Correlation of P53 Protein Expression in Nasopharyngeal Carcinoma: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 HOUWen-qun ¹ , YANGXiao-min ² , ZHANGSheng-nan ²

1. Guangdong Medical College, Zhanjiang 524000, China;
2. Huizhou Municipal Central People's Hospital, Huizhou 516000, China;

Corresponding author：

Keywords：

Nasopharyngeal carcinoma; P53; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.20160160

Video：

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Objective To systematically review the correlation between the expression of P53 and nasopharyngeal carcinoma. Methods Databases including The Cochrane Library (Issue 1, 2016), PubMed, EMbase, CBM, CNKI, VIP, and WanFang Data were searched from the inception to January 1st 2016 to collect case-control studies about the correlation between the expression of P53 and nasopharyngeal carcinoma, as well as its clinically pathologic features. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then meta-analysis was performed using RevMan 5.2 software. Results Twelve studies were finally included in this meta-analysis. There were 630 cases of nasopharyngeal carcinoma and 253 controls. The results of meta-analysis showed that, the expression of P53 protein were significantly different between the nasopharyngeal carcinoma group and the control group (OR=21.34, 95%CI 13.59 to 33.50, P < 0.000 01), between the nasopharyngeal carcinoma with lymphatic node metastasis group and without lymphatic node metastasis group (OR=3.69, 95%CI 1.67 to 8.17, P=0.001), between the clinical stage Ⅰ to Ⅱ group and the clinical stage Ⅲ to Ⅳ group (OR=0.19, 95%CI 0.08 to 0.49, P=0.000 6). However, there were no significant differences in expression of P53 between the male nasopharyngeal carcinoma group and the female nasopharyngeal carcinoma group (OR=0.92, 95%CI 0.49 to 1.74, P=0.80), and between the < 50 nasopharyngeal carcinoma group and the≥50 nasopharyngeal carcinoma group (OR=1.70, 95%CI 0.70 to 4.11, P=0.24). Conclusions Current evidence shows that, the expression of P53 protein is associated with the occurrence, development of nasopharyngeal carcinoma and may be positively correlated to degree of tumor malignance. It may be an indicator poor prognosis.

Citation： HOUWen-qun, YANGXiao-min, ZHANGSheng-nan. Correlation of P53 Protein Expression in Nasopharyngeal Carcinoma: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(9): 1040-1046. doi: 10.7507/1672-2531.20160160 Copy

