The association between the variants of <i>HNF1B</i> gene and the risk of prostate cancer: a meta-analysis _Chinese Journal of Evidence-Based Medicine

Authors：

MA Yushan ¹ , JIANG Xiaoqing ¹ , NI Juan ¹ ,  TONG Yu ^2,3

1. Department of Anesthesiology, West China Second Hospital, Sichuan University, Chengdu, 610041, P.R.China;
2. Department of Pediatrics, West China Second Hospital, Sichuan University, Chengdu, 610041, P.R.China;
3. Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Chengdu, 610041, P.R.China;

Corresponding author：

TONG Yu, Email: zisu_yu@163.com

Keywords：

HNF1B; Gene variant; Prostate cancer; Meta-analysis; Systematic review; Case-control study

DOI：

10.7507/1672-2531.201804158

Video：

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ObjectivesTo systematically review the association between the variants of HNF1B gene and the risk of prostate cancer.MethodsPubMed, EMbase, The Cochrane Library, CNKI, CBM and WanFang Data databases were electronically searched to collect case-control studies on the association between the variants of HNF1B gene and risk of prostate cancer from inception to December, 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Meta-analysis was then performed using Stata 14.0 software.ResultsA total of 15 case-control studies involving 30 532 patients and 38 832 controls were included. The results of meta-analysis showed that: there was a strong significant association between rs4430796 variants (Gvs.A: OR=0.802, 95%CI 0.784 to 0.821, P<0.001; GGvs.AA: OR=0.659, 95%CI 0.606 to 0.717, P<0.001; AGvs.AA: OR=0.762, 95%CI 0.714 to 0.814, P<0.001), rs11649743 variants (Avs.G: OR=0.875, 95%CI 0.820 to 0.941, P<0.001; AAvs.GG: OR=0.669, 95%CI 0.564 to 0.792, P<0.001; AGvs.GG: OR=0.855, 95%CI 0.798 to 0.916, P<0.001), rs7501939 variants (Avs.G: OR=0.833, 95%CI 0.807 to 0.859, P<0.001), rs3760511 variants (Avs.C: OR=0.834, 95%CI 0.803 to 0.868, P<0.001) and risk of prostate cancer.ConclusionsCurrent evidence shows that HNF1B gene variants are associated with risk of prostate cancer. Due to limited quantity and quality of the included studies, more high quality studies are required to verify the above conclusion.

Citation： MA Yushan, JIANG Xiaoqing, NI Juan, TONG Yu. The association between the variants of HNF1B gene and the risk of prostate cancer: a meta-analysis . Chinese Journal of Evidence-Based Medicine, 2018, 18(7): 662-669. doi: 10.7507/1672-2531.201804158 Copy

