睡眠对癫痫及癫痫发作的影响_Journal of Epilepsy

Authors：

袁潇 ,  孙美珍

山西医科大学第一医院神经内科（太原 030000）;

Corresponding author：

孙美珍, Email: sunmeizhen213@126.com

Keywords：

睡眠; 癫痫; 快速动眼睡眠; 非快速动眼睡眠

DOI：

10.7507/2096-0247.20190020

Video：

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癫痫是由多种原因导致的脑部神经元高度同步化异常放电所致、以具有持久性的致痫倾向为特征的脑部疾病。越来越多的研究证实，睡眠与癫痫具有十分紧密的关系，睡眠觉醒节律对癫痫发作及发作间期痫样放电有显著影响。不同类型癫痫及癫痫发作有着不同的昼夜节律，额叶癫痫较颞叶癫痫更易在睡眠中发作，但颞叶癫痫更易在睡眠中继发全面性发作。此外，不同类型癫痫发作会在特定的睡眠时相而增多，部分性发作及部分继发全面性发作在非快速动眼期睡眠明显增多，特别是在2期睡眠，而在快速动眼期睡眠则很少出现。非快速动眼期睡眠会促进发作间期痫样放电的发生，相反，快速动眼期睡眠则会抑制发作间期痫样放电的传播，进而限制其脑区的分布范围，从而有利于临床中对致痫灶的定位。

Citation： 袁潇, 孙美珍. 睡眠对癫痫及癫痫发作的影响. Journal of Epilepsy, 2019, 5(2): 113-115. doi: 10.7507/2096-0247.20190020 Copy