1.	楼建军, 朱小东, 曲颂, 等. P53基因多态性与鼻咽癌遗传易感性的关系.中国老年学杂志, 2012, 32(18): 3867-3870.
2.	Colubovskava VM, Conway-Dorset K, Edmiston SN, et al. EAK overexpression and p53 mutations are highly correlated in human breast cancer. Int J Cancer, 2009, 125(7): 1735-1738.
3.	Wickremasinghe RG, Prentice AG, Steele AJ. P53 and Notch signaling in chronic lymphocytic leukemia; clues to identifying novel therapeutic strategies. Leukemia, 2011, 25(9): 1400-1407.
4.	朱潇月. P53基因在鼻咽癌治疗中的研究进展.医学信息, 2015, 28(1): 387-388.
5.	张健, 郇小凤, 张平, 等.口腔鳞状细胞癌中CK19表达及其临床意义的Meta分析.中国循证医学杂志, 2015, 15(10): 1142-1147.
6.	Zeng X, Zhang Y, Kwong JS, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med, 2015, 8(1): 2-10.
7.	王丹, 翟俊霞, 牟振云, 等. Meta分析中的异质性及其处理方法.中国循证医学杂志, 2009, 9(10): 1115-1118.
8.	蔡晓, 钟慧玲, 甘青, 等. COX-2、P53在鼻咽癌中的表达及临床意义.青海医学院学报, 2011, 32(3): 172-175.
9.	蒋正举, 陈天会, 谢天宏, 等. P53、P63、P73在鼻咽癌中的表达及临床意义.现代预防医学, 2012, 39(18): 4870-4875.
10.	杨冶花, 折虹. P14ARF、mdm2、P53蛋白在鼻咽癌中表达的研究.宁夏医学院学报, 2008, 30(2): 155-156.
11.	张维彬, 胡少为, 何青莲, 等. PTEN和突变型p53蛋白在鼻咽癌组织中的表达及临床意义.山东医药, 2009, 49(3): 62-63.
12.	李康, 张志茂, 万敏婕. p53和nm23-H1在鼻咽癌组织中的表达及其意义.肿瘤研究与临床, 2014, 26(1): 52-55.
13.	程庆, 魏晶晶, 黄翔.增殖细胞核抗原和p53基因在鼻咽癌中的表达及相关性研究.临床耳鼻咽喉科杂志, 2005, 19(4): 643-645.
14.	苗北平, 卢永田, 许安廷. COX-2, PCNA及p53在鼻咽癌中的表达及意义.山东大学耳鼻喉眼学报, 2007, 21(3): 193-196.
15.	陈谊辉. survivin和p53的表达与鼻咽搔发生、发展的关系.陕西医学杂志, 2008, 37(6): 693-694.
16.	洪丽, 吴立连, 胡艳明. P53基因在鼻咽癌组织中的表达.咸宁学院学报(医学版), 2010, 24(1): 21-22.
17.	唐之雅, 涂青松.鼻咽癌c-src, p53与VEGF表达及其相关性研究.基础学, 2007: 107-108.
18.	钟守军, 姚运红.李飞虹, 等. EGR-1与p53, p16, Cyclin D 1在鼻咽癌中的表达及意义.肿瘤研究与临床, 2006, 10(18): 664-666.
19.	Liu XD, Ji MF. Expressions of p53 pathway genes and EZH2 in undifferentiated nasopharyngeal carcinoma. Nan Fang Yi Ke Da Xue Xue Bao, 2011, 31(6): 1029-1033.
20.	莫浩元, 张昌卿, 冯凯涛, 等.鼻咽癌组织中P53和PCNA表达与临床分期、VCA/ IgA, EA/ IgA、放射敏感性和预后的关系.癌症, 2004, 23(11): 1551-1554.
21.	Porter Ms, Field JK, Lee Jck, et al. Detection of the tumour suppressor gene p53 in nasopharyngeal carcinoma in Hong Kong Chinese. Anticancer Res, 1994, 14(2): 1357-1360.
22.	兰会华, 莫武宁, 黄华艺. WWOX, p53及Bcl-2在鼻咽癌中的表达及意义.华中科技大学学报(医学版), 2014, 43(1): 59-65.
23.	Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature, 2000, 408(6810): 307-310.
24.	Meek DW. Tumour suppression by p53: a role for the DNA damale responseb. Nat Rev Caucer, 2009, 9(10): 714-723.
25.	钟碧玲, 宗水生.鼻咽癌中p53蛋自积聚对瘤细胞有LPL分裂和凋亡的影响.癌症, 2000, 19(5): 432.
26.	Chang LJ, Eastman A. Decreased translation of p21(wafl)mRNA causes attenuated p53 signaling in some p53 wild-type tumors. Cell Cyc1e, 2012, 11(9): 1818-1826.
27.	Seong HA, Ha H. Murine protein serine/threonine kinase 38 activates p53 function through Ser15 phosphorylation. J Biol Chem, 2012, 15(25): 20797-20810.

