The Association between Glutathione S-transferase pi (GSTP1) Ile105Val Polymorphism with the Risk of Cutaneous Melanoma: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 GONGDe-hao ¹ , GONGChen ² , XIONGFang ¹

1. Dazhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Dazhou 635000, China;
2. Medical College Xiamen University, Xiamen 361102, China;

Corresponding author：

Keywords：

Glutathione S-transferase pi; GSTP1; Ile105Val; Polymorphism; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.20160159

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the association between glutathione S-transferase pi (GSTP1) Ile105Val (A/G) and the risk of cutaneous melanoma. Method We searched PubMed, EMbase, CNKI and WanFang Data to identify case-control studies which investigated the association between GSPT1 Ile105Val (A/G) polymorphism and the risk of cutaneous melanoma from their inception to June 31th 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then meta-analysis was performed by using RevMan 5.3 software. Results A total of 4 case-control studies involving 978 cutaneous melanoma cases and 796 controls were included. The results showed that: the GSPT1 Ile105Val (A/G) polymorphism was significantly associated with the risk of cutaneous melanoma in the dominant model (GG+GA vs. AA: OR=1.22, 95%CI 1.01 to 1.48, P=0.04), but no significant association was found in the recessive model, heterozygote model, and homozygote model (GG vs. CA+AA: OR=1.18, 95%CI 0.86 to 1.60, P=0.30; GA vs. AA: OR=1.20, 95%CI 0.98 to 1.47, P=0.08; GG vs. AA: OR=1.28, 95%CI 0.92 to 1.77, P=0.14). Conclusion Current evidence shows, The GSTP1 Ile105Val (A/G) polymorphism is associated with the risk of cutaneous melanoma. Due to limited quantity and quality of the included studies, more high-quality large-scale studies are needed to verify the above conclusion.

Citation： GONGDe-hao, GONGChen, XIONGFang. The Association between Glutathione S-transferase pi (GSTP1) Ile105Val Polymorphism with the Risk of Cutaneous Melanoma: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(9): 1035-1039. doi: 10.7507/1672-2531.20160159 Copy

1.	Cho YR, Chiang MP. Epidemiology, staging (new system), and prognosis of cutaneous melanoma. Clin Plast Surg, 2010, 37(1): 47-53.
2.	Lee HY, Chay WY, Tang MB, et al. Melanoma: differences between Asian and Caucasian patients. Ann Acad Med Singapore, 2012, 41(1): 17-20.
3.	Ribero S, Glass D, Bataille V. Genetic epidemiology of melanoma. Eur J Dermatol, 2016, 26(4): 335-339.
4.	Elefanti L, Sacco G, Stagni C, et al. TLR7 Gln11Leu single nucleotide polymorphism and susceptibility to cutaneous melanoma. Oncol Lett, 2016, 12(1): 275-280.
5.	Jiang H, Xu W, Zhang F, et al. Quantitative assessment of the association between XRCC1 Arg399Gln and Arg194Trp polymorphisms and risk of cutaneous melanoma. Melanoma Res, 2016, 26(3): 290-299.
6.	Field MG, Decatur CL, Kurtenbach S, et al. PRAME as an Independent Biomarker for Metastasis in Uveal Melanoma. Clin Cancer Res, 2016, 22(5): 1234-1242.
7.	Bin Q, Luo J. Role of polymorphisms of GSTM1, GSTT1 and GSTP1 Ile105Val in Hodgkin and non-Hodgkin lymphoma risk: a Human Genome Epidemiology (HuGE) review. Leuk Lymphoma, 2013, 54(1): 14-20.
8.	Bu H, Rosdahl I, Holmdahl-Kallen K, et al. Significance of glutathione S-transferases M1, T1 and P1 polymorphisms in Swedish melanoma patients. Oncol Rep, 2007, 17(4): 859-864.
9.	Ibarrola-Villava M, Martin-Gonzalez M, Lazaro P, et al. Role of glutathione S-transferases in melanoma susceptibility: association with GSTP1 rs1695 polymorphism. Br J Dermatol, 2012, 166(6): 1176-1183.
10.	Oliveira C, Rinck-Junior JA, Lourenco GJ, et al. Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma. J Cancer Res Clin Oncol, 2013, 139(7): 1199-1206.
11.	Cota GF, de Sousa MR, Fereguetti TO, et al. Efficacy of anti-leishmania therapy in visceral leishmaniasis among HIV infected patients: a systematic review with indirect comparison. PLoS Negl Trop Dis, 2013, 7(5): e2195.
12.	Dolzan V, Rudolf Z, Breskvar K. Genetic susceptibility to environmental carcinogenesis in Slovenian melanoma patients. Acta Dermatovenerol Alp Pannonica Adriat, 2006, 15(2): 69-78.
13.	Strange RC, Spiteri MA, Ramachandran S, et al. Glutathione-S-transferase family of enzymes. Mutat Res, 2001, 482(1-2): 21-26.
14.	Hayes JD, Strange RC. Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology, 2000, 61(3): 154-166.
15.	Board PG, Webb GC, Coggan M. Isolation of a cDNA clone and localization of the human glutathione S-transferase 3 genes to chromosome bands 11q13 and 12q13-14. Ann Hum Genet, 1989, 53(Pt 3): 205-213.

