Acupuncture and moxibustion for Parkinson’s disease: an overview of systematic reviews_Chinese Journal of Evidence-Based Medicine

Authors：

ZHONG Wanqi , YIN Zihan , LI Yaqin , BAO Qiongnan , ZHANG Xinyue , XIA Manze , WU Kexin , YAO Jin ,  LIANG Fanrong

School of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P. R. China;

Corresponding author：

LIANG Fanrong, Email: acuresearch@126.com

Keywords：

Acupuncture and moxibustion; Parkinson’s disease; Overview of systematic reviews

DOI：

10.7507/1672-2531.202303190

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize and evaluate the quality of methodology, report and evidence of the systematic reviews and meta-analyses (SRs/MAs) of acupuncture and moxibustion interventions for Parkinson's disease. Methods Eight databases including CNKI, WanFang Data, VIP, CBM, PubMed, EMbase, Cochrane Library and Web of Science were searched from inception to May 1, 2023. The quality of methodology, report and evidence involved in these studies were evaluated by AMSTAR 2, PRISMA and GRADE tool. Results A total of 28 SRs/MAs were included, and the findings of included studies showed that acupuncture and moxibustion had a clinical advantage for Parkinson's disease. The methodological quality of all studies was extremely low. Thirteen reports were relatively complete, 14 reports had certain flaws, and 1 report had relatively serious flaws. And of the 126 reports for seven outcomes, 1 was graded as high, 12 as moderate, 57 as low, and 56 as critically low. Conclusion The current evidence shows that acupuncture and moxibustion have a certain clinical effect for Parkinson's disease, but the methodological quality and evidence quality of related SRs/MAs are low, and the standardization still needs to be improved. The efficacy of acupuncture and moxibustion in Parkinson's disease still needs to be verified by high-quality clinical studies in the future.

Citation： ZHONG Wanqi, YIN Zihan, LI Yaqin, BAO Qiongnan, ZHANG Xinyue, XIA Manze, WU Kexin, YAO Jin, LIANG Fanrong. Acupuncture and moxibustion for Parkinson’s disease: an overview of systematic reviews. Chinese Journal of Evidence-Based Medicine, 2023, 23(8): 936-944. doi: 10.7507/1672-2531.202303190 Copy

