儿童症状性局灶性癫痫和可疑症状性局灶性癫痫：一个观察性的前瞻性多中心研究_Journal of Epilepsy

Authors：

 MarilenaVecchi , CarmenBarba , De CarloDebora , 张乐 , 慕洁

Corresponding author：

MarilenaVecchi, Email: marilena.vecchi@sanita.padova.it

Keywords：

儿童癫痫; 症状性局灶性癫痫; 认知功能; 行为障碍; 难治性癫痫

DOI：

10.7507/2096-0247.20170023

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

描述新诊断的症状性局灶性癫痫 (Symptomatic focalepilepsies，FS) 和可疑症状性局灶性癫痫 (Presumed symptomatic focalepilepsies，FCE) 患儿入组时及入组后1个月以内的临床、神经心理学和心理病理学特征。将对这些患者入组后随访2~5年，以探究癫痫的病程和药物难治性癫痫的早期预测因素。在这个观察性的多中心全国性研究中，新诊断的FS或者FCE儿童 (年龄1个月~12.9岁) 在15个意大利儿童癫痫高级研究中心被连续纳入。纳入标准如下：①后天或发育因素导致的FS，以及FCE；②首次诊断为癫痫的年龄>1个月并且 < 13岁；③签署书面的知情同意书。临床、脑电图、神经影像以及神经心理资料都用于统计分析。最终纳入259例儿童 (女116例，男143例)。年龄中位数为4.4岁 (范围：1个月~12.9岁)，46.0%(n=119)≤3岁，24%(n=61)>3~6岁，30%(n=79)>6岁。71.8%的患儿神经系统检查正常。59.9%头部核磁共振 (MRI) 检查异常。年龄≤3岁组的患儿入组后第一个月发作的频率最高 (P < 0.000 1)。67.2%的患儿第一个月为单药治疗。在基线期，30%的患儿认知功能检查异常；21%存在行为问题。多因素分析发现，年幼儿和颞叶癫痫患儿起病后第一个月内发作频率>5次的几率更大。该项前瞻性的队列研究发现，儿童期起病的FS和FCE患者的许多特征与起病的年龄以及致痫灶的部位有关。

Citation： MarilenaVecchi, CarmenBarba, De CarloDebora, 张乐, 慕洁. 儿童症状性局灶性癫痫和可疑症状性局灶性癫痫：一个观察性的前瞻性多中心研究. Journal of Epilepsy, 2017, 3(2): 150-157. doi: 10.7507/2096-0247.20170023 Copy

