Research question importance tool and its exploratory application in the field of Chinese medicine_Chinese Journal of Evidence-Based Medicine

Authors：

CHENG Ting ¹ , SONG Linjie ¹ , TANG Qi ¹ , QIU Xingying ¹ , YU Dongdong ^1,2 ,  LI Geng ³ ,  WEN Zehuai ^3,4

1. Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, P. R. China;
2. First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, P. R. China;
3. Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, P. R. China;
4. Science and Technology Innovation Center of Guangzhou University of Chinese Medicine, Guangzhou 510405, P. R. China;

Corresponding author：

LI Geng, Email: ligeng@gzucm.edu.cn; WEN Zehuai, Email: wenzh@gzucm.edu.cn

Keywords：

Research question; Importance; Assessment; Chinese medicine

DOI：

10.7507/1672-2531.2024060017

Video：

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Objective To introduce and preliminarily apply a tool for assessing the importance of research questions (Australia & New Zealand Musculoskeletal Clinical Trials Network Research Question Importance Tool, ANZMUSC-RQIT), thereby providing a methodological reference for selecting research questions. Methods An overview of the development process and main content of ANZMUSC-RQIT is provided, and an exploratory application of the tool is conducted to evaluate clinical research questions in the field of musculoskeletal disorders (MSKDs) within Chinese Medicine (CM). Results ANZMUSC-RQIT assesses the importance of specific research questions across five dimensions. Currently, clinical research on MSKDs in CM often focuses on the consensus among stakeholders regarding the importance of issues, prioritizes addressing problems that pose a significant burden on patients, and aims to alleviate clinical symptoms as the main intervention goal. The total score of ANZMUSC-RQIT is positively correlated with journal impact but shows no statistically significant relationship with citation frequency. Additionally, national funding support is positively correlated with the RQIT total score of the research question. Conclusion The development of ANZMUSC-RQIT provides valuable reference and inspiration for selecting future research questions. However, to more effectively assess the importance of CM clinical research questions, there is a pressing need to develop an evaluation tool tailored to the specific characteristics of CM clinical research.

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2.	中国卒中学会重症脑血管病分会, 中华医学会神经病学分会神经重症协作组. 中国神经重症临床研究优先发展方向科学声明. 中华医学杂志, 2022, 102(3): 166-174.
3.	孙洪娜, 姜宇婷, 赵丽军, 等. 地方病学"十四五"优先发展领域的探讨. 中华地方病学杂志, 2021, 40(11): 861-865.
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5.	Xia Y, Wu Q, Wang H, et al. Global, regional and national burden of gout, 1990-2017: a systematic analysis of the Global Burden of Disease Study. Rheumatology (Oxford), 2020, 59(7): 1529-1538.
6.	吴惠一, 袁琴, 张洋, 等. 1990―2019年我国肌肉骨骼疾病负担分析. 中华疾病控制杂志, 2023, 27(06): 655-661.
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11.	胡嘉元, 张晓雨, 蒋寅, 等. 我国临床研究发展现状及中医临床研究存在的问题、策略和实践. 世界科学技术-中医药现代化, 2018, 20(8): 1417-1421.
12.	Taylor WJ, Willink R, O'Connor DA, et al. Which clinical research questions are the most important? Development and preliminary validation of the Australia & New Zealand Musculoskeletal (ANZMUSC) Clinical Trials Network Research Question Importance Tool (ANZMUSC-RQIT). PLoS One, 2023, 18(3): e0281308.
13.	Luijendijk HJ. How to create PICO questions about diagnostic tests. BMJ Evid Based Med, 2021, 26(4): 155-157.
14.	秦裕辉. 试论中医临床研究的选题原则与方法. 湖南中医药导报, 1998, (1): 7.
15.	翁鸿, 朱风雷, 田国祥, 等. 临床研究方案设计要点之构建研究问题. 中国循证心血管医学杂志, 2017, 9(7): 769-771.
16.	张晓雨, 邱瑞瑾, 李承羽, 等. 中医临床研究优先领域/主题设置思路与方法. 中国循证医学杂志, 2019, 19(3): 373-376.
17.	陈雅馨. 中医指南临床问题优先遴选方法构建研究. 北京: 中国中医科学院, 2023.
18.	姚沙, 卢传坚, 陈耀龙, 等. 中医(中西医结合)临床实践指南制修订方法——指南选题. 中华中医药杂志, 2016, 31(2): 542-546.
19.	Bourne AM, Johnston RV, Cyril S, et al. Scoping review of priority setting of research topics for musculoskeletal conditions. BMJ Open, 2018, 8(12): e023962.
20.	Louviere JJFT, Marley AAJ. Best-worst scaling: theory, methods and applications. Cambridge: Cambridge University Press, 2015.

