Clinical analysis of phase Ⅰ total corpus callosotomy in adults with intractable epilepsy_Journal of Epilepsy

Authors：

WANG Weiwen , LIU Bei , LIU Yong , LI Huanfa , JING Xiaorong , DONG Shan , ZHANG Wei ,  ZHANG Hua

Department of Neurosurgery, Tangdu Hospital of Air Force Military Medical University, Xian 710038, China;

Corresponding author：

ZHANG Hua, Email: zhanghuadoc@126.com

Keywords：

Adult refractory epilepsy; Total corpus callosotomy; Phase Ⅰ operation; Epileptic seizures

DOI：

10.7507/2096-0247.20170074

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Objective To investigate the efficacy and safety of the phase Ⅰ corpus callosotomy in the treatment of adult refractory epilepsy. Methods We conducted a retrospective analysis of 56 adults with intractable epilepsy in Tangdu Hospital from January 2011 to July 2016.All patients were treated for the phase Ⅰ total corpus callosotomy, followed up 1~5 years after surgery. Results 14 cases (25.0%) patients achieved complete seizure free after surgery, 19 cases (33.9%) whose seizures reduced more than 90%, 10 cases (17.9%) reduced between 50%~90%, 7 cases (12.5%) between 30%~50%, 6 cases (10.7%) decreased below 30%; Drop attacks of 47 cases (83.9%) patients disappeared. Postoperative complications occurred in 13 cases(23.2%), and most of them recovered well. 5 cases(8.9%) had long-term sensory disassociation, no serious complications and death. The percentage of patients reporting improvement in quality of life was 67.9%. Conclusions For patients with intractable epilepsy who can not undergo focal resection, Ⅰ phase total corpus callosotomy has a certain effect on reducing seizure frequency, eliminating drop attacks, and improving the quality of life.

Citation： WANG Weiwen, LIU Bei, LIU Yong, LI Huanfa, JING Xiaorong, DONG Shan, ZHANG Wei, ZHANG Hua. Clinical analysis of phase Ⅰ total corpus callosotomy in adults with intractable epilepsy. Journal of Epilepsy, 2017, 3(6): 470-473. doi: 10.7507/2096-0247.20170074 Copy

1.	Turani G, Yalnizoglu D, Genc-Acikgoz D, et al. Outcome and longterm follow-up after corpus callosotomy in childhood onset intractable epilepsy. Childs Nerv Syst, 2006, 22(10): 1322-1327.
2.	Sunaga S, Shimizu H, Sugano H.Long-term follow-up of seizure outcomes aftercorpus callosotomy. Seizure, 2009, 18(2): 124-128.
3.	Hofer S, Frahm J. Topography of the human corpus callosum revisited-comprehensive fiber tractography using diffusion tensor magnetic resonance imaging. Neuroimage, 2006, 32(3): 989-994.
4.	Goncalves-Ferreira AJ, Herculano C, Melancia JP, et al. Corpus callosum:microsurgical anatomy and MRI. Surg Radiol Anat, 2001, 23(6): 409-414.
5.	Erickson TC. Spread of the epileptic discharge: an experimental study of the afterdischarge induced by electrical stimulation of the cerebralcortex. Arch Neuro Psych, 1940, 43: 429-452.
6.	van Wagenen WP, Herren RY. Surgical division of commissural pathways in the corpus callosum, relation to spread of an epileptic attack. Arch Neuro Psych, 1940, 44: 740-759.
7.	Cukiert A, Burattini JA, Mariani PP, et al. Extended, one-stage callosal section for treatment of refractory secondarily generalized epilepsy in patients with Lennox-Gastaut and Lennox-like syndromes. Epilepsia, 2006, 47(2): 371-374.
8.	Shuli L, Shaohui Z, Xiaohong H, et al. Anterior corpus callosotomy in school-aged children with Lennox-Gastaut syndrome: a prospective study. Eur J Paediatr Neurol, 2014, 18(6): 670-676.
9.	Bauer G, Plonkapoltorak E, Bauer R, et al. Corpus callosum and epilepsies. Journal of Epileptology, 2013, 21(2): 89-104.
10.	Iwasaki M, Uematsu M, Nakayama T, et al. Parental satisfaction and seizure outcome after corpus callosotomy in patients with infantile or early childhood onset epilepsy. Seizure, 2013, 22(4): 303-305.
11.	李云林, 王晓飞, 郑瑞峰, 等.胼胝体全段一期切开治疗癫痫性脑病.临床神经外科杂志, 2012, 9(4): 217-219.
12.	Park MS, Nakagawa E, Schoenberg MR, et al. Outcome of corpus callosotomy in adults. Epilepsy Behav, 2013, 28(2): 181-184.
13.	Spencer SS. Corpus callosum section and other disconnection procedures for medically intractable epilepsy. Epilepsia, 1988, 29(Suppl 2): S85-S99.
14.	Sass KJ, Spencer DD, Spencer SS, et al. Corpus callosotomy for epilepsy. Ⅱ. Neurologic and neuropsychological outcome. Neurology, 1988, 38(1): 24-28.

