• 1. Department of Epidemiology and Biostatistics, School of Public Health, Lanzhou University, Lanzhou 730000, P.R.China;
  • 2. Gansu Provincial Maternity and Child-care Hospital, Lanzhou 730000, P.R.China;
  • 3. Lanzhou Center for Disease Prevention and Control, Lanzhou 730000, P.R.China;
LIU Xiaoning, Email: liuxn@lzu.edu.cn
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Objective To perform a meta-analysis on the positive rate of hepatitis C virus (HCV) antibody among pregnant females in China from 2008 to 2018, so as to provide scientific references for the prevention and treatment of HCV infection among pregnant females.Methods Databases including PubMed, Web of Science, SinoMed, CNKI, VIP, and WanFang Data were electronically searched to collect observational studies on the positive rate of HCV antibody among pregnant females in China from January, 2008 to December, 2018. Two reviewers independently screened literature, extracted data and evaluated risk of bias of included studies. Meta-analysis was then performed using Stata 15.0 software.Results A total of 108 studies involving 657 765 individuals were included. Results of meta-analysis showed that the overall positive rate of HCV antibody among pregnant females in Chinese was 0.235% (95%CI 0.189% to 0.286%). Subgroup analysis showed that the positive rate of HCV antibody among pregnant females in western China to be the highest 0.291% (95%CI 0.221% to 0.378%), the northeast China to be 0.240% (95%CI 0.099% to 0.442%), the central China to be 0.235% (95%CI 0.016% to 0.319%), and the east China to be the lowest 0.193 % (95%CI 0.119% to 0.281%). The HCV antibody positive rate of pregnant females from hospital was 0.291% (95%CI 0.221% to 0.372%) and was higher than that from AIDS surveillance site which was 0.164% (95%CI 0.122% to 0.207%).Conclusions The prevalence of HCV antibody among pregnant females maintains at a low level in China.

Citation: MA Jing, CAO Wenpei, WANG Mei, QIAO Xiaowei, LI Juansheng, REN Xiaowei, LIU Xiaoning. Meta-analysis on the positive rate of hepatitis C antibody among pregnant females in China from 2008 to 2018. Chinese Journal of Evidence-Based Medicine, 2021, 21(4): 394-400. doi: 10.7507/1672-2531.202011063 Copy

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