伴中央颞区棘波自限性癫痫患儿的认知功能：一项系统评价和荟萃分析_Journal of Epilepsy

Authors：

 StevenWickens , Stephen C.Bowden , WendylD’Souza , 高慧　译 , 慕洁　审

Corresponding author：

StevenWickens, Email: swickens@student.unimelb.edu.au

Keywords：

良性 rolandic 癫痫; 儿童癫痫; 局灶性癫痫; 神经心理学; 认知

DOI：

10.7507/2096-0247.20180029

Video：

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现在良性癫痫伴中央颞区棘波［（Benign epilepsy with centrotemporal spikes，BECTS），或近期多被称为 ECTS］与一系列认知和行为障碍相关的观点已经被广泛接受。尽管对 ECTS 的认知功能已经有了进一步的了解，目前仍没有在综合认知框架之下进行的量化分析研究。该系统评价和荟萃分析是在 PRISMA 指南的指导之下进行的。42 项对照研究满足纳入条件，共计包含 1 237 例 ECTS 患儿和 1 137 名健康对照儿童。对 8 个认知因素以及 Cattell-Horn-Carroll（CHC）智力模型进行单变量，随机效应荟萃分析。总体来说，ECTS 患儿在神经心理学测试中所有认知方面与健康对照相比均明显偏低。观测效应从 0.42～0.81 集中标准差单位不等，其中长期存储和获取为最大效应而视觉信息处理为最小效应。目前荟萃分析的结果首次提供了 ECTS 患儿展现一系列普遍性的认知障碍的证据，因此对目前认为 ECTS 是一个良性疾病或者认为仅存在局限性、特定认知功能损害的观点提出了挑战。

Citation： StevenWickens, Stephen C.Bowden, WendylD’Souza, 高慧　译, 慕洁　审. 伴中央颞区棘波自限性癫痫患儿的认知功能：一项系统评价和荟萃分析. Journal of Epilepsy, 2018, 4(2): 150-161. doi: 10.7507/2096-0247.20180029 Copy

