Association between the Insertion/Deletion Polymorphism of ACE Gene and Athlete's Sport Performance in Mixed Sports: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 LIUYing ¹ ^# ,  AIJin-wei ^1,2 ^# , LIDe-sheng ¹ , LIUYu ¹ ,  PEIBin ^1,2

1. Department of Orthopedic Surgery, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, China;
2. Evidence-Based Medicine Center, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, China;

Corresponding author：

PEIBin, Email: xyxzyxzx@163.com

Keywords：

Peptidyl-dipeptidase A; Polymorphism; Athlete; Mixed sports; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.20160158

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Objective To systematically review the association between the insertion/deletion (I/D) polymorphism of angiotension-converting enzyme (ACE) gene and the athletes'performance in mixed sports. Methods Databases including PubMed, EMbase, CNKI, CBM, VIP, and WanFang Data were searched from inception to August 1st, 2015 to collect case-control studies about the association between ACE I/D polymorphism and the athletes'performance in mixed sports. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results A total of 13 case-control studies involving 888 athletes and 3 871 controls were included. The results of meta-analysis showed that significant association was found between ACE I/D polymorphism and the athletes'performance in mixed sports (DD vs. DI+II: OR=0.71, 95%CI 0.59 to 0.84, P < 0.01; DD vs. II: OR=0.69, 95%CI 0.54 to 0.87, P < 0.01; D vs. I: OR=0.82, 95%CI 0.72 to 0.92, P < 0.01). Specifically, the ACE I/D polymorphism was significantly associated with the performance of male athletes in endurance sports (DD vs. DI+II: OR=0.71, 95%CI 0.57 to 0.89, P < 0.01; DD vs. II: OR=0.70, 95%CI 0.51 to 0.95, P=0.02; D vs. I: OR=0.80, 95%CI 0.69 to 0.94, P=0.01). However, this significant association was not found in football and middle-distance running sports. Subgroup analysis of ethnicity showed that, the ACE I/D polymorphism was significantly associated with the performance of Caucasian (DD vs. DI+II: OR=0.71, 95%CI 0.59 to 0.87, P < 0.01; DD vs. II: OR=0.69, 95%CI 0.54 to 0.90, P=0.01; D vs. I: OR=0.80, 95%CI 0.71 to 0.92, P < 0.01) and Asian (DD vs. DI+II: OR=0.42, 95%CI 0.20 to 0.89, P < 0.01) athletes in endurance sports, but not with African athletes. Conclusions Current evidence indicates that the ACE allele D is negatively associated with the athletes'performance in mixed sports. Due to the limitations of included studies, more high quality case-control or cohort studies are needed to verify the above conclusion.

Citation： LIUYing, AIJin-wei, LIDe-sheng, LIUYu, PEIBin. Association between the Insertion/Deletion Polymorphism of ACE Gene and Athlete's Sport Performance in Mixed Sports: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(9): 1026-1034. doi: 10.7507/1672-2531.20160158 Copy

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24.	Patwardhan A, Harris J, Leng N, et al. The ACE gene and human performance: 12 years on. Sports Med, 2011, 41(6): 433-448.
25.	Guth L, Roth S. Genetic influence on athletic performance. Genetics, 2013, 25(6): 653-658.
26.	Rankinen T, Roth S, Bray M, et al. Advances in exercise, fitness, and performance genomics. Med Sci Sports Exer, 2010, 42(5): 835-846.
27.	Hagberg J, Moore G, Ferrell R. Specific genetic markers of endurance performance and V.O2max. Exerc Sport Sci Rev, 2000, 29(1): 15-19.

