Association between pregnancy induced hypertension and preterm birth and population attributable risk in pregnant females in mainland China: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

YANG Yanhong ¹ , YOU Dingyun ¹ , WANG Huaping ² , HUANG Ying ¹ ,  LIAO Rui ²

1. Department of Public Health, Kunming Medical University, Kunming, 650500, P.R.China;
2. Department of Library, Kunming Medical University, Kunming, 650500, P.R.China;

Corresponding author：

LIAO Rui, Email: reneliao@foxmail.com

Keywords：

Mainland China; Premature delivery; Pregnancy-induced hypertension; Population attributable risk; Meta-analysis; Systematic review

DOI：

10.7507/1672-2531.201905079

Video：

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Objectives To systematically review the association between pregnancy-induced hypertension (PIH) and preterm birth in mainland China.Methods PubMed, The Cochrane Library, ScienceDirect, Web of Science, CBM, CNKI, WanFang Data and VIP databases were electronically searched to collect studies on the association between PIH and preterm birth in mainland China from January, 2007 to March, 2019. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies; then, meta-analysis was performed by using Stata 12.0 software.Results A total of 48 studies were included, involving 43 276 cases of premature birth, 527 995 cases of full-term control group, in which there were 3 446 cases of PIH in premature delivery, with a prevalence rate of 7.96%. There were 14 099 cases of PIH in the full-term control group, with a prevalence rate of 2.67%. The results of meta-analysis showed that PIH was associated with preterm birth (OR=3.27, 95%CI 2.64 to 4.05, P<0.001). The overall population attributable risk was 13.0%. Subgroup analysis was conducted for different study types, and the results were unaltered.Conclusions The current evidence shows that PIH is associated with preterm birth. During pregnancy, the management and intervention of pregnant females with gestational hypertension should be strengthened, and active treatment should be supervised to prevent the occurrence of premature birth.

Citation： YANG Yanhong, YOU Dingyun, WANG Huaping, HUANG Ying, LIAO Rui. Association between pregnancy induced hypertension and preterm birth and population attributable risk in pregnant females in mainland China: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2020, 20(1): 32-39. doi: 10.7507/1672-2531.201905079 Copy

