The association between periodontal disease and the incidence risk of colorectal cancer: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

ZHENG Zhongli ^1,2 , WANG Chaoyang ^1,2 , LI Binghui ^1,2 , ZI Hao ² , CHEN Shaohua ² , XIA Lingyun ³ ,  ZENG Xiantao ^3,4 ,  REN Xuequn ^1,2

1. Department of General Surgery, Huaihe Hospital, Henan University, Kaifeng, 475000, P.R.China;
2. Evidence-Based Medicine and Clinical Research Center, Huaihe Hospital, Henan University; Evidence-Based Medicine Center, Henan University, Kaifeng, 475000, P.R.China;
3. Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, P.R.China;
4. Evidence-Based and Translational Medicine Center, Zhongnan Hospital of Wuhan University; Evidence-Based and Translational Medicine Center, Wuhan University; Department of Evidence-Based Medicine and Clinical Epidemiology, The Second Clinical Medical College of Wuhan University, Wuhan, 430071, P.R.China;

Corresponding author：

REN Xuequn, Email: renxuequn001@163.com

Keywords：

Periodontal disease; Colorectal neoplasm; Risk factor; Cohort study; Meta-analysis; Systematic review

DOI：

10.7507/1672-2531.201706089

Video：

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ObjectiveTo systematically review the association between periodontal disease and the incidence risk of colorectal cancer (CRC).MethodsPubMed, EMbase, WanFang Data and CNKI databases were searched to collect cohort studies and case-control studies for the association between periodontal disease and the incidence risk of CRC from inception to February 28^th, 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using RevMan 5.3 software.ResultsA total of 5 prospective cohort studies were included. The results from adjusted data based meta-analysis showed that the periodontal disease was not associated with the incidence risk of CRC (RR=1.14, 95%CI 0.88 to 1.49, P=0.32).ConclusionsThe current evidence suggests that periodontal disease is not associated with the risk of CRC.

Citation： ZHENG Zhongli, WANG Chaoyang, LI Binghui, ZI Hao, CHEN Shaohua, XIA Lingyun, ZENG Xiantao, REN Xuequn. The association between periodontal disease and the incidence risk of colorectal cancer: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2018, 18(3): 300-304. doi: 10.7507/1672-2531.201706089 Copy

1.	Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer, 2015, 136(5): 359-386.
2.	Courtney RJ, Paul CL, Carey ML, et al. A population-based cross-sectional study of colorectal cancer screening practices of first-degree relatives of colorectal cancer patients. BMC Cancer, 2013, 13(1): 1-11.
3.	邵红梅, 冯瑞, 朱红, 等. 中国人群结直肠癌危险因素的Meta分析. 中国慢性病预防与控制, 2014, 22(2): 174-177.
4.	Fitzpatrick SG, Katz J. The association between periodontal disease and cancer: a review of the literature. J Dent, 2010, 38(2): 83-95.
5.	Hojuel PP, Drangsholt M, Spiekerman C, et al. An exploration of the periodontitis-cancer association. Ann Epidemiol, 2003, 13(5): 312-316.
6.	Michaud DS, Liu Y, Meyer M, et al. Periodontal disease, tooth loss, and cancer risk in male health professionals: a prospective cohort study. Lancet Oncol, 2008, 9(6): 550-558.
7.	Arora M, Weuve J, Fall K, et al. An exploration of shared genetic risk factors between periodontal disease and cancers: a prospective co-twin study. Am J Epidemiol, 2010, 171(2): 253-259.
8.	Ahn J, Segers S, Hayes RB. Periodontal disease, porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality. Carcinogenesis, 2012, 33(5): 1055-1058.
9.	Momen-Heravi F, Babic A, Tworoger SS, et al. Periodontal disease, tooth loss and colorectal cancer risk: Results from the Nurses' Health Study. Int J Cancer, 2017, 140(3): 646-652.
10.	Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg, 2010, 8(5): 336-341.
11.	曾宪涛, 刘慧, 陈曦, 等. Meta分析系列之四: 观察性研究的质量评价工具. 中国循证心血管医学杂志, 2012, 4(4): 297-299.
12.	文进, 李幼平. Meta分析中效应尺度指标的选择. 中国循证医学杂志, 2007, 7(8): 606-613.
13.	沈可, 曾宪涛. 数据的转换. 罗杰, 主编. 系统评价Meta分析理论与实践(第1版). 北京: 军事医学科学出版社, 2013: 106-108.
14.	曾宪涛, 冷卫东, 郭毅, 等. Meta分析系列之一: Meta分析的类型. 中国循证心血管医学杂志, 2012, 4(1): 3-5.
15.	Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med, 2002, 21(11): 1539-1558.
16.	Coppede F. Epigenetic biomarkers of colorectal cancer: focus on DNA methylation. Cancer Lett, 2014, 342(2): 238-247.
17.	徐玉彬, 张培建, 王超臣. 结直肠癌的病因及发病机制的研究进展. 中华临床医师杂志(电子版), 2015, 9(15): 2912-2915.
18.	Venkatachalam R, Ligtenberg MJ, Hoogerbrugge N, et al. The epigenetics of (hereditary) colorectal cancer. Cancer Genet Cytogenet, 2010, 203(1): 1-6.
19.	李倩, 潘亚萍. 具核梭杆菌与全身疾病相关性的研究进展. 中国微生态学杂志, 2016, 28(11): 1353-1356.
20.	Armitage GC. Development of a classification system for periodontal diseases and conditions. Northwest Dent, 2000, 79(6): 31-35.
21.	Rubinstein MR, Wang X, Liu W, et al. Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin. Cell Host & Microbe, 2013, 14(2): 195-206.
22.	Kostic AD, Chun E, Robertson L, et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host & Microbe, 2013, 14(2): 207-215.
23.	Hwang IM, Sun LM, Lin CL, et al. Periodontal disease with treatment reduces subsequent cancer risks. QJM, 2014, 107(10): 805-812.
24.	Barton MK. Evidence accumulates indicating periodontal disease as a risk factor for colorectal cancer or lymphoma. CA Cancer J Clin, 2017, 67(3): 173-174.
25.	袁杰, 王少果, 周建业, 等. 慢性牙周炎唾液牙龈卟啉单胞菌的定量PCR检测. 口腔医学研究, 2015, 31(2): 133-136.

1. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer, 2015, 136(5): 359-386.
2. Courtney RJ, Paul CL, Carey ML, et al. A population-based cross-sectional study of colorectal cancer screening practices of first-degree relatives of colorectal cancer patients. BMC Cancer, 2013, 13(1): 1-11.
3. 邵红梅, 冯瑞, 朱红, 等. 中国人群结直肠癌危险因素的Meta分析. 中国慢性病预防与控制, 2014, 22(2): 174-177.
4. Fitzpatrick SG, Katz J. The association between periodontal disease and cancer: a review of the literature. J Dent, 2010, 38(2): 83-95.
5. Hojuel PP, Drangsholt M, Spiekerman C, et al. An exploration of the periodontitis-cancer association. Ann Epidemiol, 2003, 13(5): 312-316.
6. Michaud DS, Liu Y, Meyer M, et al. Periodontal disease, tooth loss, and cancer risk in male health professionals: a prospective cohort study. Lancet Oncol, 2008, 9(6): 550-558.
7. Arora M, Weuve J, Fall K, et al. An exploration of shared genetic risk factors between periodontal disease and cancers: a prospective co-twin study. Am J Epidemiol, 2010, 171(2): 253-259.
8. Ahn J, Segers S, Hayes RB. Periodontal disease, porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality. Carcinogenesis, 2012, 33(5): 1055-1058.
9. Momen-Heravi F, Babic A, Tworoger SS, et al. Periodontal disease, tooth loss and colorectal cancer risk: Results from the Nurses' Health Study. Int J Cancer, 2017, 140(3): 646-652.
10. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg, 2010, 8(5): 336-341.
11. 曾宪涛, 刘慧, 陈曦, 等. Meta分析系列之四: 观察性研究的质量评价工具. 中国循证心血管医学杂志, 2012, 4(4): 297-299.
12. 文进, 李幼平. Meta分析中效应尺度指标的选择. 中国循证医学杂志, 2007, 7(8): 606-613.
13. 沈可, 曾宪涛. 数据的转换. 罗杰, 主编. 系统评价Meta分析理论与实践(第1版). 北京: 军事医学科学出版社, 2013: 106-108.
14. 曾宪涛, 冷卫东, 郭毅, 等. Meta分析系列之一: Meta分析的类型. 中国循证心血管医学杂志, 2012, 4(1): 3-5.
15. Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med, 2002, 21(11): 1539-1558.
16. Coppede F. Epigenetic biomarkers of colorectal cancer: focus on DNA methylation. Cancer Lett, 2014, 342(2): 238-247.
17. 徐玉彬, 张培建, 王超臣. 结直肠癌的病因及发病机制的研究进展. 中华临床医师杂志(电子版), 2015, 9(15): 2912-2915.
18. Venkatachalam R, Ligtenberg MJ, Hoogerbrugge N, et al. The epigenetics of (hereditary) colorectal cancer. Cancer Genet Cytogenet, 2010, 203(1): 1-6.
19. 李倩, 潘亚萍. 具核梭杆菌与全身疾病相关性的研究进展. 中国微生态学杂志, 2016, 28(11): 1353-1356.
20. Armitage GC. Development of a classification system for periodontal diseases and conditions. Northwest Dent, 2000, 79(6): 31-35.
21. Rubinstein MR, Wang X, Liu W, et al. Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin. Cell Host & Microbe, 2013, 14(2): 195-206.
22. Kostic AD, Chun E, Robertson L, et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host & Microbe, 2013, 14(2): 207-215.
23. Hwang IM, Sun LM, Lin CL, et al. Periodontal disease with treatment reduces subsequent cancer risks. QJM, 2014, 107(10): 805-812.
24. Barton MK. Evidence accumulates indicating periodontal disease as a risk factor for colorectal cancer or lymphoma. CA Cancer J Clin, 2017, 67(3): 173-174.
25. 袁杰, 王少果, 周建业, 等. 慢性牙周炎唾液牙龈卟啉单胞菌的定量PCR检测. 口腔医学研究, 2015, 31(2): 133-136.

Chinese Journal of Evidence-Based Medicine

The association between periodontal disease and the incidence risk of colorectal cancer: a meta-analysis

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