1.	Cavazzutti GB. Epidemiology of different types of epilepsy in school age in the district of Modena, Italy. Epilepsia, 1980, 21(7): 57-62.
2.	Beghi E, Hesdorffer D. Prevalence of epilepsy-an unknown quantity. Epilepsia, 2014, 55(2): 963-967.
3.	Eriksson KJ, Koivikko MJ. Prevalence, classification, and severity of epilepsy and epileptic syndromes in children. Epilepsia, 1997, 38(3): 1275-1282.
4.	Oka E, Ohtsuka Y, Yoshinaga H, et al. Prevalence of childhood epilepsy and distribution of epileptic syndromes: a population-based survey in okayama Japan. Epilepsia, 2006, 47(10): 626-630.
5.	Wirrell EC, Grossardt BR, Wong-Kisiel LC, et al. Incidence and classification of new-onset epilepsy and epilepsy syndromes in children in olmsted county, minnesota from 1980 to 2004: a population-based study. Epilepsy Res, 2011, 95(1): 110-118.
6.	Berg AT, Shinnar S, Levy SR, et al. Early development of intractable epilepsy in children. Neurology, 2001, 56(6): 1445-1452.
7.	Berg AT, Rychlik K. The course of childhood-onset epilepsy over the first two decades: a prospective, longitudinal study. Epilepsia, 2015, 56(4): 40-48.
8.	Sinllanpää M, Anttinen A, Rinne JO, et al. Childhood-onset epilepsy five decades later. A prospective population-based cohort study. Epilepsia, 2015, 56(7): 1774-1783.
9.	Sinllanpää M, Saarinen M, Schmidt D. Long-term prognosis of seizures with onset in childhood. N Engl J Med, 1998, 338(8): 1715-1722.
10.	Geerts A, Brouwer O, Stroink H, et al. Onset of intractability and its course over time: the dutch study of epilepsy in childhood. Epilepsia, 2012, 53(9): 741-751.
11.	Geerts A, Arts WF, Stroink H, et al. Course and outcome of childhood epilepsy: a 15-year follow-up of the dutch study of epilepsy in childhood. Epilepsia, 2010, 51(2): 1189-1197.
12.	Sinllanpää M, Schmidt D. Is incident drug-resistance of childhoodonset epilepsy reversible?A long-term follow-up study. Brain, 2012, 135(6): 2256-2262.
13.	Berg AT, Zelko FA, Levy SR, et al. Age at onset of epilepsy, pharmacoresistance, and cognitive outcomes: a prospective cohort study. Neurology, 2012, 79(3): 1384-1391.
14.	Casetta I, Granieri E, Monetti VC, et al. Early predictors of intractability in childhood epilepsy: a community-based case-control study in copparo, italy. Acta NeurolScand, 1999, 99(11): 329-333.
15.	Cossu M, Lo Russo G, Francione S, et al. Epilepsy surgery in children: results and predictors of outcome on seizures. Epilepsia, 2008, 49(3): 65-72.
16.	Almane D, Jones J, Jackson D, et al. The social competence and behavioral problem substrate of new-and recent-onset childhood epilepsy. Epilepsy Behav, 2014, 31(2): 91-96.
17.	Baca CB, Vickrey BG, Caplan R, et al. Psychiatric and medical comorbidity and quality of life outcomes in childhood-onset epilepsy. Pediatrics, 2011, 128(3): e1532-1543.
18.	Rantanen K, Timonen S, Hagstre om K, et al. Social competence of preschool children with epilepsy. Epilepsy Behav, 2009, 14(3): 338-343.
19.	Danielsson S, Viggedal G, Steffenburg S, et al. Psychopathology, psychosocial functioning and IQ before and after epilepsy surgery in children with drug-resistant epilepsy. Epilepsy Behav, 2009, 14(2): 330-337.
20.	Blume WT, Luders HO, Mizrahi E, et al. Glossary of descriptive terminology for ictal semiology: report of the ILAE task force on classification and terminology. Epilepsia, 2001, 42(7): 1212-1218.
21.	Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE commission on classification and terminology, 2005-2009. Epilepsia, 2010, 51(2): 676-685.
22.	Sannio Fancello G, Cianchetti C. WPPSI-3: contributoallataraturaitaliana. Firenze: Giunti O. S. 2008.
23.	Achenbach TM, Ruffle TM. The child behavior checklist and related forms for assessing behavioral/emotional problems and competencies. Pediatr Rev, 2000, 21(4): 265-271.
24.	Gleissner U, Sassen R, Schramm J, et al. Greater functional recovery after temporal lobe epilepsy surgery in children. Brain, 2005, 128(4): 2822-2829.
25.	Skirrow C, Cross JH, Cormack F, et al. Long-term intellectual outcome after temporal lobe surgery in childhood. Neurology, 2011, 76(12): 1330-1337.
26.	Sherman EM, Wiebe S, Fay-Mc Clymont TB, et al. Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates. Epilepsia, 2011, 52(3): 857-869.
27.	Reinholdson J, Olsson I, Edelvik A, et al. Long-term follow-up after epilepsy surgery in infancy and early childhood-a prospective population based observational study. Seizure, 2015, 30(4): 83-89.
28.	Hallböök T, Tideman P, Rosén I, et al. Epilepsy surgery in children with drug-resistant epilepsy, a long-term follow-up. Acta NeurolScand, 2013, 128(9): 414-421.
29.	Gleissner U, Kuczaty S, Clusmann H, et al. Neuropsychological results in pediatric patients with epilepsy surgery in the parietal cortex. Epilepsia, 2008, 49(7): 700-704.
30.	Samargia SA, Kimberley TJ. Motor and cognitive outcomes in children after functional emispherectomy. Pediatr Phys Ther, 2009, 21(2): 356-361.
31.	Skirrow C, Cross JH, Harrison S, et al. Temporal lobe surgery in childhood and neuroanatomical predictors of long-term declarative memory outcome. Brain, 2015, 138(8): 80-93.
32.	D'Argenzio L, Colonnelli MC, Harrison S, et al. Cognitive outcome after extratemporal epilepsy surgery in childhood. Epilepsia, 2011, 52(10): 1966-1972.
33.	Freitag H, Tuxorn I. Cognitive function in preschool children after epilespy surgery: rationale for early intervention. Epilepsia, 2005, 46(3): 561-567.
34.	Dunn DW, Austin JK, Perkins SM.Prevalence of psychopathology in childhood epilepsy: categorical and dimensional measures. Dev Med Child Neurol, 2009, 51(2): 364-372.
35.	Jonsson P, Jonsson B, Eeg-Olofsson O. Psychological and social outcome of epilepsy in well-functioning children and adolescents. A 10-year follow-up study. Eur J PaediatrNeurol, 2014, 18(4): 381-390.
36.	Baños JH, LaGory J, Sawrie S, et al. Self-report of cognitive abilities in temporal lobe epilepsy: cognitive, psychosocial, and emotional factors. Epilepsy Behav, 2004, 5(9): 575-579.
37.	Okumura A, Hayakawa F, Kato T, et al. Five-year follow-up of patients with partial epilepsies in infancy. PediatrNeurol, 2001, 24(7): 290-296.
38.	Austin JK, Huster GA, Dunn DW, et al. Adolescents with active or inactive epilepsy or asthma: a comparison of quality of life. Epilepsia, 1996, 37(5): 1228-1238.