1. Turani G, Yalnizoglu D, Genc-Acikgoz D, et al. Outcome and longterm follow-up after corpus callosotomy in childhood onset intractable epilepsy. Childs Nerv Syst, 2006, 22(10): 1322-1327.
2. Sunaga S, Shimizu H, Sugano H.Long-term follow-up of seizure outcomes aftercorpus callosotomy. Seizure, 2009, 18(2): 124-128.
3. Hofer S, Frahm J. Topography of the human corpus callosum revisited-comprehensive fiber tractography using diffusion tensor magnetic resonance imaging. Neuroimage, 2006, 32(3): 989-994.
4. Goncalves-Ferreira AJ, Herculano C, Melancia JP, et al. Corpus callosum:microsurgical anatomy and MRI. Surg Radiol Anat, 2001, 23(6): 409-414.
5. Erickson TC. Spread of the epileptic discharge: an experimental study of the afterdischarge induced by electrical stimulation of the cerebralcortex. Arch Neuro Psych, 1940, 43: 429-452.
6. van Wagenen WP, Herren RY. Surgical division of commissural pathways in the corpus callosum, relation to spread of an epileptic attack. Arch Neuro Psych, 1940, 44: 740-759.
7. Cukiert A, Burattini JA, Mariani PP, et al. Extended, one-stage callosal section for treatment of refractory secondarily generalized epilepsy in patients with Lennox-Gastaut and Lennox-like syndromes. Epilepsia, 2006, 47(2): 371-374.
8. Shuli L, Shaohui Z, Xiaohong H, et al. Anterior corpus callosotomy in school-aged children with Lennox-Gastaut syndrome: a prospective study. Eur J Paediatr Neurol, 2014, 18(6): 670-676.
9. Bauer G, Plonkapoltorak E, Bauer R, et al. Corpus callosum and epilepsies. Journal of Epileptology, 2013, 21(2): 89-104.
10. Iwasaki M, Uematsu M, Nakayama T, et al. Parental satisfaction and seizure outcome after corpus callosotomy in patients with infantile or early childhood onset epilepsy. Seizure, 2013, 22(4): 303-305.
11. 李云林, 王晓飞, 郑瑞峰, 等.胼胝体全段一期切开治疗癫痫性脑病.临床神经外科杂志, 2012, 9(4): 217-219.
12. Park MS, Nakagawa E, Schoenberg MR, et al. Outcome of corpus callosotomy in adults. Epilepsy Behav, 2013, 28(2): 181-184.
13. Spencer SS. Corpus callosum section and other disconnection procedures for medically intractable epilepsy. Epilepsia, 1988, 29(Suppl 2): S85-S99.
14. Sass KJ, Spencer DD, Spencer SS, et al. Corpus callosotomy for epilepsy. Ⅱ. Neurologic and neuropsychological outcome. Neurology, 1988, 38(1): 24-28.

Journal of Epilepsy

Clinical analysis of phase Ⅰ total corpus callosotomy in adults with intractable epilepsy

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