Analysis of the status of evidence for disease burden research_Chinese Journal of Evidence-Based Medicine

Authors：

ZHOU Wenjing ¹ , YANG Xiao ¹ , LI Yanfei ^1,2 , WANG Weini ¹ , GUO Kangle ^1,2 ,  LI Xiuxia ^1,2 , YANG Kehu ^1,2,3

1. Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, 730000, P.R.China;
2. Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, 730000, P.R.China;
3. Evidence-Based Medicine Center, School of Basic Medicine, Lanzhou University, Lanzhou, 730000, P.R.China;

Corresponding author：

LI Xiuxia, Email: lixiuxia@lzu.edu.cn

Keywords：

Disease burden; Medical economics; Status analysis; Bibliometric analysis

DOI：

10.7507/1672-2531.201906027

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Objectives To conduct a bibliometric analysis to research the status of disease burden domestically and overseas so as to understand the status of diseases burden, and to provide scientific and reasonable reference for health disease prevention, control strategies formulation and future research.Methods PubMed, Web of Science, EMbase, The Cochrane Library, WanFang Data, CBM and CNKI databases were electronically searched to collect literature on disease burden from inception to October, 2018. Two reviewers independently screened literature and extracted data. EndNote X7 software was used for literature management, Excel 2016 software and VOS viewer software were also used to analyze data. Literature was classified by the aspects of literature publication characteristics, diseases, background areas, influencing factors, evaluation indicators and poverty caused by illness.Results A total of 325 studies were included in the bibliometric analysis. 41 articles (12.6%) were published in journals indexed by SCIE; original research evidence accounted for 97.0% (315 articles); 272 articles were from China (83.7%). The main diseases involved were malignant tumors (58 articles, 17.8%), diabetes (29 articles, 8.9%) and hypertension (24 articles, 7.4%). Factors affecting the disease burden primarily included hospitalization days (9 articles, 2.8%), complications (5 articles, 1.5%), delays in treatment (5 articles, 1.5%), and economic income (4 articles, 1.2%). Sixity-one articles (18.8%) reported poverty due to illness, and related diseases were chronic obstructive pulmonary disease (12 articles, 3.7%), hypertension (10 articles, 3.1%), diabetes (10 articles, 3.1%), malignant tumors (9 articles, 2.8%) and hepatitis B (6 articles, 1.8%).Conclusions At present, the disease burden research are focusing more on the burden of chronic non-communicable diseases such as malignant tumors, hypertension, diabetes, cardiovascular and cerebrovascular diseases in developing countries and regions. Medical costs vary from different diseases and treatment, different demographic characteristics of patients, and the coverage medical security of different population are the primary reasons for the " expensive in medical treatment” of current residents and the heavy burden of disease. DALY and total direct medical expenses are the main evaluation indexes of epidemiological burden and economic burden of disease, respectively. Future researches should focus on strengthening the scientific nature of study design to improve the quality of research, as well as paying more attention to diseases and aspects that are rarely involved, such as major diseases caused by poverty due to illness, comprehensive analysis of multiple diseases and aspects of health investment measurement, and comprehensively use the evaluation indicators of disease burden to strengthen the research on the comparability index of disease economic burden.

Citation： ZHOU Wenjing, YANG Xiao, LI Yanfei, WANG Weini, GUO Kangle, LI Xiuxia, YANG Kehu. Analysis of the status of evidence for disease burden research. Chinese Journal of Evidence-Based Medicine, 2019, 19(11): 1317-1324. doi: 10.7507/1672-2531.201906027 Copy

