癫痫躯体共患病的研究进展_Journal of Epilepsy

Authors：

王艺霖 ,  张鸿

中国医科大学附属盛京医院神经内科（沈阳 110004）;

Corresponding author：

张鸿, Email: zhangh.7211@163.com

Keywords：

癫痫; 共患病; 躯体疾病

DOI：

10.7507/2096-0247.20180055

Video：

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癫痫是最常见的慢性神经系统疾病之一，随着癫痫研究的深入，癫痫共患病引起了人们的广泛关注。目前，癫痫精神行为共患病（如焦虑、抑郁、注意缺陷多动障碍、自闭症、精神发育迟滞、精神性厌食症、双相障碍、情绪障碍等）和神经系统共患病（如偏头痛、痴呆、阿尔茨海默病、中风、帕金森病、睡眠障碍、脑肿瘤、脑病等）已有许多报道，在此不再赘述。近年来，癫痫合并躯体共患病的报道越来越多，应当给予足够重视，现就癫痫躯体共患病研究进展做一综述。

Citation： 王艺霖, 张鸿. 癫痫躯体共患病的研究进展. Journal of Epilepsy, 2018, 4(4): 334-339. doi: 10.7507/2096-0247.20180055 Copy

1.	Mula M. Epilepsy and psychiatric comorbidities: drug selection. Curr Treat Options Neurol, 2017, 19(12): 44.
2.	Yuen AWC, Keezer MR, Sander JW. Epilepsy is a neurological and a systemic disorder. EpilepsyBehav, 2017, 8: 7-61.
3.	Adebayo PB, Akinyemi RO, Oluwole F, et al. Impact of somatic comorbidities on quality of life of patients living with epilepsyin sagamu nigeria. Acta Neurol Scand, 2014, 130(6): 387-393.
4.	Gaitatzis A, Sisodiya SM, Sander JW. The somatic comorbidity of epilepsy: a weighty but often unrecognized burden. Epilepsia, 2012, 53(8): 1282-1293.
5.	Keezer MR, Sisodiya SM, Sander JW. Comorbidities of epilepsy: current concepts and future perspectives. Lancet Neurol, 2016, 15(1): 106-115.
6.	Gaitatzis A, Sander JW. The mortality of epilepsy revisited. Epileptic Disord, 2004, 6(1): 3-13.
7.	Holmes GL, Noebels JL. The epilepsy spectrum: targeting future research challenges. Cold Spring Harb Perspect Med, 2016, 6(7): a028043.
8.	Vivanco-Hidalgo RM, Gomez A, Moreira A, et al. Prevalence of cardiovascular risk factors in people with epilepsy. Brain Behav, 2016, 7(2): e00618.
9.	Vivanco-Hidalgo RM, Elosua R, Gómez González A, et al. People with epilepsy receive more statins than the general population but have no higher cardiovascular risk: results from a cross-sectional study. Eur J Neurol, 2017, 24(2): 419-426.
10.	Chen Z, Liew D, Kwan P. Excess mortality and hospitalized morbidity in newly treated epilepsy patients. Neurology, 2016, 87(7): 718-725.
11.	Roberts JI, Patten SB, Wiebe S, et al. Health-related behaviors and comorbidities in people with epilepsy: changes in the past decade. Epilepsia, 2015, 56(12): 1973-1981.
12.	Shmuely S, van der Lende M, Lamberts RJ, et al. The heart of epilepsy: current views and future concepts. Seizure, 2017, 44: 176-183.
13.	Newale S, Bachani DS. Demographic characteristics of epilepsy patients and antiepileptic drug utilization in adult patients: results of a cross-sectional survey. Neurol India, 2016, 64(6): 1180-1186.
14.	Atanasova D, Tchekalarova J, Ivanova N, et al. Losartan suppresses the kainate-induced changes of angiotensin At1 receptor expression in a model of comorbid hypertension and epilepsy. Life Sci, 2018, 193: 40-46.
15.	Geyer JD, Geyer EE, Fetterman Z, et al. Epilepsy and restless legs syndrome. Epilepsy Behav, 2017, 68: 41-44.
