Correlation between serum total cholesterol and prognosis of idiopathic sudden sensorineural hearing loss: a prospective cohort study_Chinese Journal of Evidence-Based Medicine

Authors：

SHAO Minmin ¹ , HU Jiangwen ¹ , XIANG Songjie ² , CHEN Chaowei ¹ , XIONG Guofeng ¹ , WU Aimin ³ ,  CHEN Bobei ²

1. Department of Otorhinolaryngology, Affiliated Dingli Hospital of Wenzhou Medical University and Wenzhou Central Hospital, Wenzhou, 325000, P.R.China;
2. Department of Otorhinolaryngology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, P.R.China;
3. Clinical Research Center, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, P.R.China;

Corresponding author：

CHEN Bobei, Email: wzbobei@126.com

Keywords：

Idiopathic sudden sensorineural hearing loss; Total cholesterol; Prognosis factor; Prospective cohort study

DOI：

10.7507/1672-2531.201708030

Video：

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Objectives To investigate the correlation between blood total cholesterol (TC) and prognosis of idiopathic sudden sensorineural hearing loss (ISSNHL) and to provide references for clinical treatment and prognosis assessment. Methods We included 232 ISSNHL patients with total deafness in Wenzhou Central Hospital from June 2015 to March 2017 using a prospective cohort design. Recording information including age, gender, hypertension, diabetes mellitus, vertigo, level of blood total cholesterol (TC), level of triglyceride (TG), level of low-density lipoprotein (LDL-C) and LDL/HDL ratio (LDL-C/HDL-C) were collected. Correlation between the prognosis of ISSNHL and blood total cholesterol were analyzed by univariable and multivariable logistic regression analysis. Results The clinical effective rate of patients with TC ranging from 5.2 mmol/L to 6.2 mmol/L was higher than that of patients with TC lower than 5.2 mmol/L (univariable: RR=6.49, 95%CI 3.16 to 13.30, P<0.001; multivariable-adjusted covariates: RR=6.15, 95%CI 2.66 to 14.3,P<0.001) with significant difference. No significant difference was found between patients with TC lower than 5.2 mmol/L and patients with TC higher than 6.2 mmol/L (univariable: RR=1.02, 95%CI 0.52 to 2.00,P=0.960; multivariable-adjusted covariates: RR=1.61, 95%CI 0.55 to 4.73, P=0.386). Gender-specific analysis showed for both male and female groups, the effective rates of patients with TC ranging from 5.2 mmol/L to 6.2 mmol/L were significantly higher than those of patients with TC lower than 5.2 mmol/L. There was no significant difference between patients with TC lower than 5.2 mmol/L and patients with TC higher than 6.2 mmol/L (P>0.05) in either male group or female group. Conclusion The current study suggests that patients with levels of TC ranging from 5.2 mmol/L to 6.2 mmol/L predicts the best prognosis.

Citation： SHAO Minmin, HU Jiangwen, XIANG Songjie, CHEN Chaowei, XIONG Guofeng, WU Aimin, CHEN Bobei. Correlation between serum total cholesterol and prognosis of idiopathic sudden sensorineural hearing loss: a prospective cohort study. Chinese Journal of Evidence-Based Medicine, 2018, 18(1): 8-12. doi: 10.7507/1672-2531.201708030 Copy

1.	中华耳鼻咽喉头颈外科杂志编辑委员会, 中华医学会耳鼻咽喉头颈外科学分会. 突发性耳聋诊断和治疗指南(2015). 中华耳鼻咽喉头颈外科杂志, 2015, 50(6), 443-447.
2.	Lawrence R, Thevasagayam R. Controversies in the management of sudden sensorineural hearing loss: an evidence-based review. Clin Otolaryngol, 2015, 40(3): 176-182.
3.	Muhlmeier G, Baguley D, Cox T, et al. Characteristics and spontaneous recovery of tinnitus related to idiopathic sudden sensorineural hearing loss. Otol Neurotol, 2016, 37(6): 634-641.
4.	Nogueira-Neto FB, Gallardo FP, Suzuki FA, et al. Prognostic and evolutive factors of tinnitus triggered by sudden sensorineural hearing loss. Otol Neurotol, 2016, 37(6): 627-633.
5.	Kim CH, Shin JE, Yang YS, et al. Sudden sensorineural hearing loss with positional vertigo: Initial findings of positional nystagmus and hearing outcomes. Int J Audiol, 2016, 55(10): 541-546.
6.	Lionello M, Staffieri C, Breda S, et al. Uni- and multivariate models for investigating potential prognostic factors in idiopathic sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol, 2015, 272(8): 1899-1906.
7.	Kang WS, Yang CJ, Shim M, et al. Prognostic factors for recovery from sudden sensorineural hearing loss: a retrospective study. J Audiol Otol, 2017, 21(1): 9-15.
8.	Quaranta N, Squeo V, Sangineto M, et al. High total cholesterol in peripheral blood correlates with poorer hearing recovery in idiopathic sudden sensorineural hearing loss. PLoS One, 2015, 10(7): e0133300.
9.	Lin CF, Lee KJ, Yu SS, et al. Effect of comorbid diabetes and hypercholesterolemia on the prognosis of idiopathic sudden sensorineural hearing loss. Laryngoscope, 2016, 126(1): 142-149.
10.	中国胆固醇教育计划委员会. 高甘油三酯血症及心血管危险因素管理共识. 中华心血管病杂志, 2017, 42(2): 108-115.
11.	Mohammed AA. Lipid profile among patients with sudden sensorineural hearing loss. Indian J Otolaryngol Head Neck Surg, 2014, 66(4): 425-428.
12.	Lee JS, Kim DH, Lee HJ, et al. Lipid profiles and obesity as potential risk factors of sudden sensorineural hearing loss. PLoS One, 2015, 10(4): e0122496.
13.	Weng T, Devine EE, Xu H, et al. A clinical study of serum lipid disturbance in Chinese patients with sudden deafness. Lipids Health Dis, 2013, 12: 95.
14.	Lin HC, Wang CH, Chou YC, et al. The correlation between lipoprotein ratios and hearing outcome in idiopathic sudden sensorineural hearing loss patients. Clin Otolaryngol, 2015, 40(4): 355-362.
15.	Chang IJ, Kang CJ, Yueh CY, et al. The relationship between serum lipids and sudden sensorineural hearing loss: a systematic review and meta-analysis. PLoS One, 2015, 10(4): e0121025.
16.	Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III). JAMA, 2001, 285(19): 2486-2497.
17.	许汝福. Logistic 回归变量筛选及回归方法选择实例分析. 中国循证医学杂志, 2016, 16(11): 1360-1364.
18.	田景平, 温泽淮, 郭新峰, 等. 脂必泰与阿托伐他汀比较治疗高脂血症疗效及安全性的系统评价. 中国循证医学杂志, 2013, 13(9): 1116-1122.
19.	赵水平, 谢琼. 动脉粥样硬化发病机制新认识与临床实践. 中华心血管病杂志, 2008, 36(8): 766-768.
20.	孙鑫, 谭婧, 唐立, 等. 重新认识真实世界研究. 中国循证医学杂志, 2017, 17(2): 126-130.