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1. Holmes GL. Benign focal epilepsies of childhood. Epilepsia, 1993, 34: 49-61.
2. Panayiotopoulos CP. Epileptic syndromes and their treatment. Manchester: Springer Healthcare, 2010.
3. Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: position paper of the ILAE commission for classification and terminology. Epilepsia, 2017, 58(4): 512-521.
4. Gkampeta A, Pavlou E. Emerging genetic influences in benign epilepsy with centro-temporal spikes-BECTS. Epilepsy Res, 2012, 101(3): 197-201.
5. Vadlamudi L, Kjeldsen MJ, Corey LA, et al. Analyzing the etiology of benign rolandic epilepsy: a multicenter twin collaboration. Epilepsia, 2006, 47(3): 550-555.
6. Bouma PA, Bovenkerk AC, Westendorp RG, et al. The course of benign partial epilepsy of childhood with centrotemporal spikes: a meta-analysis. Neurology, 1997, 48(2): 430-437.
7. Vannest J, Tenney JR, Gelineau-Morel R, et al. Cognitive and behavioral outcomes in benign childhood epilepsy with centrotemporal spikes. Epilepsy Behav, 2015, 45: 85-91.
8. Vinayan KP, Biji V, Thomas SV. Educational problems with underlying neuropsychological impairment are common in children with benign epilepsy of childhood with centrotemporal spikes (BECTS). Seizure, 2005, 14(3): 207-212.
9. Yung AW, Park YD, Cohen MJ, et al. Cognitive and behavioral problems in children with centrotemporal spikes. Pediatr Neurol, 2000, 23(5): 391-395.
10. Kim EH, Yum MS, Kim HW, et al. Attention-deficit/hyperactivitydisorder and attention impairment in children with benign childhood epilepsy with centrotemporal spikes. Epilepsy Behav, 2014, 37: 54-58.
11. Weglage J, Demsky A, Pietsch M, et al. Neuropsychological, intellectual, and behavioral findings in patients with centrotemporal spikes with and without seizures. Dev Med Child Neurol, 1997, 39(10): 646-651.
12. *Xiao F, Lei D, An D, et al. Functional brain connectome and sensorimotor networks in rolandic epilepsy. Epilepsy Res, 2015, 113: 113-125.
13. *Ayaz M, Karakaya I, Ayaz AB, et al. Psychiatric and neurocognitive evaluation focused on frontal lobe functions in rolandic epilepsy. Noro Psikiyatr Ars, 2013, 50(3): 209-215.
14. *Taner Y, Erdogan-Bakar E, Turanli G, et al. Psychiatric evaluationof children with CSWS (continuous spikes and waves during slow sleep) and BRE (benign childhood epilepsy with centrotemporal spikes/rolandic epilepsy) compared to children with absence epilepsy and healthy controls. Turk J Pediatr, 2007, 49(4): 397-403.
15. Connolly AM, Northcott E, Cairns DR, et al. Qualityoflifeofchildren with benign rolandic epilepsy. Pediatr Neurol, 2006, 35(4): 240-245.
16. Verrotti A, Filippini M, Matricardi S, et al. Memory impairment and benign epilepsy with centrotemporal spike (BECTS): a growing suspicion. Brain Cogn, 2014, 84(1): 123-131.
17. Kavros PM, Clarke T, Strug LJ, et al. Attentionimpairmentinrolandic epilepsy: systematic review. Epilepsia, 2008, 49(9): 1570-1580.
18. Nicolai J, Aldenkamp AP, Arends J, et al. Cognitive and behavioral effects of nocturnal epileptiform discharges in children with benign childhood epilepsy with centrotemporal spikes. Epilepsy Behav, 2006, 8(1): 56-70.
19. *Jurkeviciene_ G, Endziniene_ M, Laukiene_ I, et al. Association of language dysfunction and age of onset of benign epilepsy with centrotemporal spikes in children. Eur J Paediatr Neurol, 2012, 16(6): 653-661.
20. *Lillywhite LM, Saling MM, Harvey SA, et al. Neuropsychological and functional MRI studies provide converging evidence of anterior language dysfunction in BECTS. Epilepsia, 2009, 50(10): 2276-2284.
21. Smith AB, Bajomo O, Pal DK. A meta-analysis of literacy and language in children with rolandic epilepsy. Dev Med Child Neurol, 2015, 57(11): 1019-1026.
22. Filippini M, Boni A, Giannotta M, et al. Neuropsychological development in children belonging to BECTS spectrum: long-term effect of epileptiform activity. Epilepsy Behav, 2013, 28(3): 504-511.
23. Aldenkamp AP, Arends J. Effects of epileptiform EEG discharges on cognitive function: is the concept of " transient cognitive impairment” still valid?. Epilepsy Behav, 2004, 5(Suppl 1): 25-34.
24. Mc Grew KS. CHC theory and the human cognitive abilities project: standing on the shoulders of the giants of psychometric intelligence research. Intelligence, 2009,37: 1-10.