1. Ahmetov II, Rogozkin VA. Genes, athlete status and training --An overview. Med Sport Sci, 2009, 54: 43-71.
2. 杨若愚, 王予彬, 沈勋章, 等.基因多态性与杰出运动能力.中国组织工程研究, 2014, 18(7): 1121-1128.
3. Guth LM, Roth SM. Genetic influence on athletic performance. Curr Opin Pediatr, 2013, 25(6): 653-658.
4. Ma F, Yang Y, Li X, et al. The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis. PLoS One, 2013, 8(1): e54685.
5. 杨贤罡, 扬胡. ACE基因I/D多态性与耐力素质的关联性研究: Meta分析.体育科学, 2010, 30(7): 42-49.
6. 艾金伟, 刘盈, 李德胜, 等. ACE基因插入/缺失多态性与运动员力量型运动能力关联性的Meta分析.中国循证医学杂志, 2016, 16(3): 263-269.
7. 艾金伟, 刘盈, 李德胜, 等. ACE基因插入/缺失多态性与运动员耐力型运动能力关联性的Meta分析.中国循证医学, 2016, 16(4): 392-402.
8. Zeng X, Zhang Y, Kwong JS, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med, 2015, 8(1): 2-10.
9. Fatini C, Guazzelli R, Manetti P, et al. RAS genes influence exercise-induced left ventricular hypertrophy: an elite athletes study. Med Sci Sports Exerc, 2000, 2(11): 1868-1872.
10. Gineviciene V, Pranculis A, Jakaitiene A, et al. Genetic variation of the human ACE and ACTN3 genes and their association with functional muscle properties in Lithuanian elite athletes. Medicina (Kaunas), 2011, 47(5): 284-290.
11. Gineviciene V, Jakaitiene A, Tubelis L, et al. Variation in the ACE, PPARGC1A and PPARA genes in Lithuanian football players. Eur J Sport Sci, 2012, 14(1): 289-295.
12. Juffer P, Furrer R, Gonzalez M, et al. Genotype distributions in top-level soccer players: a role for ACE? Int J Sports Med, 2009, 30(5): 387-392.
13. Massidda M, Corrias L, Ibba G, et al. Genetic markers and explosive leg-muscle strength in elite Italian soccer players. J Sport Med Phys Fit, 2012, 52(3): 328-334.
14. Massidda M, Scorcu M, Mc C. New genetic model for predicting phenotype traits in sports. Int J Sports Physiol Perform, 2014, 9(3): 554-560.
15. Myerson S, Hemingway H, Budget R, et al. Human angiotensin I-converting enzyme gene and endurance performance. J Appl Phycol, 1999, 87: 1313-1316.
16. Nazarov I, Woods D, Montgomery H, et al. Genomics of elite sporting performance: what little we know and necessary advances. Eur J Hum Genet, 2001, 9(10): 797-801.
17. Rizzo M, Gensini F, Fatini C, et al. ACE I/D polymorphism and cardiac adaptations in adolescent athletes. Med Sci Sport Exer, 2003, 35(12): 1986-1990.
18. Sessa F, Chetta M, Petito A, et al. Gene polymorphisms and sport attitude in Italian athletes. Genet Test Mol Bioma, 2011, 15(4): 285-290.
19. Shahmoradi S, Ahmadalipour A, Salehi M. Evaluation of ACE gene I/D polymorphism in Iranian elite athletes. Adv Biomed Res, 2014, 3(1): 207-213.
20. Saber M, Nassar Y, Latif I. Angiotensin-converting enzyme I/D gene polymorphism affects early cardiac response to professional training in young footballers. J Renin Angiotensin Aldosterone Syst, 2014, 15(3): 236-242.
21. 潘力平, 郑陆, 姚维国, 等.我国优秀篮球运动员ACE基因I/D多态性频率分布特征研究.山东体育学院学报, 2011, 27(12): 46-49.
22. Sprouse C, Tosi L, Gordish-Dressman H, et al. Genetic variation and physical performance. World Rev Nutr Diet, 2014, 180(9): 1001-1005.
23. Hagberg J, Rankinen T, Loos R, et al. Advances in exercise, fitness, and performance genomics in 2010. Med Sci Sports Exer, 2011, 43(5): 743-752.
24. Patwardhan A, Harris J, Leng N, et al. The ACE gene and human performance: 12 years on. Sports Med, 2011, 41(6): 433-448.
25. Guth L, Roth S. Genetic influence on athletic performance. Genetics, 2013, 25(6): 653-658.
26. Rankinen T, Roth S, Bray M, et al. Advances in exercise, fitness, and performance genomics. Med Sci Sports Exer, 2010, 42(5): 835-846.
27. Hagberg J, Moore G, Ferrell R. Specific genetic markers of endurance performance and V.O2max. Exerc Sport Sci Rev, 2000, 29(1): 15-19.

Chinese Journal of Evidence-Based Medicine

Association between the Insertion/Deletion Polymorphism of ACE Gene and Athlete's Sport Performance in Mixed Sports: A Meta-analysis

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