Roles of Hippocampal long-term potentiation in chronic cognitive dysfunction of immature epileptic rats_Journal of Epilepsy

Authors：

 JIANGJun ¹ , LUOXiaoqing ¹ , LICheng ¹ , KUANGGuangtao ¹ , WANGXiaolu ¹ , LIANGJufang ¹ , LIUMingyang ¹ ,  LIUZhisheng ²

1. Department of Electrophysiology, Wuhan women and children health care center, Wuhan 430015, China;
2. Department of Neurology, Wuhan women and children health care center, Wuhan 430015, China;

Corresponding author：

LIUZhisheng, Email: liuzsc@126.com

Keywords：

Epilepsy; Cognitive function; Hippocampus; Long-term potentiation; Field potential; Rats

DOI：

10.7507/2096-0247.20160041

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Objective To investigate the effects of hippocampal long-term potentiation (LTP) on cognitive dysfunction in immature epileptic rats. Methods Immature epileptic rats were established by intraperitoneal injection of lithium chloride-pilocarpine (li-pilo). Racine classification standard modified by Becker was used to evaluate behavior of epileptic seizure, and the survival rats within RacineⅣmagnitude were selected in the experiment. The function of learning and memory of epileptic rats when they were adult was assessed using Morris water maze experiment, and their independent exploratory behavior was evaluated by the open-field test. Field potential was recorded by electrophysiological technology to detecte whether hippocampal LTP was essential of cognitive dysfunction. Results The function of learning and memory was significantly impaired when compared with controls(n=8, t=10.86, P < 0.05;n=8, t=9.98, P < 0.05). In addition, independent exploratory behavior was significantly reduced when compared with controls(n=8, t=12.89, P < 0.05). Besides, CA1 hippocampal LTP induced by high-frequency stimulation presented the significant inhibition in epileptic rats with cognitive dysfunction when compared with controls(Slope:n=8, t=13.32, P < 0.05;Amplitude:n=8, t=20.02, P < 0.05). Conclusion Inhibition of CA1 hippocampal LTP may be implicated in cognitive dysfunction of epileptic rats.

Citation： JIANGJun, LUOXiaoqing, LICheng, KUANGGuangtao, WANGXiaolu, LIANGJufang, LIUMingyang, LIUZhisheng. Roles of Hippocampal long-term potentiation in chronic cognitive dysfunction of immature epileptic rats. Journal of Epilepsy, 2016, 2(3): 220-223. doi: 10.7507/2096-0247.20160041 Copy

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1. Rodrigues GR, Kandratavicius L, Peixoto-Santos JE, et al. Increased frequency of hippocampal sclerosis ILAE type 2 in patients with mesial temporal lobe epilepsy with normal episodic memory. Brain, 2015, 138(6):e359.
2. Voets NL, Menke RA, Jbabdi S, et al. Thalamo-cortical disruption contributes to short-term memory deficits in patients with medial temporal lobe damage. Cereb Cortex, 2015, 25(11):4584-4595.
3. Berg AT, Langfitt JT, Testa FM, et al. Global cognitive function in children with epilepsy:a community-based study. Epilepsia, 2008, 49(4):608-614.
4. Kanner AM, Schachter SC, Barry JJ, et al. Depression and epilepsy:epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence. Epilepsy Behav, 2012, 24(2):156-168.
5. Galioto R, Blum AS, Tremont G. Subjective cognitive complaints versus objective neuropsychological performance in older adults with epilepsy. Epilepsy Behav, 2015, 51(10):48-52.
6. Englot DJ, Hinkley LB, Kort NS, et al. Global and regional functional connectivity maps of neural oscillations in focal? epilepsy. Brain, 2015, 138(8):2249-2262.
7. Saffarzadeh F, Eslamizade MJ, Ghadiri T, et al. Effects of TRPV1 on the hippocampal synaptic plasticity in the epileptic rat brain. Synapse, 2015, 69(7):375-383.
8. Bliss TV, Collingridge GL. A synaptic model of memory:long-term potentiation in the hippocampus. Nature, 1993, 361 (6407):31-39.
9. Chen Y, Chen AQ, Luo XQ, et al. Hippocampal NR2B-containing NMDA receptors enhance long-term potentiation in rats with chronic visceral pain. Brain Res, 2014, 1570(21):43-53.
10. Racine RJ. Modification of seizure activity by electrical stimulationⅡ.Motor Seizure. Electroencephogr Clin Neurophysiol, 1972, 32(6):781-794.
11. Ling DS, Benardo LS, Serrano PA, et al. Protein kinase Mzeta is necessary andsufficient for LTP maintenance. Nat Neurosci, 2002, 5(1):295-296.

Journal of Epilepsy

Roles of Hippocampal long-term potentiation in chronic cognitive dysfunction of immature epileptic rats

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