1.	陈芝君, 马建, 唐娜, 等. 中国帕金森病疾病负担变化趋势分析及预测. 中国慢性病预防与控制, 2022, 30(9): 649-654.
2.	刘涛, 王遥, 白倩, 等. 帕金森病患者的疾病经济负担现状及影响因素研究. 临床神经病学杂志, 2022, 35(3): 166-170.
3.	李雪, 姜迪, 陈金榆, 等. 基于供方视角的我国帕金森病患者直接医疗成本测算. 卫生经济研究, 2021, 38(1): 26-28.
4.	贾建平, 陈生弟. 神经病学(第8版). 北京: 人民卫生出版社, 2018: 328-329.
5.	Bega D, Gonzalez-Latapi P, Zadikoff C, et al. A review of the clinical evidence for complementary and alternative therapies in Parkinson's disease. Curr Treat Options Neurol, 2014, 16(10): 314.
6.	李艳荣, 樊慧杰, 孙芮芮, 等. 帕金森病的中医药治疗研究进展. 山西中医药大学学报, 2022, 23(4): 381-385+392.
7.	Hansen CA, Miller DR, Annarumma S, et al. Levodopa-induced dyskinesia: a historical review of Parkinson's disease, dopamine, and modern advancements in research and treatment. J Neurol, 2022, 269(6): 2892-2909.
8.	Li K, Xu S, Wang R, et al. Electroacupuncture for motor dysfunction and constipation in patients with Parkinson's disease: a randomised controlled multi-centre trial. EClinicalMedicine, 2023, 56: 101814.
9.	Fan JQ, Lu WJ, Tan WQ, et al. Effectiveness of acupuncture for anxiety among patients with Parkinson disease: a randomized clinical trial. JAMA Netw Open, 2022, 5(9): e2232133.
10.	Pereira CR, Machado J, Rodrigues J, et al. Effectiveness of acupuncture in Parkinson's disease symptoms-a systematic review. Healthcare (Basel), 2022, 10(11): 2334.
11.	中华医学会神经病学分会帕金森病及运动障碍学组, 中国医师协会神经内科医师分会帕金森病及运动障碍专业. 中国帕金森病的诊断标准(2016版). 中华神经科杂志, 2016, 49(4): 268-271.
12.	Hughes AJ, Daniel SE, Lees AJ. Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease. Neurology, 2001, 57(8): 1497-1499.
13.	陶欢, 杨乐天, 平安, 等. 随机或非随机防治性研究系统评价的质量评价工具AMSTAR2解读. 中国循证医学杂志, 2018, 18(1): 101-108.
14.	Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ, 2009, 339: b2535.
15.	Balshem H, Helfanda M, J. Schunemann H, 等. GRADE指南:Ⅲ. 证据质量分级. 中国循证医学杂志, 2011, 11(4): 451-455.
16.	杨丽红, 杜元灏, 熊俊, 等. 针灸治疗帕金森病疗效的系统评价. 中国循证医学杂志, 2010, 10(6): 711-717.
17.	孙妙璇, 张雄. 针灸治疗帕金森病非运动症状疗效的Meta分析. 上海中医药大学学报, 2013, 27(5): 41-48,69.
18.	郭敏. 针刺治疗帕金森病的系统评价和meta分析. 杭州: 浙江中医药大学, 2016.
19.	眭兰, 宋芬芬, 蔡艳. 普通针刺联合美多芭治疗帕金森病的系统评价及meta分析. 湖南中医药大学学报, 2016, 36(2): 1384-1386.
20.	尹洪娜, 韩超, 孙忠人, 等. 针刺治疗帕金森病的系统评价和meta分析. 针灸临床杂志, 2016, 32(8): 67-70.
21.	张雪淳, 蒋丽, 伍亚男, 等. 基于Meta分析的艾灸治疗帕金森病疗效研究. 亚太传统医药, 2016, 12(14): 96-100.
22.	欧阳莎, 许巍. 针灸与西药治疗帕金森病疗效比较的系统评价. 中医药通报, 2017, 16(1): 34-38.
23.	刘艳慧, 陈涛, 邓益东, 等. 针刺治疗帕金森病临床疗效的Meta分析. 中国医师杂志, 2018, 20(1): 16-23, 27.
24.	柳默涵, 王述菊, 马骏, 等. 头针治疗帕金森病的Meta分析. 时珍国医国药, 2019, 30(8): 2011-2014.
25.	李旻颖. 基于“从阳论治”针灸治疗帕金森病肌强直的临床研究与机制探索. 广州: 广州中医药大学, 2020.
26.	李晓艳, 董勤建, 马天阳, 等. 针刺治疗帕金森病随机对照试验的系统评价. 黑龙江中医药, 2020, 49(3): 398-399.
27.	周景, 李俊龙, 李建良, 等. 针刺治疗帕金森病原发性运动症状的Meta分析. 环球中医药, 2020, 13(2): 326-333.
28.	郑梦文. 针灸治疗帕金森病的系统评价与Meta分析. 广州: 暨南大学, 2019.
29.	王延庆. 针灸疗法治疗帕金森病的网状meta分析. 乌鲁木齐: 新疆医科大学, 2020.
30.	傅嘉, 时晶. 针灸治疗改善帕金森病患者睡眠情况的Meta分析. 新疆医科大学学报, 2022, 45(11): 1348-1354, 1361.
