Effectiveness of perfusion parameters of DCE-MRI in distinguishing different histological grades of rectal cancer: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

YANG Xinyue ¹ , XIAO Xiaojuan ² , LU Baolan ¹ ,  YU Shenping ¹

1. Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, P.R.China;
2. Department of Radiology, Peking University Shengzhen Hospital, Shenzhen, 518036, Guangdong, P.R.China;

Corresponding author：

YU Shenping, Email: ethan_yu@sina.com

Keywords：

DCE-MRI; Perfusion parameters; K_trans; K_ep; Rectal cancer; Meta-analysis

DOI：

10.7507/1672-2531.201608005

Video：

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Objective To systematically review the value of the perfusion paramenters of K_trans and K_ep of dynamic contrast enhanced MRI(DCE-MRI) in distinguishing different histological grades of rectal cancer. Methods Databases such as PubMed, EMbase, Web of Science, The Cochrane Library (Issue 1, 2017), CBM, CNKI, WanFang Data and VIP were searched from 1990 to Feb 6^th, 2017 to collect the studies according to the criteria. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies and then meta-analysis was performed by using STATA 12.0 software. Results A total of 11 studies involving 618 patients were included. The results of meta-analysis showed that there was significant difference of K_trans between poorly differentiated grade and moderately-well differentiated grade (SMD=1.123, 95% CI 0.334 to 1.911,P=0.005), but there was no significant difference of K_ep between these two groups (SMD=0.233, 95% CI –0.173 to 0.639,P=0.260). Conclusion Current evidence shows that K_trans can be used to distinguish different histological grades of rectal cancer. The clinical application value of K_ep still needs large sample original studies to further verify.

Citation： YANG Xinyue, XIAO Xiaojuan, LU Baolan, YU Shenping. Effectiveness of perfusion parameters of DCE-MRI in distinguishing different histological grades of rectal cancer: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2017, 17(5): 536-543. doi: 10.7507/1672-2531.201608005 Copy