16.	Montplaisir J, Lapierre O, Warnes H, et al. The treatment of the restless leg syndrome with or without periodic leg movements in sleep. Sleep, 1992, 15(5): 391-395.
17.	Chowdhury A, Brodie MJ. Pharmacological outcomes in juvenile myoclonic epilepsy: support for sodium valproate. Epilepsy Res, 2016, 119: 62-66.
18.	Aydin-Özemir Z, Matur Z, Baykan B, et al. Analysis of the tremor in juvenile myoclonic epilepsy. Epilepsy Res, 2016, 128: 140-148.
19.	Petty SJ, Milligan CJ, Todaro M, et al. The antiepileptic medications carbamazepine and phenyto in inhibit native sodium currents in murine osteoblasts. Epilepsia, 2016, 57(9): 1398-1405.
20.	Vestergaard P. Effects of antiepileptic drugs on bone health and growth potential in children withepilepsy. Paediatr Drugs, 2015, 17(2): 141-150.
21.	Gaitatzis A, Carroll K, Majeed A, et al. The epidemiology of the comorbidity of epilepsy in the general population. Epilepsia, 2004, 45(12): 1613-1622.
22.	Elliott JO, Lu B, Shneker B, et al. Comorbidity, health screening, and quality of life among persons with a history of epilepsy. Epilepsy Behav, 2009, 14(1): 125-129.
23.	Liu F, Wang X. Diagnosis and treatment of epilepsy and sleep apnea comorbidity. Expert Rev Neurother, 2017, 17(5): 475-485.
24.	Dinkelacker V. Obstructive sleep apnea in drug-resistan tepilepsy: a significant comorbidity warranting diagnosis and treatment. Rev Neurol (Paris), 2016, 172(6-7): 361-370.
25.	Jain SV, Simakajornboon S, Shapiro SM, et al. Obstructive sleep apnea in children with epilepsy: prospective pilot trial. Acta Neurol Scand, 2012, 125(1): e3-6.
26.	Garcia J, Wical B, Wical W, et al. Obstructive sleep apnea in children with cerebral palsy and epilepsy. Dev Med Child Neurol, 2016, 58(10): 1057-1062.
27.	Urquhart DS, Kehinde OO, Mclellan AE. Observational pilot study of reported symptoms of obstructive sleep apnoea in children with epilepsy. Dev Med Child Neurol, 2016, 58(10): 1063-1068.
28.	Ismayilova V, Demir AU, Tezer FI. Subjective sleep disturbance in epilepsy patients at an outpatient clinic: a questionnaire-based study on prevalence. Epilepsy Res, 2015, 115: 119-125.
29.	Elliott JO, Moore JL, Lu B. Health status and behavioral risk factors among persons with epilepsy in ohio based on the2006 behavioral risk factor surveillance system. Epilepsy Behav, 2008, 12(3): 434-444.
30.	Keezer MR, Novy J, Sander JW. Type 1 diabetes mellitus in people with pharmacoresistant epilepsy: prevalence and clinical characteristics. Epilepsy Res, 2015, 115: 55-57.
31.	Aparicio-Claure AL, Rayo-Mares JD, Nishimura-Meguro E, et al. Prevalence of subclinical hypothyroidism in pediatric patients with drug-resist antepilepsy. Rev Med Inst Mex Seguro Soc, 2017, 55(5): 579-586.
32.	Kaufman KR, Wong S, Sivaraaman K, et al. Epilepsy and AED-induced decreased libido - the unasked psychosocial comorbidity. Epilepsy Behav, 2015, 52(Pt A): 236-238.