1. Cho YR, Chiang MP. Epidemiology, staging (new system), and prognosis of cutaneous melanoma. Clin Plast Surg, 2010, 37(1): 47-53.
2. Lee HY, Chay WY, Tang MB, et al. Melanoma: differences between Asian and Caucasian patients. Ann Acad Med Singapore, 2012, 41(1): 17-20.
3. Ribero S, Glass D, Bataille V. Genetic epidemiology of melanoma. Eur J Dermatol, 2016, 26(4): 335-339.
4. Elefanti L, Sacco G, Stagni C, et al. TLR7 Gln11Leu single nucleotide polymorphism and susceptibility to cutaneous melanoma. Oncol Lett, 2016, 12(1): 275-280.
5. Jiang H, Xu W, Zhang F, et al. Quantitative assessment of the association between XRCC1 Arg399Gln and Arg194Trp polymorphisms and risk of cutaneous melanoma. Melanoma Res, 2016, 26(3): 290-299.
6. Field MG, Decatur CL, Kurtenbach S, et al. PRAME as an Independent Biomarker for Metastasis in Uveal Melanoma. Clin Cancer Res, 2016, 22(5): 1234-1242.
7. Bin Q, Luo J. Role of polymorphisms of GSTM1, GSTT1 and GSTP1 Ile105Val in Hodgkin and non-Hodgkin lymphoma risk: a Human Genome Epidemiology (HuGE) review. Leuk Lymphoma, 2013, 54(1): 14-20.
8. Bu H, Rosdahl I, Holmdahl-Kallen K, et al. Significance of glutathione S-transferases M1, T1 and P1 polymorphisms in Swedish melanoma patients. Oncol Rep, 2007, 17(4): 859-864.
9. Ibarrola-Villava M, Martin-Gonzalez M, Lazaro P, et al. Role of glutathione S-transferases in melanoma susceptibility: association with GSTP1 rs1695 polymorphism. Br J Dermatol, 2012, 166(6): 1176-1183.
10. Oliveira C, Rinck-Junior JA, Lourenco GJ, et al. Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma. J Cancer Res Clin Oncol, 2013, 139(7): 1199-1206.
11. Cota GF, de Sousa MR, Fereguetti TO, et al. Efficacy of anti-leishmania therapy in visceral leishmaniasis among HIV infected patients: a systematic review with indirect comparison. PLoS Negl Trop Dis, 2013, 7(5): e2195.
12. Dolzan V, Rudolf Z, Breskvar K. Genetic susceptibility to environmental carcinogenesis in Slovenian melanoma patients. Acta Dermatovenerol Alp Pannonica Adriat, 2006, 15(2): 69-78.
13. Strange RC, Spiteri MA, Ramachandran S, et al. Glutathione-S-transferase family of enzymes. Mutat Res, 2001, 482(1-2): 21-26.
14. Hayes JD, Strange RC. Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology, 2000, 61(3): 154-166.
15. Board PG, Webb GC, Coggan M. Isolation of a cDNA clone and localization of the human glutathione S-transferase 3 genes to chromosome bands 11q13 and 12q13-14. Ann Hum Genet, 1989, 53(Pt 3): 205-213.

Chinese Journal of Evidence-Based Medicine

The Association between Glutathione S-transferase pi (GSTP1) Ile105Val Polymorphism with the Risk of Cutaneous Melanoma: A Meta-analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content