Drug Resistance, Resistant Mechanisms and Resistant Phenotypes of Staphylococcus Aureus Isolated from Wound Secretion to Macrolides-Lincosamides-Streptogramins_Chinese Journal of Evidence-Based Medicine

Authors：

 WANGXiao-ying ¹ , YANYuan-fang ² , CHENXiong-yi ³ ,  MINGDe-song ³

1. Department of Medical Cosmetology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou 362000, China;
2. Anxi County Hospital, Quanzhou 362000, China;
3. Department of Laboratory Medicine, the First Affiliated Hospital, Fujian Medical University, Quanzhou 362000, China;

Corresponding author：

MINGDe-song, Email: mds6430@126.com

Keywords：

Wound secretion; Staphylococcus aureus; Macrolides; Tigecycline; Quinolons; Tetracyclines; Linezolid; Inducible

DOI：

10.7507/1672-2531.20160041

Video：

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Objective To explore drug resistance, resistant mechanisms and resistant phenotypes of staphylococcus aureus (SA) isolated from wound secretion to macrolides-lincosamides-streptogramins (MLS). Methods A retrospective design was used to collect clinical data and antimicrobial resistance profiles of SA in the First Affiliated Hospital and the Second Affiliated Hospital of Fujian Medical University and Anxi County Hospital from June, 2008 to October, 2015. SPSS 19.0 software was used for data analysis. Results A total of 127 isolates were included. The distribution of four resistant phenotypes of SA to MLS were all susceptibility(S) type (n=48, 37.8%), ML type (n=41, 32.3%), M/iCR+ type (n=22, 17.3%) and MLS type (n=16, 12.6%), respectively; There were three kinds of phenotypes caused by target changing including ML type, M/iCR+ type and MLS type, respectively. Moreover, no moxicaxin, linezolid or tigecyline resistant strain was detected, while quinolons and tetracyclines showed low-level resistant. Conclusion Compared with the different samples, the resistant phenotypes of SA isolated from wound secretion to MLS are few, and the total resistance ratio is low.

Citation： WANGXiao-ying, YANYuan-fang, CHENXiong-yi, MINGDe-song. Drug Resistance, Resistant Mechanisms and Resistant Phenotypes of Staphylococcus Aureus Isolated from Wound Secretion to Macrolides-Lincosamides-Streptogramins. Chinese Journal of Evidence-Based Medicine, 2016, 16(3): 254-256. doi: 10.7507/1672-2531.20160041 Copy

1.	胡志东, 王凤霞, 李金, 等. 2010年度卫生部全国细菌耐药监测网报告:伤口感染病原菌分布及耐药监测. 中华医院感染学杂志, 2012, 22(1):23-27.
2.	冯平锋, 柴志欣, 裘宇容, 等. 2042株伤口中常见病原菌种类及耐药性分析. 国际检验医学杂志, 2014, 35(6):709-711.
3.	缪应业, 谢国旗, 刘新, 等. 2009-2012年伤口分泌物病原菌分布及耐药研究. 中华医院感染学杂志, 2014, 24(3):585-587.
4.	瞿亚红, 姜妙静, 周程程. 不同种类标本分离的金黄色葡萄球菌的耐药性比较及分析. 2014年浙江省检验医学学术年会论文汇编, 2014.
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6.	刘晓强, 谢晓英, 曾华, 等. 1517株金黄色葡萄球菌的临床分布及药敏结果分析. 中国微生态学杂志, 2014, 26(8):944-946.
7.	Cetin ES, Gunes H, Kaya S, et al. Macrolide-lincosamide-streptogramin B resistance phenotypes in clinical staphylococcal isolates. Int J Antimicrob Agents, 2008, 31(4):364-368.
8.	明德松, 吴一波, 朱焱, 等. 耐甲氧西林葡萄球菌对大环内酯类抗生素的耐药性分析. 中国现代医学杂志, 2004, 22(11):100-101.
9.	张志军, 曹海燕, 刘延媛, 等. 医院感染金黄色葡萄球菌耐药表型与耐药基因研究. 中华医院感染学杂志, 2015, 25(9):1924-1926.
10.	Matsuoka M. Study of macrolide, lincosamide, and streptogramin B antibiotics resistance in Staphylococcus aureus. Yakugaku Zasshi, 2000, 120(4):374-386.
11.	Uzun B, Güngör S, Pektaş B, et al. Macrolide-lincosamide-streptogramin B (MLSB) resistance phenotypes in clinical Staphylococcus isolates and investigation of telithromycin activity. Mikrobiyol Bul, 2014, 48(3):469-476.
12.	叶应妩, 王毓三. 全国临床检验操作规程. 第3版. 南京:东南大学出版社, 2006:502-509.
13.	National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests. M100-S15, NCCLS, 2005:1-133.
14.	Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; Twentieth informational supplement. CLSI documents M100-S20. CLSI, 2010.
15.	陈惠刚, 林艳, 李晰, 等. 河北地区皮肤病住院患者金黄色葡萄球菌耐药基因检测. 中国病原生物学杂志, 2015, 10(1):29-33.
16.	张志军, 曹海燕, 刘延媛, 等. 医院感染金黄色葡萄球菌耐药表型与耐药基因研究. 中华医院感染学杂志, 2015, 25(9):1924-1926.

