Interpretation of Comprehensive intervention for sarcopenia among older adults: an evidence-based clinical practice guideline_Chinese Journal of Evidence-Based Medicine

Authors：

LI Daiping ¹ , SHEN Yanjiao ² , HAO Qiukui ¹ , ZHANG Meng ¹ , XIAN Hong ¹ , DONG Birong ¹ ,  YUE Jirong ¹

1. Department of Geriatrics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. Innovation Institute for Integration of Medicine and Engineering, Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

YUE Jirong, Email: yuejirong11@hotmail.com

Keywords：

Sarcopenia; Intervention; Nutrition; Exercise; Interpretation

DOI：

10.7507/1672-2531.202405112

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Sarcopenia, a skeletal muscle degenerative condition, is inextricably linked to the physiological processes of aging. Sarcopenia is characterized by a reduction in muscle mass, a decline in muscle strength, and/or deterioration of physical function. Comprehensive interventions are essential for the management of sarcopenia. The team from the National Clinical Research Center for Geriatrics has authored the "Comprehensive intervention for sarcopenia among older adults: an evidence-based clinical practice guideline" which discuss the specific contents of exercise, nutrition, and drug interventions for sarcopenia. This article provides a comprehensive interpretation of the guidelines to facilitate their dissemination, promotion, and application.

1.	Dent E, Morley JE, Cruz-Jentoft AJ, et al. International clinical practice guidelines for sarcopenia (ICFSR): screening, diagnosis and management. J Nutr Health Aging, 2018, 22(10): 1148-1161.
2.	Cruz-Jentoft AJ, Sayer AA. Sarcopenia. Lancet, 2019, 393(10191): 2636-2646.
3.	刘娟, 丁清清, 周白瑜, 等. 中国老年人肌少症诊疗专家共识(2021). 中华老年医学杂志, 2021, 40(8): 943-952.
4.	甄志龙, 赵建民, 孙逊, 等. 肌少症的诊疗共识解读与研究进展. 生物骨科材料与临床研究, 2023, 20(1): 71-75.
5.	Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing, 2019, 48(1): 16-31.
6.	沈妍交, 郝秋奎, 张蒙, 等. 老年肌少症综合干预循证临床实践指南. 中国循证医学杂志, 2024, 24(4): 378-384.
7.	杨玲, 杜娟, 刘荣雁, 等. 肌肉减少症病因学研究现状与展望. 中国骨质疏松杂志, 2020, 26(11): 1689-1693.
8.	Fragala MS, Cadore EL, Dorgo S, et al. Resistance training for older adults: position statement from the national strength and conditioning association. J Strength Cond Res, 2019, 33(8): 2019-2052.
9.	de Mello RGB, Dalla Corte RR, Gioscia J, et al. Effects of physical exercise programs on sarcopenia management, dynapenia, and physical performance in the elderly: a systematic review of randomized clinical trials. J Aging Res, 2019, 2019: 1959486.
10.	Lopes KG, Bottino DA, Farinatti P, et al. Strength training with blood flow restriction - a novel therapeutic approach for older adults with sarcopenia. A case report. Clin Interv Aging, 2019, 14: 1461-1469.
