Disease burden analysis of congenital birth defects in China from 1990 to 2019_Chinese Journal of Evidence-Based Medicine

Authors：

LENG Xue ¹ ,  XIAO Wenyan ² , ZHENG Juan ¹ , WANG Fengying ¹

1. The Second Department of Obstetrics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, P. R. China;
2. The Second Department of Intensive Care Unit, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, P. R. China;

Corresponding author：

XIAO Wenyan, Email: 516956335@qq.com

Keywords：

Birth defects; Morbidity; Mortality; Disease burden

DOI：

10.7507/1672-2531.202301060

Video：

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Objective To analyze the trend of disease burden changes in congenital birth defects in China from 1990 to 2019. Methods Using the global burden of disease study 2019 (GBD 2019), we analyzed the morbidity, mortality, and disability-adjusted life years (DALYs) of congenital birth defect diseases and their corresponding age-standardized rates and average annual percentage change (AAPC) to analyze the changes in the disease burden of congenital birth defects in China and compared them with global data from 1990 to 2019. Results In 2019, the age-standardized incidence, mortality, and DALY in China were 147.41/100 000, 4.62/100 000, 480.95/100 000, respectively. Compared with 1990, the age-standardized incidence rate, age-standardized mortality rate, and age-standardized DALY rate increased by 12.08% and decreased by 70.38% and 66.82%, respectively. In recent years, although the age-standardized incidence of congenital birth defect disease in China is on the rise and higher than the global level, the disease burden is roughly on the decline and lower than the global level, which is closely related to earlier intervention and treatment of the disease resulting in a lower standardized mortality rate. Conclusion The age-standardized mortality rate of children with congenital birth defects in China showed a decreasing trend from 1990 to 2019, and the burden of disease ranged from slightly higher than global to lower than global levels, but the age-standardized incidence rate was significantly higher, but the age-specific incidence rate has increased significantly.

Citation： LENG Xue, XIAO Wenyan, ZHENG Juan, WANG Fengying. Disease burden analysis of congenital birth defects in China from 1990 to 2019. Chinese Journal of Evidence-Based Medicine, 2023, 23(4): 386-390. doi: 10.7507/1672-2531.202301060 Copy

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1. 余灵辉, 李海燕, 曹登成. 围产儿出生缺陷及相关危险因素分析. 医学临床研究, 2016, 33(7): 1307-1309.
2. 李淑妮, 许晨耘, 伍芳芳, 等. 海口市2016-2019年新生儿出生缺陷情况及相关影响因素分析. 实用预防医学, 2021, 28(7): 881-884.
3. 黄欢, 孙丽洲. 出生缺陷的现状、干预措施及分析. 中国产前诊断杂志(电子版), 2016, 8(3): 1-8.
4. 中华人民共和国卫生部. 中国出生缺陷防治报告(2012).
5. GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet, 2020, 396(10258): 1204-1222.
6. Li C, Jiang S, Zhang X. Intergenerational relationship, family social support, and depression among Chinese elderly: a structural equation modeling analysis. J Affect Disord, 2019, 248: 73-80.
7. Zhou M, Wang H, Zeng X, et al. Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2019, 394(10204): 1145-1158.
8. GBD 2019 Demographics Collaborators. Global, regional, and national age-sex-specific fertility, mortality, and population estimates, 1950-2019: a comprehensive demographic analysis for the global burden of disease study 2019. Lancet, 2020, 396(10258): 1160-1203.
9. 王莉, 吴爱惜, 李娟. 围生儿发生出生缺陷的危险因素分析. 中国妇幼保健, 2021, 36(22): 5306-5308.
10. 陈爱军, 任静, 张美丽, 等. 高龄孕妇胎儿出生缺陷情况分析. 河北医药, 2017, 39(17): 2656-2658.
11. 王睁, 李利, 雷雪丫, 等. 产妇高龄对新生儿出生缺陷及生后并发症的影响. 中国当代儿科杂志, 2016, 18(11): 1084-1089.
12. 袁丽, 夏荣明. 北京市朝阳区106370例围产儿出生缺陷监测结果及相关因素分析. 中国妇幼保健, 2017, 32(1): 81-85.
13. 田晓勤, 姜红. 武汉市新生儿出生缺陷情况调查及相关危险因素分析. 中国妇幼保健, 2016, 31(5): 1021-1023.
14. 张亚丽, 蓝菊红, 吕卓超, 等. 丽水市出生缺陷影响因素的病例对照研究. 温州医科大学学报, 2017, 47(1): 56-60.
15. 章玉霜, 金海华. 新生儿出生缺陷监测及相关危险因素分析. 中国妇幼保健, 2019, 34(9): 2069-2071.
16. 吴凤妹, 林英, 谢真. 联合切面扫查在胎儿先天性心脏病筛查中的现状分析. 影像研究与医学应用, 2019, 3(4): 206-209.
17. 阙敏, 孙巧玲, 计国平, 等. 安徽省围生儿出生缺陷流行病学特征分析. 中国妇幼保健, 2021, 36(19): 4516-4519.
18. 汪桂艳, 钟红秀, 赵旭, 等. 厦门地区围产儿出生缺陷监测情况分析. 中国妇幼保健, 2018, 33(22): 5050-5052.
19. 刘珍, 周阳文, 李小洪, 等. 出生缺陷防控健康教育专家共识. 中国妇幼保健, 2022, 37(5): 775-779.
20. 蒋梦可, 陆宗庆, 周伍明, 等. 1990—2019年中国胰腺炎疾病负担分析. 中国循证医学杂志, 2022, 22(8): 869-875.

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