1. 胡志东, 王凤霞, 李金, 等. 2010年度卫生部全国细菌耐药监测网报告:伤口感染病原菌分布及耐药监测. 中华医院感染学杂志, 2012, 22(1):23-27.
2. 冯平锋, 柴志欣, 裘宇容, 等. 2042株伤口中常见病原菌种类及耐药性分析. 国际检验医学杂志, 2014, 35(6):709-711.
3. 缪应业, 谢国旗, 刘新, 等. 2009-2012年伤口分泌物病原菌分布及耐药研究. 中华医院感染学杂志, 2014, 24(3):585-587.
4. 瞿亚红, 姜妙静, 周程程. 不同种类标本分离的金黄色葡萄球菌的耐药性比较及分析. 2014年浙江省检验医学学术年会论文汇编, 2014.
5. Lavallée C, Rouleau D, Gaudreau C, et al. Performance of an agar dilution method and a Vitek 2 card for detection of inducible clindamycinresistance in Staphylococcus spp. J Clin Microbiol, 2010, 48(4):1354-1357.
6. 刘晓强, 谢晓英, 曾华, 等. 1517株金黄色葡萄球菌的临床分布及药敏结果分析. 中国微生态学杂志, 2014, 26(8):944-946.
7. Cetin ES, Gunes H, Kaya S, et al. Macrolide-lincosamide-streptogramin B resistance phenotypes in clinical staphylococcal isolates. Int J Antimicrob Agents, 2008, 31(4):364-368.
8. 明德松, 吴一波, 朱焱, 等. 耐甲氧西林葡萄球菌对大环内酯类抗生素的耐药性分析. 中国现代医学杂志, 2004, 22(11):100-101.
9. 张志军, 曹海燕, 刘延媛, 等. 医院感染金黄色葡萄球菌耐药表型与耐药基因研究. 中华医院感染学杂志, 2015, 25(9):1924-1926.
10. Matsuoka M. Study of macrolide, lincosamide, and streptogramin B antibiotics resistance in Staphylococcus aureus. Yakugaku Zasshi, 2000, 120(4):374-386.
11. Uzun B, Güngör S, Pektaş B, et al. Macrolide-lincosamide-streptogramin B (MLSB) resistance phenotypes in clinical Staphylococcus isolates and investigation of telithromycin activity. Mikrobiyol Bul, 2014, 48(3):469-476.
12. 叶应妩, 王毓三. 全国临床检验操作规程. 第3版. 南京:东南大学出版社, 2006:502-509.
13. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests. M100-S15, NCCLS, 2005:1-133.
14. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; Twentieth informational supplement. CLSI documents M100-S20. CLSI, 2010.
15. 陈惠刚, 林艳, 李晰, 等. 河北地区皮肤病住院患者金黄色葡萄球菌耐药基因检测. 中国病原生物学杂志, 2015, 10(1):29-33.
16. 张志军, 曹海燕, 刘延媛, 等. 医院感染金黄色葡萄球菌耐药表型与耐药基因研究. 中华医院感染学杂志, 2015, 25(9):1924-1926.

Chinese Journal of Evidence-Based Medicine

Drug Resistance, Resistant Mechanisms and Resistant Phenotypes of Staphylococcus Aureus Isolated from Wound Secretion to Macrolides-Lincosamides-Streptogramins

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