Traditional Chinese Medicine for Cough Variant Asthma: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 WULi-hua , JIANGHong-li , MINJie , FANTao , LIGuan-hong , LIUWei , DONGShou-jin , CAILin-li , QUBo ,  MAOBing

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

MAOBing, Email: maobing2013@yeah.net

Keywords：

Cough variant asthma; Traditional Chinese medicine; Systematic review; Randomized controlled trial

DOI：

10.7507/1672-2531.20150179

Video：

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Objective To systematically review the clinical effect and safety of traditional Chinese medicine (TCM) in the treatment of cough variant asthma (CVA). Methods We searched MEDLINE (Ovid), PubMed, EMbase, The Cochrane Library, VIP, WanFang Data, CNKI and CBM databases to collect randomized controlled trials (RCTs) about TCM for CVA from inception to May 2014. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then meta-analysis was performed by RevMan 5.2 software. Results A total of 17 RCTs were included. The results of qualitative analysis showed that:in improving cough symptom, three of four RCTs showed that TCM was superior to western medicine alone. In improving airway hyper responsiveness and overall treatment effect, the difference between TCM and western medicine alone remained uncertain. No serious adverse reactions related to TCM was reported in 17 RCTs. Conclusion Based on the current evidence, some trials suggest the TCM is superior to western medicine alone in improving cough symptom, however in the improvement of airway hyper responsiveness and overall efficacy, the difference between TCM and western medicine alone remains uncertain. Due to the variety of TCM and western medicine as well as limited methodological quality and different intervention of the included studies, more high-quality RCTs with large scale are needed to verify the above conclusion.

Citation： WULi-hua, JIANGHong-li, MINJie, FANTao, LIGuan-hong, LIUWei, DONGShou-jin, CAILin-li, QUBo, MAOBing. Traditional Chinese Medicine for Cough Variant Asthma: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2015, 15(9): 1084-1089. doi: 10.7507/1672-2531.20150179 Copy

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18.	何淑娴. 温肾镇咳方治疗咳嗽变异性哮喘疗效观察. 辽宁中医药大学学报, 2007, 9(7):7-8.
19.	杜文坚. 桑白皮汤加减治疗咳嗽变异性哮喘30例. 陕西中医, 2007, 28(7):839-840.
20.	范博音, 孙许涛, 史雅倩, 等. 咳嗽变异性哮喘的中医药研究进展. 中医药信息, 2013, 4(30):148-151.
21.	钟永红. 润肺咳喘胶囊治疗咳嗽变异性哮喘的临床研究. 北京:北京中医药大学, 2011.
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1. 马高峰. 抗敏止嗽颗粒治疗咳嗽变异性哮喘89例. 中医研究, 2006, 19(5):37-39.
2. 支艳. 杨明会教授治疗气道高反应性咳嗽的临证经验研究. 北京:中国人民解放军军医进修学院, 2010.
3. 冯文杰, 李向林. 咳嗽变异性哮喘的中医治疗现状. 临床肺科杂志, 2011, 16(1):99-100.
4. The Cochrane Collaboration. Cochrane for Systematic Review of Interventions. Version 5.1. Available at:http://www.cochrane.org/.htm.
5. Miao Q. Clinical study on treatment of cough variant asthma by Chinese medicine. Chin J Integr Med, 2013, 19(7):539-545.
6. 丛晓东. 温润辛金方对咳嗽变应性哮喘(风寒恋肺型)疗效及其生活质量的影响. 北京:北京中医药大学, 2013.
7. 陈俊榕. 加味三叶汤治疗咳嗽变异性哮喘的临床疗效观察. 广州:广州中医药大学, 2010.
8. 冯德华. "祛风止痉方"联合孟鲁司特钠治疗咳嗽变异性哮喘40例临床研究. 江苏中医药, 2012, 44(7):16-18.
9. 熊艳云. 培土肃金法治疗痰湿壅肺型咳嗽变异性哮喘肝火犯肺证30例临床观察. 广州:广州中医药大学, 2011.
10. 游柏稳, 游海, 杜海燕. 清肝宁肺方治疗咳嗽变异性哮喘肝火犯肺证30例临床观察. 中医药导报, 2012, 18(8):40-42.
11. 黄翠. 祛风解痉方治疗咳嗽变异性哮喘的临床研究. 广州:广州中医药大学, 2009.
12. 叶秀儿. 祛风解痉汤对咳嗽变异性哮喘免疫免疫细胞因子和气道反应性的影响. 广州:广州中医药大学, 2011.
13. 贾明月. 苏黄止咳胶囊治疗咳嗽变异性哮喘的临床疗效评价. 北京:北京中医药大学, 2012.
14. 曾庆霖. 风咳方治疗咳嗽变异性哮喘临床观察. 长沙:湖南中医药大学, 2011.
15. 罗社文. 疏风宣肺法对咳嗽变异性哮喘患者气道高反应的影响. 中国医药学报, 2004, 19(5):288-289.
16. 朱金凤. 固本平喘汤治疗咳嗽变异型哮喘的临床观察. 湖北中医杂志, 2006, 28(8):12-14.
17. 刘秀茹. 中西医结合治疗咳嗽变异性哮喘的临床研究. 北京:北京中医药大学, 2008.
18. 何淑娴. 温肾镇咳方治疗咳嗽变异性哮喘疗效观察. 辽宁中医药大学学报, 2007, 9(7):7-8.
19. 杜文坚. 桑白皮汤加减治疗咳嗽变异性哮喘30例. 陕西中医, 2007, 28(7):839-840.
20. 范博音, 孙许涛, 史雅倩, 等. 咳嗽变异性哮喘的中医药研究进展. 中医药信息, 2013, 4(30):148-151.
21. 钟永红. 润肺咳喘胶囊治疗咳嗽变异性哮喘的临床研究. 北京:北京中医药大学, 2011.
22. Resch KL, Ernst E. Research methodologies in complementary medicine:making sure it works. In:Ernst E, ed. Complementary Medicine:An Objective Appraisal. Oxford, Butterworth, 1996.

Chinese Journal of Evidence-Based Medicine

Traditional Chinese Medicine for Cough Variant Asthma: A Systematic Review

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