33.	Pavone C, Giacalone N, Vella M, et al. Relation between sexual dysfunctions and epilepsy, type of epilepsy, type of antiepileptic drugs:a prospective study. Urologia, 2017, 84(2): 88-92.
34.	Vieira FC, Ronsoni MF, Hohl A, et al. How predictable is the erectile function of patients with epilepsy?. Epilepsy Behav, 2015, 47: 61-65.
35.	Hamed SA, Hermann BP, Moussa EM, et al. Evaluation of penile vascular status in men with epilepsy with erectile dysfunction. Seizure, 2015, 25: 40-48.
36.	Virta LJ, Kolho KL. The risk of contracting pediatric inflammatory bowel disease in children with celiac disease, epilepsy, juvenile arthritis and type 1 diabetes - a nationwide study. J Crohns Colitis, 2013, 7(1): 53-57.
37.	Yeh CC, Wang HH, Chou YC, et al. High risk of gastrointestinal hemorrhage in patients with epilepsy: a nationwide cohort study. Mayo Clin Proc, 2013, 88(10): 1091-1098.
38.	Wills A, Hovell CJ. Neurological complications of enteric disease. Gut, 1996, 39: 501-504.
39.	Buckley MM, O'Mahony SM, O'Malley D. Convergence of neuroendocrine-immune pathways in the pathophysiology of irritable bowel syndrome. World J Gastroenterol, 2014, 27: 8846-8858.
40.	Bonaz B, Picq C, Sinniger V, et al. Vagus nerve stimulation: from epilepsy to the cholinergic anti-inflammatory pathway. Neurogastroenterol Motil, 2013, 25(3): 208-221.
41.	Camara-Lemarroy CR, Escobedo-Zúñiga N, Ortiz-Zacarias D, et al. Prevalence and impact of irritable bowel syndrome in people with epilepsy. Epilepsy Behav, 2016, 63: 29-33.
42.	Baumgartner C, Lurger S, Leutmezer F. Autonomic symptoms during epileptic seizures. Epileptic Disord, 2001, 3(3): 103-116.
43.	Téllez-Zenteno JF, Matijevic S, Wiebe S. Somatic comorbidity of epilepsy in the general population in canada. Epilepsia, 2005, 46(12): 1955-1962.
44.	Ong MS, Kohane IS, Cai T, et al. Population-level evidence for an autoimmune etiology of epilepsy. JAMA Neurol, 2014, 71(5): 569-574.
45.	Morrell MJ. Reproductive and metabolic disorders in women with epilepsy. Epilepsia, 2003, 44(Suppl 4): 11-20.
46.	Arya R, Gillespie CW, Cnaan A, et al. Obesity and overweight as CAE comorbidities and differential drug response modifiers. Neurology, 2016, 86(17): 1613-1621.
47.	Wong J, Wirrell E. Physical activity in children/teens with epilepsy compared with that in their siblings without epilepsy. Epilepsia, 2006, 47(3): 631-639.
48.	Ottman R, Lipton RB, Ettinger AB, et al. Comorbidities of epilepsy: results from the Epilepsy comorbidities and health(EPIC) survey. Epilepsia, 2011, 52(2): 308-315.
49.	Novy J, Bell GS, Peacock JL, et al. Epilepsy as a systemic condition: Link with somatic comorbidities. Acta Neurol Scand, 2017, 136(4): 352-359.
50.	Guekht A. Epilepsy comorbidities and treatments. Curr Pharm Des, 2017, 23(37): 5702-5726.