25. Floyd RG, Bergeron R, Hamilton G, et al. How do executive functions fit with the Cattell-Horn-Carroll model? Some evidence from a joint factor analysis of the Delis-Kaplan executive function system and the Woodcock-Johnson III tests of cognitive abilities. Psychol Sch, 2010, 47: 721-738.
26. Larrabee GJ. Association between IQ and neuropsychological test performance: commentary on tremont, hoffman, scott, and adams (1998). Clin Neuropsychol 2000, 14(1): 139-145.
27. Loring DW, Larrabee GJ. Sensitivity of the Halstead and Wechsler test batteries to brain damage: evidence from reitan’s original validation sample. Clin Neuropsychol, 2006, 20(2): 221-229.
28. Loughman A, Bowden SC, D’souza W. Cognitive functioning in idiopathic generalised epilepsies: a systematic review and meta-analysis. Neurosci Biobehav Rev, 2014, 43: 20-34.
29. Jewsbury PA, Bowden SC. Construct validity of fluency and implications for the factorial structure of memory. J Psychoeduc Assess, 2016, 35: 460-481.
30. Jewsbury PA, Bowden SC, Strauss ME. Integrating the switching, inhibition, and updating model of executive function with the Cattell-Horn-Carroll model. J Exp Psychol Gen, 2016, 145(2): 220-245.
31. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg, 2010, 8(5): 336-341.
32. Newton JH, Mc Grew KS. Introduction to the special issue: current research in Cattell-Horn-Carroll-based assessment. Psychol Sch, 2010, 47: 621-634.
33. *D’Alessandro P, Piccirilli M, Tiacci C, et al. Neuropsychological features of benign partial epilepsy in children. Ital J Neurol Sci, 1990, 11(3): 265-269.
34. *Piccirilli M, D’Alessandro P, Sciarma T, et al. Attention problems in epilepsy: possible significance of the epileptogenic focus. Epilepsia, 1994, 35(5): 1091-1096.
35. *Riva D, Vago C, Franceschetti S, et al. Intellectual and language findings and their relationship to EEG characteristics in benign childhood epilepsy with centrotemporal spikes. Epilepsy Behav, 2007, 10(2): 278-285.
36. *Verrotti A, D’Egidio C, Agostinelli S, et al. Cognitive and linguistic abnormalities in benign childhood epilepsy with centrotemporal spikes. Acta Paediatr, 2011, 100(5): 768-772.
37. *Zhu Y, Yu Y, Shinkareva SV, et al. Intrinsic brain activity as a diagnostic biomarker in children with benign epilepsy with centrotemporal spikes. Hum Brain Mapp, 2015, 36(10): 3878-3889.
38. *Baglietto MG, Battaglia FM, Nobili L, et al. Neuropsychological disorders related to interictal epileptic discharges during sleep in benign epilepsy of childhood with centrotemporal or rolandic spikes. Dev Med Child Neurol, 2001, 43(6): 407-412.
39. *Tzitiridou M, Panou T, Ramantani G, et al. Oxcarbazepine monotherapy in benign childhood epilepsy with centrotemporal spikes: a clinical and cognitive evaluation. Epilepsy Behav, 2005, 7(3): 458-467.
40. *Vago C, Bulgheroni S, Franceschetti S, et al. Memory performance on the California Verbal Learning Test of children with benign childhood epilepsy with centrotemporal spikes. Epilepsy Behav, 2008, 13(4): 600-606.
41. *Lopes AF, Sim-oes MR, Monteiro JP, et al. Intellectual functioning in children with epilepsy: frontal lobe epilepsy, childhood absence epilepsy and benign epilepsy with centro-temporal spikes. Seizure, 2013, 22(10): 886-892.
42. *Lopes AF, Monteiro JP, Fonseca MJ, et al. Memory functioning in children with epilepsy: frontal lobe epilepsy, childhood absence epilepsy, and benign epilepsy with centrotemporal spikes. Behav Neurol, 2014, 2014: 218637.
43. Borenstein M, Hedges L, Higgins J, et al. Comprehensive meta analysis [computer program]. Englewood, NJ: Biostat, 2000.
44. Borenstein M, Hedges LV, Higgins J, et al. Introduction to meta-analysis. Hoboken, NJ: John Wiley & Sons, 2009.
45. Cohen J. The earth is round (P <. 05). Am Psychol, 1994, 49: 997-1003.
46. Sanderson S, Tatt ID, Higgins JP. Tools for assessing quality and susceptibility to bias in observational studies in epidemiology: a systematic review and annotated bibliography. Int J Epidemiol, 2007, 36(3): 666-676.
47. Wells GA, Shea B, O’connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses, 2008. Available at: http://ohri.ca/programs/ clinical_epidemiology/oxford.asp. Accessed January 27, 2016.
48. Stang A. Critical evaluation of the newcastle-ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
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