1.	胡善联. 疾病负担的研究(上). 卫生经济研究, 2005, (5): 22-27.
2.	周尚成, 万崇华, 蔡乐. 疾病负担研究现状及问题. 国外医学(卫生经济分册), 2004, 21(4): 145-149.
3.	徐张燕, 张敏, 崔亚萍. 疾病负担研究的发展与应用. 中国肿瘤, 2013, 22(8): 638-643.
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12.	王亭艳, 曹凤, 胡刚, 等. 新疆肺癌患者疾病经济负担及其影响因素分析. 卫生软科学, 2016, 30(09): 17-20.
13.	孟庆跃, 马彦强, 刘兴柱, 等. 山东省麻风病人疾病经济负担分析. 中国卫生事业管理, 1997, (11): 606-607.
14.	罗惠文, 丰燕, 季明, 等. 江苏某农村地区结核病患者疾病经济负担及其影响因素分析. 中华疾病控制杂志, 2012, 16(10): 877-880.
15.	罗惠文, 戴垚垚, 王建明. 肺结核病患者疾病经济负担及其影响因素分析. 中国初级卫生保健, 2012, 26(3): 4-7.
16.	辛英, 饶克勤, 徐玲. 我国城乡居民家庭高血压疾病经济负担分析. 中国卫生经济, 2010, 29(5): 69-71.
17.	冯达, 赵锐, 田淼淼, 等. 山西省农村慢性病疾病经济负担与风险研究. 中国卫生经济, 2013, (10): 48-50.
18.	门可, 殷尚炯, 徐德忠, 等. 精神分裂症危险因素的病例对照研究. 中国公共卫生, 2003, 19(5): 599-600.
19.	王琳, 李革. 精神障碍的社会心理因素研究现况. 中国公共卫生, 2006, 22(2): 130-131.
20.	仇冰玉, 孙尚文, 王延祜, 等. 山东省重性精神疾病患者门诊诊疗和家庭经济负担情况调查. 预防医学论坛, 2014, (01): 4-7.
21.	崔俊丹, 周子深, 田庆丰, 等. 河南省终末期肾病透析患者门诊诊疗和家庭经济负担研究. 医药论坛杂志, 2017, 38(10): 7-14.
22.	杨莉, 李欣雅, 陈政淳, 等. 我国透析患者高磷血症疾病负担研究. 中国医疗保险, 2015, (7): 57-60.
23.	王敏, 张开金, 姜丽, 等. 恶性肿瘤住院患者直接经济负担影响因素及医疗保障制度研究. 中国全科医学, 2010, (36): 4115-4118.
24.	桑新刚, 尹爱田, 宋春燕, 等. 农村慢性病患者疾病负担及新农合补偿分析. 中国公共卫生, 2010, (05): 606-608.
25.	Black CM, Fillit H, Xie L, et al. Economic burden, mortality, and institutionalization in patients newly diagnosed with Alzheimer's disease. J Alzheimers Dis, 2018, 61(1): 185-193.
26.	王霞, 王文志. 卒中的疾病负担评价. 国外医学(脑血管疾病分册), 2004, (7): 487-490.
27.	Essink-Bot ML, Pereira J, Packer C, et al. Cross-national comparability of burden of disease estimates: the European Disability Weights Project. Bull World Health Organ, 2002, 80(8): 644-652.
28.	杨克虎, 李秀霞, 拜争刚. 循证社会科学研究方法: 系统评价与 Meta 分析（第 1 版）. 兰州: 兰州大学出版社, 2018.

