Efficacy of Electroacupuncture in Animal Hyperlipidemia Models: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 LIUMai-lan , LICheng-wen , WANGHou-lian , GUOAn-lin , LIUMi ,  CHANGXiao-rong

College of Acupuncture & Moxibustion and Tui-na, Hunan University of Chinese Medicine, Changsha 410007, China;

Corresponding author：

CHANGXiao-rong, Email: xrchang1956@163.com

Keywords：

Electroacupuncture; Animal hyperlipidemia models; Meta-analysis; Animal study

DOI：

10.7507/1672-2531.20150059

Video：

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Objective To systematically review the efficacy and safety of electroacupuncture in animal hyperlipidemia models. Methods Databases such as CNKI, WanFang Data, VIP, CBM, PubMed, EMbase and The Cochrane Library (Issue 12, 2013) were searched for studies concerning the efficacy and safety of electroacupuncture in animal hyperlipidemia models up to December 2013. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data and assessed the methodological quality of included studies by using reformative CAMARADES List. Then, meta-analysis was performed by using RevMan 5.2 software. Results A total of 4 studies involving 89 rats were included. The average score of CAMARADES List was 4. The results of meta-analysis showed that:there were no significant differences between electroacupuncture group and medication group in reducing the levels of TC (MD=0.06, 95%CI -0.08 to 0.20, P=0.40), TG (MD=-0.01, 95%CI -0.08 to 0.06, P=0.74), LDL-C (MD=0.01, 95%CI -0.04 to 0.03, P=0.65) and increasing the level of HDL-C (MD=-0.00, 95%CI -0.09 to 0.08, P=0.93). Conclusion Current evidence shows that there are no differences between electroacupuncture and medication in reducing levels of TC, TG, LDL-C and increasing the level of HDL-C in hyperlipidaemia rats. But due to the limitation of sample size of included studies, more large-scale, high quality studies are needed.

Citation： LIUMai-lan, LICheng-wen, WANGHou-lian, GUOAn-lin, LIUMi, CHANGXiao-rong. Efficacy of Electroacupuncture in Animal Hyperlipidemia Models: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(3): 353-357. doi: 10.7507/1672-2531.20150059 Copy

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21.	张宝珍, 张凯, 刘玉珍. 针灸丰隆治疗高脂血症临床随机对照试验Meta分析. 中国中医药信息杂志, 2014,21(8):11-15.
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1. 姜志莹. 脑血管病与血脂异常的前瞻性研究. 中国医药指南, 2013, 11(2):76-78.
2. 赵水平. 临床血脂学. 长沙:湖南科学括术出版社, 1997:169-198.
3. 乐薇. 电针丰隆对高脂血症模型大鼠胆固醇逆转运通路的影响. 湖北中医药大学学位论文, 2013.
4. 中国成人血脂异常防治指南. 中华心血管病杂志, 2007, 5:390-419.
5. 汤茜, 余焯燊, 伍洲梁, 等. 针灸治疗高脂血症的临床研究综述. 中国医药指南, 2013, 11(21):95-97.
6. 马占强. 针灸治疗高脂血症安全性和有效性的荟萃分析. 河南中医, 2012, 32(10):1398-1401.
7. 卫生部法监司. 保健食品检验与评价技术规范. 北京:卫生部法监司, 2003:35-37.
8. Peters JL, Sutton AJ, Jones DR, et al. A systematic review of systematic reviews and meta-analyses of animal experiment with guidelines for reporting. J Environ Sci Health B, 2006, 41(7):1245-1258.
9. Crossley NA, Sena E, Goehler J, et al. Empirical evidence of bias in the design of experimental stroke studies:a metaepidemiologic approach. Stroke, 2008, 39(3):929-934.
10. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses:the PRISMA statement. J Clin Epidemiol, 2009, 62(10):1006-1012.
11. 周利, 万文俊, 刘灵光, 等. 电针"丰隆"穴对高脂血症大鼠NO、ET及CGRP的影响. 中国针灸, 2008, 28(1):57-60.
12. 张红星, 王英淑, 周利, 等. 电针丰隆穴对高血脂症型地鼠肝脏LPL、HL的影响. 中国康复, 2011, 26(4):250-252.
13. 杨金梅, 张唐法, 张红星, 等. 电针丰隆穴早期干预金黄地鼠高脂血症的机制. 中国康复, 2011, 26(2):89-90.
14. 齐凤军, 孙国杰. 电针对高脂血症大鼠脂肪肝的影响. 中华中医药学刊, 2007, 25(6):1281-1283.
15. 罗杰, 冷卫东, 主编. 系统评价/Meta分析理论与实践. 北京:军事医学科学出版社, 2013:490.
16. Macleod MR, O'Collins T, Horky LL. FK506对实验性卒中疗效的系统评价和Meta分析. 中国循证医学杂志, 2006, 6(5):430-438.
17. Pound P, Ebrahim S, Sandercock P, et al. Where is the evidence that animal research benefits humans? BMJ, 2004, 328(7438):514-517.
18. Peters JL, Sutton AJ, Jones DR, et al. A systematic review of systematic reviews and meta-analyses of animal experiment with guidelines for reporting. J Environ Sci Health B, 2006, 41(7):1245-1258.
19. Macleod MR, O'Collins T, Howells DW, et al. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke, 2004, 35(5):1203-1208.
20. 陈华, 苗华, 田婷, 等. 代谢组学技术在高脂血症研究中的应用. 药物分析杂志, 2014, 34(4):563-569.
21. 张宝珍, 张凯, 刘玉珍. 针灸丰隆治疗高脂血症临床随机对照试验Meta分析. 中国中医药信息杂志, 2014,21(8):11-15.
22. 吴思丹, 王茎. 针灸治疗高脂血症研究进展. 中医药临床杂志, 2012, 14(6):583-586.

Chinese Journal of Evidence-Based Medicine

Efficacy of Electroacupuncture in Animal Hyperlipidemia Models: A Meta-analysis

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