Implement Meta-analysis of Diagnostic Accuracy Tests Using mada Package of R_Chinese Journal of Evidence-Based Medicine

Authors：

 LISheng ^1,2,3 , ZHANGChao ⁴ , TAOHua ⁵ , YANJin-zhu ⁴ , WENGHong ⁴ ,  ZENGXian-tao ^1,2,4,6

1. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;
2. Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan 430071, China;
3. Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;
4. Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China;
5. Management Office for Medical Research and Education, Zhengzhou Second Hospital, Zhengzhou 450006, China;
6. Clinical Research and Evaluation Unit, Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

ZENGXian-tao, Email: zengxiantao1128@163.com

Keywords：

Diagnostic accuracy test; Meta-analysis; mada package; R software

DOI：

10.7507/1672-2531.20140244

Video：

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The mada package is a type of package that is especially used for implementing meta-analysis of diagnostic accuracy tests. This package is developed on basis of classical statistical theories and it can be used to calculate all relevant effect size of diagnostic accuracy tests; however, it does not provide pooled values of sensitivity and specificity. This article uses an example to introduce the whole functions of mada package in implementing meta-analysis of diagnostic accuracy tests, including data preparation, calculation implementation, result summary, and plots drawing.

Citation： LISheng, ZHANGChao, TAOHua, YANJin-zhu, WENGHong, ZENGXian-tao. Implement Meta-analysis of Diagnostic Accuracy Tests Using mada Package of R. Chinese Journal of Evidence-Based Medicine, 2014, 14(12): 1527-1532. doi: 10.7507/1672-2531.20140244 Copy

1.	曾宪涛, 何明武, 主编.诊断准确性试验Meta分析软件一本通.北京:军事医学科学出版社, 2014.
2.	董碧蓉.循证实验诊断医学——实验诊断医学发展的新思路.中国循证医学杂志, 2004, 4(11):8750-751.
3.	Leeflang MM. Systematic reviews and meta-analyses of diagnostic test accuracy. Clin Microbiol Infect, 2014, 20(2):105-113.
4.	何俐, 卫茂玲, 刘荣波, 等.中国循证医学/Cochrane中心临床治疗和诊断试验数据库的建立.中国循证医学杂志, 2004, 4(11):806-810.
5.	曾宪涛, 田国祥, 张超, 等. Meta分析系列之十五:Meta分析的进展与思考.中国循证心血管医学杂志, 2013, 5(6):561-563, 587.
6.	曾宪涛, 李胜, 雷晋, 等. Review Manager 5软件在诊断准确性的Meta分析中的应用.湖北医药学院学报, 2013, 32(1):6-16.
7.	鄢金柱, 翁鸿, 冷卫东, 等.诊断准确性试验Meta分析分层受试者工作特征曲线的SAS实现.湖北医药学院学报, 2014, 33(4):365-369.
8.	Doebler P. mada:Meta-Analysis of Diagnostic Accuracy (mada), Version 0.5.5. Available at:http://r-forge.r-project.org/projects/mada/http://r-forge.r-project.org/projects/mada/ .
9.	Walusimbi S, Bwanga F, de Costa A, et al. Meta-analysis to compare the accuracy of GeneXpert, MODS and the WHO 2007 algorithm for diagnosis of smear-negative pulmonary tuberculosis. BMC Infect Dis, 2013, 13:507.
10.	董圣杰, 曾宪涛, 郭毅. R软件Metafor程序包在Meta分析中的应用.中国循证医学杂志, 2012, 12(9):1141-1147.
11.	刘关键, 吴泰相.诊断性试验的Meta分析——SROC曲线法介绍.中国循证医学杂志, 2003, 3(1):41-44.
12.	张俊, 徐志伟, 李克.诊断性试验Meta分析的效应指标评价.中国循证医学杂志, 2014, 13(7):890-895.
13.	吴泰相, 刘关键. Bayes Library简介与诊断试验系统评价方法.中国循证医学杂志, 2002, 2(3):182-186.
14.	张天嵩, 熊茜. HSROC模型在诊断试验Meta分析中的应用及Stata实现.循证医学, 2012, 12(4); 241-243, 247.
15.	刘文华, 吴家利, 杨扬, 等.多变量随机效应模型在诊断试验Meta分析中的应用与SAS实现.中国循证医学杂志, 2012, 12(2):231-237.
16.	张天嵩, 钟文昭. Meta-DiSc软件在诊断试验Meta分析中的应用.循证医学, 2008, 8(2):97-100, 108.
17.	刘俊平.诊断试验偏倚来源的研究进展.中国循证医学杂志, 2011, 11(7):835-840.
18.	Clarke M, 刁骧, 李幼平.非随机对照试验和诊断性试验准确度系统评价的新挑战.中国循证医学杂志, 2006, 6(4):236-242.
19.	Parker LA, Saez NG, Porta M, et al. The impact of including different study designs in meta-analyses of diagnostic accuracy studies. Eur J Epidemiol, 2013, 28(9):713-720.
20.	邬兰, 张永, 曾宪涛. QUADAS-2在诊断准确性研究的质量评价工具中的应用.湖北医药学院学报, 2013, 32(3):201-208.
21.	马章淳, 钱楠. QUADAS评价:一种用于诊断性研究的质量评价工具(修订版).中国循证医学杂志, 2007, 7(7):531-536.

