Analysis on the status and temporal trend of dementia burden in Guangzhou from 2008 to 2019 and burden attributable to smoking_Chinese Journal of Evidence-Based Medicine

Authors：

GAO Jing ^1,2 , TAN Wenjing ¹ , ZHANG Xinmei ² ,  ZHOU Shangcheng ³ , LI Chengcheng ³ , XIONG Xuejun ²

1. School of Public Health and Management, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P. R. China;
2. School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P. R. China;
3. College of Humanities and Management, Zhejiang Chinese Medical University, Hangzhou, 310053, P. R. China;

Corresponding author：

ZHOU Shangcheng, Email: whzsc2008@hotmail.com

Keywords：

Dementia; Alzheimer’s disease; Mortality; Disease burden; Smoking

DOI：

10.7507/1672-2531.202402067

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To analyze the characteristic and temporal trend in mortality and disease burden of Alzheimer’s disease (AD) and other forms of dementia in Guangzhou from 2008 to 2019, and estimate the disease burden attributable to smoking to provide evidence for promoting local health policy of prevention and intervention of dementia. Methods Based on the data of Guangzhou surveillance point of the National Mortality Surveillance System (NMSS), the crude mortality, standardized mortality, years of life lost (YLL) of AD and other dementia were calculated. The indirect method was used to estimate years lived with disability (YLD) and disability-adjusted lifeyears (DALY).The distribution and changing trends of the index rates were compared from 2008 to 2019 using Joinpoint Regression Program.Based on the data of Guangzhou Chronic Disease and Risk Factors Monitoring System in 2013, the indexes of disease burden of AD and other forms of dementia attributable to smoking in 2018 was calculated. Results The standardized mortality rate, YLL rate, YLD rate and DALY rate of AD and other forms of dementia in Guangzhou increased from 0.45/100 000, 0.05‰, 0.02‰ and 0.07 ‰ in 2008 to 1.28/100 000, 0.15‰, 0.07‰ and 0.22‰ in 2019, respectively. The average annual changing trend was statistically significant (AAPC=11.30%, 13.09%, 13.09%, 13.09%, P<0.001）. In most years, the mortality and disease burden of women were higher than those of men, but men had higher growing trend than women in standardized mortality rate, YLL rate, YLD rate and DALY rate from 2008 to 2019, with a slower growing speed after the year 2012.The disease burden of dementia attributable to smoking in men was significantly higher than that in women. Conclusion The mortality and disease burden of AD and other forms of dementia in Guangzhou have dramatically increased over the past twelve years. Intervention against modifiable factors such as smoking, and prevention and screening for dementia in key populations should be strengthened. Support policies for dementia care management should be adopted to reduce the disease burden caused by premature death and disability.

