Activating blood circulation herbs for prevention and treatment of coronary heart disease: the evidence and prospect_Chinese Journal of Evidence-Based Medicine

Authors：

LIU Yue ^1,2 , GAO Zhuye ^1,2 , FU Changgeng ^1,2 , XU Hao ^1,2 ,  SHI Dazhuo ^1,2 ,  CHEN Keji ^1,2

1. Cardiovascular Diseases Center, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, 100091, P.R.China;
2. Institute of Cardiovascular Disease, Chinese Academy of Chinese Medical Science, Beijing, 100091, P.R.China;

Corresponding author：

SHI Dazhuo, Email: shidazhuo@126.com; CHEN Keji, Email: kjchenvip@163.com

Keywords：

Activating blood circulation; Blood stasis syndrome; Coronary heart disease; Evidence-based medicine

DOI：

10.7507/1672-2531.201809110

Video：

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The theoretical innovation and new drug research on the prevention and treatment of cardiovascular diseases by activating blood circulation has been one of the most active and outstanding achievements in the field of integrated Chinese and western medicine for the past 60 years. Research on blood stasis syndrome (BSS) and activating blood circulation (ABC) was the first to be awarded the first prize of National Award for Science and Technology Progress in Chinese Medicine since the founding of the People's Republic of China. The research team headed by prof. Keji CHEN has obtained abundant research achievements. Taking coronary heart disease, a major clinical cardiovascular disease as the entry point, the team explored the development of the diagnostic criteria for the combination of BSS, the interpretation of the modern connotation of ABC, the development of a series of new drugs for ABC, clinical efficacy evaluation and mechanism of its action. It promotes the standardization and internationalization of traditional Chinese medicine and forms high-quality evidence for clinical transformation. It has also made outstanding contributions to the prevention and treatment of cardiovascular diseases with original features. In this paper, the history of prevention and treatment of cardiovascular diseases by ABC after the founding of the People's Republic of China was reviewed. The representative research findings of several domestic academic teams, including prof. Keji CHEN's team, over the past 60 years were expounded emphatically so as to provide reference for promoting and innovating research in activating blood circulation and removing blood stasis.

Citation： LIU Yue, GAO Zhuye, FU Changgeng, XU Hao, SHI Dazhuo, CHEN Keji. Activating blood circulation herbs for prevention and treatment of coronary heart disease: the evidence and prospect. Chinese Journal of Evidence-Based Medicine, 2018, 18(11): 1145-1150. doi: 10.7507/1672-2531.201809110 Copy