1. Mula M. Epilepsy and psychiatric comorbidities: drug selection. Curr Treat Options Neurol, 2017, 19(12): 44.
2. Yuen AWC, Keezer MR, Sander JW. Epilepsy is a neurological and a systemic disorder. EpilepsyBehav, 2017, 8: 7-61.
3. Adebayo PB, Akinyemi RO, Oluwole F, et al. Impact of somatic comorbidities on quality of life of patients living with epilepsyin sagamu nigeria. Acta Neurol Scand, 2014, 130(6): 387-393.
4. Gaitatzis A, Sisodiya SM, Sander JW. The somatic comorbidity of epilepsy: a weighty but often unrecognized burden. Epilepsia, 2012, 53(8): 1282-1293.
5. Keezer MR, Sisodiya SM, Sander JW. Comorbidities of epilepsy: current concepts and future perspectives. Lancet Neurol, 2016, 15(1): 106-115.
6. Gaitatzis A, Sander JW. The mortality of epilepsy revisited. Epileptic Disord, 2004, 6(1): 3-13.
7. Holmes GL, Noebels JL. The epilepsy spectrum: targeting future research challenges. Cold Spring Harb Perspect Med, 2016, 6(7): a028043.
8. Vivanco-Hidalgo RM, Gomez A, Moreira A, et al. Prevalence of cardiovascular risk factors in people with epilepsy. Brain Behav, 2016, 7(2): e00618.
9. Vivanco-Hidalgo RM, Elosua R, Gómez González A, et al. People with epilepsy receive more statins than the general population but have no higher cardiovascular risk: results from a cross-sectional study. Eur J Neurol, 2017, 24(2): 419-426.
10. Chen Z, Liew D, Kwan P. Excess mortality and hospitalized morbidity in newly treated epilepsy patients. Neurology, 2016, 87(7): 718-725.
11. Roberts JI, Patten SB, Wiebe S, et al. Health-related behaviors and comorbidities in people with epilepsy: changes in the past decade. Epilepsia, 2015, 56(12): 1973-1981.
12. Shmuely S, van der Lende M, Lamberts RJ, et al. The heart of epilepsy: current views and future concepts. Seizure, 2017, 44: 176-183.
13. Newale S, Bachani DS. Demographic characteristics of epilepsy patients and antiepileptic drug utilization in adult patients: results of a cross-sectional survey. Neurol India, 2016, 64(6): 1180-1186.
14. Atanasova D, Tchekalarova J, Ivanova N, et al. Losartan suppresses the kainate-induced changes of angiotensin At1 receptor expression in a model of comorbid hypertension and epilepsy. Life Sci, 2018, 193: 40-46.
15. Geyer JD, Geyer EE, Fetterman Z, et al. Epilepsy and restless legs syndrome. Epilepsy Behav, 2017, 68: 41-44.
16. Montplaisir J, Lapierre O, Warnes H, et al. The treatment of the restless leg syndrome with or without periodic leg movements in sleep. Sleep, 1992, 15(5): 391-395.
17. Chowdhury A, Brodie MJ. Pharmacological outcomes in juvenile myoclonic epilepsy: support for sodium valproate. Epilepsy Res, 2016, 119: 62-66.
18. Aydin-Özemir Z, Matur Z, Baykan B, et al. Analysis of the tremor in juvenile myoclonic epilepsy. Epilepsy Res, 2016, 128: 140-148.
19. Petty SJ, Milligan CJ, Todaro M, et al. The antiepileptic medications carbamazepine and phenyto in inhibit native sodium currents in murine osteoblasts. Epilepsia, 2016, 57(9): 1398-1405.
20. Vestergaard P. Effects of antiepileptic drugs on bone health and growth potential in children withepilepsy. Paediatr Drugs, 2015, 17(2): 141-150.
21. Gaitatzis A, Carroll K, Majeed A, et al. The epidemiology of the comorbidity of epilepsy in the general population. Epilepsia, 2004, 45(12): 1613-1622.
22. Elliott JO, Lu B, Shneker B, et al. Comorbidity, health screening, and quality of life among persons with a history of epilepsy. Epilepsy Behav, 2009, 14(1): 125-129.
23. Liu F, Wang X. Diagnosis and treatment of epilepsy and sleep apnea comorbidity. Expert Rev Neurother, 2017, 17(5): 475-485.
24. Dinkelacker V. Obstructive sleep apnea in drug-resistan tepilepsy: a significant comorbidity warranting diagnosis and treatment. Rev Neurol (Paris), 2016, 172(6-7): 361-370.
25. Jain SV, Simakajornboon S, Shapiro SM, et al. Obstructive sleep apnea in children with epilepsy: prospective pilot trial. Acta Neurol Scand, 2012, 125(1): e3-6.
26. Garcia J, Wical B, Wical W, et al. Obstructive sleep apnea in children with cerebral palsy and epilepsy. Dev Med Child Neurol, 2016, 58(10): 1057-1062.
