• 1. Department of Oral and Maxillofacial Oncology & Surgery, the First Affiliated Hospital / Affiliated Stomatological Hospital of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Uygur Autonomous Region, Urumqi 830054, P. R. China;
  • 2. Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P. R. China;
  • 3. Center for Disease Control and Prevention, Xinjiang Production and Construction Corps, Urumqi 830092, P. R. China;
  • 4. Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing 400014, P. R. China;
  • 5. Department of Obstetrics and Gynecology, University Hospital Hamburg-Eppendorf (UKE), Hamburg 20246, Germany;
LI Chenxi, Email: lichenximed@163.com
Export PDF Favorites Scan Get Citation

Objective To systematically review the risk of hemorrhage in pregnant cerebral arteriovenous malformation (CAVM) patients. Methods The Web of Science, PubMed, Cochrane Library, WanFang Data, VIP and CNKI databases were electronically searched to collect clinical studies related to hemorrhage in pregnant CAVM patients from inception to June, 2023. Two reviewers independently screened literature, extracted data and assessed the risk of bias of the included studies. Meta-analysis was then performed by using Stata 13.1 and R 4.0.4 software. Results A total of 13 studies involving 2 273 patients were included. The results of meta-analysis showed that the pooled incidence of hemorrhage in pregnant CAVM patients was 0.18 (95%CI 0.12 to 0.24). The subgroup analyses were carried out based on world regions and the study duration, with the higher pooled incidence of 0.37 (95%CI 0.05 to 0.80) in Europe and 10 to 20 years of study duration of 0.37 (95%CI 0.17 to 0.57). Conclusion  Current evidence shows that the incidence of hemorrhage in pregnant CAVM patients is about 18%. Due to the limited quality and quantity of the included studies, more high quality studies are needed to verify the above conclusion.

Citation: LI Xinghong, LI Chenxi, WANG Zhengye, HUANG Dishu, DING Yi, ZHOU Yuchuan. Risk of hemorrhage in pregnant cerebral arteriovenous malformation patients: a systematic review. Chinese Journal of Evidence-Based Medicine, 2024, 24(9): 1016-1020. doi: 10.7507/1672-2531.202312131 Copy

  • Previous Article

    A survey on the demand for entrustable professional activities (EPAs) in the standardized training of general practitioners in the context of medical and educational collaboration
  • Next Article

    Methodological guidelines for health technology assessment: a systematic review