1.	中国痴呆与认知障碍指南写作组, 中国医师协会神经内科医师分会认知障碍疾病专业委员会. 2018中国痴呆与认知障碍诊治指南(一): 痴呆及其分类诊断标准. 中华医学杂志, 2018, 98(13): 965-970.
2.	Gauthier S, Albert M, Fox N, et al. Why has therapy development for dementia failed in the last two decades. Alzheimers Dement, 2016, 12(1): 60-64.
3.	No authors listed. 2020 Alzheimer's disease facts and figures. Alzheimers Dement. 2020. Epub ahead of print.
4.	GBD 2016 Dementia Collaborators. Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol, 2019, 18(1): 88-106.
5.	Livingston G, Huntley J, Liu KY, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Standing Commission. Lancet, 2024, 404(10452): 572-628.
6.	Batty GD, Shipley MJ, Kvaavik E, et al. Biomarker assessment of tobacco smoking exposure and risk of dementia death: pooling of individual participant data from 14 cohort studies. J Epidemiol Community Health, 2018, 72(6): 513-515.
7.	Zhong G, Wang Y, Zhang Y, et al. Smoking is associated with an increased risk of dementia: a meta-analysis of prospective cohort studies with investigation of potential effect modifiers. PLoS One, 2015, 10(3): e0118333.
8.	Mukadam N, Sommerlad A, Huntley J, et al. Population attributable fractions for risk factors for dementia in low-income and middle-income countries: an analysis using cross-sectional survey data. Lancet Glob Health, 2019, 7(5): e596-e603.
9.	任汝静, 殷鹏, 王志会, 等. 中国阿尔茨海默病报告2021. 诊断学理论与实践, 2021, 20(4): 317-337.
10.	Jia L, Du Y, Chu L, et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study. Lancet Public Health, 2020, 5(12): e661-e671.
11.	张静雅, 鲁永博, 李浩然, 等. 中国居民1990—2019年老年痴呆症疾病负担年龄–时期–队列分析及预测. 中国公共卫生, 2022, 38(5): 523-528.
12.	Wang M, Luo X, Xu S, et al. Trends in smoking prevalence and implication for chronic diseases in China: serial national cross-sectional surveys from 2003 to 2013. Lancet Respir Med, 2019, 7(1): 35-45.
13.	Jiang Y, Man Q, Liu Z, et al. Temporal trends in the mortality rate of Alzheimer's disease and other dementias attributable to smoking, 1990-2017. Environ Res, 2020, 184: 109183.
14.	尹孟凡, 崔玉蓉, 陈芝蕙, 等. 1990―2019年中国阿尔茨海默病疾病负担及危险因素. 中华疾病控制杂志, 2024, 28(1): 32-39.
15.	Li R, Qi J, Yang Y, et al. Disease burden and attributable risk factors of Alzheimer's disease and dementia in China from 1990 to 2019. J Prev Alzheimers Dis, 2022, 9(2): 306-314.
16.	卢添欢, 宇传华. 基于全球视角的中国痴呆症疾病负担现状及趋势分析. 中华疾病控制杂志, 2022, 26(6): 684-690.
17.	葛珊珊, 张志将. 1990—2017年中国阿尔茨海默病疾病负担趋势分析. 中国慢性病预防与控制, 2021, 29(9): 718-722.
18.	黄磊, 孟令昊, 欧汝威, 等. 1990—2019年中国人群阿尔茨海默病与其他痴呆症的疾病负担分析. 现代预防医学, 2021, 48(14): 2515-2519.
19.	Bo Z, Wan Y, Meng SS, et al. The temporal trend and distribution characteristics in mortality of Alzheimer's disease and other forms of dementia in China: based on the National Mortality Surveillance System (NMS) from 2009 to 2015. PLoS One, 2019, 14(1): e0210621.
20.	沈银. 广州地区城乡65岁及以上老人轻度认知障碍和痴呆的流行病学调查. 广州: 广州医学院, 2011.
21.	GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet, 2020, 396(10258): 1223-1249.
22.	GBD 2017 Risk Factor Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2018, 392(10159): 1923-1994.
23.	袁晓霞, 周尚成, 高昭昇, 等. 2017—2019年广州市脑卒中疾病负担分析. 中国慢性病预防与控制, 2021, 29(6): 474-478.
24.	GBD 2016 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 2017, 390(10100): 1345-1422.
25.	中国疾病预防控制中心. 中国慢性病及其危险因素监测报告2013. 北京: 军事医学出版社, 2016.
26.	丁贤彬, 焦艳, 毛德强, 等. 2012—2018年重庆市阿尔茨海默病死亡率及疾病负担变化趋势. 中国慢性病预防与控制, 2020, 28(9): 665-668.
27.	王浩, 李娜, 俞佳男, 等. 2003—2017年浙江省阿尔茨海默病发病和死亡趋势分析. 预防医学, 2022, 34(3): 227-231,239.
28.	Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet, 2020, 396(10248): 413-446.
29.	国家卫生健康委员会. 2019年中国卫生统计年鉴. 北京: 中国卫生出版社, 2020.
30.	Rahman A, Schelbaum E, Hoffman K, et al. Sex-driven modifiers of Alzheimer risk: a multimodality brain imaging study. Neurology, 2020, 95(2): e166-e178.
31.	陈可冀, 唐希灿, 何新贵, 等. 《中国应对阿尔茨海默病战略行动计划》建议书. 阿尔茨海默病及相关病杂志, 2021, 4(2): 91-97.
32.	张波, 张连生, 程桂荣, 等. 痴呆危险因素人群归因分值的城乡差异. 中华疾病控制杂志, 2021, 25(7): 854-858,863.
33.	GBD 2015 Tobacco Collaborators. Smoking prevalence and attributable disease burden in 195 countries and territories, 1990-2015: a systematic analysis from the Global Burden of Disease Study 2015. Lancet, 2017, 389(10082): 1885-1906.
34.	Ng M, Freeman MK, Fleming TD, et al. Smoking prevalence and cigarette consumption in 187 countries, 1980-2012. JAMA, 2014, 311(2): 183-192.
35.	Durazzo TC, Mattsson N, Weiner MW, et al. Smoking and increased Alzheimer's disease risk: a review of potential mechanisms. Alzheimers Dement, 2014, 10(3 Suppl): S122-145.