1. 胡善联. 疾病负担的研究(上). 卫生经济研究, 2005, (5): 22-27.
2. 周尚成, 万崇华, 蔡乐. 疾病负担研究现状及问题. 国外医学(卫生经济分册), 2004, 21(4): 145-149.
3. 徐张燕, 张敏, 崔亚萍. 疾病负担研究的发展与应用. 中国肿瘤, 2013, 22(8): 638-643.
4. 中华人民共和国国家卫生健康委员会. 国家卫生计生委、国务院扶贫办启动建档立卡农村贫困人口" 因病致贫、因病返贫”调查工作. Available at: http://www.nhfpc.gov.cn/caiwusi/s7786/201604/fc6d02a21134e5ebf71bb7f19cb1216.shtml.
5. Sackett DL, Straus SE, Richardson WS, et al. Evidence based medicine: how to practice and teach EBM (2nd edition). New York: Churchill Livingstone, 2000: 1-2.
6. Guyatt G, Rennie D, Meade M, et al. Users' guides to the medical literature: a manual for evidence-based clinical practice (2nd edition). New York: McGraw-Hill Professional, 2008.
7. 张洁, 钱序, 陈英耀. 疾病负担研究进展. 中国卫生经济, 2005, 24(5): 69-71.
8. World Health Organization.ICD-11 for mortality and morbidity statistics. Available at: https://icd.who.int/browse11/l-m/en.
9. 卢国萍. 慢性病成为全球健康的主要威胁. 第45届亚太地区公共卫生联盟大会, 2013: 10-27.
10. 刘竟芳, 陈哲, 杨非柯, 等. 我国老年人慢性病现状及应对策略. 中外医疗, 2014, (23): 194-195, 198.
11. 国家食品药品监督管理总局. 中共中央国务院关于深化医药卫生体制改革的意见. Available at: http://www.sda.gov.cn/WS01/CL0611/41193.html.
12. 王亭艳, 曹凤, 胡刚, 等. 新疆肺癌患者疾病经济负担及其影响因素分析. 卫生软科学, 2016, 30(09): 17-20.
13. 孟庆跃, 马彦强, 刘兴柱, 等. 山东省麻风病人疾病经济负担分析. 中国卫生事业管理, 1997, (11): 606-607.
14. 罗惠文, 丰燕, 季明, 等. 江苏某农村地区结核病患者疾病经济负担及其影响因素分析. 中华疾病控制杂志, 2012, 16(10): 877-880.
15. 罗惠文, 戴垚垚, 王建明. 肺结核病患者疾病经济负担及其影响因素分析. 中国初级卫生保健, 2012, 26(3): 4-7.
16. 辛英, 饶克勤, 徐玲. 我国城乡居民家庭高血压疾病经济负担分析. 中国卫生经济, 2010, 29(5): 69-71.
17. 冯达, 赵锐, 田淼淼, 等. 山西省农村慢性病疾病经济负担与风险研究. 中国卫生经济, 2013, (10): 48-50.
18. 门可, 殷尚炯, 徐德忠, 等. 精神分裂症危险因素的病例对照研究. 中国公共卫生, 2003, 19(5): 599-600.
19. 王琳, 李革. 精神障碍的社会心理因素研究现况. 中国公共卫生, 2006, 22(2): 130-131.
20. 仇冰玉, 孙尚文, 王延祜, 等. 山东省重性精神疾病患者门诊诊疗和家庭经济负担情况调查. 预防医学论坛, 2014, (01): 4-7.
21. 崔俊丹, 周子深, 田庆丰, 等. 河南省终末期肾病透析患者门诊诊疗和家庭经济负担研究. 医药论坛杂志, 2017, 38(10): 7-14.
22. 杨莉, 李欣雅, 陈政淳, 等. 我国透析患者高磷血症疾病负担研究. 中国医疗保险, 2015, (7): 57-60.
23. 王敏, 张开金, 姜丽, 等. 恶性肿瘤住院患者直接经济负担影响因素及医疗保障制度研究. 中国全科医学, 2010, (36): 4115-4118.
24. 桑新刚, 尹爱田, 宋春燕, 等. 农村慢性病患者疾病负担及新农合补偿分析. 中国公共卫生, 2010, (05): 606-608.
25. Black CM, Fillit H, Xie L, et al. Economic burden, mortality, and institutionalization in patients newly diagnosed with Alzheimer's disease. J Alzheimers Dis, 2018, 61(1): 185-193.
26. 王霞, 王文志. 卒中的疾病负担评价. 国外医学(脑血管疾病分册), 2004, (7): 487-490.
27. Essink-Bot ML, Pereira J, Packer C, et al. Cross-national comparability of burden of disease estimates: the European Disability Weights Project. Bull World Health Organ, 2002, 80(8): 644-652.
28. 杨克虎, 李秀霞, 拜争刚. 循证社会科学研究方法: 系统评价与 Meta 分析（第 1 版）. 兰州: 兰州大学出版社, 2018.

Chinese Journal of Evidence-Based Medicine

Analysis of the status of evidence for disease burden research

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