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1. 卫生部心血管病防治研究中心. 中国心血管病报告 2017. 北京: 中国大百科全书出版社, 2018.
2. 陈可冀, 陈贵廷, 张问渠. 日本活血化瘀研究进展. 中国中西医结合杂志, 1985, 5(3): 185-189, 174.
3. 史载祥. 韩国学者在血瘀证及其治疗方面的新进展. 中国中西医结合杂志, 1998, 18(5): 307.
4. 北京地区防治冠心病协助组. 冠心Ⅰ号、Ⅱ号方(活血化瘀途径)治疗冠心病心绞痛的初步报告. 内部资料, 1972.
5. 陈可冀, 钱振淮, 张问渠, 等. 精制冠心片双盲法治疗冠心病心绞痛 112 例疗效分析. 中华心血管病杂志, 1982, 10(2): 85-89.
6. 聂阳, 焦豪妍, 何盛江, 等. 基于多指标综合评价优选乐脉颗粒提取工艺. 中药新药与临床药理, 2016, 27(2): 273-277.
7. 乔雪, 徐曼, 韩健, 等. 中药复方冠心Ⅱ号的化学成分及药理研究进展. 世界科学技术-中医药现代化, 2007, 9(3): 86-95, 106.
8. 中医研究院西苑医院内科(陈可冀, 等). 川芎一号碱(川芎嗪)对冠心病患者血小板影响的电子显微镜观察. 中华内科杂志, 1976, 2: 89-91.
9. Chang FC, Chen KJ, Lin JG, et al. Effects of tetramethylpyrazine on portal hypertensive rats. J Pharm Pharmacol, 1998, 50(8): 881-884.
10. 陈可冀. 川芎嗪的化学、药理与临床应用. 北京: 人民卫生出版社, 1999.
11. 陈可冀. 川芎嗪的化学、药理与临床应用(第二版). 北京: 人民卫生出版社, 2014.
12. 高洁. 川芎嗪调控相关 microRNAs 干预冠心病血栓前状态的研究. 北京: 北京中医药大学, 2018.
13. 雷燕, 刘建勋, 周亚伟, 等. 愈心痛胶囊对急性心肌缺血犬血浆内皮素和血清一氧化氮的影响. 中国中西医结合杂志, 1996, 16(5): 289-291.
14. 雷燕, 陈可冀, 柯元南, 等. 愈心痛胶囊治疗不稳定性心绞痛临床研究. 中国中西医结合杂志, 1996, 16(10): 580-584.
15. Qiu Y, Xu H, Shi D. Traditional chinese herbal products for coronary heart disease: an overview of cochrane reviews. Evid Based Complement Alternat Med, 2012, 2012: 417387.
16. Duan X, Zhou L, Wu T, et al. Chinese herbal medicine suxiao jiuxin wan for angina pectoris. Cochrane Database Syst Rev, 2008, (1): CD004473.
17. 史大卓, 李静, 马晓昌, 等. 血府逐瘀浓缩丸预防冠心病病人经皮冠状动脉腔内成形术后再狭窄的临床观察. 中医杂志, 1997, (1): 27-29, 4.
18. 王伟, 马晓昌, 汪晓芳, 等. 精制血府胶囊治疗冠心病心绞痛 30 例临床观察. 中医杂志, 2000, (8): 471-473, 478.
19. 汪晓芳, 陈可远, 王伟, 等. 精制血府胶囊治疗冠心病心绞痛的临床研究. 中国中西医结合杂志, 1998, 18(7): 399-401.
20. 徐凤芹, 史大卓, 陈可冀, 等. 精制血府胶囊对犬急性心肌缺血心脏血流动力学和心肌耗氧量的影响. 中国中西医结合杂志, 1998, 18(1): 32-34.
21. 王伟, 史大卓, 陈可冀, 等. 精制血府胶囊刺激缺氧缺糖心肌细胞 RNA 及蛋白质合成的研究. 北京中医药大学学报, 1997, (2): 18-20, 71.
22. 徐浩, 史大卓, 陈可冀, 等. 芎芍胶囊对猪冠状动脉球囊损伤后血管重塑的影响. 中国中西医结合杂志, 2001, 21(8): 591-594.
23. Chen KJ, Shi DZ, Xu H, et al. XS0601 reduces the incidence of restenosis: a prospective study of 335 patients undergoing percutaneous coronary intervention in China. Chin Med J (Engl), 2006, 119(1): 6-13.
24. Zheng GH, Liu JP, Chu JF, et al. Xiongshao for restenosis after percutaneous coronary intervention in patients with coronary heart disease. Cochrane Database Syst Rev, 2013, (5): CD009581.
25. Tu Y. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat Med, 2011, 17(10): 1217-1220.
26. Wang SL, Wang CL, Wang PL, et al. Combination of Chinese herbal medicines and conventional treatment versus conventional treatment alone in patients with acute coronary syndrome after percutaneous coronary intervention (5c trial): an open-label randomized controlled, multicenter study. Evid Based Complement Alternat Med, 2013, 2013: 741518.
27. Zhang L, Li Y, Yang BS, et al. A multicenter, randomized, double-blind, and placebo-controlled study of the effects of tongxinluo capsules in acute coronary syndrome patients with high on-treatment platelet reactivity. Chin Med J (Engl), 2018, 131(5): 508-515.
28. 董静, 陈韵岱, 智光, 等. 应用速度向量成像技术评价丹红注射液的 PCI 围术期心肌保护作用. 中华医学杂志, 2014, 94(30): 2346-2349.
29. 胡国英, 毛燕玲, 王秀君, 等. 抗心梗合剂对心肌梗塞病人血小板聚集功能的变化(摘要). 心肺血管病杂志, 1983, (1): 15-16.
30. 翁心植, 赵荔雍, 陈鼎祺. 抗心梗合剂治疗急性心肌梗塞的疗效总结(摘要). 心肺血管病杂志, 1982, (1): 5.
31. 廖欣, 罗陆一. 愈梗通瘀汤治疗冠心病心绞痛的临床观察. 中国中西医结合杂志, 1998, 18(10): 594-597.
32. 李思铭. 愈梗通瘀汤对急性心肌梗死早期预后及生活质量影响的临床研究. 北京: 北京中医药大学, 2011.
33. Shang H, Zhang J, Yao C, et al. Qi-shen-yi-qi dripping pills for the secondary prevention of myocardial infarction: a randomised clinical trial. Evid Based Complement Alternat Med, 2013, 2013: 738391.
34. 尤士杰, 陈可冀, 杨跃进, 等. 通心络胶囊干预急性心肌梗死早期血运重建后自发性改善的临床研究. 中国中西医结合杂志, 2005, 25(7): 604-607.
35. 徐浩, 史大卓, 殷惠军. " 瘀毒致变”与急性心血管事件: 假说的提出与临床意义. 中国中西医结合杂志, 2008, 28(10): 934-938.
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