1. 中华耳鼻咽喉头颈外科杂志编辑委员会, 中华医学会耳鼻咽喉头颈外科学分会. 突发性耳聋诊断和治疗指南(2015). 中华耳鼻咽喉头颈外科杂志, 2015, 50(6), 443-447.
2. Lawrence R, Thevasagayam R. Controversies in the management of sudden sensorineural hearing loss: an evidence-based review. Clin Otolaryngol, 2015, 40(3): 176-182.
3. Muhlmeier G, Baguley D, Cox T, et al. Characteristics and spontaneous recovery of tinnitus related to idiopathic sudden sensorineural hearing loss. Otol Neurotol, 2016, 37(6): 634-641.
4. Nogueira-Neto FB, Gallardo FP, Suzuki FA, et al. Prognostic and evolutive factors of tinnitus triggered by sudden sensorineural hearing loss. Otol Neurotol, 2016, 37(6): 627-633.
5. Kim CH, Shin JE, Yang YS, et al. Sudden sensorineural hearing loss with positional vertigo: Initial findings of positional nystagmus and hearing outcomes. Int J Audiol, 2016, 55(10): 541-546.
6. Lionello M, Staffieri C, Breda S, et al. Uni- and multivariate models for investigating potential prognostic factors in idiopathic sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol, 2015, 272(8): 1899-1906.
7. Kang WS, Yang CJ, Shim M, et al. Prognostic factors for recovery from sudden sensorineural hearing loss: a retrospective study. J Audiol Otol, 2017, 21(1): 9-15.
8. Quaranta N, Squeo V, Sangineto M, et al. High total cholesterol in peripheral blood correlates with poorer hearing recovery in idiopathic sudden sensorineural hearing loss. PLoS One, 2015, 10(7): e0133300.
9. Lin CF, Lee KJ, Yu SS, et al. Effect of comorbid diabetes and hypercholesterolemia on the prognosis of idiopathic sudden sensorineural hearing loss. Laryngoscope, 2016, 126(1): 142-149.
10. 中国胆固醇教育计划委员会. 高甘油三酯血症及心血管危险因素管理共识. 中华心血管病杂志, 2017, 42(2): 108-115.
11. Mohammed AA. Lipid profile among patients with sudden sensorineural hearing loss. Indian J Otolaryngol Head Neck Surg, 2014, 66(4): 425-428.
12. Lee JS, Kim DH, Lee HJ, et al. Lipid profiles and obesity as potential risk factors of sudden sensorineural hearing loss. PLoS One, 2015, 10(4): e0122496.
13. Weng T, Devine EE, Xu H, et al. A clinical study of serum lipid disturbance in Chinese patients with sudden deafness. Lipids Health Dis, 2013, 12: 95.
14. Lin HC, Wang CH, Chou YC, et al. The correlation between lipoprotein ratios and hearing outcome in idiopathic sudden sensorineural hearing loss patients. Clin Otolaryngol, 2015, 40(4): 355-362.
15. Chang IJ, Kang CJ, Yueh CY, et al. The relationship between serum lipids and sudden sensorineural hearing loss: a systematic review and meta-analysis. PLoS One, 2015, 10(4): e0121025.
16. Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III). JAMA, 2001, 285(19): 2486-2497.
17. 许汝福. Logistic 回归变量筛选及回归方法选择实例分析. 中国循证医学杂志, 2016, 16(11): 1360-1364.
18. 田景平, 温泽淮, 郭新峰, 等. 脂必泰与阿托伐他汀比较治疗高脂血症疗效及安全性的系统评价. 中国循证医学杂志, 2013, 13(9): 1116-1122.
19. 赵水平, 谢琼. 动脉粥样硬化发病机制新认识与临床实践. 中华心血管病杂志, 2008, 36(8): 766-768.
20. 孙鑫, 谭婧, 唐立, 等. 重新认识真实世界研究. 中国循证医学杂志, 2017, 17(2): 126-130.

Chinese Journal of Evidence-Based Medicine

Correlation between serum total cholesterol and prognosis of idiopathic sudden sensorineural hearing loss: a prospective cohort study

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