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2.	Seyom E, Abera M, Tesfaye M, et al. Maternal and fetal outcome of pregnancy related hypertension in Mettu Karl Referral Hospital, Ethiopia. J Ovarian Res, 2015, 8(1): 10.
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1. Gemmell L, Martin L, Murphy KE, et al. Hypertensive disorders of pregnancy and outcomes of preterm infants of 24 to 28 weeks' gestation. J Perinatol, 2016, 36(12): 1067-1072.
2. Seyom E, Abera M, Tesfaye M, et al. Maternal and fetal outcome of pregnancy related hypertension in Mettu Karl Referral Hospital, Ethiopia. J Ovarian Res, 2015, 8(1): 10.
3. Lu CQ, Jie L, Lin Y, et al. Authors of manusript pregnancy induced hypertension and outcomes in early and moderate preterm infant. Pregnan Hypert, 2018: S2210778917303665.
4. Bramham K, Parnell B, Nelson-Piercy C, et al. Chronic hypertension and pregnancy outcomes: systematic review and meta-analysis. BMJ, 2014, 348(15): g2301.
5. Razak A, Florendo-Chin A, Banfield L, et al. Pregnancy-induced hypertension and neonatal outcomes: a systematic review and meta-analysis. J Perinatol, 2018, 38(1): 46-53.
6. 中华医学会妇产科学分会产科学组. 早产的临床诊断和治疗指南(2014). 中国实用乡村医生杂志, 2015, (12): 9-11.
7. 吴琳琳, 周欣, 牛建民. 《妊娠期高血压疾病: 国际妊娠期高血压研究学会分类、诊断和管理指南(2018)》解读. 中国实用妇科与产科杂志, 2018, 34(7): 758-763.
8. Lo KL, Mertz D, Loeb M. Newcastle-Ottawa Scale: comparing reviewers’ to authors’ assessments. BMC Med Res Meth, 2014, 14(1): 45.
9. 王丽红, 安篆仙, 侯丽蓉, 等. 162 例早产原因及对母婴影响的分析. 中国妇幼保健, 2007, 22(6): 752-753.
10. 陈丽娟, 强萍. 早产相关因素 87 例分析. 临床和实验医学杂志, 2007, (12): 72-73.
11. 朱轶. 早产及其预后相关因素分析. 重庆: 重庆医科大学, 2008.
12. 陶真兰. 早产危险因素临床观察与防治. 现代预防医学, 2008, (9): 1632, 1635.
13. 黄蕾, 赵玉环. 徐州地区 334 例早产儿临床分析. 中国优生与遗传杂志, 2008, 16(5): 89-90.
14. 陈宝莲. 早产相关临床因素 608 例分析. 重庆医学, 2008, 37(20): 2340-2342.
15. 王晶清. 早产 236 例原因分析. 中国医药导报, 2009, 6(10): 50-51.
16. 李文红. 220 例产科病例的早产危险因素分析. 长春: 吉林大学, 2009.
17. 张艳波. 早产病因的分析与防治. 中国妇幼保健, 2010, 25(2): 284-285.
18. 彭来勤. 引起早产相关因素的病例-对照研究. 中国现代医生, 2010, 48(17): 132, 141.
19. 徐燕. 早产 268 例临床分析. 苏州: 苏州大学, 2011.
20. 丁琥. 母血 CRP 水平与早产及早产儿近期不良预后的相关性分析. 南京: 东南大学, 2011.
21. 邹海燕. 258 例早产的临床因素分析. 现代预防医学, 2012, 39(13): 3250-3251, 3256.
22. 刘晓红, 张运平, 高素红, 等. 早产影响因素的多中心病例-对照研究. 中国妇产科临床杂志, 2012, 13(5): 345-348.
23. 冯轶, 蔺莉. 自发性早产高危因素的分析. 首都医科大学学报, 2012, 33(1): 45-49.
24. Sun L, Tao F, Hao J, et al. First trimester vaginal bleeding and adverse pregnancy outcomes among Chinese women: from a large cohort study in China. J Matern Fetal Neonatal Med, 2012, 25(8): 1297-1301.
25. Zhang YP, Liu XH, Gao SH, et al. Risk factors for preterm birth in five maternal and child health hospitals in Beijing. PLoS One, 2012, 7(12): e52780.
26. 顾春健, 林梅芳. 393 例晚期早产儿早产危险因素及并发症分析. 浙江预防医学, 2013, 25(9): 74-75, 78.
27. 张建伟. 200 例早产危险因素分析. 中国生育健康杂志, 2014, 25(6): 553-555.
28. 原孟. 241 例早产相关因素及早产儿结局病例分析. 大连: 大连医科大学, 2014.
29. 蒋秀. 早产相关因素的临床研究. 郑州: 郑州大学, 2014.
30. 翟晓蔚, 吴田英, 梁思铭, 等. 早产低出生体质量儿影响因素探讨. 蚌埠医学院学报, 2014, 39(11): 1544-1546.
31. 林国敬, 黄水清, 王俊平. 408 例晚期早产儿临床分析. 中国妇幼保健, 2014, 29(13): 2033-2036.
32. 张莹, 赫英东, 陈倩. 晚期早产的危险因素及围产期并发症分析. 中华围产医学杂志, 2014, (6): 379-383.
33. Chen YP, Lu YP, Li J, et al. Fetal and maternal angiotensin (1-7) are associated with preterm birth. J Hypertens, 2014, 32(9): 1833-1841.
34. 刘秋明. 北京市大兴区早产儿危险因素分析. 实用预防医学, 2015, 22(3): 330-332.
35. 王彩芳, 刘妙珍, 黄丽君. 应用 logistic 回归模型分析孕妇早产的高危因素. 全科医学临床与教育, 2015, 13(5): 522-525.
36. 蔺茹, 王卫凯, 白岩, 等. 母亲既往生育史与早产儿发生的相关性分析. 中国妇幼保健, 2015, 30(29): 5023-5026.
37. 陈艳, 孙小英. 自发性早产高危因素及其对早产儿窒息影响的流行病学研究. 中国妇幼保健, 2015, 30(18): 2966-2968.
38. 翁叶蕊, 符爱贞. 162 例早产危险因素分析. 中国妇幼保健, 2015, 30(30): 5153-5154.
39. Lu L, Qu Y, Tang J, et al. Risk factors associated with late preterm births in the underdeveloped region of China: a cohort study and systematic review. Taiwan J Obstet Gynecol, 2015, 54(6): 647-653.
40. Yang Y, He Y, Li Q, et al. Preconception blood pressure and risk of preterm birth: a large historical cohort study in a Chinese rural population. Fertil Steril, 2015, 104(1): 124-130.
41. 王文第, 陈亚, 张春花, 等. 母亲不良孕产史对早产发生的影响. 中国优生与遗传杂志, 2016, 24(9): 56-59, 68.
42. 张丹丹, 谈迪心, 王斌, 等. 孕期增重与早产关联的流行病学分析. 中华流行病学杂志, 2016, 37(7): 1012-1016.
43. 王立芳, 周虹, 张妍, 等. 孕前体质指数与早产的关系. 北京大学学报(医学版), 2016, 48(3): 414-417.
44. 张小松, 赵更力, 杨慧霞, 等. 15 家城市医疗机构早产发生情况及影响因素分析. 中华围产医学杂志, 2016, 19(6): 456-461.
45. 王海霞. 应用多元 COX 回归模型分析早产的危险因素. 中国妇幼保健, 2016, 31(2): 268-270.
46. 胡彦, 李岚, 黄文珍, 等. 我院近 10 年早产危险因素改变的回顾性研究. 海南医学, 2016, 27(20): 3356-3358.
47. 何永华, 韦榕静, 谭盛葵, 等. 孕妇早产的社会和行为影响因素. 环境与职业医学, 2016, 33(2): 147-151.
48. 李姗姗, 屈鹏飞, 雷方良, 等. 早产危险因素的 1:2 配对病例-对照研究. 中国妇幼保健, 2016, 31(7): 1395-1397.
49. 詹钟平, 杨颖, 詹雁峰, 等. 系统性红斑狼疮妊娠患者早产的临床特点和危险因素分析. 中山大学学报(医学科学版), 2016, 37(6): 893-897, 918.
50. 程雁鹏, 冯永亮, 段小丽, 等. 孕期大气细颗粒物 PM2.5 暴露及对早产的影响研究. 中华流行病学杂志, 2016, 37(4): 572-577.
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Association between pregnancy induced hypertension and preterm birth and population attributable risk in pregnant females in mainland China: a meta-analysis

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