AIJin-wei 1,2 # , LIUYing 1,2 # , GUANXiang-fei 2 , CHENQiong 2 , ZHANGWei 2 , DENGJin 2 , PEIBin 1,2
  • 1. Evidence-based Medicine Center, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, China;
  • 2. Department of Micro-orthopedic Surgery, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, China;
PEIBin, Email: xyxzyxzx@163.com
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Objective To explore the diagnostic value of HLA-B27 for ankylosing spondylitis (AS) in Chinese population. Methods We searched PubMed, EMbase, The Cochrane Library (Issue 8, 2015), CNKI, and WanFang data from inception to August 2015, to collect diagnostic studies about HLA-B27 for AS in Chinese population. Two reviewers independently screened literature, extracted data, and assessed the methodological quality of included studies. Then meta-analysis was performed by using Stata12.0 software. Results A total of 16 studies involving 3137 AS and 5617 suspect patients were finally included. The results of meta-analysis showed that the pooled Sen, Spe, +LR, -LR and DOR were 0.91(95%CI 0.89 to 0.93), 0.94(95%CI 0.91 to 0.96), 14.90(95%CI 9.60 to 23.10), 0.09(95%CI 0.08 to 0.12) and 157.00(95%CI 90.00 to 275.00), respectively. The AUC of SROC was 0.98(95%CI 0.93 to 0.97). Conclusions HLA-B27 detection is of great diagnostic value for AS in Chinese population. However, due to the limited quality and quantity of the included studies, more long-term follow-up prospective studies are needed to verify the above conclusion.

Citation: AIJin-wei, LIUYing, GUANXiang-fei, CHENQiong, ZHANGWei, DENGJin, PEIBin. Diagnostic Value of HLA-B27 Tests for Ankylosing Spondylitis in Chinese Population: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(7): 802-808. doi: 10.7507/1672-2531.20160124 Copy

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