27. Urquhart DS, Kehinde OO, Mclellan AE. Observational pilot study of reported symptoms of obstructive sleep apnoea in children with epilepsy. Dev Med Child Neurol, 2016, 58(10): 1063-1068.
28. Ismayilova V, Demir AU, Tezer FI. Subjective sleep disturbance in epilepsy patients at an outpatient clinic: a questionnaire-based study on prevalence. Epilepsy Res, 2015, 115: 119-125.
29. Elliott JO, Moore JL, Lu B. Health status and behavioral risk factors among persons with epilepsy in ohio based on the2006 behavioral risk factor surveillance system. Epilepsy Behav, 2008, 12(3): 434-444.
30. Keezer MR, Novy J, Sander JW. Type 1 diabetes mellitus in people with pharmacoresistant epilepsy: prevalence and clinical characteristics. Epilepsy Res, 2015, 115: 55-57.
31. Aparicio-Claure AL, Rayo-Mares JD, Nishimura-Meguro E, et al. Prevalence of subclinical hypothyroidism in pediatric patients with drug-resist antepilepsy. Rev Med Inst Mex Seguro Soc, 2017, 55(5): 579-586.
32. Kaufman KR, Wong S, Sivaraaman K, et al. Epilepsy and AED-induced decreased libido - the unasked psychosocial comorbidity. Epilepsy Behav, 2015, 52(Pt A): 236-238.
33. Pavone C, Giacalone N, Vella M, et al. Relation between sexual dysfunctions and epilepsy, type of epilepsy, type of antiepileptic drugs:a prospective study. Urologia, 2017, 84(2): 88-92.
34. Vieira FC, Ronsoni MF, Hohl A, et al. How predictable is the erectile function of patients with epilepsy?. Epilepsy Behav, 2015, 47: 61-65.
35. Hamed SA, Hermann BP, Moussa EM, et al. Evaluation of penile vascular status in men with epilepsy with erectile dysfunction. Seizure, 2015, 25: 40-48.
36. Virta LJ, Kolho KL. The risk of contracting pediatric inflammatory bowel disease in children with celiac disease, epilepsy, juvenile arthritis and type 1 diabetes - a nationwide study. J Crohns Colitis, 2013, 7(1): 53-57.
37. Yeh CC, Wang HH, Chou YC, et al. High risk of gastrointestinal hemorrhage in patients with epilepsy: a nationwide cohort study. Mayo Clin Proc, 2013, 88(10): 1091-1098.
38. Wills A, Hovell CJ. Neurological complications of enteric disease. Gut, 1996, 39: 501-504.
39. Buckley MM, O'Mahony SM, O'Malley D. Convergence of neuroendocrine-immune pathways in the pathophysiology of irritable bowel syndrome. World J Gastroenterol, 2014, 27: 8846-8858.
40. Bonaz B, Picq C, Sinniger V, et al. Vagus nerve stimulation: from epilepsy to the cholinergic anti-inflammatory pathway. Neurogastroenterol Motil, 2013, 25(3): 208-221.
41. Camara-Lemarroy CR, Escobedo-Zúñiga N, Ortiz-Zacarias D, et al. Prevalence and impact of irritable bowel syndrome in people with epilepsy. Epilepsy Behav, 2016, 63: 29-33.
42. Baumgartner C, Lurger S, Leutmezer F. Autonomic symptoms during epileptic seizures. Epileptic Disord, 2001, 3(3): 103-116.
43. Téllez-Zenteno JF, Matijevic S, Wiebe S. Somatic comorbidity of epilepsy in the general population in canada. Epilepsia, 2005, 46(12): 1955-1962.
44. Ong MS, Kohane IS, Cai T, et al. Population-level evidence for an autoimmune etiology of epilepsy. JAMA Neurol, 2014, 71(5): 569-574.
45. Morrell MJ. Reproductive and metabolic disorders in women with epilepsy. Epilepsia, 2003, 44(Suppl 4): 11-20.
46. Arya R, Gillespie CW, Cnaan A, et al. Obesity and overweight as CAE comorbidities and differential drug response modifiers. Neurology, 2016, 86(17): 1613-1621.
47. Wong J, Wirrell E. Physical activity in children/teens with epilepsy compared with that in their siblings without epilepsy. Epilepsia, 2006, 47(3): 631-639.
48. Ottman R, Lipton RB, Ettinger AB, et al. Comorbidities of epilepsy: results from the Epilepsy comorbidities and health(EPIC) survey. Epilepsia, 2011, 52(2): 308-315.
49. Novy J, Bell GS, Peacock JL, et al. Epilepsy as a systemic condition: Link with somatic comorbidities. Acta Neurol Scand, 2017, 136(4): 352-359.
50. Guekht A. Epilepsy comorbidities and treatments. Curr Pharm Des, 2017, 23(37): 5702-5726.

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癫痫躯体共患病的研究进展

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