低血糖生成指数饮食治疗癫痫研究进展_Journal of Epilepsy

Authors：

尚丽 ¹ , 龚德山 ¹ , 郭辉 ¹ , 张翠荣 ¹ ,  王开颜 ²

1. ;
2. ;

Corresponding author：

王开颜, Email: 13917806739@163.com

Keywords：

生酮饮食; 低血糖生成指数饮食; 难治性癫痫

DOI：

10.7507/2096-0247.20180014

Video：

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Abstract Full text Figures/Tables Video References Cited by

尽管生酮饮食（Ketogenic diet，KD）可有效治疗难治性癫痫，但因其脂肪含量较高，口感油腻，且饮食限制过于严格，配餐制作繁琐，很多患者常难以耐受及坚持。低血糖生成指数饮食（Low glycemic index treatment，LGIT）做为改良的 KD，降低了脂肪比例，改善了饮食口感，更容易操作和耐受，且有效率与 KD 接近。现就 LGIT 的机制、实施方法及不良反应等进行阐述，以让更多的临床工作者进一步了解 LGIT。

Citation： 尚丽, 龚德山, 郭辉, 张翠荣, 王开颜. 低血糖生成指数饮食治疗癫痫研究进展. Journal of Epilepsy, 2018, 4(1): 56-58. doi: 10.7507/2096-0247.20180014 Copy

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6.	Pfeifer HH, Lyczkowski DA, Thiele EA. Low glycemic index treatment: implementation and new insights into efficacy. Epilepsia, 2008, 49(Suppl 8): 42-45.
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14.	Larson AM, Pfeifer HH, Thiele EA. Low glycemic index treatment for epilepsy in tuberous sclerosis complex. Epilepsy Res, 2012, 99(1-2): 180-182.
15.	Coppola G, D'Aniello A, Messana T, et al. Low glycemic index diet in children and young adults with refractory epilepsy: first Italian experience. Seizure, 2011, 20(7): 526-528.
16.	Kim SH, Kang HC, Lee EJ, et al. Low glycemic index treatment in patients with drug-resistant epilepsy. Brain Dev, 2017, 39(8): 687-692.
17.	Kizirian NV, Kong Y, Muirhead R, et al. Effects of alow-glycemic indexdiet during pregnancy on offspring growth, body composition, and vascular health: a pilot randomized controlled trial. Am J Clin Nutr, 2016, 103(4): 1073-1082.

1. Dhamija R, Eckert S, Wirrell E. Ketogenic diet. Can J Neurol Sci, 2013, 40(2): 158-167.
2. Gano LB, PatelM, Rho JM. Ketogenic diets, mitochondria, and neurological diseases. J Lipid Res, 2014, 55(11): 2211-2228.
3. Verrotti A, Iapadre G, Pisano S, et al.Ketogenic dietand childhood neurological disorders other than epilepsy: an overview. Expert Rev Neurother, 2017, 17(5): 461-473.
4. Sampaio LP. Ketogenic dietfor epilepsy treatment. Arq Neuropsiquiatr, 2016, 74(10): 842-848.
5. Kossoff EH, McGrogan JR, Bluml RM, et al. A modified Atkins diet is effective for the treatment of intractable pediatric epilepsy. Epilepsia, 2006, 47(2): 421-424.
6. Pfeifer HH, Lyczkowski DA, Thiele EA. Low glycemic index treatment: implementation and new insights into efficacy. Epilepsia, 2008, 49(Suppl 8): 42-45.
7. Pfeifer HH, Thiele EA. Low-glycemic-index treatment: a liberalized ketogenic diet for treatment of intractable epilepsy. Neurology, 2005, 65(11): 1810-1812.
8. Jenkins DJ, Wolever TM, Taylor RH, et al. Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr, 1981, 34(3): 362-366.
9. Bell SJ, Sears B. Low-glycemic-load diets: impact on obesity and chronic diseases. Crit Rev Food Sci Nutr, 2003, 43(4): 357-377.
10. Boison D. New insights into the mechanisms of theketogenic diet. Curr Opin Neurol, 2017, 30(2): 187-192.
11. Schwechter EM, Veliskova J, Velisek L. Correlation between extracellular glucose and seizure susceptibility in adult rats. Ann Neurol, 2003, 53(1): 91-101.
12. Muzykewicz DA, Lyczkowski DA, Memon N, et al. Efficacy, safety, and tolerability of the low glycemic index treatment in pediatric epilepsy. Epilepsia, 2009, 50(5): 1118-1126.
13. Karimzadeh P, Sedighi M, Beheshti M, et al. Low Glycemic Index Treatment in pediatric refractory epilepsy: the first Middle East report. Seizure, 2014, 23(7): 570-572.
14. Larson AM, Pfeifer HH, Thiele EA. Low glycemic index treatment for epilepsy in tuberous sclerosis complex. Epilepsy Res, 2012, 99(1-2): 180-182.
15. Coppola G, D'Aniello A, Messana T, et al. Low glycemic index diet in children and young adults with refractory epilepsy: first Italian experience. Seizure, 2011, 20(7): 526-528.
16. Kim SH, Kang HC, Lee EJ, et al. Low glycemic index treatment in patients with drug-resistant epilepsy. Brain Dev, 2017, 39(8): 687-692.
17. Kizirian NV, Kong Y, Muirhead R, et al. Effects of alow-glycemic indexdiet during pregnancy on offspring growth, body composition, and vascular health: a pilot randomized controlled trial. Am J Clin Nutr, 2016, 103(4): 1073-1082.

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低血糖生成指数饮食治疗癫痫研究进展

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