1. 中国痴呆与认知障碍指南写作组, 中国医师协会神经内科医师分会认知障碍疾病专业委员会. 2018中国痴呆与认知障碍诊治指南(一): 痴呆及其分类诊断标准. 中华医学杂志, 2018, 98(13): 965-970.
2. Gauthier S, Albert M, Fox N, et al. Why has therapy development for dementia failed in the last two decades. Alzheimers Dement, 2016, 12(1): 60-64.
3. No authors listed. 2020 Alzheimer's disease facts and figures. Alzheimers Dement. 2020. Epub ahead of print.
4. GBD 2016 Dementia Collaborators. Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol, 2019, 18(1): 88-106.
5. Livingston G, Huntley J, Liu KY, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Standing Commission. Lancet, 2024, 404(10452): 572-628.
6. Batty GD, Shipley MJ, Kvaavik E, et al. Biomarker assessment of tobacco smoking exposure and risk of dementia death: pooling of individual participant data from 14 cohort studies. J Epidemiol Community Health, 2018, 72(6): 513-515.
7. Zhong G, Wang Y, Zhang Y, et al. Smoking is associated with an increased risk of dementia: a meta-analysis of prospective cohort studies with investigation of potential effect modifiers. PLoS One, 2015, 10(3): e0118333.
8. Mukadam N, Sommerlad A, Huntley J, et al. Population attributable fractions for risk factors for dementia in low-income and middle-income countries: an analysis using cross-sectional survey data. Lancet Glob Health, 2019, 7(5): e596-e603.
9. 任汝静, 殷鹏, 王志会, 等. 中国阿尔茨海默病报告2021. 诊断学理论与实践, 2021, 20(4): 317-337.
10. Jia L, Du Y, Chu L, et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study. Lancet Public Health, 2020, 5(12): e661-e671.
11. 张静雅, 鲁永博, 李浩然, 等. 中国居民1990—2019年老年痴呆症疾病负担年龄–时期–队列分析及预测. 中国公共卫生, 2022, 38(5): 523-528.
12. Wang M, Luo X, Xu S, et al. Trends in smoking prevalence and implication for chronic diseases in China: serial national cross-sectional surveys from 2003 to 2013. Lancet Respir Med, 2019, 7(1): 35-45.
13. Jiang Y, Man Q, Liu Z, et al. Temporal trends in the mortality rate of Alzheimer's disease and other dementias attributable to smoking, 1990-2017. Environ Res, 2020, 184: 109183.
14. 尹孟凡, 崔玉蓉, 陈芝蕙, 等. 1990―2019年中国阿尔茨海默病疾病负担及危险因素. 中华疾病控制杂志, 2024, 28(1): 32-39.
15. Li R, Qi J, Yang Y, et al. Disease burden and attributable risk factors of Alzheimer's disease and dementia in China from 1990 to 2019. J Prev Alzheimers Dis, 2022, 9(2): 306-314.
16. 卢添欢, 宇传华. 基于全球视角的中国痴呆症疾病负担现状及趋势分析. 中华疾病控制杂志, 2022, 26(6): 684-690.