1.	Nam RK, Toi A, Klotz LH, et al. Assessing individual risk for prostate cancer. J Clin Oncol, 2007, 25(24): 3582-3588.
2.	Soliman PT, Broaddus RR, Schmeler KM, et al. Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome? J Clin Oncol, 2005, 23(36): 9344-9350.
3.	Pfeiffer RM, Park Y, Kreimer AR, et al. Risk prediction for breast, endometrial, and ovarian cancer in white women aged 50y or older: derivation and validation from population-based cohort studies. PLoS Med, 2013, 10(7): e1001492.
4.	So HC, Kwan JS, Cherny SS, et al. Risk prediction of complex diseases from family history and known susceptibility loci, with applications for cancer screening. Am J Hum Genet, 2011, 88(5): 548-565.
5.	Ivanovich J, Babb S, Goodfellow P, et al. Evaluation of the family history collection process and the accuracy of cancer reporting among a series of women with endometrial cancer. Clin Cancer Res, 2002, 8(6): 1849-1856.
6.	Samimi G, Bernardini MQ, Brody LC, et al. Traceback: a proposed framework to increase identification and genetic counseling of brca1 and brca2 mutation carriers through family-based outreach. J Clin Oncol, 2017, 35(20): 2329-2337.
7.	Rebbeck TR. Prostate cancer genetics: variation by race, ethnicity, and geography. Semin Radiat Oncol, 2017, 27(1): 3-10.
8.	Kuchenbaecker KB, McGuffog L, Barrowdale D, et al. Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in brca1 and brca2 mutation carriers. J Natl Cancer Inst, 2017, 109(7): 10.
9.	Mhatre S, Wang Z, Nagrani R, et al. Common genetic variation and risk of gallbladder cancer in India: a case-control genome-wide association study. Lancet Oncol, 2017, 18(4): 535-544.
10.	Sun J, Zheng SL, Wiklund F, et al. Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. Nat Genet, 2008, 40(10): 1153-1155.
11.	Stevens VL, Ahn J, Sun J, et al. HNF1B and JAZF1 genes, diabetes, and prostate cancer risk. Prostate, 2010, 70(6): 601-607.
12.	Painter JN, O'Mara TA, Batra J, et al. Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. Hum Mol Genet, 2015, 24(5): 1478-1492.
13.	Sun JZ, Yang XX, Hu NY, et al. Genetic variants in MMP9 and TCF2 contribute to susceptibility to lung cancer. Chin J Cancer Res, 2011, 23(3): 183-187.
14.	Massa F, Garbay S, Bouvier R, et al. Hepatocyte nuclear factor 1beta controls nephron tubular development. Development, 2013, 140(4): 886-896.
15.	Heliot C, Desgrange A, Buisson I, et al. HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2. Development, 2013, 140(4): 873-885.
16.	Raile K, Klopocki E, Holder M, et al. Expanded clinical spectrum in hepatocyte nuclear factor 1b-maturity-onset diabetes of the young. J Clin Endocrinol Metab, 2009, 94(7): 2658-2664.
17.	Thomas G, Jacobs KB, Yeager M, et al. Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet, 2008, 40(3): 310-315.
18.	Pharoah PD, Tsai YY, Ramus SJ, et al. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet, 2013, 45(4): 362-370.
19.	Burghaus S, Fasching PA, Hberle L, et al. Genetic risk factors for ovarian cancer and their role for endometriosis risk. Gynecol Oncol, 2017, 145(1): 142-147.
20.	Shen H, Fridley BL, Song H, et al. Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun, 2013, 4: 1628.
21.	Mandato VD, Farnetti E, Torricelli F, et al. HNF1B polymorphism influences the prognosis of endometrial cancer patients: a cohort study. BMC Cancer, 2015, 15: 229.
22.	De Vivo I, Prescott J, Setiawan VW, et al. Genome-wide association study of endometrial cancer in E2C2. Hum Genet, 2014, 133(2): 211-224.
23.	Ríos-Tamayo R, Lupiañez CB, Campa D, et al. A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis. Oncotarget, 2016, 7(37): 59029-59048.
24.	Berndt SI, Sampson J, Yeager M, et al. Large-scale fine mapping of the HNF1B locus and prostate cancer risk. Hum Mol Genet, 2011, 20(16): 3322-3329.
25.	Gudmundsson J, Sulem P, Steinthorsdottir V, et al. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet, 2007, 39(8): 977-983.
26.	Levin AM, Machiela MJ, Zuhlke KA, et al. Chromosome 17q12 variants contribute to risk of early-onset prostate cancer. Cancer Res, 2008, 68(16): 6492-6495.
27.	Sun J, Purcell L, Gao Z, et al. Association between sequence variants at 17q12 and 17q24.3 and prostate cancer risk in European and African Americans. Prostate, 2008, 68(7): 691-697.
28.	Lange EM, Salinas CA, Zuhlke KA, et al. Early onset prostate cancer has a significant genetic component. Prostate, 2012, 72(2): 147-156.
29.	Rojas PA, Torres-Estay V, Cerda-Infante J, et al. Association of a single-nucleotide polymorphism from chromosome 17q12 with the aggressiveness of prostate cancer in a Hispanic population. J Cancer Res Clin Oncol, 2014, 140(5): 783-788.
30.	Zhang YR, Xu Y, Yang K, et al. Association of six susceptibility Loci with prostate cancer in northern Chinese men. Asian Pac J Cancer Prev, 2012, 13(12): 6273-6276.
31.	Kim HJ, Bae JS, Lee J, et al. HNF1B polymorphism associated with development of prostate cancer in Korean patients. Urology, 2011, 78(4): 969, e1-e6.
32.	Yamada H, Penney KL, Takahashi H, et al. Replication of prostate cancer risk loci in a Japanese case-control association study. J Natl Cancer Inst, 2009, 101(19): 1330-1336.
33.	Zhou CH, Wang JY, Cao SY, et al. Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population. Chin J Cancer, 2011, 30(10): 721-730.
34.	Liu M, Suzuki M, Arai T, et al. A replication study examining three common single-nucleotide polymorphisms and the risk of prostate cancer in a Japanese population. Prostate, 2011, 71(10): 1023-1032.
35.	Chan JY, Li H, Singh O, et al. 8q24 and 17q prostate cancer susceptibility loci in a multiethnic Asian cohort. Urol Oncol, 2013, 31(8): 1553-1560.
36.	Hooker S, Hernandez W, Chen H, et al. Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans. Prostate, 2010, 70(3): 270-275.
37.	Helfand BT, Fought AJ, Loeb S, et al. Genetic prostate cancer risk assessment: common variants in 9 genomic regions are associated with cumulative risk. J Urol, 2010, 184(2): 501-505.
38.	Zhao Y, Liang J, Qi JG, et al. Meta-analysis of the association between the HNF1B rs4430796(A>G) polymorphism and risk of prostate cancer based on case-control studies. Genet Mol Res, 2015, 14(3): 7426-7435.