1. Cavazzutti GB. Epidemiology of different types of epilepsy in school age in the district of Modena, Italy. Epilepsia, 1980, 21(7): 57-62.
2. Beghi E, Hesdorffer D. Prevalence of epilepsy-an unknown quantity. Epilepsia, 2014, 55(2): 963-967.
3. Eriksson KJ, Koivikko MJ. Prevalence, classification, and severity of epilepsy and epileptic syndromes in children. Epilepsia, 1997, 38(3): 1275-1282.
4. Oka E, Ohtsuka Y, Yoshinaga H, et al. Prevalence of childhood epilepsy and distribution of epileptic syndromes: a population-based survey in okayama Japan. Epilepsia, 2006, 47(10): 626-630.
5. Wirrell EC, Grossardt BR, Wong-Kisiel LC, et al. Incidence and classification of new-onset epilepsy and epilepsy syndromes in children in olmsted county, minnesota from 1980 to 2004: a population-based study. Epilepsy Res, 2011, 95(1): 110-118.
6. Berg AT, Shinnar S, Levy SR, et al. Early development of intractable epilepsy in children. Neurology, 2001, 56(6): 1445-1452.
7. Berg AT, Rychlik K. The course of childhood-onset epilepsy over the first two decades: a prospective, longitudinal study. Epilepsia, 2015, 56(4): 40-48.
8. Sinllanpää M, Anttinen A, Rinne JO, et al. Childhood-onset epilepsy five decades later. A prospective population-based cohort study. Epilepsia, 2015, 56(7): 1774-1783.
9. Sinllanpää M, Saarinen M, Schmidt D. Long-term prognosis of seizures with onset in childhood. N Engl J Med, 1998, 338(8): 1715-1722.
10. Geerts A, Brouwer O, Stroink H, et al. Onset of intractability and its course over time: the dutch study of epilepsy in childhood. Epilepsia, 2012, 53(9): 741-751.
11. Geerts A, Arts WF, Stroink H, et al. Course and outcome of childhood epilepsy: a 15-year follow-up of the dutch study of epilepsy in childhood. Epilepsia, 2010, 51(2): 1189-1197.
12. Sinllanpää M, Schmidt D. Is incident drug-resistance of childhoodonset epilepsy reversible?A long-term follow-up study. Brain, 2012, 135(6): 2256-2262.
13. Berg AT, Zelko FA, Levy SR, et al. Age at onset of epilepsy, pharmacoresistance, and cognitive outcomes: a prospective cohort study. Neurology, 2012, 79(3): 1384-1391.
14. Casetta I, Granieri E, Monetti VC, et al. Early predictors of intractability in childhood epilepsy: a community-based case-control study in copparo, italy. Acta NeurolScand, 1999, 99(11): 329-333.
15. Cossu M, Lo Russo G, Francione S, et al. Epilepsy surgery in children: results and predictors of outcome on seizures. Epilepsia, 2008, 49(3): 65-72.
16. Almane D, Jones J, Jackson D, et al. The social competence and behavioral problem substrate of new-and recent-onset childhood epilepsy. Epilepsy Behav, 2014, 31(2): 91-96.
17. Baca CB, Vickrey BG, Caplan R, et al. Psychiatric and medical comorbidity and quality of life outcomes in childhood-onset epilepsy. Pediatrics, 2011, 128(3): e1532-1543.
18. Rantanen K, Timonen S, Hagstre om K, et al. Social competence of preschool children with epilepsy. Epilepsy Behav, 2009, 14(3): 338-343.
19. Danielsson S, Viggedal G, Steffenburg S, et al. Psychopathology, psychosocial functioning and IQ before and after epilepsy surgery in children with drug-resistant epilepsy. Epilepsy Behav, 2009, 14(2): 330-337.