17. 葛珊珊, 张志将. 1990—2017年中国阿尔茨海默病疾病负担趋势分析. 中国慢性病预防与控制, 2021, 29(9): 718-722.
18. 黄磊, 孟令昊, 欧汝威, 等. 1990—2019年中国人群阿尔茨海默病与其他痴呆症的疾病负担分析. 现代预防医学, 2021, 48(14): 2515-2519.
19. Bo Z, Wan Y, Meng SS, et al. The temporal trend and distribution characteristics in mortality of Alzheimer's disease and other forms of dementia in China: based on the National Mortality Surveillance System (NMS) from 2009 to 2015. PLoS One, 2019, 14(1): e0210621.
20. 沈银. 广州地区城乡65岁及以上老人轻度认知障碍和痴呆的流行病学调查. 广州: 广州医学院, 2011.
21. GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet, 2020, 396(10258): 1223-1249.
22. GBD 2017 Risk Factor Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2018, 392(10159): 1923-1994.
23. 袁晓霞, 周尚成, 高昭昇, 等. 2017—2019年广州市脑卒中疾病负担分析. 中国慢性病预防与控制, 2021, 29(6): 474-478.
24. GBD 2016 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 2017, 390(10100): 1345-1422.
25. 中国疾病预防控制中心. 中国慢性病及其危险因素监测报告2013. 北京: 军事医学出版社, 2016.
26. 丁贤彬, 焦艳, 毛德强, 等. 2012—2018年重庆市阿尔茨海默病死亡率及疾病负担变化趋势. 中国慢性病预防与控制, 2020, 28(9): 665-668.
27. 王浩, 李娜, 俞佳男, 等. 2003—2017年浙江省阿尔茨海默病发病和死亡趋势分析. 预防医学, 2022, 34(3): 227-231,239.
28. Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet, 2020, 396(10248): 413-446.
29. 国家卫生健康委员会. 2019年中国卫生统计年鉴. 北京: 中国卫生出版社, 2020.
30. Rahman A, Schelbaum E, Hoffman K, et al. Sex-driven modifiers of Alzheimer risk: a multimodality brain imaging study. Neurology, 2020, 95(2): e166-e178.
31. 陈可冀, 唐希灿, 何新贵, 等. 《中国应对阿尔茨海默病战略行动计划》建议书. 阿尔茨海默病及相关病杂志, 2021, 4(2): 91-97.
32. 张波, 张连生, 程桂荣, 等. 痴呆危险因素人群归因分值的城乡差异. 中华疾病控制杂志, 2021, 25(7): 854-858,863.
33. GBD 2015 Tobacco Collaborators. Smoking prevalence and attributable disease burden in 195 countries and territories, 1990-2015: a systematic analysis from the Global Burden of Disease Study 2015. Lancet, 2017, 389(10082): 1885-1906.
34. Ng M, Freeman MK, Fleming TD, et al. Smoking prevalence and cigarette consumption in 187 countries, 1980-2012. JAMA, 2014, 311(2): 183-192.
35. Durazzo TC, Mattsson N, Weiner MW, et al. Smoking and increased Alzheimer's disease risk: a review of potential mechanisms. Alzheimers Dement, 2014, 10(3 Suppl): S122-145.

Chinese Journal of Evidence-Based Medicine

Latest ArticlesAnalysis on the status and temporal trend of dementia burden in Guangzhou from 2008 to 2019 and burden attributable to smoking

Abstract Full text Figures/Tables Video References Cited by

Format

Content