11.	中华医学会老年医学分会老年康复学组, 肌肉衰减综合征专家共识撰写组. 肌肉衰减综合征中国专家共识(草案). 中华老年医学杂志, 2017, 36(7): 711-718.
12.	Ossowski ZM, Skrobot W, Aschenbrenner P, et al. Effects of short-term Nordic walking training on sarcopenia-related parameters in women with low bone mass: a preliminary study. Clin Interv Aging, 2016, 11: 1763-1771.
13.	Yang LJ, Wu GH, Yang YL, et al. Nutrition, physical exercise, and the prevalence of sarcopenia in elderly residents in nursing homes in China. Med Sci Monit, 2019, 25: 4390-4399.
14.	Shen Y, Shi Q, Nong K, et al. Exercise for sarcopenia in older people: a systematic review and network meta-analysis. J Cachexia Sarcopenia Muscle, 2023, 14(3): 1199-1211.
15.	闵文珺, 陈亚梅, 卢群, 等. 老年肌少症患者运动干预的最佳证据总结. 解放军护理杂志, 2022, 39(3): 75-78.
16.	Liu X, Xia X, Hu F, et al. Nutrition status mediates the association between cognitive decline and sarcopenia. Aging (Albany NY), 2021, 13(6): 8599-8610.
17.	Beaudart C, Sanchez-Rodriguez D, Locquet M, et al. Malnutrition as a strong predictor of the onset of sarcopenia. Nutrients, 2019, 11(12): 2883.
18.	Sieber CC. Malnutrition and sarcopenia. Aging Clin Exp Res, 2019, 31(6): 793-798.
19.	崔华, 王朝晖, 吴剑卿, 等. 老年人肌少症防控干预中国专家共识(2023). 中华老年医学杂志, 2023, 42(2): 144-153.
20.	周晓宁, 许金海, 王国栋, 等. 肌少症治疗. 中华骨质疏松和骨矿盐疾病杂志, 2020, 13(3): 272-279.
21.	Brioche T, Kireev RA, Cuesta S, et al. Growth hormone replacement therapy prevents sarcopenia by a dual mechanism: improvement of protein balance and of antioxidant defenses. J Gerontol A Biol Sci Med Sci, 2014, 69(10): 1186-1198.
22.	Giannoulis MG, Martin FC, Nair KS, et al. Hormone replacement therapy and physical function in healthy older men. Time to talk hormones? Endocr Rev, 2012, 33(3): 314-377.
23.	Morley JE. Pharmacologic options for the treatment of sarcopenia. Calcif Tissue Int, 2016, 98(4): 319-333.
24.	Nieschlag E. Current topics in testosterone replacement of hypogonadal men. Best Pract Res Clin Endocrinol Metab, 2015, 29(1): 77-90.
25.	Papanicolaou DA, Ather SN, Zhu H, et al. A phase ⅡA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia. J Nutr Health Aging, 2013, 17(6): 533-543.
26.	Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol, 2013, 14(4): 335-345.
27.	White HK, Petrie CD, Landschulz W, et al. Effects of an oral growth hormone secretagogue in older adults. J Clin Endocrinol Metab, 2009, 94(4): 1198-1206.
28.	杨惠, 额尔敦木图, 姜建强, 等. 肌肉生长抑制素对骨骼肌作用研究进展. 动物医学进展, 2016, 37(5): 77-81,82.
29.	Padhi D, Higano CS, Shore ND, et al. Pharmacological inhibition of myostatin and changes in lean body mass and lower extremity muscle size in patients receiving androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab, 2014, 99(10): E1967-E1975.
30.	梁清月, 王仲, 刘戎, 等. 加减八珍汤联合营养支持治疗老年骨骼肌减少症疗效观察. 中国中西医结合杂志, 2019, 39(7): 821-825.
31.	陈欢, 张莉, 崔强, 等. 电针阿是穴对骨骼肌损伤大鼠肌肉再生及碱性成纤维细胞生长因子表达的影响. 中国康复理论与实践, 2013, 19(4): 334-340.

