颞叶癫痫术后癫痫无发作不能使已改变的功能连接正常化_Journal of Epilepsy

Authors：

LuigiMaccotta ,  Mayra A.Lopez , BabatundeAdeyemo , 江欣玥　译 , 熊维希 , 慕洁　审

Corresponding author：

Mayra A.Lopez, Email: l.maccotta@wustl.edu

Keywords：

颞叶癫痫; 癫痫手术; 功能核磁共振; 功能网络; 纵向研究

DOI：

10.7507/2096-0247.20180045

Video：

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癫痫患者大脑网络的功能连接存在特异性改变。然而这种改变是疾病本身或是癫痫发作产生的结果尚不明确。研究为纵向研究，找对难治性颞叶癫痫患者（Temporal lobe epilepsy，TLE）手术前及术后发作得到控制后的标准认知功能网络连接。该研究纳入 17 例手术预后达到 Engel I 级的难治性 TLE 患者作为试验组，同时纳入 17 例匹配的正常受试者作为对照组。在手术前后使用经典认知任务以评估认知网络的功能连接（含对照组），并使用严格的方法消除伪影。TLE 患者在术前与健康对照组相比，功能连接存在显著差异，这种差异是广泛而非唯一的，包括默认网络以及颞叶/听觉子网络。然而，接受癫痫手术并且发作得到控制后患者的网络连接并未得到明显改善，术后功能网络的异常与术前几乎一致。研究结果提示，癫痫对大脑功能连接存在长期而持续的影响，当难治性 TLE 患者进行手术时（一般发生在首次诊断的数年后）此种改变已经不可逆转。此结果对于顽固性癫痫的治疗具有潜在的意义，提示延迟的手术治疗可能控制癫痫发作，但不能逆转疾病所导致的功能性大脑网络改变。

Citation： LuigiMaccotta, Mayra A.Lopez, BabatundeAdeyemo, 江欣玥　译, 熊维希, 慕洁　审. 颞叶癫痫术后癫痫无发作不能使已改变的功能连接正常化. Journal of Epilepsy, 2018, 4(3): 257-272. doi: 10.7507/2096-0247.20180045 Copy

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8.	Doucet GE, Rider R, Taylor N, et al. Presurgery resting-state local graph-theory measures predict neurocognitive outcomes after brain surgery in temporal lobe epilepsy. Epilepsia, 2015, 56(4): 517-526.
9.	Negishi M, Martuzzi R, Novotny EJ, et al. Functional MRI connectivity as a predictor of the surgical outcome of epilepsy. Epilepsia, 2011, 52(9): 1733-1740.
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14.	Pizoli CE, Shah MN, Snyder AZ, et al. Resting-state activity in development and maintenance of normal brain function. Proc Natl Acad Sci USA, 2011, 108(28): 11638-11643.
15.	Johnston JM, Vaishnavi SN, Smyth MD, et al. Loss of resting interhemispheric functional connectivity after complete section of the corpus callosum. J Neurosci, 2008, 28(25): 6453-6458.
16.	Engel J Jr, Van Ness PC, Rasmussen TB, et al. Outcome with respect to epileptic seizures. In: Engel J Jr (Ed)//Surgical treatment of the epilepsies. New York: Raven Press, 1993: 609-621.
17.	Power JD, Cohen AL, Nelson SM, et al. Functional network organization of the human brain. Neuron, 2011, 72(4): 665-678.
18.	Power JD, Mitra A, Laumann TO, et al. Methods to detect, characterize, and remove motion artifact in resting state fMRI. Neuroimage, 2014, 84: 320-341.
19.	Wieser HG. Ictal manifestations of temporal lobe seizures. Adv Neurol, 1991, 55: 301-315.
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22.	Bernhardt BC, Worsley KJ, Kim H, et al. Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy. Neurology, 2009, 72(20): 1747-1754.
23.	Song M, Du H, Wu N, et al. Impaired resting-state functional integrations within default mode network of generalized tonic-clonic seizures epilepsy. PLoS One, 2011, 6(2): e17294.
24.	Voets NL, Beckmann CF, Cole DM, et al. Structural substrates for resting network disruption in temporal lobe epilepsy. Brain, 2012, 135(Pt 8): 2350-2357.
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28.	Bernhardt BC, Bernasconi N, Concha L, et al. Cortical thickness analysis in temporal lobe epilepsy: reproducibility and relation to outcome. Neurology, 2010, 74(22): 1776-1784.
29.	Xiao F, An D, Lei D, et al. Real-time effects of centrotemporal spikes on cognition in rolandic epilepsy: an EEG-fMRI study. Neurology, 2016, 86(6): 544-551.
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31.	Baxendale S, Thompson P. Beyond localization: the role of traditional neuropsychological tests in an age of imaging. Epilepsia, 2010, 51(11): 2225-2230.
32.	Sherman EM, Wiebe S, Fay-McClymont TB, et al. Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates. Epilepsia, 2011, 52(5): 857-869.
33.	Detre JA, Maccotta L, King D, et al. Functional MRI lateralization of memory in temporal lobe epilepsy. Neurology, 1998, 50(4): 926-932.
34.	Jokeit H, Okujava M, Woermann FG. Memory fMRI lateralizes temporal lobe epilepsy. Neurology, 2001, 57(10): 1786-1793.
35.	Voets NL, Zamboni G, Stokes MG, et al. Aberrant functional connectivity in dissociable hippocampal networks is associated with deficits in memory. J Neurosci, 2014, 34(14): 4920-4928.
36.	Baldassarre A, Ramsey L, Hacker CL, et al. Large-scale changes in network interactions as a physiological signature of spatial neglect. Brain, 2014, 137(Pt 12): 3267-3283.
37.	Makin TR, Filippini N, Duff EP, et al. Network-level reorganisation of functional connectivity following arm amputation. Neuroimage, 2015, 114: 217-225.
38.	Glasser MF, Coalson TS, Robinson EC, et al. A multi-modal parcellation of human cerebral cortex. Nature, 2016, 536(7615): 171-178.
39.	Van Essen DC, Smith SM, Barch DM, et al. The wu-minn human connectome project: an overview. Neuroimage, 2013, 80: 62-79.
40.	Van Essen DC, Glasser MF, Dierker DL, et al. Parcellations and hemispheric asymmetries of human cerebral cortex analyzed on surfacebased atlases. Cereb Cortex, 2012, 22(10): 2241-2262.

