Association between <i>TNF-α</i> -308G/A gene polymorphism and susceptibility to coronary atherosclerotic heart disease in Chinese population: a meta-analysis _Chinese Journal of Evidence-Based Medicine

Authors：

LI Wei ¹ ,  FU Lingyu ²

1. Medical Records Management Center, The First Hospital of China Medical University, Shenyang, 110001, P.R.China;
2. Department of Clinical Epidemiology and Center of Evidence-based Medicine, The First Hospital of China Medical University, Shenyang, 110001, P.R.China;

Corresponding author：

FU Lingyu, Email: fulingyucmu@sina.com.cn

Keywords：

TNF-α; Polymorphism; Coronary atherosclerotic heart disease; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.201704018

Video：

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ObjectiveTo investigate the association between TNF-α gene -308G/A polymorphism and the risk of coronary atherosclerotic heart disease (CHD) in Chinese population.MethodsWe searched PubMed, Web of Science, CNKI, WanFang Data and VIP Databases from inception to February 2017, to collect case-control studies about the association between TNF-α gene -308G/A polymorphism and risk of CHD in Chinese population. Two reviewers independently screened literature, extracted data and assessed the risk of bias of the included studies. Meta-analysis was performed by Stata 12.0 software.ResultsA total of 10 case-control studies were included. The results of meta-analysis showed a significant association between the TNF-α gene -308G/A polymorphism and CHD risk in Chinese population (A vs. G: OR=1.13, 95%CI 1.02 to 1.26, P=0.020; AA vs. GA/GG: OR=1.47, 95%CI 1.02 to 2.12, P=0.038; AA vs. GG: OR=1.50, 95%CI 1.04 to 2.16, P=0.029).ConclusionThe current evidence shows that the TNF-α gene -308G/A polymorphism may be associated with CHD risk in Chinese population and A allele may be a risk factor. Due to the limited quantity and quality of included studies, more high quality studies are needed to verify the above conclusion.

Citation： LI Wei, FU Lingyu. Association between TNF-α -308G/A gene polymorphism and susceptibility to coronary atherosclerotic heart disease in Chinese population: a meta-analysis . Chinese Journal of Evidence-Based Medicine, 2017, 17(9): 1015-1020. doi: 10.7507/1672-2531.201704018 Copy

1.	Murray CJ, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 2012, 380(9859): 2197-2223.
2.	Hajeer AH, Hutchinson IV. Influence of TNF alpha gene polymorphisms on TNF alpha production and disease. Human Immunol, 2001, 62(11): 1191-1199.
3.	Hou L, Huang J, Lu X, et al. Polymorphisms of tumor necrosis factor alpha gene and coronary heart disease in a Chinese Han population: interaction with cigarette smoking. Thromb Res, 2009, 123(6): 822-826.
4.	孙书昱, 曾雄群, 靳安民, 等. 肿瘤坏死因子-α 启动子区基因多态性与慢性牙周炎及冠心病的相关性研究. 临床口腔医学杂志, 2009, 25(5): 279-282.
5.	Pereira TV, Rudnicki M, Franco RF, et al. Effect of the G-308A polymorphism of the tumor necrosis factor alpha gene on the risk of ischemic heart disease and ischemic stroke: A meta-analysis. Am Heart J, 2007, 153(5): 821-830.
6.	Wang J, He Y, Yang Y, et al. Association between the TNF-alpha G-308A polymorphism and risk of ischemic heart disease: a meta-analysis. Int J Clin Exp Med, 2015, 8(6): 8880-8892.
7.	陈志群, 郑宗富, 马建芳, 等. 老年冠心病患者肿瘤坏死因子基因多态性的研究. 实用老年医学, 2001, 15(3): 159-160.
8.	向萍霞, 李艳, 张平安, 等. 冠心病患者肿瘤坏死因子 α 水平及其基因多态性的研究. 检验医学, 2004, 19(5): 434-437.
9.	刘艳, 陆林, 吴志俊, 等. 肿瘤坏死因子 α 基因与上海地区汉族人群冠心病发病风险的关系. 上海交通大学学报(医学版), 2011, 31(5): 592-597.
10.	Chu H, Yang J, Mi S, et al. Tumor necrosis factor-alpha G-308 A polymorphism and risk of coronary heart disease and myocardial infarction: A case-control study and meta-analysis. J Cardiovasc Dis Res, 2012, 3(2): 84-90.
11.	Chen W, Hua K, Gu H, et al. Methylenetetrahydrofolate reductase C667T polymorphism is associated with increased risk of coronary artery disease in a Chinese population. Scand J Immunol, 2014, 80(5): 346-353.
12.	齐晓明, 张蕊, 李倩男, 等. 高分辨率熔解技术检测冠心病患者 TNF-α 及其受体基因多态性. 临床检验杂志, 2014, 32(6): 405-409.
13.	Cheng Y, An B, Jiang M, et al. Association of tumor necrosis factor-alpha polymorphisms and risk of coronary artery disease in patients with non-alcoholic fatty liver disease. Hepat Mon, 2015, 15(3): e26818.
14.	赵小蕾, 林美华, 范安, 等. 肿瘤坏死因子单核苷酸多态性与广东人群冠心病的关联分析. 现代预防医学, 2015, 42(13): 2389-2392.
15.	Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med, 2005, 352(16): 1685-1695.
16.	Wilson AG, Symons JA, McDowell TL, et al. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci U S A, 1997, 94(7): 3195-3199.
17.	Sbarsi I, Falcone C, Boiocchi C, et al. Inflammation and atherosclerosis: the role of TNF and TNF receptors polymorphisms in coronary artery disease. Int J Immunopathol Pharmacol, 2007, 20(1): 145-154.
18.	Sargi SC, Dalalio MM, Visentainer JV, et al. Production of TNF-alpha, nitric oxide and hydrogen peroxide by macrophages from mice with paracoccidioidomycosis that were fed a linseed oil-enriched diet. Mem Inst Oswaldo Cruz, 2012, 107(3): 303-309.
19.	Zhang HF, Zhong BL, Zhu WL, et al. CD14 C-260T gene polymorphism and ischemic heart disease susceptibility: a HuGE review and meta-analysis. Genet Med, 2009, 11(6): 403-408.
20.	Zheng RL, Zhang H, Jiang WL. Tumor necrosis factor-alpha 308G>A polymorphism and risk of rheumatic heart disease: a meta-analysis. Sci Rep, 2014, 4: 4731.