1. Dent E, Morley JE, Cruz-Jentoft AJ, et al. International clinical practice guidelines for sarcopenia (ICFSR): screening, diagnosis and management. J Nutr Health Aging, 2018, 22(10): 1148-1161.
2. Cruz-Jentoft AJ, Sayer AA. Sarcopenia. Lancet, 2019, 393(10191): 2636-2646.
3. 刘娟, 丁清清, 周白瑜, 等. 中国老年人肌少症诊疗专家共识(2021). 中华老年医学杂志, 2021, 40(8): 943-952.
4. 甄志龙, 赵建民, 孙逊, 等. 肌少症的诊疗共识解读与研究进展. 生物骨科材料与临床研究, 2023, 20(1): 71-75.
5. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing, 2019, 48(1): 16-31.
6. 沈妍交, 郝秋奎, 张蒙, 等. 老年肌少症综合干预循证临床实践指南. 中国循证医学杂志, 2024, 24(4): 378-384.
7. 杨玲, 杜娟, 刘荣雁, 等. 肌肉减少症病因学研究现状与展望. 中国骨质疏松杂志, 2020, 26(11): 1689-1693.
8. Fragala MS, Cadore EL, Dorgo S, et al. Resistance training for older adults: position statement from the national strength and conditioning association. J Strength Cond Res, 2019, 33(8): 2019-2052.
9. de Mello RGB, Dalla Corte RR, Gioscia J, et al. Effects of physical exercise programs on sarcopenia management, dynapenia, and physical performance in the elderly: a systematic review of randomized clinical trials. J Aging Res, 2019, 2019: 1959486.
10. Lopes KG, Bottino DA, Farinatti P, et al. Strength training with blood flow restriction - a novel therapeutic approach for older adults with sarcopenia. A case report. Clin Interv Aging, 2019, 14: 1461-1469.
11. 中华医学会老年医学分会老年康复学组, 肌肉衰减综合征专家共识撰写组. 肌肉衰减综合征中国专家共识(草案). 中华老年医学杂志, 2017, 36(7): 711-718.
12. Ossowski ZM, Skrobot W, Aschenbrenner P, et al. Effects of short-term Nordic walking training on sarcopenia-related parameters in women with low bone mass: a preliminary study. Clin Interv Aging, 2016, 11: 1763-1771.
13. Yang LJ, Wu GH, Yang YL, et al. Nutrition, physical exercise, and the prevalence of sarcopenia in elderly residents in nursing homes in China. Med Sci Monit, 2019, 25: 4390-4399.
14. Shen Y, Shi Q, Nong K, et al. Exercise for sarcopenia in older people: a systematic review and network meta-analysis. J Cachexia Sarcopenia Muscle, 2023, 14(3): 1199-1211.
15. 闵文珺, 陈亚梅, 卢群, 等. 老年肌少症患者运动干预的最佳证据总结. 解放军护理杂志, 2022, 39(3): 75-78.
16. Liu X, Xia X, Hu F, et al. Nutrition status mediates the association between cognitive decline and sarcopenia. Aging (Albany NY), 2021, 13(6): 8599-8610.
17. Beaudart C, Sanchez-Rodriguez D, Locquet M, et al. Malnutrition as a strong predictor of the onset of sarcopenia. Nutrients, 2019, 11(12): 2883.
18. Sieber CC. Malnutrition and sarcopenia. Aging Clin Exp Res, 2019, 31(6): 793-798.
19. 崔华, 王朝晖, 吴剑卿, 等. 老年人肌少症防控干预中国专家共识(2023). 中华老年医学杂志, 2023, 42(2): 144-153.
20. 周晓宁, 许金海, 王国栋, 等. 肌少症治疗. 中华骨质疏松和骨矿盐疾病杂志, 2020, 13(3): 272-279.
21. Brioche T, Kireev RA, Cuesta S, et al. Growth hormone replacement therapy prevents sarcopenia by a dual mechanism: improvement of protein balance and of antioxidant defenses. J Gerontol A Biol Sci Med Sci, 2014, 69(10): 1186-1198.
22. Giannoulis MG, Martin FC, Nair KS, et al. Hormone replacement therapy and physical function in healthy older men. Time to talk hormones? Endocr Rev, 2012, 33(3): 314-377.
23. Morley JE. Pharmacologic options for the treatment of sarcopenia. Calcif Tissue Int, 2016, 98(4): 319-333.
24. Nieschlag E. Current topics in testosterone replacement of hypogonadal men. Best Pract Res Clin Endocrinol Metab, 2015, 29(1): 77-90.
25. Papanicolaou DA, Ather SN, Zhu H, et al. A phase ⅡA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia. J Nutr Health Aging, 2013, 17(6): 533-543.
26. Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol, 2013, 14(4): 335-345.
27. White HK, Petrie CD, Landschulz W, et al. Effects of an oral growth hormone secretagogue in older adults. J Clin Endocrinol Metab, 2009, 94(4): 1198-1206.
28. 杨惠, 额尔敦木图, 姜建强, 等. 肌肉生长抑制素对骨骼肌作用研究进展. 动物医学进展, 2016, 37(5): 77-81,82.
29. Padhi D, Higano CS, Shore ND, et al. Pharmacological inhibition of myostatin and changes in lean body mass and lower extremity muscle size in patients receiving androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab, 2014, 99(10): E1967-E1975.
30. 梁清月, 王仲, 刘戎, 等. 加减八珍汤联合营养支持治疗老年骨骼肌减少症疗效观察. 中国中西医结合杂志, 2019, 39(7): 821-825.
31. 陈欢, 张莉, 崔强, 等. 电针阿是穴对骨骼肌损伤大鼠肌肉再生及碱性成纤维细胞生长因子表达的影响. 中国康复理论与实践, 2013, 19(4): 334-340.

Chinese Journal of Evidence-Based Medicine

Latest ArticlesInterpretation of Comprehensive intervention for sarcopenia among older adults: an evidence-based clinical practice guideline

Abstract Full text Figures/Tables Video References Cited by

Format

Content