1.	Hylton N. Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker. J Clin Oncol, 2006, 24(20): 3293-3298.
2.	Verma S, Turkbey B, Muradyan N, et al. Overview of Dynamic Contrast-Enhanced MRI in Prostate Cancer Diagnosis and Management. AJR Am J Roentgenol, 2012, 198(6): 1277-1288.
3.	de Vries A, Griebel J, Kremser C, et al. Monitoring of Tumor Microcirculation during Fractionated Radiation Therapy in Patients with Rectal Carcinoma: Preliminary Results and Implications for Therapy1. Radiology, 2000, 217(2): 385-391.
4.	Beaumont C, Pandey T, Gaines Fricke R, et al. MR Evaluation of Rectal Cancer: Current Concepts. Curr Probl Diagn Radiol, 2013, 42(3): 99-112.
5.	Kaur H, Choi H, You YN, et al. MR Imaging for Preoperative Evaluation of Primary Rectal Cancer: Practical Considerations. Radiographics, 2012, 32(2): 389-409.
6.	Nougaret S, Reinhold C, Mikhael HW, et al. The Use of MR Imaging in Treatment Planning for Patients with Rectal Carcinoma: Have You Checked the " DISTANCE”? Radiology, 2013, 268(2): 330-344.
7.	张文文, 黄刚, 周星, 等. DCE-MRI 定量参数与直肠癌病理分期及分级的相关性研究. 临床放射学杂志, 2016, 35(7): 1058-1061.
8.	Yu J, Xu Q, Huang DY, et al. Prognostic aspects of dynamic contrast-enhanced magnetic resonance imaging in synchronous distant metastatic rectal cancer. Eur Radiol, 2017, 27(5): 1840-1847.
9.	岳倩. 直肠癌动态增强 MRI 定量参数与 Ki67、HER-2 的相关性研究. 兰州: 兰州大学, 2016.
10.	方梦诗. 基于 MR 多模态扫描技术的直肠癌分期/分级的前瞻性研究. 安徽: 蚌埠医学院, 2016.
11.	陈露方. ADC 值和 DCE-MRI 定量参数值对直肠癌临床病理的相关性研究. 兰州: 兰州大学, 2016.
12.	朱丽娜, 张曦, 颜社平, 等. 3.0T 动态对比增强磁共振与直肠癌组织分化程度关系的探讨. 现代医用影像学, 2016, 25(2): 292-294.
13.	沈浮, 陆建平, 陈录广, 等. 动态增强磁共振成像在直肠癌术前分化程度评估中的应用价值. 临床放射学杂志, 2016, 35(1): 96-100.
14.	肖晓娟, 卢宝兰, 杨心悦, 等. 定量磁共振灌注成像用于评价直肠癌的微血管灌注及渗透性. 中国病理生理杂志, 2015, 17(12): 2164-2168.
15.	谢宗源. 直肠癌 DCE-MRI 参数与病理特征的相关性研究. 宁夏: 宁夏医科大学, 2015.
16.	李鹏. 直肠恶性肿瘤 CT 和 MRI 灌注成像研究. 天津: 天津医科大学, 2014.
17.	Yao WW, Zhang H, Ding B, et al. Rectal cancer: 3D dynamic contrast-enhanced MRI; correlation with microvascular density and clinicopathological features. Radiol Med, 2011, 116(3): 366-374.
18.	文进, 李幼平. Meta 分析中效应尺度指标的选择. 中国循证医学杂志, 2007, 7(8): 606-613.
19.	王丹, 翟俊霞, 牟振云, 等. Meta 分析中的异质性及其处理方法. 中国循证医学杂志, 2009, 9(10): 1115-1118.
20.	万德森. 结直肠癌临床病理学. 见: 万德森, 郑树, 主编. 结直肠癌. 第一版. 北京大学医学出版社, 北京: 2008.
21.	Mehrkhani F, Nasiri S, Donboli K, et al. Prognostic factors in survival of colorectal cancer patients after surgery. Colorectal Dis, 2009, 11(2): 157-161.
22.	刘彦龙, 赵发林, 王锡山. 2414 例直肠癌患者的临床病理特征及预后分析. 中华胃肠外科杂志, 2010, 13(12): 913-916.
23.	陈创奇, 方乐堃, 马晋平, 等. 结直肠癌 2042 例临床病理特点及预后回归分析. 中华医学杂志, 2010, 90(26): 1804-1807.
24.	方伟岗, 贺慧颖. 肿瘤. 见: 孙保存主编. 病理学. 北京大学医学出版社, 北京: 2009.
25.	Choi HJ, Hyun MS, Jung GJ, et al. Tumor angiogenesis as a prognostic predictor in colorectal carcinoma with special reference to mode of metastasis and recurrence. Oncology, 1998, 55(6): 575-581.
26.	Kim YE, Lim JS, Choi J, et al. Perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging in patients with rectal cancer: Correlation with microvascular density and vascular endothelial growth factor expression. Korean J of Radiol, 2013, 14(6): 878-885.
27.	Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science, 2005, 307(5706): 58-62.
28.	Tofts PS, Brix G, Buckley DL, et al. Estimating Kinetic Parameters From Dynamic Contrast-Enhanced T1-Weighted MRI of a Diffusable Tracer: Standardized Quantities and Symbols. J Magn Reson Imaging, 1999, 10(3): 223-232.
29.	Goldis DS, Sferdian MF, Tarta C, et al. Comparative analysis of microvessel density quantified through the immunohistochemistry expression of CD34 and CD105 in rectal cancer. Rom J Morphol Embryol, 2015, 56(2): 419-424.
30.	Atkin G, Taylor NJ, Daley FM, et al. Dynamic contrast-enhanced magnetic resonance imaging is a poor measure of rectal cancer angiogenesis? Br J Surg, 2006, 93(8): 992-1000.
31.	Kim DJ, Kim JH, Lim JS, et al. Restaging of Rectal Cancer with MR Imaging after Concurrent Chemotherapy and Radiation Therapy. Radiographics, 2010, 30(2): 503-516.
32.	Yeo D, Oh SN, Jung C, et al. Correlation of dynamic contrast-enhanced MRI perfusion parameters with angiogenesis and biologic aggressiveness of rectal cancer: Preliminary results. J Magn Reson Imaging, 2015, 41(2): 474-480.

