Efficacy and aging comparative study of different doses and sources of lamotrigine on cortex convulsive threshold in electrical stimulated rats_Journal of Epilepsy

Authors：

 SUYu ¹ , HAOWeicheng ¹ , LIUCongxi ¹ , ZHAOYongxiong ¹ ,  LIUYuxi ²

1. West courtyard of the Second Hospital of Shanxi Medical University, Taiyuan 030024, China;
2. Institute of Epilepsy of Shanxi Medical University, Taiyuan 030053, China;

Corresponding author：

LIUYuxi, Email: liuyuxi2003@163.com

Keywords：

Epilepsy; Lamotrigine; Different sources; Convulsions threshold; Rats

DOI：

10.7507/2096-0247.20160022

Video：

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Objective Using cortex convulsions threshold detector and electrical stimulation in rats cortex convulsions threshold model, compare the efficacy and aging of domestic lamotrigine (LTG) and imported LTG. Methods Electrical stimulation convulsions threshold model in rats after stability, 40 rats were randomly divided into A、B、C、D groups,AandBgroup were divided into three different dose groups: domestic LTG low dose (12.5 mg/kg/d), middle dose (25 mg/kg·d), high dose group (37.5 mg/kg·d); imported LTG low doses (12.5 mg/kg·d), middle dose (25 mg/kg·d), high dose group (37.5 mg/kg·d); Carbamazepine middle dose group (72 mg/kg·d); the control group (normal saline 2 ml/time). Recording electrical stimulation in rats cortex convulsions threshold model after administration, compare the differences before and after the administration. Results Three different dose groups of domestic LTG and imported LTG all hadahigher level of electrical stimulation cortex convulsions threshold, and showedadose-response relationship. Onset time of LTG after administration was 1 to 2 hours, peak time was 3 to 4 hours, maintaining time was 8 to 10 hours. Conclusion LTG can improve cortex convulsions threshold in the electrical stimulated rats, there was no significant difference with carbamazepine, and showedadose-response relationship; Repeat dosing for 4 days, both domestic and imported LIG can maintain effective anticonvulsive effect, the efficacy and the aging of two groups of LTG have no significant difference (P＞0.05).

Citation： SUYu, HAOWeicheng, LIUCongxi, ZHAOYongxiong, LIUYuxi. Efficacy and aging comparative study of different doses and sources of lamotrigine on cortex convulsive threshold in electrical stimulated rats. Journal of Epilepsy, 2016, 2(2): 118-122. doi: 10.7507/2096-0247.20160022 Copy

1.	Liu Yuxi, Geng Leiyu. Experimental research on physiological and pathological electric convulsion thresholds in rats. Neural Regeneration Research, 2008, 3(3): 250-257.
2.	郝卫成, 苏彧, 刘玉玺. 伊来西胺与卡马西平在抗癫痫治疗中的时效与药效比较研究.中国药物与临床, 2012, 16(6): 739-741.
3.	Voskuyl RA, Dingemanse J, Danhof M. Determination of the threshold for convulsions by direct cortical stimulation. Epelepsy Res, 1989, 13(3): 120-129.
4.	Voskuyl RA,Hoogerkamp A, Danhof M. Properties of the convulsive threshold determined by direct cortical stimulation in rats. Epilepsy Res,1992, 12(6): 111-120.
5.	郝卫成, 刘玉玺. 拉莫三嗪对电刺激大鼠运动皮层惊厥模型干预的病理生理学研究. 中国药物与临床, 2008, 12(8): 963-966.
6.	苏彧,刘玉玺.迷走神经、躯体神经与运动皮质电刺激对戊四氮点燃大鼠惊厥行为影响的实验研究.中华神经科杂志,2010,43(7): 267-271.
7.	落成寿,康宏春,刘玉玺.拉莫三嗪消化道给药对大鼠惊厥阈值的影响,实用医技杂志, 2013, 20(7): 721-722.
8.	刘春, 任惠. 新型抗癫痫药物拉莫三嗪研究进展. 实用临床医学, 2015, 16(2): 104-107.
9.	邓洪, 廖齐. 林原斌.拉莫三嗪的合成. 中国医药工业杂志, 2006, 37(10): 657-658.
10.	王学峰, 晏勇, 沈鼎烈. 拉莫三嗪对难治性癫痫的治疗作用. 新药与临床, 1997, 16 (5): 260-263.
11.	Adachi M, Kawasaki Y. The effects of lamotrigine on refractory epilepsies in persons with severe motor and intellectual disabilities. Brain and Development, 2012, 44(6): 445-449.
12.	Saetre E, Abdelnoor M, Perucca E, et al. Aatiepileptic drugs and quality of life in the elderly:results fromarandomized double-blind trail of carbamazepine and lamotrigine in patients with onset of epilepsy in old age. Epilepsy & Behavior, 2001,17(3): 395-401.
13.	Tomson T, Hirsch LJ, Friedman D, et al. Sudden unexpected death in epilepey in lamotrigine tandomized-controlled trials. Epilepsia, 2013, 54(1): 135-140.
14.	郝卫成,苏彧,刘聪喜,等.利用电刺激大鼠皮层惊厥阈值模型测定不同剂量国产和进口左乙拉西坦的药效与时效.中国药物与临床,2015,(9):1261-1264.