31.	孙英, 潘佳慧, 张方圆, 等. 针灸治疗帕金森病非运动症状的Meta分析. 广州中医药大学学报, 2023, 40(2): 516-525.
32.	Cho KH, Kim TH, Kwon S, et al. Moxibustion for idiopathic Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials. Eur J Integr Med, 2017, 13: 26-33.
33.	Ko JH, Lee H, Kim SN, et al. Does acupuncture protect dopamine neurons in Parkinson's disease rodent model?: a systematic review and meta-analysis. Front Aging Neurosci, 2019, 11(5): 102.
34.	Lee HS, Park HL, Lee SJ, et al. Scalp acupuncture for Parkinson's disease: a systematic review of randomized controlled trials. Chin J Integr Med, 2013, 19(4): 297-306.
35.	Lee MS, Shin BC, Kong JC, et al. Effectiveness of acupuncture for Parkinson's disease: a systematic review. Mov Disord, 2008, 23(11): 1505-1515.
36.	Lee SH, Lim S. Clinical effectiveness of acupuncture on Parkinson disease: a PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore), 2017, 96(3): e5836.
37.	Li Q, Wu C, Wang X, et al. Effect of acupuncture for non-motor symptoms in patients with Parkinson's disease: a systematic review and meta-analysis. Front Aging Neurosci, 2022, 14: 995850.
38.	Liu H, Chen L, Zhang Z, et al. Effectiveness and safety of acupuncture combined with madopar for Parkinson's disease: a systematic review with meta-analysis. Acupunct Med, 2017, 35(6): 404-412.
39.	Qiang T, Sun H, Gai C, et al, Combination therapy of scalp electro-acupuncture and medication for the treatment of Parkinson's disease: a systematic review and meta-analysis. J Tradit Chin Med Sci, 2019, 6(1): 26-34.
40.	Wei Y, Yao QP, Zhang PF, et al, Efficacy and safety of acupuncture in the treatment of Parkinson's: a meta analysis. Acta Medica Mediterranea, 2022, 38: 2003.
41.	Wen X, Li K, Wen H, et al. Acupuncture-related therapies for Parkinson's disease: a meta-analysis and qualitative review. Front Aging Neurosci, 2021, 13: 676827.
42.	Kwon M, Cheong MJ, Leem J, et al. Effect of acupuncture on movement function in patients with Parkinson's disease: network meta-analysis of randomized controlled trials. Healthcare (Basel), 2021, 9(11): 1502.
43.	Noh H, Kwon S, Cho SY, et al. Effectiveness and safety of acupuncture in the treatment of Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials. Complement Ther Med, 2017, 34: 86-103.
44.	Sun Y, Sheng J, Liu T, et al. Combination treatment of acupoint therapy and conventional medication for motor function of Parkinson's disease: a systematic review and meta-analysis. Complement Ther Clin Pract, 2023, 50: 101677.
45.	Ruppar T. Meta-analysis: how to quantify and explain heterogeneity. Eur J Cardiovasc Nurs, 2020, 19(7): 646-652.
46.	张卓文, 翁晓兰. "双一流"背景下期刊论文规范"四要素"结构式摘要的实践优势. 浙江中医药大学学报, 2022, 46(11): 1292-1294,1300.
47.	Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ, 2004, 328(7454): 1490.