1. Cataldi M, Avoli M, de Villers-Sidani E. Resting state networks in temporal lobe epilepsy. Epilepsia, 2013, 54(12): 2048-2059.
2. Liao W, Zhang Z, Pan Z, et al. Default mode network abnormalities in mesial temporal lobe epilepsy: a study combining fMRI and DTI. Hum Brain Mapp, 2011, 32(6): 883-895.
3. Maccotta L, He BJ, Snyder AZ, et al. Impaired and facilitated functional networks in temporal lobe epilepsy. Neuroimage Clin, 2013, 2: 862-872.
4. Douw L, DeSalvo MN, Tanaka N, et al. Dissociated multimodal hubs and seizures in temporal lobe epilepsy. Ann Clin Transl Neurol, 2015, 2(4): 338-352.
5. Tellez-Zenteno JF, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain, 2005, 128(Pt 5): 1188-1198.
6. McIntosh AM, Averill CA, Kalnins RM, et al. Long-term seizure outcome and risk factors for recurrence after extratemporal epilepsy surgery. Epilepsia, 2012, 53(6): 970-978.
7. Osipowicz K, Sperling MR, Sharan AD, et al. Functional MRI, resting state fMRI, and DTI for predicting verbal fluency outcome following resective surgery for temporal lobe epilepsy. J Neurosurg, 2016, 124(4): 929-937.
8. Doucet GE, Rider R, Taylor N, et al. Presurgery resting-state local graph-theory measures predict neurocognitive outcomes after brain surgery in temporal lobe epilepsy. Epilepsia, 2015, 56(4): 517-526.
9. Negishi M, Martuzzi R, Novotny EJ, et al. Functional MRI connectivity as a predictor of the surgical outcome of epilepsy. Epilepsia, 2011, 52(9): 1733-1740.
10. Weaver KE, Chaovalitwongse WA, Novotny EJ, et al. Local functional connectivity as a pre-surgical tool for seizure focus identification in non-lesion, focal epilepsy. Front Neurol, 2013, 4: 43.
11. Morgan VL, Sonmezturk HH, Gore JC, et al. Lateralization of temporal lobe epilepsy using resting functional magnetic resonance imaging connectivity of hippocampal networks. Epilepsia, 2012, 53(9): 1628-1635.
12. Ibrahim GM, Morgan BR, Smith ML, et al. Thalamocortical connectivity is enhanced following functional hemispherotomy for intractable lateralized epilepsy. Epilepsy Behav, 2015, 51: 281-285.
13. McCormick C, Quraan M, Cohn M, et al. Default mode network connectivity indicates episodic memory capacity in mesial temporal lobe epilepsy. Epilepsia, 2013, 54(5): 809-818.
14. Pizoli CE, Shah MN, Snyder AZ, et al. Resting-state activity in development and maintenance of normal brain function. Proc Natl Acad Sci USA, 2011, 108(28): 11638-11643.
15. Johnston JM, Vaishnavi SN, Smyth MD, et al. Loss of resting interhemispheric functional connectivity after complete section of the corpus callosum. J Neurosci, 2008, 28(25): 6453-6458.
16. Engel J Jr, Van Ness PC, Rasmussen TB, et al. Outcome with respect to epileptic seizures. In: Engel J Jr (Ed)//Surgical treatment of the epilepsies. New York: Raven Press, 1993: 609-621.
17. Power JD, Cohen AL, Nelson SM, et al. Functional network organization of the human brain. Neuron, 2011, 72(4): 665-678.
18. Power JD, Mitra A, Laumann TO, et al. Methods to detect, characterize, and remove motion artifact in resting state fMRI. Neuroimage, 2014, 84: 320-341.
19. Wieser HG. Ictal manifestations of temporal lobe seizures. Adv Neurol, 1991, 55: 301-315.
20. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. New York: Thieme Medical, 1988.
