Value of Ultrasound Contrast Agents Injected Subcutaneously for Diagnosing Sentinel Lymph Nodes of Breast Cancer: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 WANGYan , NaDi-re D·Teliewuhan , MUYan ,  YAOLan-hui

Department of Ultrasound, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China;

Corresponding author：

YAOLan-hui, Email: yaolanhui6082@yahoo.com.cn

Keywords：

Contrast-enhanced ultrasound; Breast neoplasms; Lymphatic metastasis; Sentinel lymphatic node; Meta-analysis; Systematic review

DOI：

10.7507/1672-2531.20150090

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the value of ultrasound contrast agents injected subcutaneously for diagnosing sentinel lymph nodes of breast cancer. Methods We electronically searched databases including PubMed, EMbase, The Cochrane Library, CNKI, CBM, WanFang Data, and Medalink from their inception to July 2014, to collect diagnostic accuracy studies of ultrasound contrast agents injected subcutaneously for diagnosing sentinel lymph nodes of breast cancer. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data and assessed the methodological quality of included studies. Then, meta-analysis was performed by using Meta-Disc 1.4 software. Results Eight studies involving 311 sentinel lymph nodes were included. The results of meta-analysis showed that, the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and the area under curve (AUC) of SROC were 0.89 (95%CI 0.84 to 0.93), 0.81 (95%CI 0.72 to 0.87), 4.14 (95%CI 2.20 to 7.79), 0.15 (95%CI 0.10 to 0.25), 33.23 (95%CI 11.17 to 98.83), and 0.96 respectively. Conclusion Contrast-enhanced ultrasound has a high value in diagnosis of sentinel lymph nodes of breast cancer. Due to limited quality and quantity of the included studies, more high quality and large-scale studies are needed to verify the above conclusion.

Citation： WANGYan, NaDi-re D·Teliewuhan, MUYan, YAOLan-hui. Value of Ultrasound Contrast Agents Injected Subcutaneously for Diagnosing Sentinel Lymph Nodes of Breast Cancer: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(5): 537-541. doi: 10.7507/1672-2531.20150090 Copy

1.	Morrow M, Gradishar W. Breast cancer. BMJ, 2002, 324(7334):410-414.
2.	钟丽瑶, 周平, 李瑞珍, 等. 经皮下注射超声造影剂在乳腺癌前哨淋巴结诊断中的价值. 中华超声影像学杂志, 2007, 16(9):770-772.
3.	米成嵘, 何雁, 王文. 经皮下注射超声造影剂在乳腺肿块前哨淋巴结检测中的应用价值. 中华超声影像学杂志, 2010, 19(11):970-973.
4.	张茂春, 顾鹏. 超声造影判定乳腺癌前哨淋巴结的性质. 中国医学影像技术, 2012, 28(3):516-519.
5.	孙艳娟, 米成嵘. 经静脉注射与经皮下注射超声造影剂检查乳腺癌前哨淋巴结的比较. 中国超声医学杂志, 2012, 28(7):601-604.
6.	于志强, 李志旺, 韦伟, 等. 超声造影指导乳腺癌前哨淋巴结活检的价值. 中国老年学杂志, 2013, 33(3):533-535.
7.	Podkrajsek M, Hocevar M. The role of contrast enhanced axillary ultrasonography in early breast cancer patients. Coll Antropol, 2011, 35(1):37.
8.	Ouyang Q, Chen L, Zhao H, et al. Detecting Metastasis of Lymph Nodes and Predicting Aggressiveness in Patients With Breast Carcinomas. J Ultrasound Med, 2010, 29(3):343-352.
9.	Sever A, Jones S, Cox K, et al. Preoperative localization of sentinel lymph nodes using intradermal microbubbles and contrast-enhanced ultrasonography in patients with breast cancer. Br J Surg, 2009, 96(11):1295-1299.
10.	Salvatore S, Quaia E, Bertolotto M, et al. The application of ultrasound contrast agents in the characterization of renal tumors. World J Urol, 2004, 22(5):316-322.
11.	Krag DN, Anderson SJ, Julian TB, et al. Sentinel-lymph-node resection compared with conventional axillary lymph-node dissection in clinically node-negative patients with breast cancer:Overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet Oncol, 2010, 11(10):927-933.
12.	Soni NK, Spillane AJ. Experience of sentinel node biopsy alone in early breast cancer without further axillary dissection in patients with negative sentinel node. ANZ J Surg, 2005, 75(5):292-299.
13.	Iannacc C, Di LL, Lepore M, et al. Prognostic and curative value of sentinel node in breast cancer. A377 patients experience, Annital Chir, 2010, 81(2):103-113.
14.	Schmid-Schonbein GW. Mircrolymphatics and lymph flow. Physiol Rev, 1990, 70(4):987-1028.

1. Morrow M, Gradishar W. Breast cancer. BMJ, 2002, 324(7334):410-414.
2. 钟丽瑶, 周平, 李瑞珍, 等. 经皮下注射超声造影剂在乳腺癌前哨淋巴结诊断中的价值. 中华超声影像学杂志, 2007, 16(9):770-772.
3. 米成嵘, 何雁, 王文. 经皮下注射超声造影剂在乳腺肿块前哨淋巴结检测中的应用价值. 中华超声影像学杂志, 2010, 19(11):970-973.
4. 张茂春, 顾鹏. 超声造影判定乳腺癌前哨淋巴结的性质. 中国医学影像技术, 2012, 28(3):516-519.
5. 孙艳娟, 米成嵘. 经静脉注射与经皮下注射超声造影剂检查乳腺癌前哨淋巴结的比较. 中国超声医学杂志, 2012, 28(7):601-604.
6. 于志强, 李志旺, 韦伟, 等. 超声造影指导乳腺癌前哨淋巴结活检的价值. 中国老年学杂志, 2013, 33(3):533-535.
7. Podkrajsek M, Hocevar M. The role of contrast enhanced axillary ultrasonography in early breast cancer patients. Coll Antropol, 2011, 35(1):37.
8. Ouyang Q, Chen L, Zhao H, et al. Detecting Metastasis of Lymph Nodes and Predicting Aggressiveness in Patients With Breast Carcinomas. J Ultrasound Med, 2010, 29(3):343-352.
9. Sever A, Jones S, Cox K, et al. Preoperative localization of sentinel lymph nodes using intradermal microbubbles and contrast-enhanced ultrasonography in patients with breast cancer. Br J Surg, 2009, 96(11):1295-1299.
10. Salvatore S, Quaia E, Bertolotto M, et al. The application of ultrasound contrast agents in the characterization of renal tumors. World J Urol, 2004, 22(5):316-322.
11. Krag DN, Anderson SJ, Julian TB, et al. Sentinel-lymph-node resection compared with conventional axillary lymph-node dissection in clinically node-negative patients with breast cancer:Overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet Oncol, 2010, 11(10):927-933.
12. Soni NK, Spillane AJ. Experience of sentinel node biopsy alone in early breast cancer without further axillary dissection in patients with negative sentinel node. ANZ J Surg, 2005, 75(5):292-299.
13. Iannacc C, Di LL, Lepore M, et al. Prognostic and curative value of sentinel node in breast cancer. A377 patients experience, Annital Chir, 2010, 81(2):103-113.
14. Schmid-Schonbein GW. Mircrolymphatics and lymph flow. Physiol Rev, 1990, 70(4):987-1028.

Chinese Journal of Evidence-Based Medicine

Value of Ultrasound Contrast Agents Injected Subcutaneously for Diagnosing Sentinel Lymph Nodes of Breast Cancer: A Meta-analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content