1. 陈芝君, 马建, 唐娜, 等. 中国帕金森病疾病负担变化趋势分析及预测. 中国慢性病预防与控制, 2022, 30(9): 649-654.
2. 刘涛, 王遥, 白倩, 等. 帕金森病患者的疾病经济负担现状及影响因素研究. 临床神经病学杂志, 2022, 35(3): 166-170.
3. 李雪, 姜迪, 陈金榆, 等. 基于供方视角的我国帕金森病患者直接医疗成本测算. 卫生经济研究, 2021, 38(1): 26-28.
4. 贾建平, 陈生弟. 神经病学(第8版). 北京: 人民卫生出版社, 2018: 328-329.
5. Bega D, Gonzalez-Latapi P, Zadikoff C, et al. A review of the clinical evidence for complementary and alternative therapies in Parkinson's disease. Curr Treat Options Neurol, 2014, 16(10): 314.
6. 李艳荣, 樊慧杰, 孙芮芮, 等. 帕金森病的中医药治疗研究进展. 山西中医药大学学报, 2022, 23(4): 381-385+392.
7. Hansen CA, Miller DR, Annarumma S, et al. Levodopa-induced dyskinesia: a historical review of Parkinson's disease, dopamine, and modern advancements in research and treatment. J Neurol, 2022, 269(6): 2892-2909.
8. Li K, Xu S, Wang R, et al. Electroacupuncture for motor dysfunction and constipation in patients with Parkinson's disease: a randomised controlled multi-centre trial. EClinicalMedicine, 2023, 56: 101814.
9. Fan JQ, Lu WJ, Tan WQ, et al. Effectiveness of acupuncture for anxiety among patients with Parkinson disease: a randomized clinical trial. JAMA Netw Open, 2022, 5(9): e2232133.
10. Pereira CR, Machado J, Rodrigues J, et al. Effectiveness of acupuncture in Parkinson's disease symptoms-a systematic review. Healthcare (Basel), 2022, 10(11): 2334.
11. 中华医学会神经病学分会帕金森病及运动障碍学组, 中国医师协会神经内科医师分会帕金森病及运动障碍专业. 中国帕金森病的诊断标准(2016版). 中华神经科杂志, 2016, 49(4): 268-271.
12. Hughes AJ, Daniel SE, Lees AJ. Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease. Neurology, 2001, 57(8): 1497-1499.
13. 陶欢, 杨乐天, 平安, 等. 随机或非随机防治性研究系统评价的质量评价工具AMSTAR2解读. 中国循证医学杂志, 2018, 18(1): 101-108.
14. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ, 2009, 339: b2535.
15. Balshem H, Helfanda M, J. Schunemann H, 等. GRADE指南:Ⅲ. 证据质量分级. 中国循证医学杂志, 2011, 11(4): 451-455.
16. 杨丽红, 杜元灏, 熊俊, 等. 针灸治疗帕金森病疗效的系统评价. 中国循证医学杂志, 2010, 10(6): 711-717.
17. 孙妙璇, 张雄. 针灸治疗帕金森病非运动症状疗效的Meta分析. 上海中医药大学学报, 2013, 27(5): 41-48,69.
18. 郭敏. 针刺治疗帕金森病的系统评价和meta分析. 杭州: 浙江中医药大学, 2016.
19. 眭兰, 宋芬芬, 蔡艳. 普通针刺联合美多芭治疗帕金森病的系统评价及meta分析. 湖南中医药大学学报, 2016, 36(2): 1384-1386.
20. 尹洪娜, 韩超, 孙忠人, 等. 针刺治疗帕金森病的系统评价和meta分析. 针灸临床杂志, 2016, 32(8): 67-70.
21. 张雪淳, 蒋丽, 伍亚男, 等. 基于Meta分析的艾灸治疗帕金森病疗效研究. 亚太传统医药, 2016, 12(14): 96-100.
22. 欧阳莎, 许巍. 针灸与西药治疗帕金森病疗效比较的系统评价. 中医药通报, 2017, 16(1): 34-38.
23. 刘艳慧, 陈涛, 邓益东, 等. 针刺治疗帕金森病临床疗效的Meta分析. 中国医师杂志, 2018, 20(1): 16-23, 27.
24. 柳默涵, 王述菊, 马骏, 等. 头针治疗帕金森病的Meta分析. 时珍国医国药, 2019, 30(8): 2011-2014.
25. 李旻颖. 基于“从阳论治”针灸治疗帕金森病肌强直的临床研究与机制探索. 广州: 广州中医药大学, 2020.
26. 李晓艳, 董勤建, 马天阳, 等. 针刺治疗帕金森病随机对照试验的系统评价. 黑龙江中医药, 2020, 49(3): 398-399.
27. 周景, 李俊龙, 李建良, 等. 针刺治疗帕金森病原发性运动症状的Meta分析. 环球中医药, 2020, 13(2): 326-333.
28. 郑梦文. 针灸治疗帕金森病的系统评价与Meta分析. 广州: 暨南大学, 2019.
29. 王延庆. 针灸疗法治疗帕金森病的网状meta分析. 乌鲁木齐: 新疆医科大学, 2020.
30. 傅嘉, 时晶. 针灸治疗改善帕金森病患者睡眠情况的Meta分析. 新疆医科大学学报, 2022, 45(11): 1348-1354, 1361.
31. 孙英, 潘佳慧, 张方圆, 等. 针灸治疗帕金森病非运动症状的Meta分析. 广州中医药大学学报, 2023, 40(2): 516-525.
