• Women’s Hospital School of Medicine Zhejiang university, Hangzhou 310002, China;
TANG Yingying, Email: 5514048@zju.edu.cn
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ObjectivesUsing systematic literature review to analyze the effects of levetiracetam (LEV) on neonatal safety during early pregnancy.MethodsThe scope of the literature must be English literature, published from 1997 to 2018. Meta-analysis was performed by random effects models.ResultsSeven literatures were included. A total of 672 cases exposed to LEV in treatment group and 772 234 cases in control groups were selected for meta-analysis. There was no significant difference in neonatal malignancy between treatment group and control group[OR=1.05, 95% CI (0.54, 2.02), P=0.37]. Further, we evaluated the effect of LEV monotherapy and polytherapy on neonatal safety, a total of 464 monotherapy cases and 632 polytherapy cases respectively were selected for meta-analysis. The results showed that there was no significant difference between these two therapies in neonatal malignancy [OR=0.54, 95% CI(0.31, 0.96), P=0.32].ConclusionsAs the papers we included, levetiracetam in the treatment of epilepsy during pregnancy is relatively safe for newborn.

Citation: TANG Yingying. The effects of levetiracetam on neonatal safety during early pregnancy: a meta analysis. Journal of Epilepsy, 2018, 4(5): 387-390. doi: 10.7507/2096-0247.20180063 Copy

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