20. Blume WT, Luders HO, Mizrahi E, et al. Glossary of descriptive terminology for ictal semiology: report of the ILAE task force on classification and terminology. Epilepsia, 2001, 42(7): 1212-1218.
21. Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE commission on classification and terminology, 2005-2009. Epilepsia, 2010, 51(2): 676-685.
22. Sannio Fancello G, Cianchetti C. WPPSI-3: contributoallataraturaitaliana. Firenze: Giunti O. S. 2008.
23. Achenbach TM, Ruffle TM. The child behavior checklist and related forms for assessing behavioral/emotional problems and competencies. Pediatr Rev, 2000, 21(4): 265-271.
24. Gleissner U, Sassen R, Schramm J, et al. Greater functional recovery after temporal lobe epilepsy surgery in children. Brain, 2005, 128(4): 2822-2829.
25. Skirrow C, Cross JH, Cormack F, et al. Long-term intellectual outcome after temporal lobe surgery in childhood. Neurology, 2011, 76(12): 1330-1337.
26. Sherman EM, Wiebe S, Fay-Mc Clymont TB, et al. Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates. Epilepsia, 2011, 52(3): 857-869.
27. Reinholdson J, Olsson I, Edelvik A, et al. Long-term follow-up after epilepsy surgery in infancy and early childhood-a prospective population based observational study. Seizure, 2015, 30(4): 83-89.
28. Hallböök T, Tideman P, Rosén I, et al. Epilepsy surgery in children with drug-resistant epilepsy, a long-term follow-up. Acta NeurolScand, 2013, 128(9): 414-421.
29. Gleissner U, Kuczaty S, Clusmann H, et al. Neuropsychological results in pediatric patients with epilepsy surgery in the parietal cortex. Epilepsia, 2008, 49(7): 700-704.
30. Samargia SA, Kimberley TJ. Motor and cognitive outcomes in children after functional emispherectomy. Pediatr Phys Ther, 2009, 21(2): 356-361.
31. Skirrow C, Cross JH, Harrison S, et al. Temporal lobe surgery in childhood and neuroanatomical predictors of long-term declarative memory outcome. Brain, 2015, 138(8): 80-93.
32. D'Argenzio L, Colonnelli MC, Harrison S, et al. Cognitive outcome after extratemporal epilepsy surgery in childhood. Epilepsia, 2011, 52(10): 1966-1972.
33. Freitag H, Tuxorn I. Cognitive function in preschool children after epilespy surgery: rationale for early intervention. Epilepsia, 2005, 46(3): 561-567.
34. Dunn DW, Austin JK, Perkins SM.Prevalence of psychopathology in childhood epilepsy: categorical and dimensional measures. Dev Med Child Neurol, 2009, 51(2): 364-372.
35. Jonsson P, Jonsson B, Eeg-Olofsson O. Psychological and social outcome of epilepsy in well-functioning children and adolescents. A 10-year follow-up study. Eur J PaediatrNeurol, 2014, 18(4): 381-390.
36. Baños JH, LaGory J, Sawrie S, et al. Self-report of cognitive abilities in temporal lobe epilepsy: cognitive, psychosocial, and emotional factors. Epilepsy Behav, 2004, 5(9): 575-579.
37. Okumura A, Hayakawa F, Kato T, et al. Five-year follow-up of patients with partial epilepsies in infancy. PediatrNeurol, 2001, 24(7): 290-296.
38. Austin JK, Huster GA, Dunn DW, et al. Adolescents with active or inactive epilepsy or asthma: a comparison of quality of life. Epilepsia, 1996, 37(5): 1228-1238.

Previous Article
micro RNA调控癫痫的发生发展
Next Article
局灶性皮质发育不良和神经发育肿瘤的癫痫发作模式与手术预后和神经病理亚型的联系

Journal of Epilepsy

儿童症状性局灶性癫痫和可疑症状性局灶性癫痫：一个观察性的前瞻性多中心研究

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content