1. 楼建军, 朱小东, 曲颂, 等. P53基因多态性与鼻咽癌遗传易感性的关系.中国老年学杂志, 2012, 32(18): 3867-3870.
2. Colubovskava VM, Conway-Dorset K, Edmiston SN, et al. EAK overexpression and p53 mutations are highly correlated in human breast cancer. Int J Cancer, 2009, 125(7): 1735-1738.
3. Wickremasinghe RG, Prentice AG, Steele AJ. P53 and Notch signaling in chronic lymphocytic leukemia; clues to identifying novel therapeutic strategies. Leukemia, 2011, 25(9): 1400-1407.
4. 朱潇月. P53基因在鼻咽癌治疗中的研究进展.医学信息, 2015, 28(1): 387-388.
5. 张健, 郇小凤, 张平, 等.口腔鳞状细胞癌中CK19表达及其临床意义的Meta分析.中国循证医学杂志, 2015, 15(10): 1142-1147.
6. Zeng X, Zhang Y, Kwong JS, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med, 2015, 8(1): 2-10.
7. 王丹, 翟俊霞, 牟振云, 等. Meta分析中的异质性及其处理方法.中国循证医学杂志, 2009, 9(10): 1115-1118.
8. 蔡晓, 钟慧玲, 甘青, 等. COX-2、P53在鼻咽癌中的表达及临床意义.青海医学院学报, 2011, 32(3): 172-175.
9. 蒋正举, 陈天会, 谢天宏, 等. P53、P63、P73在鼻咽癌中的表达及临床意义.现代预防医学, 2012, 39(18): 4870-4875.
10. 杨冶花, 折虹. P14ARF、mdm2、P53蛋白在鼻咽癌中表达的研究.宁夏医学院学报, 2008, 30(2): 155-156.
11. 张维彬, 胡少为, 何青莲, 等. PTEN和突变型p53蛋白在鼻咽癌组织中的表达及临床意义.山东医药, 2009, 49(3): 62-63.
12. 李康, 张志茂, 万敏婕. p53和nm23-H1在鼻咽癌组织中的表达及其意义.肿瘤研究与临床, 2014, 26(1): 52-55.
13. 程庆, 魏晶晶, 黄翔.增殖细胞核抗原和p53基因在鼻咽癌中的表达及相关性研究.临床耳鼻咽喉科杂志, 2005, 19(4): 643-645.
14. 苗北平, 卢永田, 许安廷. COX-2, PCNA及p53在鼻咽癌中的表达及意义.山东大学耳鼻喉眼学报, 2007, 21(3): 193-196.
15. 陈谊辉. survivin和p53的表达与鼻咽搔发生、发展的关系.陕西医学杂志, 2008, 37(6): 693-694.
16. 洪丽, 吴立连, 胡艳明. P53基因在鼻咽癌组织中的表达.咸宁学院学报(医学版), 2010, 24(1): 21-22.
17. 唐之雅, 涂青松.鼻咽癌c-src, p53与VEGF表达及其相关性研究.基础学, 2007: 107-108.
18. 钟守军, 姚运红.李飞虹, 等. EGR-1与p53, p16, Cyclin D 1在鼻咽癌中的表达及意义.肿瘤研究与临床, 2006, 10(18): 664-666.
19. Liu XD, Ji MF. Expressions of p53 pathway genes and EZH2 in undifferentiated nasopharyngeal carcinoma. Nan Fang Yi Ke Da Xue Xue Bao, 2011, 31(6): 1029-1033.
20. 莫浩元, 张昌卿, 冯凯涛, 等.鼻咽癌组织中P53和PCNA表达与临床分期、VCA/ IgA, EA/ IgA、放射敏感性和预后的关系.癌症, 2004, 23(11): 1551-1554.
21. Porter Ms, Field JK, Lee Jck, et al. Detection of the tumour suppressor gene p53 in nasopharyngeal carcinoma in Hong Kong Chinese. Anticancer Res, 1994, 14(2): 1357-1360.
22. 兰会华, 莫武宁, 黄华艺. WWOX, p53及Bcl-2在鼻咽癌中的表达及意义.华中科技大学学报(医学版), 2014, 43(1): 59-65.
23. Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature, 2000, 408(6810): 307-310.
24. Meek DW. Tumour suppression by p53: a role for the DNA damale responseb. Nat Rev Caucer, 2009, 9(10): 714-723.
25. 钟碧玲, 宗水生.鼻咽癌中p53蛋自积聚对瘤细胞有LPL分裂和凋亡的影响.癌症, 2000, 19(5): 432.
26. Chang LJ, Eastman A. Decreased translation of p21(wafl)mRNA causes attenuated p53 signaling in some p53 wild-type tumors. Cell Cyc1e, 2012, 11(9): 1818-1826.
27. Seong HA, Ha H. Murine protein serine/threonine kinase 38 activates p53 function through Ser15 phosphorylation. J Biol Chem, 2012, 15(25): 20797-20810.

Chinese Journal of Evidence-Based Medicine

Correlation of P53 Protein Expression in Nasopharyngeal Carcinoma: A Meta-analysis

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