Efficacy and safety of major ozonated autohemotherapy in the treatment of ischemic stroke: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

LI Jingwen ^1,2,3 , ZHANG Na ^1,2,3 , GU Qinghong ^2,3 , LI Jieyun ^2,3 , GUO Kangle ^1,2,3 , LI Meixuan ^1,2,3 , LI Yanfei ^1,2,3 , ZHANG Hairong ¹ , ZHANG Yunqi ¹ , LIU Xingrong ¹ , BAI Fei ⁴ ,  LI Xiuxia ^1,2,3 ,  YANG Kehu ^1,2,3

1. Evidence-Based Social Science Research Center, Health Technology Assessment Center, School of Public Health, Lanzhou University, Lanzhou 730000, P.R.China;
2. Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, P.R.China;
3. Evidence-Based Social Science Research Center of Lanzhou University, School of Public Health, Lanzhou University, Lanzhou 730000, P.R.China;
4. Guidance Center for Medical Management Services of the National Health Commission, Beijing 100044, P.R.China;

Corresponding author：

LI Xiuxia, Email: lixiuxia@lzu.edu.cn; YANG Kehu, Email: kehuyangebm2006@126.com

Keywords：

Major ozonated autohemotherapy; Ischemic stroke; Systematic review; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.202011034

Video：

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Objective To systematically review the efficacy and safety of major ozonated autohemotherapy in the treatment of ischemic stroke.Methods PubMed, EMbase, The Cochrane Library, Web of Science, CBM, WanFang Data, VIP and CNKI were electronically searched to collect randomized controlled trials (RCTs) of the efficacy and safety of major ozonated autohemotherapy in the treatment of ischemic stroke from inception to July 1^st, 2020. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies. Meta-analysis was then performed by using RevMan 5.3 software.Results A total of 25 RCTs involving 3 681 patients were included. The results of meta-analysis showed that the major ozonated autohemotherapy combined with conventional therapy in the treatment of patients with ischemic stroke in terms of total effective rate (RR=1.20, 95%CI 1.15 to 1.25, P<0.001), national institutes of health stroke scale (MD=−3.15, 95%CI −4.72 to −1.59, P<0.001), total cholesterol (MD=−1.00, 95%CI −1.48 to −0.53, P<0.001), triglyceride (MD=−0.74, 95%CI −1.04 to −0.43, P<0.001), low-density lipoprotein cholesterol (MD=−0.65, 95%CI −1.22 to −0.09, P=0.02), and activity of daily living (MD=11.97, 95%CI 4.48 to 19.47, P=0.002) were superior to the conventional treatment group. There was no significant difference between the two groups in high-density lipoprotein cholesterol (MD=0.25, 95%CI −0.46 to 0.96, P=0.49) and the incidence of adverse effects (OR=3.15, 95%CI 0.93 to 10.63, P=0.06).Conclusions The major ozonated autohemotherapy can significantly improve the prognosis of patients with ischemic stroke while not affecting the adverse effects. Due to the limited quality and quantity of the included studies, more high-quality studies are needed to verify the above conclusions.

Citation： LI Jingwen, ZHANG Na, GU Qinghong, LI Jieyun, GUO Kangle, LI Meixuan, LI Yanfei, ZHANG Hairong, ZHANG Yunqi, LIU Xingrong, BAI Fei, LI Xiuxia, YANG Kehu. Efficacy and safety of major ozonated autohemotherapy in the treatment of ischemic stroke: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2021, 21(8): 889-897. doi: 10.7507/1672-2531.202011034 Copy

