Registration of acupuncture clinical trials on WHO ICTRP from 2014 to 2018_Chinese Journal of Evidence-Based Medicine

Authors：

YIN Zihan , SUN Mingsheng , XU Guixing , XIE Yujie , YAN Mingxi , LI Zhiwei , ZHAO Ling ,  LIANG Fanrong

School of Acupuncture-moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, P.R.China;

Corresponding author：

LIANG Fanrong, Email: acuresearch@126.com

Keywords：

Acupuncture; Clinical trial registration; Data mining; WHO international clinical trial registration platform

DOI：

10.7507/1672-2531.201906023

Video：

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Objectives To analyze the development of acupuncture registered trials based on WHO international clinical trial registration platform (ICTRP) in the past 5 years.Methods WHO ICTRP database was electronically searched to collect acupuncture-related clinical trials registered from January 1^st, 2014 to December 31^st, 2018. Two reviewers independently screened items, extracted data, and descriptive analysis was performed for the included trials.Results The results showed that there were 1 556 registered clinical trials on acupuncture, and the most registered year was 2017. China was in the main country in applying for acupuncture-related clinical trials, however, the most registered unit was Kyung Hee University in Korea. The trials were mainly interventional research, mostly used randomized, blinded methods, and design modes were mainly based on parallel trials. In clinical trial phase, the majority were in the clinical trial period of treatment of new technologies. The field of clinical research was expected to be on pain in the future.Conclusions Although acupuncture research is currently in a good stage of development, it should still value on the quality and innovative training of relevant trials, strengthen Chinese ties with other countries, focus on regional, domestic and international cooperation, expand research types, and enhance acupuncture applicability.

Citation： YIN Zihan, SUN Mingsheng, XU Guixing, XIE Yujie, YAN Mingxi, LI Zhiwei, ZHAO Ling, LIANG Fanrong. Registration of acupuncture clinical trials on WHO ICTRP from 2014 to 2018. Chinese Journal of Evidence-Based Medicine, 2019, 19(12): 1395-1399. doi: 10.7507/1672-2531.201906023 Copy

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11.	习近平主席向世界卫生组织赠送" 针灸铜人”. 习近平主席向世界卫生组织赠送" 针灸铜人”. 针刺研究, 2017, 42(1): 55.
12.	孙忠人, 田洪昭, 尹洪娜, 等. 基于" 医工结合”探讨针灸发展演变. 中华中医药杂志, 2019, 34(3): 1117-1119.
13.	Breivik H, Collett B, Ventafridda V, et al. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain, 2006, 10(4): 287-333.
14.	O'Regan D, Filshie J. Acupuncture and cancer. Auton Neurosci, 2010, 157(1-2): 96-100.
15.	Khalil R, Khalil R, Shao X. Battlefield acupuncture for pain management after hip surgery. J Ame Med Direct Associa, 2018, 19(3): B5-B6.
16.	Ezzo J, Vickers A, Richardson MA, et al. Acupuncture-point stimulation for chemotherapy-induced nausea and vomiting. J Clin Oncol, 2005, 23(28): 7188-7198.
17.	Sarzi-Puttini P, Cimmino MA, Scarpa R, et al. Osteoarthritis: an overview of the disease and its treatment strategies. Semin Arthritis Rheum, 2005, 35(1 Suppl 1): 1-10.
18.	石云舟, 周思远, 郑倩华, 等. 国际高质量针灸随机对照试验特征分析. 世界中医药, 2018, 13(7): 1580-1583.
19.	Ma Y, Dong M, Zhou K, et al. Publication trends in acupuncture research: a 20-year bibliometric analysis based on PubMed. PLoS One, 2016, 11(12): e0168123.
20.	李政杰, 刘迈兰, 王君南, 等. 针灸临床研究的国际注册方法及现状. 针刺研究, 2012, 37(1): 86-87.
21.	胥莹, 陈波, 郭义. 针灸临床研究注册现状分析与探讨. 中国针灸, 2015, 35(6): 605-607.
22.	黄明安. 中医药现状与发展趋势研究. 时珍国医国药, 2016, 27(8): 1956-1960.
23.	Zeng F, Qin W, Liang F, et al. Abnormal resting brain activity in patients with functional dyspepsia is related to symptom severity. Gastroenterology, 2011, 141(2): 499-506.
24.	Zhao L, Chen J, Li Y, et al. The long-term effect of acupuncture for migraine prophylaxis: a randomized clinical trial. JAMA Intern Med, 2017, 177(4): 508-515.
25.	Liu Z, Liu Y, Xu H, et al. Effect of electroacupuncture on urinary leakage among women with stress urinary incontinence: a randomized clinical trial. JAMA, 2017, 60(24): 2493.

