Arc调控神经元突触可塑性作用_Journal of Epilepsy

Authors：

颜艳 ,  罗朝辉 , 龙泓羽 , 肖波

中南大学湘雅医院神经内科(长沙，410008);

Corresponding author：

罗朝辉, Email: xiaobo_xy@126.com

Keywords：

活性调节的细胞骨架蛋白; 突触可塑性; 癫痫; 海马

DOI：

10.7507/2096-0247.20160027

Video：

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Abstract Full text Figures/Tables Video References Cited by

癫痫是常见的神经系统疾病之一，为脑部神经元高度同步化异常放电，其发病机制尚不明确。海马结构的苔藓纤维出芽和突触重塑学说是其形成的主要病理基础，也是癫痫长期、反复发作的重要原因。活性调节的细胞骨架蛋白(Activity regulated cytoskeletal protein，Arc)是一种谷氨酸神经元突触后细胞骨架相关蛋白，属于即刻早期基因，在脊椎动物中高度保守，被认为是参与突触重塑的重要因子。现将Arc的表达转录特征、Arc参与神经元细胞突触可塑性的结构性和功能性改变、突触可塑性参与海马苔藓纤维出芽诱发癫痫的发病、Arc通过调控海马神经元细胞突触可塑性及MFS参与癫痫的发病进行阐述，为研究Arc的突触可塑性作用为阐明癫痫致病机制提供新的方向和思路。

Citation： 颜艳, 罗朝辉, 龙泓羽, 肖波. Arc调控神经元突触可塑性作用. Journal of Epilepsy, 2016, 2(2): 141-144. doi: 10.7507/2096-0247.20160027 Copy

1.	Liu YW, Mee EW. Adult neurogenesis in mesial temporal lobe epilepsy:areview of recent animal and human studies. Current Pharmaceutical Biotechnology, 2007, 8(3): 187-194.
2.	Sutula TP, Dudek FE. Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property ofacomplex system. Progress in Brain Research, 2007, 163(2): 541-563.
3.	Lyford GL, Yamagata K. Arc,agrowth factor and activity-regulated gene, encodesanovel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron, 1995, 14(2): 433-445.
4.	Shepherd JD, Bear T. New views of Arc,amaster regulator of synaptic plasticity. Nature Neuroscience, 2011, 14(3): 279-284.
5.	Szyndler J, Maciejak P. Changes in the Egr1 and Arc expression in brain structures of pentylenetetrazole-kindled rats. Pharmacological Reports, 2013, 65(2): 368-378.
6.	Saha RN, Wissink EM. Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II. Nat Neurosci, 2011, 14(7): 848-856.
7.	Giorgi C, Yeo GW. The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression. Cell, 2007, 130(1): 179-191.
8.	Ramirez-Amaya V, Vazdarjanova A. Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation. The Journal of Neuroscience, 2005, 25(7): 1761-1768.
9.	Moga DE, Calhoun ME. Activity-regulated cytoskeletal-associated protein is localized to recently activated excitatory synapses. Neuroscience, 2004, 125(1):7-11.
10.	Yilmaz-Rastoder E, Miyamae T. LTP- and LTD-inducing stimulations cause opposite changes in arc/arg3.1 mRNA level in hippocampal area CA1 in vivo. Hippocampus, 2011, 21(12): 1290-1301.
11.	Vazdarjanova A, Ramirez-Amaya V. Spatial exploration induces ARC,aplasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain. The Journal of Comparative Neurology, 2006, 498(3): 317-329.
12.	Chowdhury S, Shepherd JD. Arc/Arg 3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron, 2006, 52(3): 445-459.
13.	Peebles CL, Yoo J. Arc regulates spine morphology and maintains network stability in vivo. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107(42): 18173-18178.
14.	Montag-Sallaz M, Montag D. Learning-induced arg 3.1/arc mRNA expression in the mouse brain. Learning & Memory, 2003, 10(2): 99-107.
15.	Bramham CR, Alme MN. The Arc of synaptic memory. Experimental Brain Research, 2010, 200(2): 125-140.
16.	Guzowski JF, Lyford GR. Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. The Journal of Neuroscience, 2000, 20(11): 3993-4001.
17.	Rodriguez JJ, Davies HA. Long-term potentiation in the rat dentate gyrus is associated with enhanced Arc/Arg3.1 protein expression in spines, dendrites and glia. The European Journal of Neuroscience, 2005, 21(9): 2384-2396.
18.	Beique JC, Na Y. Arc-dependent synapse-specific homeostatic plasticity. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(2): 816-821.
19.	Chang BS, Lowenstein DH. Epilepsy. The New England Journal of Medicine, 2003, 349(13): 1257-1266.
20.	Zhang W, Thamattoor AK. Surviving mossy cells enlarge and receive more excitatory synaptic input inamouse model of temporal lobe epilepsy. Hippocampus, 2015, 25(5): 594-604.
21.	Gorter JA, van Vliet EA. Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and soma tostatin-immunore active neurons.The European Journal of Neuroscience, 2001, 13(4): 657-669.
22.	Ndode-Ekane XE, Hayward N. Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. Neuroscience, 2010, 166(1): 312-332.
23.	Wilkerson JR, Tsai NP. Arole for dendritic mGluR5-mediated local translation of Arc/Arg3.1 in MEF2-dependent synapse elimination. Cell Reports, 2014, 7(5): 1589-1600.
24.	Wang DC, Chen SS. Amyloid-beta at sublethal level impairs BDNF-induced arc expression in cortical neurons. Neuroscience Letters, 2006, 398(1-2): 78-82.
25.	Heinrich C, Lahteinen S. Increase in BDNF-mediated TrkB signaling promotes epileptogenesis inamouse model of mesial temporal lobe epilepsy. Neurobiology of Disease, 2011, 42(1): 35-47.
26.	You C, Zhang H. Reversal of deficits in dendritic spines, BDNF and Arc expression in the amygdala during alcohol dependence by HDAC inhibitor treatment. IntJNeuropsychopharmacol, 2014, 17(2): 313-322.
27.	Gu B, Huang YZ.Apeptide uncoupling BDNF receptor TrkB from phospholipase Cgamma1 prevents epilepsy induced by status epilepticus. Neuron, 2015, 88(3): 484-491.