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1. GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2018, 392(10159): 1736-1788.
2. 陈伟伟, 高润霖, 刘力生, 等. 《中国心血管病报告 2017》概要. 中国循环杂志, 2018, 33(1): 1-8.
3. GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet, 2015, 385(9963): 117-171.
4. 国家卫生和计划生育委员会. 中国卫生和计划生育统计年鉴 2017. 北京: 中国协和医科大学出版社, 2018.
5. 吴亚哲, 陈伟伟. 中国脑卒中流行概况. 心脑血管病防治, 2016, 16(6): 410-414.
6. 中华医学会神经病学分会中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南 2018. 中华神经科杂志, 2018, 51(9): 666-682.
7. Saver JL, Fonarow GC, Smith EE, et al. Time to treatment with intravenous tissue plasminogen activator and outcome from acute ischemic stroke. JAMA, 2013, 309(23): 2480-2488.
8. Ng SH, Wong AWK, Chen CH, et al. Stroke factors associated with thrombolysis use in hospitals in Singapore and us: a cross-registry comparative study. Cerebrovasc Dis, 2019, 47(5-6): 291-298.
9. 孟文婷, 李东翔, 佟玲. 缺血性脑卒中的治疗研究进展. 中国新药杂志, 2016, 25(10): 1114-1120.
10. 陶希, 黄靓, 蔡华安, 等. 臭氧氧化与缺血再灌注损伤的研究进展. 中国康复理论与实践, 2016, 22(12): 1420-1424.
11. 胡俊桥. 医用三氧临床应用研究进展. 实用中医药杂志, 2017, 33(2): 211-213.
12. 中华医学会麻醉学分会疼痛学组中国医师协会麻醉医师分会中国民族医药学会疼痛分会三氧学组. 三氧自体血疗法专家共识. 转化医学杂志, 2018, 7(6): 326-328, 345.
13. 杨克虎. 循证社会科学的产生, 发展与未来. 图书与情报, 2018, (3): 1-10.
14. Zhang J, Li Y, Zhang B, et al. Evidence-based traditional Chinese medicine research: Beijing declaration. J Evid Based Med, 2020, 13(2): 91-92.
15. 中国神经科学会, 中华神经外科学会. 各类脑血管疾病诊断要点(1995). 临床和实验医学杂志, 2013, 12(7): 559.
16. Ni X, Lin H, Li H, et al. Evidence-based practice guideline on integrative medicine for stroke 2019. J Evid Based Med, 2020, 13(2): 137-152.
17. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions (version 5.1.0). The Cochrane Collaboration, 2011. Available at: http://www.cochrane-handbook.org.
18. Wu XN, Zhang T, Wang J, et al. Magnetic resonance diffusion tensor imaging following major ozonated autohemotherapy for treatment of acute cerebral infarction. Neural Regen Res, 2016, 11(7): 1115-1121.
19. 包颖, 陈晓虹, 姜海涛. 臭氧大自血疗法联合辛伐他汀对缺血性卒中患者血脂水平的影响. 中风与神经疾病杂志, 2011, 28(4): 353-354.
20. 陈敏. 臭氧自血疗法辅助治疗急性脑梗死的疗效观察. 吉林: 吉林大学, 2014.
21. 崔小妮. 臭氧(O3)自体血回输联合常规方法治疗急性脑梗塞的效果分析. 临床医学研究与实践, 2018, 3(5): 26-27.
22. 邓美杰. 用医用臭氧自血疗法对老年缺血性脑卒中患者进行治疗的效果探析. 当代医药论丛, 2018, 16(19): 44-45.
23. 黄雁, 赵焕宁, 王扬广. 臭氧自血疗法对急性脑梗塞疗效及对血液相关指标的影响. 右江民族医学院学报, 2010, 32(4): 511-512.
24. 郭明远, 陈建平, 郭媛媛, 等. 臭氧大自血疗法治疗急性缺血性脑梗死患者的临床疗效评估. 现代生物医学进展, 2016, 16(23): 4475-4477, 4515.
25. 李寒姝, 裴梓峰, 潘薇, 等. 三氧自体血回输疗法对急性脑梗死患者血脂的作用分析. 当代医学, 2018, 24(36): 116-118.
26. 李辉, 汤永红. 臭氧自血回输在急性脑梗死患者中的应用研究. 现代医药卫生, 2015, 31(12): 1836-1837.
27. 宁显武. 探讨免疫三氧自血回输治疗急性脑梗死患者的临床效果. 世界最新医学信息文摘(连续型电子期刊), 2016, 17(71): 360.
28. 覃翠, 李贤. 药物联合臭氧大自血治疗急性脑梗死的疗效观察. 中西医结合心血管病电子杂志, 2016, 4(31): 197-198.
29. 刘晓燕. 臭氧自体血回输治疗急性脑梗死临床观察. 广州: 广州中医药大学, 2010.
30. 陶东霞, 王璐, 马兰, 等. 臭氧自体血回输疗法治疗急性脑梗死的疗效分析. 中国医科大学学报, 2017, 46(9): 860-861.
31. 王莉娟. 臭氧自体血回输治疗急性脑梗死对患者血脂的影响. 中外女性健康研究, 2017, (2): 136-137.
32. 刘丹, 苏丙贺, 赵春阳, 等. 臭氧大自血疗法对急性脑梗死的临床应用分析. 世界最新医学信息文摘(电子版), 2013, (11): 114-115.
33. 王生锋. 免疫三氧血回输疗法治疗 170 例急性脑梗死的临床疗效. 中国医药科学, 2014, 4(10): 158-160.
34. 吴娜. 臭氧自体血回输治疗急性脑梗死的临床分析. 中国医药指南, 2017, 15(4): 25-26.
35. 王昕, 张月秋, 王俊清, 等. 高压臭氧大自血治疗脑梗死临床观察. 中国保健营养: 临床医学学刊, 2009, 18(7): 276-277.
36. 徐家萍, 郭爱红, 徐巧绒. 臭氧自体血回输疗法对急性期脑梗死患者脑功能重塑的影响. 临床医学研究与实践, 2019, 4(5): 15-16.
37. 武肖娜, 彭凯润, 杨红军, 等. 臭氧自体血回输治疗对急性脑梗死患者血脂的影响. 中国实用神经疾病杂志, 2013, 16(7): 34-36.
38. 杨继群, 黄红丽, 代龙玉. 臭氧自血疗法辅助治疗急性期脑梗死的疗效和安全性研究. 黑龙江医学, 2020, 44(3): 310-313.
39. 杨改清, 胥丽霞. 疏血通注射液联合臭氧治疗脑梗死临床研究. 河南中医, 2015, 35(3): 525-528.
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Chinese Journal of Evidence-Based Medicine

Efficacy and safety of major ozonated autohemotherapy in the treatment of ischemic stroke: a meta-analysis

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