1. Liu Yuxi, Geng Leiyu. Experimental research on physiological and pathological electric convulsion thresholds in rats. Neural Regeneration Research, 2008, 3(3): 250-257.
2. 郝卫成, 苏彧, 刘玉玺. 伊来西胺与卡马西平在抗癫痫治疗中的时效与药效比较研究.中国药物与临床, 2012, 16(6): 739-741.
3. Voskuyl RA, Dingemanse J, Danhof M. Determination of the threshold for convulsions by direct cortical stimulation. Epelepsy Res, 1989, 13(3): 120-129.
4. Voskuyl RA,Hoogerkamp A, Danhof M. Properties of the convulsive threshold determined by direct cortical stimulation in rats. Epilepsy Res,1992, 12(6): 111-120.
5. 郝卫成, 刘玉玺. 拉莫三嗪对电刺激大鼠运动皮层惊厥模型干预的病理生理学研究. 中国药物与临床, 2008, 12(8): 963-966.
6. 苏彧,刘玉玺.迷走神经、躯体神经与运动皮质电刺激对戊四氮点燃大鼠惊厥行为影响的实验研究.中华神经科杂志,2010,43(7): 267-271.
7. 落成寿,康宏春,刘玉玺.拉莫三嗪消化道给药对大鼠惊厥阈值的影响,实用医技杂志, 2013, 20(7): 721-722.
8. 刘春, 任惠. 新型抗癫痫药物拉莫三嗪研究进展. 实用临床医学, 2015, 16(2): 104-107.
9. 邓洪, 廖齐. 林原斌.拉莫三嗪的合成. 中国医药工业杂志, 2006, 37(10): 657-658.
10. 王学峰, 晏勇, 沈鼎烈. 拉莫三嗪对难治性癫痫的治疗作用. 新药与临床, 1997, 16 (5): 260-263.
11. Adachi M, Kawasaki Y. The effects of lamotrigine on refractory epilepsies in persons with severe motor and intellectual disabilities. Brain and Development, 2012, 44(6): 445-449.
12. Saetre E, Abdelnoor M, Perucca E, et al. Aatiepileptic drugs and quality of life in the elderly:results fromarandomized double-blind trail of carbamazepine and lamotrigine in patients with onset of epilepsy in old age. Epilepsy & Behavior, 2001,17(3): 395-401.
13. Tomson T, Hirsch LJ, Friedman D, et al. Sudden unexpected death in epilepey in lamotrigine tandomized-controlled trials. Epilepsia, 2013, 54(1): 135-140.
14. 郝卫成,苏彧,刘聪喜,等.利用电刺激大鼠皮层惊厥阈值模型测定不同剂量国产和进口左乙拉西坦的药效与时效.中国药物与临床,2015,(9):1261-1264.

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