1. Hylton N. Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker. J Clin Oncol, 2006, 24(20): 3293-3298.
2. Verma S, Turkbey B, Muradyan N, et al. Overview of Dynamic Contrast-Enhanced MRI in Prostate Cancer Diagnosis and Management. AJR Am J Roentgenol, 2012, 198(6): 1277-1288.
3. de Vries A, Griebel J, Kremser C, et al. Monitoring of Tumor Microcirculation during Fractionated Radiation Therapy in Patients with Rectal Carcinoma: Preliminary Results and Implications for Therapy1. Radiology, 2000, 217(2): 385-391.
4. Beaumont C, Pandey T, Gaines Fricke R, et al. MR Evaluation of Rectal Cancer: Current Concepts. Curr Probl Diagn Radiol, 2013, 42(3): 99-112.
5. Kaur H, Choi H, You YN, et al. MR Imaging for Preoperative Evaluation of Primary Rectal Cancer: Practical Considerations. Radiographics, 2012, 32(2): 389-409.
6. Nougaret S, Reinhold C, Mikhael HW, et al. The Use of MR Imaging in Treatment Planning for Patients with Rectal Carcinoma: Have You Checked the " DISTANCE”? Radiology, 2013, 268(2): 330-344.
7. 张文文, 黄刚, 周星, 等. DCE-MRI 定量参数与直肠癌病理分期及分级的相关性研究. 临床放射学杂志, 2016, 35(7): 1058-1061.
8. Yu J, Xu Q, Huang DY, et al. Prognostic aspects of dynamic contrast-enhanced magnetic resonance imaging in synchronous distant metastatic rectal cancer. Eur Radiol, 2017, 27(5): 1840-1847.
9. 岳倩. 直肠癌动态增强 MRI 定量参数与 Ki67、HER-2 的相关性研究. 兰州: 兰州大学, 2016.
10. 方梦诗. 基于 MR 多模态扫描技术的直肠癌分期/分级的前瞻性研究. 安徽: 蚌埠医学院, 2016.
11. 陈露方. ADC 值和 DCE-MRI 定量参数值对直肠癌临床病理的相关性研究. 兰州: 兰州大学, 2016.
12. 朱丽娜, 张曦, 颜社平, 等. 3.0T 动态对比增强磁共振与直肠癌组织分化程度关系的探讨. 现代医用影像学, 2016, 25(2): 292-294.
13. 沈浮, 陆建平, 陈录广, 等. 动态增强磁共振成像在直肠癌术前分化程度评估中的应用价值. 临床放射学杂志, 2016, 35(1): 96-100.
14. 肖晓娟, 卢宝兰, 杨心悦, 等. 定量磁共振灌注成像用于评价直肠癌的微血管灌注及渗透性. 中国病理生理杂志, 2015, 17(12): 2164-2168.
15. 谢宗源. 直肠癌 DCE-MRI 参数与病理特征的相关性研究. 宁夏: 宁夏医科大学, 2015.
16. 李鹏. 直肠恶性肿瘤 CT 和 MRI 灌注成像研究. 天津: 天津医科大学, 2014.
17. Yao WW, Zhang H, Ding B, et al. Rectal cancer: 3D dynamic contrast-enhanced MRI; correlation with microvascular density and clinicopathological features. Radiol Med, 2011, 116(3): 366-374.
18. 文进, 李幼平. Meta 分析中效应尺度指标的选择. 中国循证医学杂志, 2007, 7(8): 606-613.
19. 王丹, 翟俊霞, 牟振云, 等. Meta 分析中的异质性及其处理方法. 中国循证医学杂志, 2009, 9(10): 1115-1118.
20. 万德森. 结直肠癌临床病理学. 见: 万德森, 郑树, 主编. 结直肠癌. 第一版. 北京大学医学出版社, 北京: 2008.
21. Mehrkhani F, Nasiri S, Donboli K, et al. Prognostic factors in survival of colorectal cancer patients after surgery. Colorectal Dis, 2009, 11(2): 157-161.
22. 刘彦龙, 赵发林, 王锡山. 2414 例直肠癌患者的临床病理特征及预后分析. 中华胃肠外科杂志, 2010, 13(12): 913-916.
23. 陈创奇, 方乐堃, 马晋平, 等. 结直肠癌 2042 例临床病理特点及预后回归分析. 中华医学杂志, 2010, 90(26): 1804-1807.
24. 方伟岗, 贺慧颖. 肿瘤. 见: 孙保存主编. 病理学. 北京大学医学出版社, 北京: 2009.
25. Choi HJ, Hyun MS, Jung GJ, et al. Tumor angiogenesis as a prognostic predictor in colorectal carcinoma with special reference to mode of metastasis and recurrence. Oncology, 1998, 55(6): 575-581.
26. Kim YE, Lim JS, Choi J, et al. Perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging in patients with rectal cancer: Correlation with microvascular density and vascular endothelial growth factor expression. Korean J of Radiol, 2013, 14(6): 878-885.
27. Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science, 2005, 307(5706): 58-62.
28. Tofts PS, Brix G, Buckley DL, et al. Estimating Kinetic Parameters From Dynamic Contrast-Enhanced T1-Weighted MRI of a Diffusable Tracer: Standardized Quantities and Symbols. J Magn Reson Imaging, 1999, 10(3): 223-232.
29. Goldis DS, Sferdian MF, Tarta C, et al. Comparative analysis of microvessel density quantified through the immunohistochemistry expression of CD34 and CD105 in rectal cancer. Rom J Morphol Embryol, 2015, 56(2): 419-424.
30. Atkin G, Taylor NJ, Daley FM, et al. Dynamic contrast-enhanced magnetic resonance imaging is a poor measure of rectal cancer angiogenesis? Br J Surg, 2006, 93(8): 992-1000.
31. Kim DJ, Kim JH, Lim JS, et al. Restaging of Rectal Cancer with MR Imaging after Concurrent Chemotherapy and Radiation Therapy. Radiographics, 2010, 30(2): 503-516.
32. Yeo D, Oh SN, Jung C, et al. Correlation of dynamic contrast-enhanced MRI perfusion parameters with angiogenesis and biologic aggressiveness of rectal cancer: Preliminary results. J Magn Reson Imaging, 2015, 41(2): 474-480.

Chinese Journal of Evidence-Based Medicine

Effectiveness of perfusion parameters of DCE-MRI in distinguishing different histological grades of rectal cancer: a meta-analysis

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