1. 曾宪涛, 何明武, 主编.诊断准确性试验Meta分析软件一本通.北京:军事医学科学出版社, 2014.
2. 董碧蓉.循证实验诊断医学——实验诊断医学发展的新思路.中国循证医学杂志, 2004, 4(11):8750-751.
3. Leeflang MM. Systematic reviews and meta-analyses of diagnostic test accuracy. Clin Microbiol Infect, 2014, 20(2):105-113.
4. 何俐, 卫茂玲, 刘荣波, 等.中国循证医学/Cochrane中心临床治疗和诊断试验数据库的建立.中国循证医学杂志, 2004, 4(11):806-810.
5. 曾宪涛, 田国祥, 张超, 等. Meta分析系列之十五:Meta分析的进展与思考.中国循证心血管医学杂志, 2013, 5(6):561-563, 587.
6. 曾宪涛, 李胜, 雷晋, 等. Review Manager 5软件在诊断准确性的Meta分析中的应用.湖北医药学院学报, 2013, 32(1):6-16.
7. 鄢金柱, 翁鸿, 冷卫东, 等.诊断准确性试验Meta分析分层受试者工作特征曲线的SAS实现.湖北医药学院学报, 2014, 33(4):365-369.
8. Doebler P. mada:Meta-Analysis of Diagnostic Accuracy (mada), Version 0.5.5. Available at:http://r-forge.r-project.org/projects/mada/http://r-forge.r-project.org/projects/mada/ .
9. Walusimbi S, Bwanga F, de Costa A, et al. Meta-analysis to compare the accuracy of GeneXpert, MODS and the WHO 2007 algorithm for diagnosis of smear-negative pulmonary tuberculosis. BMC Infect Dis, 2013, 13:507.
10. 董圣杰, 曾宪涛, 郭毅. R软件Metafor程序包在Meta分析中的应用.中国循证医学杂志, 2012, 12(9):1141-1147.
11. 刘关键, 吴泰相.诊断性试验的Meta分析——SROC曲线法介绍.中国循证医学杂志, 2003, 3(1):41-44.
12. 张俊, 徐志伟, 李克.诊断性试验Meta分析的效应指标评价.中国循证医学杂志, 2014, 13(7):890-895.
13. 吴泰相, 刘关键. Bayes Library简介与诊断试验系统评价方法.中国循证医学杂志, 2002, 2(3):182-186.
14. 张天嵩, 熊茜. HSROC模型在诊断试验Meta分析中的应用及Stata实现.循证医学, 2012, 12(4); 241-243, 247.
15. 刘文华, 吴家利, 杨扬, 等.多变量随机效应模型在诊断试验Meta分析中的应用与SAS实现.中国循证医学杂志, 2012, 12(2):231-237.
16. 张天嵩, 钟文昭. Meta-DiSc软件在诊断试验Meta分析中的应用.循证医学, 2008, 8(2):97-100, 108.
17. 刘俊平.诊断试验偏倚来源的研究进展.中国循证医学杂志, 2011, 11(7):835-840.
18. Clarke M, 刁骧, 李幼平.非随机对照试验和诊断性试验准确度系统评价的新挑战.中国循证医学杂志, 2006, 6(4):236-242.
19. Parker LA, Saez NG, Porta M, et al. The impact of including different study designs in meta-analyses of diagnostic accuracy studies. Eur J Epidemiol, 2013, 28(9):713-720.
20. 邬兰, 张永, 曾宪涛. QUADAS-2在诊断准确性研究的质量评价工具中的应用.湖北医药学院学报, 2013, 32(3):201-208.
21. 马章淳, 钱楠. QUADAS评价:一种用于诊断性研究的质量评价工具(修订版).中国循证医学杂志, 2007, 7(7):531-536.

Chinese Journal of Evidence-Based Medicine

Implement Meta-analysis of Diagnostic Accuracy Tests Using mada Package of R

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