Toll样受体信号通道在大脑皮层发育畸形中的研究_Journal of Epilepsy

Authors：

泸州医学院附属第一医院神经内科, 泸州 646000;

Corresponding author：

Keywords：

Toll样受体信号通道; 皮层发育畸形; 炎性反应; 难治性癫痫

DOI：

10.7507/2096-0247.20160047

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大脑皮层发育畸形(Malformation of cortical development, MCD)是导致难治性癫痫的常见原因之一。随着神经影像学、神经生理学、分子生物学、基因组学的发展, 国内外学者对MCD发病机制研究的不断深入, 越来越多的证据表明大脑内Toll样受体(Toll-like receptors, TLR)信号通道参与其中。TLR信号通道作为一种重要的炎性信号介导通道, 广泛存在于机体各系统组织, 参与多种免疫炎性反应的发生、发展。最近的实验研究表明, 存在于大脑组织中的TLR信号通道可能介导MCD的产生, 从而导致难治性癫痫。现就围绕TLR信号通道与MCD关系作一综述, 为MCD的信号通道研究提供依据

Citation： 毛福群, 马勋泰. Toll样受体信号通道在大脑皮层发育畸形中的研究. Journal of Epilepsy, 2016, 2(3): 252-254. doi: 10.7507/2096-0247.20160047 Copy

1.	Leventer RJ, Guerrini R, Dobyns WB, et al. Malformations of cortical development and epilepsy. Dialogues Clin Neurosci, 2008, 10(1):47-62.
2.	AJ Barkovich, R Guerrini, RI Kuzniecky, et al. A developmental and genetic classification for malformations of cortical development. Brain, 2012, 135 (5):1348-1369.
3.	A Ishii, A Matsuo, H Sawa, et al. Lamprey TLRs with Properties Distinct from Those of the Variable Lymphocyte Receptors. The Journal of Immunology, 2007, 178(1):397-406.
4.	EM Jimenez-Mateos, DC Henshall. Epilepsy and microRNA. Neuroscience, 2013, 238(6):218-229.
5.	B Manning, L Cantley. AKT/PKB signaling:navigating downstream. Cell, 2007, 129 (7):1261-1274.
6.	KS Michelsen, M Arditi. Toll-like receptors and innate immunity in gut homeostasis and pathology. Current Opinion in Hematology, 2007, 14(1):48-54.
7.	T Kawai, S Akira. The role of pattern-recognition receptors in innate immunity:update on Toll-like receptors. Nature Immunology, 2010, 11(5):373-384.
8.	A Iyer, E Zurolo, A Prabowo, et al. MicroRNA-146a:a key regulator of astrocyte-mediated inflammatory response. Plos One, 2012, 7 (9):e44789.
9.	AS Prabowo, JJ Anink, M Lammens, et al. Fetal brain lesions in tuberous sclerosis complex:TORC1 activation and inflammation. Brain Pathol, 2013, 23 (1):45-59.
10.	Zurolo E, Iyer A, Maroso M, et al. Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development. Brain, 2011, 134(4):1015-1032.
11.	A Mazarati, M Maroso, V Iori, et al. High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and receptor for advanced glycation end products. Experimental Neurology, 2011, 232(2):143-148.
12.	Rosen GD, Azoulay NG, Griffin EG, et al. Bilateral subcortical heterotopia with partial callosal agenesis in a mouse mutant. Cereb Cortex, 2013, 23(4):859-872.
13.	Vontell R, Supramaniam V, Thornton C, et al. Toll-like receptor 3 expression in glia and neurons alters in response to white matter injury in preterm infants. Developmental Neuroscience, 2013, 35 (2-3):130-139.
14.	JJ Volpe. Neonatal encephalitis and white matter injury:more than just inflammation?. Annals of Neurology, 2008, 64(3):232-236.

1. Leventer RJ, Guerrini R, Dobyns WB, et al. Malformations of cortical development and epilepsy. Dialogues Clin Neurosci, 2008, 10(1):47-62.
2. AJ Barkovich, R Guerrini, RI Kuzniecky, et al. A developmental and genetic classification for malformations of cortical development. Brain, 2012, 135 (5):1348-1369.
3. A Ishii, A Matsuo, H Sawa, et al. Lamprey TLRs with Properties Distinct from Those of the Variable Lymphocyte Receptors. The Journal of Immunology, 2007, 178(1):397-406.
4. EM Jimenez-Mateos, DC Henshall. Epilepsy and microRNA. Neuroscience, 2013, 238(6):218-229.
5. B Manning, L Cantley. AKT/PKB signaling:navigating downstream. Cell, 2007, 129 (7):1261-1274.
6. KS Michelsen, M Arditi. Toll-like receptors and innate immunity in gut homeostasis and pathology. Current Opinion in Hematology, 2007, 14(1):48-54.
7. T Kawai, S Akira. The role of pattern-recognition receptors in innate immunity:update on Toll-like receptors. Nature Immunology, 2010, 11(5):373-384.
8. A Iyer, E Zurolo, A Prabowo, et al. MicroRNA-146a:a key regulator of astrocyte-mediated inflammatory response. Plos One, 2012, 7 (9):e44789.
9. AS Prabowo, JJ Anink, M Lammens, et al. Fetal brain lesions in tuberous sclerosis complex:TORC1 activation and inflammation. Brain Pathol, 2013, 23 (1):45-59.
10. Zurolo E, Iyer A, Maroso M, et al. Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development. Brain, 2011, 134(4):1015-1032.
11. A Mazarati, M Maroso, V Iori, et al. High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and receptor for advanced glycation end products. Experimental Neurology, 2011, 232(2):143-148.
12. Rosen GD, Azoulay NG, Griffin EG, et al. Bilateral subcortical heterotopia with partial callosal agenesis in a mouse mutant. Cereb Cortex, 2013, 23(4):859-872.
13. Vontell R, Supramaniam V, Thornton C, et al. Toll-like receptor 3 expression in glia and neurons alters in response to white matter injury in preterm infants. Developmental Neuroscience, 2013, 35 (2-3):130-139.
14. JJ Volpe. Neonatal encephalitis and white matter injury:more than just inflammation?. Annals of Neurology, 2008, 64(3):232-236.

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Toll样受体信号通道在大脑皮层发育畸形中的研究

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