1. Liu YW, Mee EW. Adult neurogenesis in mesial temporal lobe epilepsy:areview of recent animal and human studies. Current Pharmaceutical Biotechnology, 2007, 8(3): 187-194.
2. Sutula TP, Dudek FE. Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property ofacomplex system. Progress in Brain Research, 2007, 163(2): 541-563.
3. Lyford GL, Yamagata K. Arc,agrowth factor and activity-regulated gene, encodesanovel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron, 1995, 14(2): 433-445.
4. Shepherd JD, Bear T. New views of Arc,amaster regulator of synaptic plasticity. Nature Neuroscience, 2011, 14(3): 279-284.
5. Szyndler J, Maciejak P. Changes in the Egr1 and Arc expression in brain structures of pentylenetetrazole-kindled rats. Pharmacological Reports, 2013, 65(2): 368-378.
6. Saha RN, Wissink EM. Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II. Nat Neurosci, 2011, 14(7): 848-856.
7. Giorgi C, Yeo GW. The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression. Cell, 2007, 130(1): 179-191.
8. Ramirez-Amaya V, Vazdarjanova A. Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation. The Journal of Neuroscience, 2005, 25(7): 1761-1768.
9. Moga DE, Calhoun ME. Activity-regulated cytoskeletal-associated protein is localized to recently activated excitatory synapses. Neuroscience, 2004, 125(1):7-11.
10. Yilmaz-Rastoder E, Miyamae T. LTP- and LTD-inducing stimulations cause opposite changes in arc/arg3.1 mRNA level in hippocampal area CA1 in vivo. Hippocampus, 2011, 21(12): 1290-1301.
11. Vazdarjanova A, Ramirez-Amaya V. Spatial exploration induces ARC,aplasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain. The Journal of Comparative Neurology, 2006, 498(3): 317-329.
12. Chowdhury S, Shepherd JD. Arc/Arg 3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron, 2006, 52(3): 445-459.
13. Peebles CL, Yoo J. Arc regulates spine morphology and maintains network stability in vivo. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107(42): 18173-18178.
14. Montag-Sallaz M, Montag D. Learning-induced arg 3.1/arc mRNA expression in the mouse brain. Learning & Memory, 2003, 10(2): 99-107.
15. Bramham CR, Alme MN. The Arc of synaptic memory. Experimental Brain Research, 2010, 200(2): 125-140.
16. Guzowski JF, Lyford GR. Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. The Journal of Neuroscience, 2000, 20(11): 3993-4001.
17. Rodriguez JJ, Davies HA. Long-term potentiation in the rat dentate gyrus is associated with enhanced Arc/Arg3.1 protein expression in spines, dendrites and glia. The European Journal of Neuroscience, 2005, 21(9): 2384-2396.
18. Beique JC, Na Y. Arc-dependent synapse-specific homeostatic plasticity. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(2): 816-821.
19. Chang BS, Lowenstein DH. Epilepsy. The New England Journal of Medicine, 2003, 349(13): 1257-1266.
20. Zhang W, Thamattoor AK. Surviving mossy cells enlarge and receive more excitatory synaptic input inamouse model of temporal lobe epilepsy. Hippocampus, 2015, 25(5): 594-604.
21. Gorter JA, van Vliet EA. Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and soma tostatin-immunore active neurons.The European Journal of Neuroscience, 2001, 13(4): 657-669.
22. Ndode-Ekane XE, Hayward N. Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. Neuroscience, 2010, 166(1): 312-332.
23. Wilkerson JR, Tsai NP. Arole for dendritic mGluR5-mediated local translation of Arc/Arg3.1 in MEF2-dependent synapse elimination. Cell Reports, 2014, 7(5): 1589-1600.
24. Wang DC, Chen SS. Amyloid-beta at sublethal level impairs BDNF-induced arc expression in cortical neurons. Neuroscience Letters, 2006, 398(1-2): 78-82.
25. Heinrich C, Lahteinen S. Increase in BDNF-mediated TrkB signaling promotes epileptogenesis inamouse model of mesial temporal lobe epilepsy. Neurobiology of Disease, 2011, 42(1): 35-47.
26. You C, Zhang H. Reversal of deficits in dendritic spines, BDNF and Arc expression in the amygdala during alcohol dependence by HDAC inhibitor treatment. IntJNeuropsychopharmacol, 2014, 17(2): 313-322.
27. Gu B, Huang YZ.Apeptide uncoupling BDNF receptor TrkB from phospholipase Cgamma1 prevents epilepsy induced by status epilepticus. Neuron, 2015, 88(3): 484-491.

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