1. 张俊, 陈国强. 聚焦临床关键科学问题充实科学基金资助体系. 中国科学基金, 2024, 38(2): 308-313.
2. 中国卒中学会重症脑血管病分会, 中华医学会神经病学分会神经重症协作组. 中国神经重症临床研究优先发展方向科学声明. 中华医学杂志, 2022, 102(3): 166-174.
3. 孙洪娜, 姜宇婷, 赵丽军, 等. 地方病学"十四五"优先发展领域的探讨. 中华地方病学杂志, 2021, 40(11): 861-865.
4. GBD 2021 Other Musculoskeletal Disorders Collaborators. Global, regional, and national burden of other musculoskeletal disorders, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol, 2023, 5(11): e670-e682.
5. Xia Y, Wu Q, Wang H, et al. Global, regional and national burden of gout, 1990-2017: a systematic analysis of the Global Burden of Disease Study. Rheumatology (Oxford), 2020, 59(7): 1529-1538.
6. 吴惠一, 袁琴, 张洋, 等. 1990―2019年我国肌肉骨骼疾病负担分析. 中华疾病控制杂志, 2023, 27(06): 655-661.
7. Kerr R. Concerns about the Australian Institute of health and welfare's information on capital investment for healthcare. Aust Health Rev, 2015, 39(4): 453-454.
8. Chalmers I, Glasziou P. Avoidable waste in the production and reporting of research evidence. Obstet Gynecol, 2009, 114(6): 1341-1345.
9. Bourne AM, Whittle SL, Richards BL, et al. The scope, funding and publication of musculoskeletal clinical trials performed in Australia. Med J Aust, 2014, 200(2): 88-91.
10. 张晓雨, 商洪才. 近十年国内中医药临床研究发展现状及存在的问题. 中医杂志, 2018, 59(21): 1808-1811.
11. 胡嘉元, 张晓雨, 蒋寅, 等. 我国临床研究发展现状及中医临床研究存在的问题、策略和实践. 世界科学技术-中医药现代化, 2018, 20(8): 1417-1421.
12. Taylor WJ, Willink R, O'Connor DA, et al. Which clinical research questions are the most important? Development and preliminary validation of the Australia & New Zealand Musculoskeletal (ANZMUSC) Clinical Trials Network Research Question Importance Tool (ANZMUSC-RQIT). PLoS One, 2023, 18(3): e0281308.
13. Luijendijk HJ. How to create PICO questions about diagnostic tests. BMJ Evid Based Med, 2021, 26(4): 155-157.
14. 秦裕辉. 试论中医临床研究的选题原则与方法. 湖南中医药导报, 1998, (1): 7.
15. 翁鸿, 朱风雷, 田国祥, 等. 临床研究方案设计要点之构建研究问题. 中国循证心血管医学杂志, 2017, 9(7): 769-771.
16. 张晓雨, 邱瑞瑾, 李承羽, 等. 中医临床研究优先领域/主题设置思路与方法. 中国循证医学杂志, 2019, 19(3): 373-376.
17. 陈雅馨. 中医指南临床问题优先遴选方法构建研究. 北京: 中国中医科学院, 2023.
18. 姚沙, 卢传坚, 陈耀龙, 等. 中医(中西医结合)临床实践指南制修订方法——指南选题. 中华中医药杂志, 2016, 31(2): 542-546.
19. Bourne AM, Johnston RV, Cyril S, et al. Scoping review of priority setting of research topics for musculoskeletal conditions. BMJ Open, 2018, 8(12): e023962.
20. Louviere JJFT, Marley AAJ. Best-worst scaling: theory, methods and applications. Cambridge: Cambridge University Press, 2015.

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