1. Murray CJ, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 2012, 380(9859): 2197-2223.
2. Hajeer AH, Hutchinson IV. Influence of TNF alpha gene polymorphisms on TNF alpha production and disease. Human Immunol, 2001, 62(11): 1191-1199.
3. Hou L, Huang J, Lu X, et al. Polymorphisms of tumor necrosis factor alpha gene and coronary heart disease in a Chinese Han population: interaction with cigarette smoking. Thromb Res, 2009, 123(6): 822-826.
4. 孙书昱, 曾雄群, 靳安民, 等. 肿瘤坏死因子-α 启动子区基因多态性与慢性牙周炎及冠心病的相关性研究. 临床口腔医学杂志, 2009, 25(5): 279-282.
5. Pereira TV, Rudnicki M, Franco RF, et al. Effect of the G-308A polymorphism of the tumor necrosis factor alpha gene on the risk of ischemic heart disease and ischemic stroke: A meta-analysis. Am Heart J, 2007, 153(5): 821-830.
6. Wang J, He Y, Yang Y, et al. Association between the TNF-alpha G-308A polymorphism and risk of ischemic heart disease: a meta-analysis. Int J Clin Exp Med, 2015, 8(6): 8880-8892.
7. 陈志群, 郑宗富, 马建芳, 等. 老年冠心病患者肿瘤坏死因子基因多态性的研究. 实用老年医学, 2001, 15(3): 159-160.
8. 向萍霞, 李艳, 张平安, 等. 冠心病患者肿瘤坏死因子 α 水平及其基因多态性的研究. 检验医学, 2004, 19(5): 434-437.
9. 刘艳, 陆林, 吴志俊, 等. 肿瘤坏死因子 α 基因与上海地区汉族人群冠心病发病风险的关系. 上海交通大学学报(医学版), 2011, 31(5): 592-597.
10. Chu H, Yang J, Mi S, et al. Tumor necrosis factor-alpha G-308 A polymorphism and risk of coronary heart disease and myocardial infarction: A case-control study and meta-analysis. J Cardiovasc Dis Res, 2012, 3(2): 84-90.
11. Chen W, Hua K, Gu H, et al. Methylenetetrahydrofolate reductase C667T polymorphism is associated with increased risk of coronary artery disease in a Chinese population. Scand J Immunol, 2014, 80(5): 346-353.
12. 齐晓明, 张蕊, 李倩男, 等. 高分辨率熔解技术检测冠心病患者 TNF-α 及其受体基因多态性. 临床检验杂志, 2014, 32(6): 405-409.
13. Cheng Y, An B, Jiang M, et al. Association of tumor necrosis factor-alpha polymorphisms and risk of coronary artery disease in patients with non-alcoholic fatty liver disease. Hepat Mon, 2015, 15(3): e26818.
14. 赵小蕾, 林美华, 范安, 等. 肿瘤坏死因子单核苷酸多态性与广东人群冠心病的关联分析. 现代预防医学, 2015, 42(13): 2389-2392.
15. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med, 2005, 352(16): 1685-1695.
16. Wilson AG, Symons JA, McDowell TL, et al. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci U S A, 1997, 94(7): 3195-3199.
17. Sbarsi I, Falcone C, Boiocchi C, et al. Inflammation and atherosclerosis: the role of TNF and TNF receptors polymorphisms in coronary artery disease. Int J Immunopathol Pharmacol, 2007, 20(1): 145-154.
18. Sargi SC, Dalalio MM, Visentainer JV, et al. Production of TNF-alpha, nitric oxide and hydrogen peroxide by macrophages from mice with paracoccidioidomycosis that were fed a linseed oil-enriched diet. Mem Inst Oswaldo Cruz, 2012, 107(3): 303-309.
19. Zhang HF, Zhong BL, Zhu WL, et al. CD14 C-260T gene polymorphism and ischemic heart disease susceptibility: a HuGE review and meta-analysis. Genet Med, 2009, 11(6): 403-408.
20. Zheng RL, Zhang H, Jiang WL. Tumor necrosis factor-alpha 308G>A polymorphism and risk of rheumatic heart disease: a meta-analysis. Sci Rep, 2014, 4: 4731.

Chinese Journal of Evidence-Based Medicine

Association between TNF-α -308G/A gene polymorphism and susceptibility to coronary atherosclerotic heart disease in Chinese population: a meta-analysis

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