1.	中华医学会. 临床诊疗指南—癫痫病分册. 北京: 人民卫生出版社, 2007: 35-36.
2.	王兆瑞, 郑宽, 丁季强, 等. 癫痫病灶的定位研究与进展. 实用医学杂志, 2018, 34(6): 1036-1038.
3.	Passouant P. Historical views on sleep and epilepsy. In: Sterman MB, Shouse MN, Passouant P, eds. Sleep and epilepsy. New York: Academic Press, 1982: 1-6.
4.	Loddenkemper T, Vendrame M, Gotman J, et al. Circadian patterns of pediatric seizures. Neurology, 2011, 76: 145-153.
5.	Passouant P. Historical aspects of sleep and epilepsy. In: Degen R, Rodin EA, eds. Epilepsy, sleep, and sleep deprivation. 2nd ed. (Epilepsy Res Suppl2). Amsterdam: Elsevier scientific publishers, 1991: 19-22.
6.	Ng M, Pavlova M. Why are seizures rare in rapid eye movement sleep? review of the frequency of seizures in different sleep stages. Epilepsy Res Treat, 2013: 1-10.
7.	Bazil CW, Walczak TS. Effects of sleep and sleep stage on epileptic and nonepileptic seizures. Epilepsia, 1997, 38(1): 56-62.
8.	Crespel A, Coubes P, Baldy-Moulinier M. Sleep influence on seizuresand epilepsy effects on sleep in partial frontal and temporal lobe epilepsies. Clin Neurophysiol, 2000, 111(Suppl 2): 54-59.
9.	孙萍. 数字化长程视频脑电图在癫痫诊断中的应用研究. 大连: 大连医科大学, 硕士学位论文, 2008: 1-13.
10.	刘晓燕. 临床脑电图学. 北京: 人民卫生出版社, 2006: 126-240.
11.	Malow BA, Lin X, Kushwaha R, et al. Interictal spiking increases with sleep depth in temporal lobe epilepsy. Epilepsia, 1998, 39(12): 1309-1316.
12.	Malow BA, Kushwahab R, Lin X, et al. Relationship of interictal epileptiform discharges to sleep depth in partial epilepsy. Electroencephalogr and Clin Neurophysiol, 1997, 102(1): 20-26.
13.	吕王丹, 初凤娜, 孟红梅, 等. 癫痫患者 240 发作间期癫痫样放电与睡眠周期的关系. 中华神经科杂志, 2014, 47(1): 35-38.
14.	吴菡, 王钟瑾, 明文杰, 等. 长程视频脑电图监测癫痫患者发作间期痫样放电的时段分析. 浙江大学学报, 2017, 46(1): 30-35.
15.	Sammaritano M, Gigli GL, Gotman J. Interictal spiking during wakefulness and sleep and the localization of foci in temporal lobe epilepsy. Neurology, 1991, 41: 290-297.
16.	Ochi A, Hung R, Weiss S, et al. Lateralized interictal epileptiform discharges during rapid eye movement sleep correlate with epileptogenic hemisphere in children with intractable epilepsy secondary to tuberous sclerosis complex. Epilepsia, 2011, 52(11): 1986-1994.
17.	Minecan D, Natarajan A, Marzec M, et al. Relationship of epileptic seizures to sleep stage and sleep depth. Sleep, 2002, 25(8): 56-61.
18.	曾祥俊, 李晓泉. 痫样放电与睡眠周期的临床研究. 中国医药指南, 2017, 15(8): 137.
19.	Shouse MN, Siegel JM, Wu MF, et al. Mechanisms of seizure suppression during rapid- eye-movement (REM) sleep incats. Brain Res, 1989, 505(2): 271-282.
20.	Shouse MN, Farber PR, Staba RJ. Physiological basis: how NREM sleep components can promote and REM sleep components can suppress seizure discharge propagation. Clin Neurophysiol, 2000, 111(2): 9-18.
21.	何明颖. 无影像学改变的癫痫脑部结构变化的磁共振研究. 西安: 第四军医大学, 硕士学位论文, 2008: 1-19.
22.	Badawy RA, Harvey AS, Macdonell RA, et al. Cortical hyperexcitability and epileptogenesis: understanding the mechanisms of epilepsy-part 1. J Clin Neurosci, 2009, 16(3): 355-365.
23.	Frauscher B, von Ellenrieder N, Dubeau F, et al. EEG desynchronization during phasic REM sleep suppresses interictal epileptic activity in humans. Epilepsia, 2016, 57(6): 879-888.
24.	肖宇寒, 廖建湘, 黄娟, 等. 癫痫儿童发作间期癫痫样放电特点初步研究. 中国当代儿科杂志, 2008, 10(3): 322-324.
25.	黄远桂, 吴声伶. 临床脑电图学. 西安: 陕西科学技术出版社. 1984: 116-141.
26.	周升, 刘巧英. 癫痫与睡眠的相关性研究. 中国现代医学杂志, 2011, 21(1): 111-114.
27.	RocamoraR, Andrzejak RG, Jimenez-Conde J, et al. Sleep modulation of epileptic activity in mesial and neocortical temporal lobe epilepsy: a study with depth and subdural electrodes. Epilepsy Behav, 2013, 28(2): 185-190.
28.	赵莉. 癫痫与睡眠关系的脑电图分析. 山西医药杂志, 2013, 42(11): 1223-1224.
29.	Yu YL, Yan YL, Tian SF, et al. Circadian rhythm of interictal epileptiform discharges and changes of spindles in patients with temporal lobe epilepsy. Biomedi Res, 2018, 29(6): 1263-1267.
30.	Nobili L, Baglietto GM, Beelke EM, et al. Spindles-inducing mechanism modulates sleep activation of interictal epileptiform discharges in the Landua-Kleffner syndrome. Epilepsia, 2000, 41(1): 201-206.
31.	Drake ME Jr, PakalniA, Padamadan H, et al. Sleep spindles in epilepsy. Clin Electroencephalogr, 1991, 22(3): 144-149.
32.	Busek P, Buskova J, Nevsimalova S, et al. Interictal epileptiform discharges and phasic phenomena of REM sleep. Epileptic Disord, 2010, 12(3): 217-221.