21. Briellmann RS, Wellard RM, Jackson GD. Seizure-associated abnormalities in epilepsy: evidence from MR imaging. Epilepsia, 2005, 46(5): 760-766.
22. Bernhardt BC, Worsley KJ, Kim H, et al. Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy. Neurology, 2009, 72(20): 1747-1754.
23. Song M, Du H, Wu N, et al. Impaired resting-state functional integrations within default mode network of generalized tonic-clonic seizures epilepsy. PLoS One, 2011, 6(2): e17294.
24. Voets NL, Beckmann CF, Cole DM, et al. Structural substrates for resting network disruption in temporal lobe epilepsy. Brain, 2012, 135(Pt 8): 2350-2357.
25. Hogan RE, Kaiboriboon K, Bertrand ME, et al. Composite SISCOM perfusion patterns in right and left temporal seizures. Arch Neurol, 2006, 63(10): 1419-1426.
26. Tae WS, Joo EY, Kim JH, et al. Cerebral perfusion changes in mesial temporal lobe epilepsy: SPM analysis of ictal and interictal SPECT. Neuroimage, 2005, 24(1): 101-110.
27. Van Paesschen W, Dupont P, Van Driel G, et al. SPECT perfusion changes during complex partial seizures in patients with hippocampal sclerosis. Brain, 2003, 126(Pt 5): 1103-1111.
28. Bernhardt BC, Bernasconi N, Concha L, et al. Cortical thickness analysis in temporal lobe epilepsy: reproducibility and relation to outcome. Neurology, 2010, 74(22): 1776-1784.
29. Xiao F, An D, Lei D, et al. Real-time effects of centrotemporal spikes on cognition in rolandic epilepsy: an EEG-fMRI study. Neurology, 2016, 86(6): 544-551.
30. Vogt VL, Aikia M, Del Barrio A, et al. Current standards of neuropsychological assessment in epilepsy surgery centers across Europe. Epilepsia, 2017, 58(3): 343-355.
31. Baxendale S, Thompson P. Beyond localization: the role of traditional neuropsychological tests in an age of imaging. Epilepsia, 2010, 51(11): 2225-2230.
32. Sherman EM, Wiebe S, Fay-McClymont TB, et al. Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates. Epilepsia, 2011, 52(5): 857-869.
33. Detre JA, Maccotta L, King D, et al. Functional MRI lateralization of memory in temporal lobe epilepsy. Neurology, 1998, 50(4): 926-932.
34. Jokeit H, Okujava M, Woermann FG. Memory fMRI lateralizes temporal lobe epilepsy. Neurology, 2001, 57(10): 1786-1793.
35. Voets NL, Zamboni G, Stokes MG, et al. Aberrant functional connectivity in dissociable hippocampal networks is associated with deficits in memory. J Neurosci, 2014, 34(14): 4920-4928.
36. Baldassarre A, Ramsey L, Hacker CL, et al. Large-scale changes in network interactions as a physiological signature of spatial neglect. Brain, 2014, 137(Pt 12): 3267-3283.
37. Makin TR, Filippini N, Duff EP, et al. Network-level reorganisation of functional connectivity following arm amputation. Neuroimage, 2015, 114: 217-225.
38. Glasser MF, Coalson TS, Robinson EC, et al. A multi-modal parcellation of human cerebral cortex. Nature, 2016, 536(7615): 171-178.
39. Van Essen DC, Smith SM, Barch DM, et al. The wu-minn human connectome project: an overview. Neuroimage, 2013, 80: 62-79.
40. Van Essen DC, Glasser MF, Dierker DL, et al. Parcellations and hemispheric asymmetries of human cerebral cortex analyzed on surfacebased atlases. Cereb Cortex, 2012, 22(10): 2241-2262.

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颞叶癫痫术后癫痫无发作不能使已改变的功能连接正常化

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