1. 刘佳, 何丽云, 赵玉凤, 等. 基于真实世界国际针灸病例注册登记研究的关键技术. 世界科学技术-中医药现代化, 2017, 19(12): 1920-1923.
2. 魏辉, 巩昌镇, 田海河, 等. 针灸发展方向访谈(一). 中医药导报, 2018, 24(9): 1-7.
3. 中国肿瘤. 凡临床试验都应在中国临床试验注册中心注册. 中国肿瘤, 2018, 27(10): 812.
4. 杨德强. 国际针灸临床试验注册研究. 北京: 北京中医药大学, 2008.
5. 邬兰, 田国祥, 王行环, 等. 临床试验的注册及注册平台比较分析. 中国循证心血管医学杂志, 2017, 9(2): 129-134.
6. 吴泰相, 米娜瓦尔·阿不都, 郝园, 等. 中国临床试验注册10年: 现状与问题. 中国循证医学杂志, 2018, 18(6): 522-525.
7. 吴泰相, 卞兆祥, 李幼平, 等. 临床试验原始数据透明化与共享: 关于医学研究伦理的哲学命题及其对临床试验的意义. 中国循证医学杂志, 2018, 18(6): 538-542.
8. 吴泰相, 米娜瓦尔·阿不都, 卞兆祥, 等. 基于临床试验注册信息调查影响我国临床试验质量的因素. 中国循证医学杂志, 2018, 18(6): 526-531.
9. Goldacre B. The WHO joint statement from funders on trials transparency. BMJ, 2017, 357: j2816.
10. 陈君超. 从试验注册到结果公开进一步提高临床试验的透明化. 中国新药杂志, 2018, 27(20): 2357-2360.
11. 习近平主席向世界卫生组织赠送" 针灸铜人”. 习近平主席向世界卫生组织赠送" 针灸铜人”. 针刺研究, 2017, 42(1): 55.
12. 孙忠人, 田洪昭, 尹洪娜, 等. 基于" 医工结合”探讨针灸发展演变. 中华中医药杂志, 2019, 34(3): 1117-1119.
13. Breivik H, Collett B, Ventafridda V, et al. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain, 2006, 10(4): 287-333.
14. O'Regan D, Filshie J. Acupuncture and cancer. Auton Neurosci, 2010, 157(1-2): 96-100.
15. Khalil R, Khalil R, Shao X. Battlefield acupuncture for pain management after hip surgery. J Ame Med Direct Associa, 2018, 19(3): B5-B6.
16. Ezzo J, Vickers A, Richardson MA, et al. Acupuncture-point stimulation for chemotherapy-induced nausea and vomiting. J Clin Oncol, 2005, 23(28): 7188-7198.
17. Sarzi-Puttini P, Cimmino MA, Scarpa R, et al. Osteoarthritis: an overview of the disease and its treatment strategies. Semin Arthritis Rheum, 2005, 35(1 Suppl 1): 1-10.
18. 石云舟, 周思远, 郑倩华, 等. 国际高质量针灸随机对照试验特征分析. 世界中医药, 2018, 13(7): 1580-1583.
19. Ma Y, Dong M, Zhou K, et al. Publication trends in acupuncture research: a 20-year bibliometric analysis based on PubMed. PLoS One, 2016, 11(12): e0168123.
20. 李政杰, 刘迈兰, 王君南, 等. 针灸临床研究的国际注册方法及现状. 针刺研究, 2012, 37(1): 86-87.
21. 胥莹, 陈波, 郭义. 针灸临床研究注册现状分析与探讨. 中国针灸, 2015, 35(6): 605-607.
22. 黄明安. 中医药现状与发展趋势研究. 时珍国医国药, 2016, 27(8): 1956-1960.
23. Zeng F, Qin W, Liang F, et al. Abnormal resting brain activity in patients with functional dyspepsia is related to symptom severity. Gastroenterology, 2011, 141(2): 499-506.
24. Zhao L, Chen J, Li Y, et al. The long-term effect of acupuncture for migraine prophylaxis: a randomized clinical trial. JAMA Intern Med, 2017, 177(4): 508-515.
25. Liu Z, Liu Y, Xu H, et al. Effect of electroacupuncture on urinary leakage among women with stress urinary incontinence: a randomized clinical trial. JAMA, 2017, 60(24): 2493.

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