1. 中华医学会. 临床诊疗指南—癫痫病分册. 北京: 人民卫生出版社, 2007: 35-36.
2. 王兆瑞, 郑宽, 丁季强, 等. 癫痫病灶的定位研究与进展. 实用医学杂志, 2018, 34(6): 1036-1038.
3. Passouant P. Historical views on sleep and epilepsy. In: Sterman MB, Shouse MN, Passouant P, eds. Sleep and epilepsy. New York: Academic Press, 1982: 1-6.
4. Loddenkemper T, Vendrame M, Gotman J, et al. Circadian patterns of pediatric seizures. Neurology, 2011, 76: 145-153.
5. Passouant P. Historical aspects of sleep and epilepsy. In: Degen R, Rodin EA, eds. Epilepsy, sleep, and sleep deprivation. 2nd ed. (Epilepsy Res Suppl2). Amsterdam: Elsevier scientific publishers, 1991: 19-22.
6. Ng M, Pavlova M. Why are seizures rare in rapid eye movement sleep? review of the frequency of seizures in different sleep stages. Epilepsy Res Treat, 2013: 1-10.
7. Bazil CW, Walczak TS. Effects of sleep and sleep stage on epileptic and nonepileptic seizures. Epilepsia, 1997, 38(1): 56-62.
8. Crespel A, Coubes P, Baldy-Moulinier M. Sleep influence on seizuresand epilepsy effects on sleep in partial frontal and temporal lobe epilepsies. Clin Neurophysiol, 2000, 111(Suppl 2): 54-59.
9. 孙萍. 数字化长程视频脑电图在癫痫诊断中的应用研究. 大连: 大连医科大学, 硕士学位论文, 2008: 1-13.
10. 刘晓燕. 临床脑电图学. 北京: 人民卫生出版社, 2006: 126-240.
11. Malow BA, Lin X, Kushwaha R, et al. Interictal spiking increases with sleep depth in temporal lobe epilepsy. Epilepsia, 1998, 39(12): 1309-1316.
12. Malow BA, Kushwahab R, Lin X, et al. Relationship of interictal epileptiform discharges to sleep depth in partial epilepsy. Electroencephalogr and Clin Neurophysiol, 1997, 102(1): 20-26.
13. 吕王丹, 初凤娜, 孟红梅, 等. 癫痫患者 240 发作间期癫痫样放电与睡眠周期的关系. 中华神经科杂志, 2014, 47(1): 35-38.
14. 吴菡, 王钟瑾, 明文杰, 等. 长程视频脑电图监测癫痫患者发作间期痫样放电的时段分析. 浙江大学学报, 2017, 46(1): 30-35.
15. Sammaritano M, Gigli GL, Gotman J. Interictal spiking during wakefulness and sleep and the localization of foci in temporal lobe epilepsy. Neurology, 1991, 41: 290-297.
16. Ochi A, Hung R, Weiss S, et al. Lateralized interictal epileptiform discharges during rapid eye movement sleep correlate with epileptogenic hemisphere in children with intractable epilepsy secondary to tuberous sclerosis complex. Epilepsia, 2011, 52(11): 1986-1994.
17. Minecan D, Natarajan A, Marzec M, et al. Relationship of epileptic seizures to sleep stage and sleep depth. Sleep, 2002, 25(8): 56-61.
18. 曾祥俊, 李晓泉. 痫样放电与睡眠周期的临床研究. 中国医药指南, 2017, 15(8): 137.
19. Shouse MN, Siegel JM, Wu MF, et al. Mechanisms of seizure suppression during rapid- eye-movement (REM) sleep incats. Brain Res, 1989, 505(2): 271-282.
20. Shouse MN, Farber PR, Staba RJ. Physiological basis: how NREM sleep components can promote and REM sleep components can suppress seizure discharge propagation. Clin Neurophysiol, 2000, 111(2): 9-18.
21. 何明颖. 无影像学改变的癫痫脑部结构变化的磁共振研究. 西安: 第四军医大学, 硕士学位论文, 2008: 1-19.
22. Badawy RA, Harvey AS, Macdonell RA, et al. Cortical hyperexcitability and epileptogenesis: understanding the mechanisms of epilepsy-part 1. J Clin Neurosci, 2009, 16(3): 355-365.
23. Frauscher B, von Ellenrieder N, Dubeau F, et al. EEG desynchronization during phasic REM sleep suppresses interictal epileptic activity in humans. Epilepsia, 2016, 57(6): 879-888.
24. 肖宇寒, 廖建湘, 黄娟, 等. 癫痫儿童发作间期癫痫样放电特点初步研究. 中国当代儿科杂志, 2008, 10(3): 322-324.
25. 黄远桂, 吴声伶. 临床脑电图学. 西安: 陕西科学技术出版社. 1984: 116-141.
26. 周升, 刘巧英. 癫痫与睡眠的相关性研究. 中国现代医学杂志, 2011, 21(1): 111-114.
27. RocamoraR, Andrzejak RG, Jimenez-Conde J, et al. Sleep modulation of epileptic activity in mesial and neocortical temporal lobe epilepsy: a study with depth and subdural electrodes. Epilepsy Behav, 2013, 28(2): 185-190.
28. 赵莉. 癫痫与睡眠关系的脑电图分析. 山西医药杂志, 2013, 42(11): 1223-1224.
29. Yu YL, Yan YL, Tian SF, et al. Circadian rhythm of interictal epileptiform discharges and changes of spindles in patients with temporal lobe epilepsy. Biomedi Res, 2018, 29(6): 1263-1267.
30. Nobili L, Baglietto GM, Beelke EM, et al. Spindles-inducing mechanism modulates sleep activation of interictal epileptiform discharges in the Landua-Kleffner syndrome. Epilepsia, 2000, 41(1): 201-206.
31. Drake ME Jr, PakalniA, Padamadan H, et al. Sleep spindles in epilepsy. Clin Electroencephalogr, 1991, 22(3): 144-149.
32. Busek P, Buskova J, Nevsimalova S, et al. Interictal epileptiform discharges and phasic phenomena of REM sleep. Epileptic Disord, 2010, 12(3): 217-221.

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