1. Nam RK, Toi A, Klotz LH, et al. Assessing individual risk for prostate cancer. J Clin Oncol, 2007, 25(24): 3582-3588.
2. Soliman PT, Broaddus RR, Schmeler KM, et al. Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome? J Clin Oncol, 2005, 23(36): 9344-9350.
3. Pfeiffer RM, Park Y, Kreimer AR, et al. Risk prediction for breast, endometrial, and ovarian cancer in white women aged 50y or older: derivation and validation from population-based cohort studies. PLoS Med, 2013, 10(7): e1001492.
4. So HC, Kwan JS, Cherny SS, et al. Risk prediction of complex diseases from family history and known susceptibility loci, with applications for cancer screening. Am J Hum Genet, 2011, 88(5): 548-565.
5. Ivanovich J, Babb S, Goodfellow P, et al. Evaluation of the family history collection process and the accuracy of cancer reporting among a series of women with endometrial cancer. Clin Cancer Res, 2002, 8(6): 1849-1856.
6. Samimi G, Bernardini MQ, Brody LC, et al. Traceback: a proposed framework to increase identification and genetic counseling of brca1 and brca2 mutation carriers through family-based outreach. J Clin Oncol, 2017, 35(20): 2329-2337.
7. Rebbeck TR. Prostate cancer genetics: variation by race, ethnicity, and geography. Semin Radiat Oncol, 2017, 27(1): 3-10.
8. Kuchenbaecker KB, McGuffog L, Barrowdale D, et al. Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in brca1 and brca2 mutation carriers. J Natl Cancer Inst, 2017, 109(7): 10.
9. Mhatre S, Wang Z, Nagrani R, et al. Common genetic variation and risk of gallbladder cancer in India: a case-control genome-wide association study. Lancet Oncol, 2017, 18(4): 535-544.
10. Sun J, Zheng SL, Wiklund F, et al. Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. Nat Genet, 2008, 40(10): 1153-1155.
11. Stevens VL, Ahn J, Sun J, et al. HNF1B and JAZF1 genes, diabetes, and prostate cancer risk. Prostate, 2010, 70(6): 601-607.
12. Painter JN, O'Mara TA, Batra J, et al. Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. Hum Mol Genet, 2015, 24(5): 1478-1492.
13. Sun JZ, Yang XX, Hu NY, et al. Genetic variants in MMP9 and TCF2 contribute to susceptibility to lung cancer. Chin J Cancer Res, 2011, 23(3): 183-187.
14. Massa F, Garbay S, Bouvier R, et al. Hepatocyte nuclear factor 1beta controls nephron tubular development. Development, 2013, 140(4): 886-896.
15. Heliot C, Desgrange A, Buisson I, et al. HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2. Development, 2013, 140(4): 873-885.
16. Raile K, Klopocki E, Holder M, et al. Expanded clinical spectrum in hepatocyte nuclear factor 1b-maturity-onset diabetes of the young. J Clin Endocrinol Metab, 2009, 94(7): 2658-2664.
17. Thomas G, Jacobs KB, Yeager M, et al. Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet, 2008, 40(3): 310-315.
18. Pharoah PD, Tsai YY, Ramus SJ, et al. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet, 2013, 45(4): 362-370.
19. Burghaus S, Fasching PA, Hberle L, et al. Genetic risk factors for ovarian cancer and their role for endometriosis risk. Gynecol Oncol, 2017, 145(1): 142-147.
20. Shen H, Fridley BL, Song H, et al. Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun, 2013, 4: 1628.
