and kidney leisions. EJR, 2007, 64(2):231-238.
17. 杜联芳, 李凡, 姜露莹, 等.超声造影在肾占位性病变中的应用.中华超声影像学杂志, 2006, 11(51):813-815.
18. 傅宁华, 杨斌, 孟庆欣, 等.肾恶性肿瘤超声造影与病理对照分析.中国医学影像技术, 2008, 24(5):725-727.

Chinese Journal of Evidence-Based Medicine

Value of Contrast-enhanced Ultrasound in Diagnosis of Benign and Malignant Renal Tumors: A Meta-Analysis

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