Efficacy of mineral trioxide aggregate for partial pulpotomy in cariously exposure pulps of young permanent teeth: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

LIU Yunkun , WANG Yan , GU Zhiyu , WU Qi , XU Xin ,  ZHOU Xuedong

State Key Laboratory of Oral Diseases, National Clinical Research for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R.China;

Corresponding author：

ZHOU Xuedong, Email: zhouxd@scu.edu.cn

Keywords：

Mineral trioxide aggregate; Calcium hydroxide; Pulpotomy; Exposed pulp; Systematic review; Randomized controlled trial; Meta-analysis

DOI：

10.7507/1672-2531.201704030

Video：

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Objectives To systematically review the efficacy of mineral trioxide aggregate (MTA) for partial pulpotomy in cariously exposed pulps of young permanent teeth. Methods Databases including PubMed, EMbase, The Cochrane Library, CNKI, CBM and WanFang Data were searched to collect randomized controlled trials (RCTs) on mineral trioxide aggregate for partial pulpotomy in cariously exposed pulps of young permanent teeth from inception to February 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed by RevMan 5.3 software. Results A total of three RCTs including 199 teeth were eventually included. The results of meta-analysis showed that: there were no statistically significant differences in efficacy between the MTA group and the calcium hydroxide treatment groups at time points of 3, 6, 12, 24 and over 24 months. None of three studies reported adverse events. Conclusions The current study shows that MTA and calcium hydroxide have similar short-term and long-term clinical efficacy in cariously exposed pulps of young permanent teeth, but more high quality and large-scale studies are required to verify the above conclusion.

Citation： LIU Yunkun, WANG Yan, GU Zhiyu, WU Qi, XU Xin, ZHOU Xuedong. Efficacy of mineral trioxide aggregate for partial pulpotomy in cariously exposure pulps of young permanent teeth: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2017, 17(12): 1437-1441. doi: 10.7507/1672-2531.201704030 Copy

1.	杜芹, 田鲲, 周村, 等. MTA 用于外伤年轻恒牙活髓切断的疗效观察. 四川医学, 2013, 34(6): 738-740.
2.	Fong CD, Davis MJ. Partial pulpotomy for immature permanent teeth, its present and future. Pediatr Dent, 2002, 24 (1): 29-32.
3.	Stanley HR. Criteria for standardizing and increasing credibility of direct pulp capping studies. Am J Dent, 1998, 11(Suppl): 17-34.
4.	Cox CF, Subay RK, Ostro E, et al. Tunnel defects in dentin bridges: their formation following direct pulp capping. Oper Dent, 1996, 21(1): 4-11.
5.	Aeinehchi M, Eslami B, Ghanbariha M, et al. Mineral trioxide aggregate (MTA) and calcium hydroxide as pulp-capping agents in human teeth: a preliminary report. Int Endod J, 2003, 36(3): 225-231.
6.	邓文丽. MTA 用于龋源性露髓年轻恒牙部分活髓切断治疗的效果观察. 基层医学论坛, 2015, 19(11): 1449-1450.
7.	Chailertvanitkul P, Paphangkorakit J, Sooksantisakoonchai N, et al. Randomized control trial comparing calcium hydroxide and mineral trioxide aggregate for partial pulpotomies in cariously exposed pulps of permanent molars. Int Endod J, 2014, 47(9): 835-842.
8.	Qudeimat MA, Barrieshi-Nusair KM, Owais AI. Calcium hydroxide vs mineral trioxide aggregates for partial pulpotomy of permanent molars with deep caries. Eur Arch Paediatr Dent, 2007, 8(2): 99-104.
9.	Kang CM, Sun Y, Song JS, et al. A randomized controlled trial of various MTA materials for partial pulpotomy in permanent teeth. J Dent, 2017, 60: 8-13.
10.	Kiatwateeratana T, Kintarak S, Piwat S, et al. Partial pulpotomy on caries-free teeth using enamel matrix derivative or calcium hydroxide: a randomized controlled trial. Int Endod J, 2009, 42(7): 584-592.
11.	Barrieshi-Nusair KM, Qudeimat MA. A prospective clinical study of mineral trioxide aggregate for partial pulpotomy in cariously exposed permanent teeth. J Endod, 2006, 32(8): 731-735.
12.	Mass E, Zilberman U. Long-term radiologic pulp evaluation after partial pulpotomy in young permanent molars. Quintessence Int, 2011, 42(7): 547-554.
13.	Schwendicke F, Brouwer F, Schwendicke A, et al. Different materials for direct pulp capping: systematic review and meta-analysis and trial sequential analysis. Clin Oral Investig, 2016, 20(6): 1121-1132.
14.	Parirokh M, Torabinejad M. Mineral trioxide aggregate: a comprehensive literature review-Part I: chemical, physical, and antibacterial properties. J Endod, 2010, 36(1): 16-27.
15.	Parirokh M, Torabinejad M. Mineral trioxide aggregate: a comprehensive literature review-Part III: Clinical applications, drawbacks, and mechanism of action. J Endod, 2010, 36(3): 400-413.
16.	孙燕, 宋光泰. MTA 用于龋源性露髓年轻恒牙部分活髓切断治疗的初步研究. 口腔医学研究, 2009, 25(4): 475-477.
17.	Akhlaghi N, Khademi A. Outcomes of vital pulp therapy in permanent teeth with different medicaments based on review of the literature. Dent Res J (Isfahan), 2015, 12(5): 406-417.