21. Mandato VD, Farnetti E, Torricelli F, et al. HNF1B polymorphism influences the prognosis of endometrial cancer patients: a cohort study. BMC Cancer, 2015, 15: 229.
22. De Vivo I, Prescott J, Setiawan VW, et al. Genome-wide association study of endometrial cancer in E2C2. Hum Genet, 2014, 133(2): 211-224.
23. Ríos-Tamayo R, Lupiañez CB, Campa D, et al. A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis. Oncotarget, 2016, 7(37): 59029-59048.
24. Berndt SI, Sampson J, Yeager M, et al. Large-scale fine mapping of the HNF1B locus and prostate cancer risk. Hum Mol Genet, 2011, 20(16): 3322-3329.
25. Gudmundsson J, Sulem P, Steinthorsdottir V, et al. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet, 2007, 39(8): 977-983.
26. Levin AM, Machiela MJ, Zuhlke KA, et al. Chromosome 17q12 variants contribute to risk of early-onset prostate cancer. Cancer Res, 2008, 68(16): 6492-6495.
27. Sun J, Purcell L, Gao Z, et al. Association between sequence variants at 17q12 and 17q24.3 and prostate cancer risk in European and African Americans. Prostate, 2008, 68(7): 691-697.
28. Lange EM, Salinas CA, Zuhlke KA, et al. Early onset prostate cancer has a significant genetic component. Prostate, 2012, 72(2): 147-156.
29. Rojas PA, Torres-Estay V, Cerda-Infante J, et al. Association of a single-nucleotide polymorphism from chromosome 17q12 with the aggressiveness of prostate cancer in a Hispanic population. J Cancer Res Clin Oncol, 2014, 140(5): 783-788.
30. Zhang YR, Xu Y, Yang K, et al. Association of six susceptibility Loci with prostate cancer in northern Chinese men. Asian Pac J Cancer Prev, 2012, 13(12): 6273-6276.
31. Kim HJ, Bae JS, Lee J, et al. HNF1B polymorphism associated with development of prostate cancer in Korean patients. Urology, 2011, 78(4): 969, e1-e6.
32. Yamada H, Penney KL, Takahashi H, et al. Replication of prostate cancer risk loci in a Japanese case-control association study. J Natl Cancer Inst, 2009, 101(19): 1330-1336.
33. Zhou CH, Wang JY, Cao SY, et al. Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population. Chin J Cancer, 2011, 30(10): 721-730.
34. Liu M, Suzuki M, Arai T, et al. A replication study examining three common single-nucleotide polymorphisms and the risk of prostate cancer in a Japanese population. Prostate, 2011, 71(10): 1023-1032.
35. Chan JY, Li H, Singh O, et al. 8q24 and 17q prostate cancer susceptibility loci in a multiethnic Asian cohort. Urol Oncol, 2013, 31(8): 1553-1560.
36. Hooker S, Hernandez W, Chen H, et al. Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans. Prostate, 2010, 70(3): 270-275.
37. Helfand BT, Fought AJ, Loeb S, et al. Genetic prostate cancer risk assessment: common variants in 9 genomic regions are associated with cumulative risk. J Urol, 2010, 184(2): 501-505.
38. Zhao Y, Liang J, Qi JG, et al. Meta-analysis of the association between the HNF1B rs4430796(A>G) polymorphism and risk of prostate cancer based on case-control studies. Genet Mol Res, 2015, 14(3): 7426-7435.

Chinese Journal of Evidence-Based Medicine

The association between the variants of HNF1B gene and the risk of prostate cancer: a meta-analysis

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