32. Cho KH, Kim TH, Kwon S, et al. Moxibustion for idiopathic Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials. Eur J Integr Med, 2017, 13: 26-33.
33. Ko JH, Lee H, Kim SN, et al. Does acupuncture protect dopamine neurons in Parkinson's disease rodent model?: a systematic review and meta-analysis. Front Aging Neurosci, 2019, 11(5): 102.
34. Lee HS, Park HL, Lee SJ, et al. Scalp acupuncture for Parkinson's disease: a systematic review of randomized controlled trials. Chin J Integr Med, 2013, 19(4): 297-306.
35. Lee MS, Shin BC, Kong JC, et al. Effectiveness of acupuncture for Parkinson's disease: a systematic review. Mov Disord, 2008, 23(11): 1505-1515.
36. Lee SH, Lim S. Clinical effectiveness of acupuncture on Parkinson disease: a PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore), 2017, 96(3): e5836.
37. Li Q, Wu C, Wang X, et al. Effect of acupuncture for non-motor symptoms in patients with Parkinson's disease: a systematic review and meta-analysis. Front Aging Neurosci, 2022, 14: 995850.
38. Liu H, Chen L, Zhang Z, et al. Effectiveness and safety of acupuncture combined with madopar for Parkinson's disease: a systematic review with meta-analysis. Acupunct Med, 2017, 35(6): 404-412.
39. Qiang T, Sun H, Gai C, et al, Combination therapy of scalp electro-acupuncture and medication for the treatment of Parkinson's disease: a systematic review and meta-analysis. J Tradit Chin Med Sci, 2019, 6(1): 26-34.
40. Wei Y, Yao QP, Zhang PF, et al, Efficacy and safety of acupuncture in the treatment of Parkinson's: a meta analysis. Acta Medica Mediterranea, 2022, 38: 2003.
41. Wen X, Li K, Wen H, et al. Acupuncture-related therapies for Parkinson's disease: a meta-analysis and qualitative review. Front Aging Neurosci, 2021, 13: 676827.
42. Kwon M, Cheong MJ, Leem J, et al. Effect of acupuncture on movement function in patients with Parkinson's disease: network meta-analysis of randomized controlled trials. Healthcare (Basel), 2021, 9(11): 1502.
43. Noh H, Kwon S, Cho SY, et al. Effectiveness and safety of acupuncture in the treatment of Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials. Complement Ther Med, 2017, 34: 86-103.
44. Sun Y, Sheng J, Liu T, et al. Combination treatment of acupoint therapy and conventional medication for motor function of Parkinson's disease: a systematic review and meta-analysis. Complement Ther Clin Pract, 2023, 50: 101677.
45. Ruppar T. Meta-analysis: how to quantify and explain heterogeneity. Eur J Cardiovasc Nurs, 2020, 19(7): 646-652.
46. 张卓文, 翁晓兰. "双一流"背景下期刊论文规范"四要素"结构式摘要的实践优势. 浙江中医药大学学报, 2022, 46(11): 1292-1294,1300.
47. Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ, 2004, 328(7454): 1490.

Chinese Journal of Evidence-Based Medicine

Acupuncture and moxibustion for Parkinson’s disease: an overview of systematic reviews

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