The sample size of a meta-analysis should not be less than a single randomized controlled trial. Trial sequential analysis (TSA) can provide required information size and monitoring boundary to justify the conclusion of meta-analysis. However, the TSA software is only suitable for binary and continuous data, and it cannot analyze the time-to-event data. This paper aimed to introduce how to analyze the time-to-event data using TSA approach.
Citation: WENGHong, GONGKan, LIUXiaoping, LIXudong, PENGJianping, ZENGXiantao. Application of trial sequential analysis in time-to-event data. Chinese Journal of Evidence-Based Medicine, 2017, 17(2): 239-242. doi: 10.7507/1672-2531.201607062 Copy