1. 杜芹, 田鲲, 周村, 等. MTA 用于外伤年轻恒牙活髓切断的疗效观察. 四川医学, 2013, 34(6): 738-740.
2. Fong CD, Davis MJ. Partial pulpotomy for immature permanent teeth, its present and future. Pediatr Dent, 2002, 24 (1): 29-32.
3. Stanley HR. Criteria for standardizing and increasing credibility of direct pulp capping studies. Am J Dent, 1998, 11(Suppl): 17-34.
4. Cox CF, Subay RK, Ostro E, et al. Tunnel defects in dentin bridges: their formation following direct pulp capping. Oper Dent, 1996, 21(1): 4-11.
5. Aeinehchi M, Eslami B, Ghanbariha M, et al. Mineral trioxide aggregate (MTA) and calcium hydroxide as pulp-capping agents in human teeth: a preliminary report. Int Endod J, 2003, 36(3): 225-231.
6. 邓文丽. MTA 用于龋源性露髓年轻恒牙部分活髓切断治疗的效果观察. 基层医学论坛, 2015, 19(11): 1449-1450.
7. Chailertvanitkul P, Paphangkorakit J, Sooksantisakoonchai N, et al. Randomized control trial comparing calcium hydroxide and mineral trioxide aggregate for partial pulpotomies in cariously exposed pulps of permanent molars. Int Endod J, 2014, 47(9): 835-842.
8. Qudeimat MA, Barrieshi-Nusair KM, Owais AI. Calcium hydroxide vs mineral trioxide aggregates for partial pulpotomy of permanent molars with deep caries. Eur Arch Paediatr Dent, 2007, 8(2): 99-104.
9. Kang CM, Sun Y, Song JS, et al. A randomized controlled trial of various MTA materials for partial pulpotomy in permanent teeth. J Dent, 2017, 60: 8-13.
10. Kiatwateeratana T, Kintarak S, Piwat S, et al. Partial pulpotomy on caries-free teeth using enamel matrix derivative or calcium hydroxide: a randomized controlled trial. Int Endod J, 2009, 42(7): 584-592.
11. Barrieshi-Nusair KM, Qudeimat MA. A prospective clinical study of mineral trioxide aggregate for partial pulpotomy in cariously exposed permanent teeth. J Endod, 2006, 32(8): 731-735.
12. Mass E, Zilberman U. Long-term radiologic pulp evaluation after partial pulpotomy in young permanent molars. Quintessence Int, 2011, 42(7): 547-554.
13. Schwendicke F, Brouwer F, Schwendicke A, et al. Different materials for direct pulp capping: systematic review and meta-analysis and trial sequential analysis. Clin Oral Investig, 2016, 20(6): 1121-1132.
14. Parirokh M, Torabinejad M. Mineral trioxide aggregate: a comprehensive literature review-Part I: chemical, physical, and antibacterial properties. J Endod, 2010, 36(1): 16-27.
15. Parirokh M, Torabinejad M. Mineral trioxide aggregate: a comprehensive literature review-Part III: Clinical applications, drawbacks, and mechanism of action. J Endod, 2010, 36(3): 400-413.
16. 孙燕, 宋光泰. MTA 用于龋源性露髓年轻恒牙部分活髓切断治疗的初步研究. 口腔医学研究, 2009, 25(4): 475-477.
17. Akhlaghi N, Khademi A. Outcomes of vital pulp therapy in permanent teeth with different medicaments based on review of the literature. Dent Res J (Isfahan), 2015, 12(5): 406-417.

Chinese Journal of Evidence-Based Medicine

Efficacy of mineral trioxide aggregate for partial pulpotomy in cariously exposure pulps of young permanent teeth: a meta-analysis

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