Analysis of rural epilepsy management program tracking investigation and analysis in Hailin City Heilongjiang Province_Journal of Epilepsy

Authors：

HE Weili ¹ , YAN Shichun ¹ , MA Guangyu ² , HE Yizhan ² , Xu Lili ¹ ,  ZHANG Yaxu ¹

1. Division of Chronic Disease Control and Prevention, Heilongjiang Provincial Center for Disease Control and Prevention, Harbin 150030, China;
2. Mudanjiang Humanity Elderly Hospital, Mudanjiang 157003, China;

Corresponding author：

ZHANG Yaxu, Email: Dorcas555@163.com

Keywords：

Rural epilepsy; Follow-up management; Tracking investigation

DOI：

10.7507/2096-0247.20190056

Video：

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Objective To understand the treatment status and economic burden of convulsive epilepsy patients in Hailin City, Heilongjiang Province, who had received an epilepsy management program that was terminated for 6 years, and to estimate the long-term effect of the epilepsy management program.Methods Follow up the 234 patients in the program of epilepsy prevention and management in rural areas at the end of December 2011 by standardized questionnaire and interview.Results Among the 234 patients who received antiepileptic drugs (AEDs) and follow-up management at the end of epilepsy prevention and management program in rural areas, 172 patients received Phenobarbitone (PB) and 62 patients received Sodium valproate (VPA). 86 patients completed the survey. Among them, 46 (53.49%) were still taking original drugs, 31 (36.05%) changed to other AEDs, 9(10.47%) gave up the treatment due to the closure of the program. The treatment costs of patients in adherence group were also lower than that of other patients, and the average cost was only 43.61% of that of the replace group. There were statistical significant differences in annual household income, drug costs, offset seizure frequency and current seizure frequency between the two groups.Conclusion The epilepsy management program had remarkable long-term effects and short-term effects, it had advantages in treatment effect and reducing drug costs. It could be recommended throughout rural China.

Citation： HE Weili, YAN Shichun, MA Guangyu, HE Yizhan, Xu Lili, ZHANG Yaxu. Analysis of rural epilepsy management program tracking investigation and analysis in Hailin City Heilongjiang Province. Journal of Epilepsy, 2019, 5(5): 351-355. doi: 10.7507/2096-0247.20190056 Copy

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14.	王文志, 吴建中, 李世绰, 等. 我国农村地区 607 例癫痫患者应用丙戊酸钠治疗效果评价. 中华神经科杂志, 2011, 44(1): 15-19.
15.	Li LM, Fernandes PT, Noronha AL, et al. Demonstration project on epilepsy in Brazil: outcome assessment. Arquivos de Neuro-Psiquiatria, 2007, 65(28): 58.
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17.	Mani KS, Rangan G, Srinivas HV, et al. Epilepsy control with phenobarbital or phenytoin in rural south india: the yelandur stud. Lancet, 2001, 357(9265): 1316-1320.
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1. 常琳, 王小姗. 中国癫痫流行病学调查研究进展. 国际神经病学神经外科学杂志, 2012, 39(2): 161-164.
2. WHO. Epilepsy management at primary health level in rural China: WHO/ILAE/IBE. A Global Campaign Against Epilepsy Demonstration Project, 2009.
3. Liu L, Zhang Q, Yao Z, et al. The operational model of network for managing patients with convulsive epilepsy in rural West China. Epilepsy & Behavior, 2010, 17(1): 75-81.
4. Huang DH, Zheng JO, Chen J, et al. Treatment gaps of epilepsy and retention rates of sodium valproate in rural Guangxi, China. Genetics & Molecular Research Gmr, 2014, 13(3): 6202.
5. Kwan P, Wang W, Wu J, et al. Long-term outcome of phenobarbital treatment for epilepsy in rural China: a prospective cohort study. Epilepsia, 2013, 54(3): 537-542.
6. 李晓裔, 邵西仓, 陈佐俊, 等. 贵州农村惊厥性癫痫巴比妥治疗依从性分析. 世界最新医学信息文摘, 2016, (82): 11-12.
7. 王文志, 李涤, 茹晓娟, 等. 中国农村癫痫防治管理项目介绍. 癫痫杂志, 2016, 2(5): 414-417.
8. 王文志, 吴建忠, 戴秀英, 等. 应用苯巴比妥治疗中国农村地区 2455 例癫痫患者效果评估. 中华医学杂志, 2006, 86(19): 1297.
9. 王文志, 吴建忠, 戴秀英, 等. 中国六省农村地区 2455 例癫痫患者治疗管理效果观察. 中国现代神经疾病杂志, 2006, 6(5): 375-376.
10. 杨洪超, 王文志, 吴建中, 等. 世界卫生组织全球抗癫痫运动中国农村癫痫示范项目结束后四年随访结果. 中国现代神经疾病杂志, 2012, 12(5): 530-535.
11. Tracy G, Elinor BM, Blaise B, et al. ILAE treatment guidelines:evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Journal of Neurology & Neurorehabilitation, 2010, 47(7): 1094-1120.
12. Patrick K, Brodie MJ. Phenobarbital for the treatment of epilepsy in the 21st century: a critical review. Epilepsia, 2010, 45(9): 1141-1149.
13. Wang Wz, Wu Jz, Li Sc, et al. Sodium valproate for epilepsy in rural China: an efficacy and safety assessment in primary care. Epilepsy Research, 2012, 102(3): 201-205.
14. 王文志, 吴建中, 李世绰, 等. 我国农村地区 607 例癫痫患者应用丙戊酸钠治疗效果评价. 中华神经科杂志, 2011, 44(1): 15-19.
15. Li LM, Fernandes PT, Noronha AL, et al. Demonstration project on epilepsy in Brazil: outcome assessment. Arquivos de Neuro-Psiquiatria, 2007, 65(28): 58.
16. Feksi AT, Kaamugisha J, Sander JW, et al. Comprehensive primary health care antiepileptic drug treatment programme in rural and semi-urban Kenya. (International Community-based Epilepsy Research Group). Lancet, 1991, 337(8738): 406-409.
17. Mani KS, Rangan G, Srinivas HV, et al. Epilepsy control with phenobarbital or phenytoin in rural south india: the yelandur stud. Lancet, 2001, 357(9265): 1316-1320.
18. Wang WZ, Wu JZ, Ma GY, et al. Efficacy assessment of phenobarbital in epilepsy: a large community-based intervention trial in rural China. Lancet Neurology, 2006, 5(1): 46-52.
19. 国家统计局编. 《中国统计年鉴 2018》, 北京: 中国统计出版社: 1-949.
20. 赵否曦, 刘涛, 张益霞, 等. 农村癫痫人群癫痫治疗的成本-效果分析. 中国卫生经济, 2015, 34(12): 82-84.

Journal of Epilepsy

Analysis of rural epilepsy management program tracking investigation and analysis in Hailin City Heilongjiang Province

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